Targeting JAK/STAT pathway in Takayasu’s arteritis - Régnier, Paul; Le Joncour, Alexandre; Maciejewski-Duval, Anna; Desbois, Anne-Claire; Comarmond, Cloé; Rosenzwajg, Michelle; Klatzmann, David; Cacoub, Patrice; Saadoun, David (Annals of the rheumatic diseases, 2020)
Keywords: Adult; Aorta; Arteritis; C-reactive protein; CD25 antigen; CD4 antigen; CD8 antigen; Cell differentiation; Chemokines; Coronary vessels; Corticosteroids; Cytokines; Female; Flow cytometry; Gene expression; Helper cells; Humans; Immunomodulators; Inflammation; Interferon; Interferons; Janus kinase; Janus Kinase Inhibitors - pharmacology; Janus Kinases - metabolism; Kinases; Life Sciences; Lymphocyte Activation - drug effects; Lymphocytes; Lymphocytes T; Male; MAP Kinase Signaling System - genetics; Middle Aged; Patients; Polymerase chain reaction; Reverse transcription; Signal transduction; STAT Transcription Factors - metabolism; Takayasu Arteritis - drug therapy; Takayasu Arteritis - genetics; Th1 Cells; Th17 Cells; Transcription factors; Vasculitis; Vein & artery diseases; systemic vasculitis; cytokines; T cells; chemokines; inflammation