Association of Genetic Polymorphisms With Histological Grading of Necroinflammation, Staging of Fibrosis, and Liver Function in Mexicans With Chronic Hepatitis C Virus Infection
Background/AimThe aim of this work was to establish an association between the single-nucleotide polymorphisms (SNPs) of TGFB1 (rs1800471), AT (rs3789679), MMP-1 (rs17886084), MMP-3 (rs35068180), and PAI-1 (rs1799889) and the histological grading of necroinflammation, staging of hepatic fibrosis, an...
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| Published in | Journal of investigative medicine Vol. 61; no. 7; pp. 1088 - 1096 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Los Angeles, CA
SAGE Publications
01.10.2013
Sage Publications Ltd |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1081-5589 1708-8267 1708-8267 |
| DOI | 10.2310/JIM.0b013e3182a32e24 |
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| Abstract | Background/AimThe aim of this work was to establish an association between the single-nucleotide polymorphisms (SNPs) of TGFB1 (rs1800471), AT (rs3789679), MMP-1 (rs17886084), MMP-3 (rs35068180), and PAI-1 (rs1799889) and the histological grading of necroinflammation, staging of hepatic fibrosis, and liver function in Mexican patients with advanced liver fibrosis due to chronic hepatitis C virus infection.Methods AT, MMP-1, MMP-3, and PAI-1 gene polymorphisms were analyzed by polymerase chain reaction in real time, whereas TGFB1 polymorphism was detected by polymerase chain reaction–based restriction fragment length polymorphism in 38 patients with established advanced liver fibrosis and 50 subjects from the general population. Grading of necroinflammation and staging of liver fibrosis were assessed by liver biopsy and graded according to modified histological activity index Ishak score.ResultsRegarding TGFB1 SNP, significant differences were found between G/G and G/C genotypes of patients with hepatic necroinflammation (P = 0.05) and hepatic fibrosis (P = 0.002). There were also significant differences among genotypes of patients with the AT SNP in hepatic necroinflammation (P = 0.01). The albumin-globulin ratio between genotypes of patients with the MMP-3 SNP gene showed significant differences (P = 0.02).ConclusionOur findings demonstrate that a specific combination of genotypes associated with biochemical values and a histological high score determine more severe liver disease. The presence of the G/G genotype of TGFB1 SNP in patients was significantly associated with severity of liver necroinflammation and fibrosis. Patients with the G/G genotype of AT SNP were associated with severe necroinflammation. The albumin-globulin ratio was increased in patients with the 6A allele of MMP-3 SNP. These results might contribute to diagnosis and further establishment of liver disease treatment. |
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| AbstractList | The aim of this work was to establish an association between the single-nucleotide polymorphisms (SNPs) of TGFB1 (rs1800471), AT (rs3789679), MMP-1 (rs17886084), MMP-3 (rs35068180), and PAI-1 (rs1799889) and the histological grading of necroinflammation, staging of hepatic fibrosis, and liver function in Mexican patients with advanced liver fibrosis due to chronic hepatitis C virus infection.BACKGROUND/AIMThe aim of this work was to establish an association between the single-nucleotide polymorphisms (SNPs) of TGFB1 (rs1800471), AT (rs3789679), MMP-1 (rs17886084), MMP-3 (rs35068180), and PAI-1 (rs1799889) and the histological grading of necroinflammation, staging of hepatic fibrosis, and liver function in Mexican patients with advanced liver fibrosis due to chronic hepatitis C virus infection.AT, MMP-1, MMP-3, and PAI-1 gene polymorphisms were analyzed by polymerase chain reaction in real time, whereas TGFB1 polymorphism was detected by polymerase chain reaction-based restriction fragment length polymorphism in 38 patients with established advanced liver fibrosis and 50 subjects from the general population. Grading of necroinflammation and staging of liver fibrosis were assessed by liver biopsy and graded according to modified histological activity index Ishak score.METHODSAT, MMP-1, MMP-3, and PAI-1 gene polymorphisms were analyzed by polymerase chain reaction in real time, whereas TGFB1 polymorphism was detected by polymerase chain reaction-based restriction fragment length polymorphism in 38 patients with established advanced liver fibrosis and 50 subjects from the general population. Grading of necroinflammation and staging of liver fibrosis were assessed by liver biopsy and graded according to modified histological activity index Ishak score.Regarding TGFB1 SNP, significant differences were found between G/G and G/C genotypes of patients with hepatic necroinflammation (P = 0.05) and hepatic fibrosis (P = 0.002). There were also significant differences among genotypes of patients with the AT SNP in hepatic necroinflammation (P = 0.01). The albumin-globulin ratio between genotypes of patients with the MMP-3 SNP gene showed significant differences (P = 0.02).RESULTSRegarding TGFB1 SNP, significant differences were found between G/G and G/C genotypes of patients with hepatic necroinflammation (P = 0.05) and hepatic fibrosis (P = 0.002). There were also significant differences among genotypes of patients with the AT SNP in hepatic necroinflammation (P = 0.01). The albumin-globulin ratio between genotypes of patients with the MMP-3 SNP gene showed significant differences (P = 0.02).Our findings demonstrate that a specific combination of genotypes associated with biochemical values and a histological high score determine more severe liver disease. The presence of the G/G genotype of TGFB1 SNP in patients was significantly associated with severity of liver necroinflammation and fibrosis. Patients with the G/G genotype of AT SNP were associated with severe necroinflammation. The albumin-globulin ratio was increased in patients with the 6A allele of MMP-3 SNP. These results might contribute to diagnosis and further establishment of liver disease treatment.CONCLUSIONOur findings demonstrate that a specific combination of genotypes associated with biochemical values and a histological high score determine more severe liver disease. The presence of the G/G genotype of TGFB1 SNP in patients was significantly associated with severity of liver necroinflammation and fibrosis. Patients with the G/G genotype of AT SNP were associated with severe necroinflammation. The albumin-globulin ratio was increased in patients with the 6A allele of MMP-3 SNP. These results might contribute to diagnosis and further establishment of liver disease treatment. Background/Aim The aim of this work was to establish an association between the single-nucleotide polymorphisms (SNPs) of TGFB1 (rs1800471), AT (rs3789679), MMP-1 (rs17886084), MMP-3 (rs35068180), and PAI-1 (rs1799889) and the histological grading of necroinflammation, staging of hepatic fibrosis, and liver function in Mexican patients with advanced liver fibrosis due to chronic hepatitis C virus infection. Methods AT , MMP-1 , MMP-3 , and PAI-1 gene polymorphisms were analyzed by polymerase chain reaction in real time, whereas TGFB1 polymorphism was detected by polymerase chain reaction-based restriction fragment length polymorphism in 38 patients with established advanced liver fibrosis and 50 subjects from the general population. Grading of necroinflammation and staging of liver fibrosis were assessed by liver biopsy and graded according to modified histological activity index Ishak score. Results Regarding TGFB1 SNP, significant differences were found between G/G and G/C genotypes of patients with hepatic necroinflammation (P = 0.05) and hepatic fibrosis (P = 0.002). There were also significant differences among genotypes of patients with the AT SNP in hepatic necroinflammation (P = 0.01). The albumin-globulin ratio between genotypes of patients with the MMP-3 SNP gene showed significant differences (P = 0.02). Conclusion Our findings demonstrate that a specific combination of genotypes associated with biochemical values and a histological high score determine more severe liver disease. The presence of the G/G genotype of TGFB1 SNP in patients was significantly associated with severity of liver necroinflammation and fibrosis. Patients with the G/G genotype of AT SNP were associated with severe necroinflammation. The albumin-globulin ratio was increased in patients with the 6A allele of MMP-3 SNP. These results might contribute to diagnosis and further establishment of liver disease treatment. Background/AimThe aim of this work was to establish an association between the single-nucleotide polymorphisms (SNPs) of TGFB1 (rs1800471), AT (rs3789679), MMP-1 (rs17886084), MMP-3 (rs35068180), and PAI-1 (rs1799889) and the histological grading of necroinflammation, staging of hepatic fibrosis, and liver function in Mexican patients with advanced liver fibrosis due to chronic hepatitis C virus infection.Methods AT, MMP-1, MMP-3, and PAI-1 gene polymorphisms were analyzed by polymerase chain reaction in real time, whereas TGFB1 polymorphism was detected by polymerase chain reaction–based restriction fragment length polymorphism in 38 patients with established advanced liver fibrosis and 50 subjects from the general population. Grading of necroinflammation and staging of liver fibrosis were assessed by liver biopsy and graded according to modified histological activity index Ishak score.ResultsRegarding TGFB1 SNP, significant differences were found between G/G and G/C genotypes of patients with hepatic necroinflammation (P = 0.05) and hepatic fibrosis (P = 0.002). There were also significant differences among genotypes of patients with the AT SNP in hepatic necroinflammation (P = 0.01). The albumin-globulin ratio between genotypes of patients with the MMP-3 SNP gene showed significant differences (P = 0.02).ConclusionOur findings demonstrate that a specific combination of genotypes associated with biochemical values and a histological high score determine more severe liver disease. The presence of the G/G genotype of TGFB1 SNP in patients was significantly associated with severity of liver necroinflammation and fibrosis. Patients with the G/G genotype of AT SNP were associated with severe necroinflammation. The albumin-globulin ratio was increased in patients with the 6A allele of MMP-3 SNP. These results might contribute to diagnosis and further establishment of liver disease treatment. Background/Aim The aim of this work was to establish an association between the single-nucleotide polymorphisms (SNPs) of TGFB1 (rs1800471), AT (rs3789679), MMP-1 (rs17886084), MMP-3 (rs35068180), and PAI-1 (rs1799889) and the histological grading of necroinflammation, staging of hepatic fibrosis, and liver function in Mexican patients with advanced liver fibrosis due to chronic hepatitis C virus infection. Methods AT, MMP-1, MMP-3, and PAI-1 gene polymorphisms were analyzed by polymerase chain reaction in real time, whereas TGFB1 polymorphism was detected by polymerase chain reaction–based restriction fragment length polymorphism in 38 patients with established advanced liver fibrosis and 50 subjects from the general population. Grading of necroinflammation and staging of liver fibrosis were assessed by liver biopsy and graded according to modified histological activity index Ishak score. Results Regarding TGFB1 SNP, significant differences were found between G/G and G/C genotypes of patients with hepatic necroinflammation (P = 0.05) and hepatic fibrosis (P = 0.002). There were also significant differences among genotypes of patients with the AT SNP in hepatic necroinflammation (P = 0.01). The albumin-globulin ratio between genotypes of patients with the MMP-3 SNP gene showed significant differences (P = 0.02). Conclusion Our findings demonstrate that a specific combination of genotypes associated with biochemical values and a histological high score determine more severe liver disease. The presence of the G/G genotype of TGFB1 SNP in patients was significantly associated with severity of liver necroinflammation and fibrosis. Patients with the G/G genotype of AT SNP were associated with severe necroinflammation. The albumin-globulin ratio was increased in patients with the 6A allele of MMP-3 SNP. These results might contribute to diagnosis and further establishment of liver disease treatment. The aim of this work was to establish an association between the single-nucleotide polymorphisms (SNPs) of TGFB1 (rs1800471), AT (rs3789679), MMP-1 (rs17886084), MMP-3 (rs35068180), and PAI-1 (rs1799889) and the histological grading of necroinflammation, staging of hepatic fibrosis, and liver function in Mexican patients with advanced liver fibrosis due to chronic hepatitis C virus infection. AT, MMP-1, MMP-3, and PAI-1 gene polymorphisms were analyzed by polymerase chain reaction in real time, whereas TGFB1 polymorphism was detected by polymerase chain reaction-based restriction fragment length polymorphism in 38 patients with established advanced liver fibrosis and 50 subjects from the general population. Grading of necroinflammation and staging of liver fibrosis were assessed by liver biopsy and graded according to modified histological activity index Ishak score. Regarding TGFB1 SNP, significant differences were found between G/G and G/C genotypes of patients with hepatic necroinflammation (P = 0.05) and hepatic fibrosis (P = 0.002). There were also significant differences among genotypes of patients with the AT SNP in hepatic necroinflammation (P = 0.01). The albumin-globulin ratio between genotypes of patients with the MMP-3 SNP gene showed significant differences (P = 0.02). Our findings demonstrate that a specific combination of genotypes associated with biochemical values and a histological high score determine more severe liver disease. The presence of the G/G genotype of TGFB1 SNP in patients was significantly associated with severity of liver necroinflammation and fibrosis. Patients with the G/G genotype of AT SNP were associated with severe necroinflammation. The albumin-globulin ratio was increased in patients with the 6A allele of MMP-3 SNP. These results might contribute to diagnosis and further establishment of liver disease treatment. |
| Author | Sánchez-Orozco, Laura Verónica Gómez-Meda, Belinda Claudia Landeros, Martha Silvia Lucano Sánchez-Parada, María Guadalupe Alvarez-Rodríguez, Bertha Adriana Troyo-Sanromán, Rogelio Zamora-Perez, Ana Lourdes Armendáriz-Borunda, Juan |
| Author_xml | – sequence: 1 givenname: María Guadalupe surname: Sánchez-Parada fullname: Sánchez-Parada, María Guadalupe email: armdbo@gmail.com organization: From the Institute of Molecular Biology in Medicine and Gene Therapy, Department of Molecular Biology and Genomics, †Research Coordination, and ‡Research Institute of Dentistry, University Center of Health Sciences, University of Guadalajara, Jalisco, México; and §INNOVARE, Guadalajara, Jalisco, México – sequence: 2 givenname: Bertha Adriana surname: Alvarez-Rodríguez fullname: Alvarez-Rodríguez, Bertha Adriana email: armdbo@gmail.com organization: From the Institute of Molecular Biology in Medicine and Gene Therapy, Department of Molecular Biology and Genomics, †Research Coordination, and ‡Research Institute of Dentistry, University Center of Health Sciences, University of Guadalajara, Jalisco, México; and §INNOVARE, Guadalajara, Jalisco, México – sequence: 3 givenname: Belinda Claudia surname: Gómez-Meda fullname: Gómez-Meda, Belinda Claudia email: armdbo@gmail.com organization: From the Institute of Molecular Biology in Medicine and Gene Therapy, Department of Molecular Biology and Genomics, †Research Coordination, and ‡Research Institute of Dentistry, University Center of Health Sciences, University of Guadalajara, Jalisco, México; and §INNOVARE, Guadalajara, Jalisco, México – sequence: 4 givenname: Rogelio surname: Troyo-Sanromán fullname: Troyo-Sanromán, Rogelio email: armdbo@gmail.com organization: From the Institute of Molecular Biology in Medicine and Gene Therapy, Department of Molecular Biology and Genomics, †Research Coordination, and ‡Research Institute of Dentistry, University Center of Health Sciences, University of Guadalajara, Jalisco, México; and §INNOVARE, Guadalajara, Jalisco, México – sequence: 5 givenname: Laura Verónica surname: Sánchez-Orozco fullname: Sánchez-Orozco, Laura Verónica email: armdbo@gmail.com organization: From the Institute of Molecular Biology in Medicine and Gene Therapy, Department of Molecular Biology and Genomics, †Research Coordination, and ‡Research Institute of Dentistry, University Center of Health Sciences, University of Guadalajara, Jalisco, México; and §INNOVARE, Guadalajara, Jalisco, México – sequence: 6 givenname: Ana Lourdes surname: Zamora-Perez fullname: Zamora-Perez, Ana Lourdes email: armdbo@gmail.com organization: From the Institute of Molecular Biology in Medicine and Gene Therapy, Department of Molecular Biology and Genomics, †Research Coordination, and ‡Research Institute of Dentistry, University Center of Health Sciences, University of Guadalajara, Jalisco, México; and §INNOVARE, Guadalajara, Jalisco, México – sequence: 7 givenname: Martha Silvia Lucano surname: Landeros fullname: Landeros, Martha Silvia Lucano email: armdbo@gmail.com organization: From the Institute of Molecular Biology in Medicine and Gene Therapy, Department of Molecular Biology and Genomics, †Research Coordination, and ‡Research Institute of Dentistry, University Center of Health Sciences, University of Guadalajara, Jalisco, México; and §INNOVARE, Guadalajara, Jalisco, México – sequence: 8 givenname: Juan surname: Armendáriz-Borunda fullname: Armendáriz-Borunda, Juan email: armdbo@gmail.com organization: From the Institute of Molecular Biology in Medicine and Gene Therapy, Department of Molecular Biology and Genomics, †Research Coordination, and ‡Research Institute of Dentistry, University Center of Health Sciences, University of Guadalajara, Jalisco, México; and §INNOVARE, Guadalajara, Jalisco, México |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23941979$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1038_s41598_022_07548_y crossref_primary_10_1111_1744_9987_13913 crossref_primary_10_1016_j_circir_2015_06_033 crossref_primary_10_1016_j_circen_2015_12_013 crossref_primary_10_1016_j_jri_2020_103147 crossref_primary_10_5501_wjv_v6_i2_36 crossref_primary_10_1007_s11033_021_06640_2 crossref_primary_10_1038_jhg_2017_75 |
| Cites_doi | 10.1097/00007890-199810270-00009 10.1590/S0036-36342004000400009 10.1111/j.1365-2893.2011.01485.x 10.1172/JCI119343 10.1136/jmg.2005.032557 10.1042/CS20100246 10.1016/j.cyto.2003.08.007 10.1016/S0009-8981(01)00738-0 10.1007/s10620-007-9937-7 10.1111/j.1478-3231.2008.01716.x 10.1007/s12072-010-9232-0 10.1111/j.1440-1746.2005.03860.x 10.1053/he.2000.6253 10.1161/01.ATV.18.4.562 10.1074/jbc.274.31.21491 10.1161/01.CIR.87.6.1969 10.1002/lt.22190 10.1053/jhep.2003.50127 10.1164/rccm.200210-1165OC 10.1097/SAP.0b013e31822284f4 10.1097/FPC.0b013e32834c3e74 10.1016/S1286-4579(99)00250-6 10.1016/S0016-5085(03)00695-4 10.1016/0168-8278(95)80226-6 10.1002/jmv.23259 10.3748/wjg.15.6023 10.1093/nar/15.7.3188 10.1055/s-0038-1649834 10.1056/NEJM199411103311907 10.2310/JIM.0b013e3181891512 10.1016/S0016-5085(00)70368-4 10.1186/1471-2350-11-172 10.1074/jbc.271.22.13055 10.1016/S1665-2681(19)31383-3 10.1093/nar/16.3.1215 10.3748/wjg.v11.i13.1929 10.1016/0006-291X(91)91056-I 10.1016/S0168-8278(03)00459-8 10.1016/j.recesp.2011.09.022 10.1097/00000441-198506000-00005 |
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| Copyright | 2015 American Federation for Medical Research, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions 2013 American Federation for Medical Research Copyright: 2015 (c) 2015 American Federation for Medical Research, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions |
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| References | Ishak, Baptista, Bianchi 1995; 22 Gálvez-Gastélum, Sandoval-Rodríguez, Armendáriz-Borunda 2004; 46 Shin, Lee, Jung 2008; 53 Dixon, Bhathal, Jonsson 2003; 39 Ridker, Gaboury, Conclin 1993; 87 Mansfield, Stickland, Grant 1995; 74 Gewalting, Mangasser, Gartung 2002; 316 Bataller, Gines, Nicolas 2000; 118 Hotta, Yoneda, Hyogo 2010; 11 Branton, Kopp 1999; 1 Lacha, Hubacek, Potmesil 2001; 6 Curto, Lagier, Lok 2011; 21 Nagase, Woessner 1999; 274 Wang, Mengsteab, Tag 2005; 11 Friedman, Schiff 2003 Karp, Subramanyam, Ho 1985; 289 Sánchez, Galaviz, Sierra 2012; 65 Iwata, Baur, Stieger 2011; 120 Borde, Noble 1994; 331 Okamoto, Mimura, Murawaki 2005; 20 Powell, Edwards, Hay 2000; 31 Awad, El-Gamel, Hasleton 1998; 66 Bataller, North, Brenner 2003; 37 La, Soresi, Giannitrapani 2013; 12 Margaglione, Cappucci, d’Addedda 1998; 18 Duvnjak, Barsic, Tomasic 2009; 15 Bataller, Sancho-Bru, Gines 2003; 125 Bouzgarrou, Hassen, Bahri 2011; 5 Richardson, Powell, Barrie 2005; 42 Hahn, Resink, Bernhardt 1991; 178 Derynck, Rhee, Chen 1987; 15 Fevery 2008; 28 Xaubet, Marin, Lario 2003; 168 Veras, Cardenas, González 2013; 70 Ye, Eriksson, Hamsten 1996; 271 Tag, Mengsteab, Hellerbrand 2003; 24 Eurich, Bahra, Boas 2011; 17 Fabris, Falleti, Cussigh 2012; 84 Armendáriz-Borunda, Rincón, Muñoz-Valle 2008; 56 Rutter, Mitchell, Bauttice 1998; 58 Inoue, Nakajima, Williams 1997; 99 Miller, Dykes, Polesky 1988; 16 Puoti, Guarisco, Spilabotti 2012; 19 Margaglione, Cappucci, d'Addedda 1998; 18 bibr11-JIM.0b013e3182a32e24 bibr23-JIM.0b013e3182a32e24 bibr28-JIM.0b013e3182a32e24 bibr1-JIM.0b013e3182a32e24 bibr30-JIM.0b013e3182a32e24 bibr42-JIM.0b013e3182a32e24 bibr3-JIM.0b013e3182a32e24 bibr8-JIM.0b013e3182a32e24 Rutter JL (bibr22-JIM.0b013e3182a32e24) 1998; 58 bibr16-JIM.0b013e3182a32e24 bibr35-JIM.0b013e3182a32e24 bibr9-JIM.0b013e3182a32e24 bibr4-JIM.0b013e3182a32e24 bibr33-JIM.0b013e3182a32e24 bibr38-JIM.0b013e3182a32e24 bibr40-JIM.0b013e3182a32e24 bibr21-JIM.0b013e3182a32e24 bibr12-JIM.0b013e3182a32e24 Lacha J (bibr34-JIM.0b013e3182a32e24) 2001; 6 bibr14-JIM.0b013e3182a32e24 bibr19-JIM.0b013e3182a32e24 bibr6-JIM.0b013e3182a32e24 bibr26-JIM.0b013e3182a32e24 bibr43-JIM.0b013e3182a32e24 bibr31-JIM.0b013e3182a32e24 bibr7-JIM.0b013e3182a32e24 bibr15-JIM.0b013e3182a32e24 bibr24-JIM.0b013e3182a32e24 bibr17-JIM.0b013e3182a32e24 bibr29-JIM.0b013e3182a32e24 bibr36-JIM.0b013e3182a32e24 bibr41-JIM.0b013e3182a32e24 bibr2-JIM.0b013e3182a32e24 bibr10-JIM.0b013e3182a32e24 Friedman SL (bibr20-JIM.0b013e3182a32e24) 2003 bibr18-JIM.0b013e3182a32e24 bibr25-JIM.0b013e3182a32e24 bibr37-JIM.0b013e3182a32e24 bibr39-JIM.0b013e3182a32e24 bibr5-JIM.0b013e3182a32e24 bibr27-JIM.0b013e3182a32e24 bibr13-JIM.0b013e3182a32e24 bibr32-JIM.0b013e3182a32e24 |
| References_xml | – volume: 12 start-page: 36 issue: 1 year: 2013 article-title: Long-term follow-up of hepatitis C virus-positive patients with persistently normal serum transaminases publication-title: Ann Hepatol – volume: 22 start-page: 696 year: 1995 article-title: Histological grading and staging of chronic hepatitis publication-title: J Hepatol – volume: 56 start-page: 944 year: 2008 article-title: Fibrogenic polymorphisms (TGF-beta, PAI-1, AT) in Mexican patients with established liver fibrosis. Potential correlation with pirfenidone treatment publication-title: J Investig Med – volume: 271 start-page: 13050 year: 1996 article-title: Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression publication-title: J Biol Chem – volume: 316 start-page: 83 year: 2002 article-title: Association of polymorphisms of the transforming growth factor-beta 1 gene with the rate of progression of HCV-induced liver fibrosis publication-title: Clin Chim Acta – volume: 289 start-page: 236 issue: 6 year: 1985 article-title: Drugs affecting bilirubin uptake by human erythrocyte ghosts publication-title: Am J Med Sci – volume: 274 start-page: 21491 year: 1999 article-title: Matrix metalloproteinase publication-title: J Biol Chem – volume: 42 start-page: e45 year: 2005 article-title: A combination of genetic polymorphisms increases the risk of progressive disease in chronic hepatitis C publication-title: J Med Genet – volume: 1 start-page: 1349 year: 1999 article-title: TGF-beta and fibrosis publication-title: Microbes Inf – volume: 15 start-page: 6023 year: 2009 article-title: Genetic polymorphisms in non-alcoholic fatty liver disease: clues to pathogenesis and disease progression publication-title: World J Gastroenterol – volume: 28 start-page: 592 issue: 5 year: 2008 article-title: Bilirubin in clinical practice: a review publication-title: Liver Int – volume: 31 start-page: 828 issue: 4 year: 2000 article-title: Host genetic factors influence disease progression in chronic hepatitis C publication-title: Hepatology – volume: 74 start-page: 842 year: 1995 article-title: Environmental and genetic factors in relation to elevated circulating levels of plasminogen activator inhibitor-1 in Caucasian patients with non insulin-dependent diabetes mellitus publication-title: Thromb Haemost – volume: 331 start-page: 1286 year: 1994 article-title: Mechanisms of disease: transforming growth factor-beta in tissue fibrosis publication-title: N Engl J Med – volume: 6 start-page: 39 year: 2001 article-title: TGF- beta I gene polymorphism in heart transplant recipients—effect on renal function publication-title: Ann Transplant – volume: 120 start-page: 287 year: 2011 article-title: Swiss Hepatitis C Cohort Study Group. A common polymorphism in the ABCBII gene is associated with advanced fibrosis in hepatitis C but not in non-alcoholic fatty liver disease publication-title: Clin Sci (Lond) – volume: 17 start-page: 279 year: 2011 article-title: Transforming growth factor β1 polymorphisms and progression of graft fibrosis after liver transplantation for hepatitis C virus induced liver disease publication-title: Liver Transpl – volume: 37 start-page: 493 year: 2003 article-title: Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal publication-title: Hepatology – volume: 46 start-page: 341 year: 2004 article-title: El factor de crecimiento transformante β como blanco terapéutico publication-title: Salud Pública Méx – volume: 178 start-page: 1451 year: 1991 article-title: Stimulation of autocrine platelet derived growth factor AA-homodimer and transforming growth factor beta in vascular smooth muscle cells publication-title: Biochem Biophys Res Commun – volume: 11 start-page: 1929 issue: 13 year: 2005 article-title: Transforming growth factor-β1 gene polymorphisms are associated with progression of liver fibrosis in Caucasians with chronic hepatitis C infection publication-title: World J Gastroenterol – volume: 24 start-page: 173 year: 2003 article-title: Analysis of the transforming growth factor-β1 (TGF-β1) codon 25 gene polymorphism by LightCycler-analysis in patients with chronic hepatitis C infection publication-title: Cytokine – volume: 66 start-page: 1014 year: 1998 article-title: Genotypic variation in the transforming growth factor β1 gene: association with transforming growth factor β1 production, fibrotic lung diseases, and graft fibrosis after lung transplantation publication-title: Transplantation – volume: 58 start-page: 5321 year: 1998 article-title: Single nucleotide polymorphism in the matrix metalloproteinase-1 promoter creates and Ets binding site and augments transcription publication-title: Cancer Res – start-page: 409 year: 2003 publication-title: Schiff& die;s Diseases of the Liver – volume: 53 start-page: 823 year: 2008 article-title: Matrix metalloproteinase (MMP)-3 polymorphism in patients with HBV related chronic liver disease publication-title: Dig Dis Sci – volume: 19 start-page: 229 year: 2012 article-title: Should we treat HCV carriers with normal ALT levels? The `5Ws’ dilemma publication-title: J Viral Hepat – volume: 125 start-page: 117 year: 2003 article-title: Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II publication-title: Gastroenterology – volume: 70 start-page: 16 issue: 1 year: 2013 article-title: Controlled clinical trial with pirfenidone in the treatment of breast capsular contracture publication-title: Ann Plast Surg – volume: 21 start-page: 851 year: 2011 article-title: Predicting cirrhosis and clinical outcomes in patients with advanced chronic C with a panel of genetic markers (CRS7) publication-title: Pharmacogenet Genomics – volume: 65 start-page: 158 issue: 2 year: 2012 article-title: Polimorfismo 677CT del gen de la metilentetradihidrofolato reductasa y cardiopatías congenitas aisladas en población Mexicana publication-title: Rev Esp Cardiol – volume: 11 start-page: 172 year: 2010 article-title: Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of non-alcoholic fatty liver disease publication-title: BMC Med Genet – volume: 5 start-page: 681 year: 2011 article-title: Combined effect of pro and anti-inflammatory cytokine gene polymorphisms on susceptibility to liver cirrhosis in Tunisian HCV-infected patients publication-title: Hepatol Int – volume: 168 start-page: 431 year: 2003 article-title: Transforming growth factor b1 gene polymorphisms are associated with disease progression in idiopathic pulmonary fibrosis publication-title: Am J Respir Crit Care Med – volume: 99 start-page: 1786 year: 1997 article-title: A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and effects basal transcription in vitro publication-title: J Clin Invest – volume: 118 start-page: 1149 year: 2000 article-title: Angiotensin II induces contraction and proliferation of human hepatic stellate cells publication-title: Gastroenterology – volume: 16 start-page: 1215 year: 1988 article-title: A simple salting out procedure for extracting DNA from human nucleated cells publication-title: Nucleic Acids Res – volume: 20 start-page: 1102 year: 2005 article-title: Association of functional gene polymorphisms of matrix metalloproteinase (MMP)-1, MMP-3 and MMP-9 with the progression of chronic liver disease publication-title: J Gastroenterol Hepatol – volume: 84 start-page: 747 year: 2012 article-title: The interleukin 28B rs12979860 C/T polymorphism and serum cholesterol as predictors of fibrosis progression in patients with chronic hepatitis C and persistently normal transaminases publication-title: J Med Virol – volume: 87 start-page: 1969 year: 1993 article-title: Stimulation of plasminogen activator inhibitor in vivo by infusion of angiotensin II. Evidence of a potential interaction between the rennin- angiotensin system and fibrinolytic function publication-title: Circulation – volume: 15 start-page: 3188 year: 1987 article-title: Intron-exon structure of the human transforming growth factor beta precursor gene publication-title: Nucleic Acid Res – volume: 39 start-page: 967 year: 2003 article-title: Pro fibrotic polymorphisms predictive of advanced liver fibrosis in the severely obese publication-title: J Hepatol – volume: 18 start-page: 562 year: 1998 article-title: PAI-1 plasma levels in a general population without clinical evidence of atherosclerosis: relation to environmental and genetic determinants arteriosclerosis publication-title: Thromb Vasc Biol – volume: 15 start-page: 3188 year: 1987 end-page: 3189 article-title: Intron-exon structure of the human transforming growth factor beta precursor gene – volume: 65 start-page: 158 issue: 2 year: 2012 end-page: 163 article-title: Polimorfismo 677CT del gen de la metilentetradihidrofolato reductasa y cardiopatías congenitas aisladas en población Mexicana – volume: 42 start-page: e45 year: 2005 article-title: A combination of genetic polymorphisms increases the risk of progressive disease in chronic hepatitis C – volume: 178 start-page: 1451 year: 1991 end-page: 1458 article-title: Stimulation of autocrine platelet derived growth factor AA-homodimer and transforming growth factor beta in vascular smooth muscle cells – volume: 53 start-page: 823 year: 2008 end-page: 829 article-title: Matrix metalloproteinase (MMP)-3 polymorphism in patients with HBV related chronic liver disease – volume: 66 start-page: 1014 year: 1998 end-page: 1020 article-title: Genotypic variation in the transforming growth factor β1 gene: association with transforming growth factor β1 production, fibrotic lung diseases, and graft fibrosis after lung transplantation – volume: 1 start-page: 1349 year: 1999 end-page: 1365 article-title: TGF-beta and fibrosis – volume: 6 start-page: 39 year: 2001 end-page: 43 article-title: TGF- beta I gene polymorphism in heart transplant recipients—effect on renal function – volume: 17 start-page: 279 year: 2011 end-page: 288 article-title: Transforming growth factor β1 polymorphisms and progression of graft fibrosis after liver transplantation for hepatitis C virus induced liver disease – volume: 24 start-page: 173 year: 2003 end-page: 181 article-title: Analysis of the transforming growth factor-β1 (TGF-β1) codon 25 gene polymorphism by LightCycler-analysis in patients with chronic hepatitis C infection – volume: 316 start-page: 83 year: 2002 end-page: 94 article-title: Association of polymorphisms of the transforming growth factor-beta 1 gene with the rate of progression of HCV-induced liver fibrosis – volume: 20 start-page: 1102 year: 2005 end-page: 1108 article-title: Association of functional gene polymorphisms of matrix metalloproteinase (MMP)-1, MMP-3 and MMP-9 with the progression of chronic liver disease – volume: 15 start-page: 6023 year: 2009 end-page: 6027 article-title: Genetic polymorphisms in non-alcoholic fatty liver disease: clues to pathogenesis and disease progression – volume: 46 start-page: 341 year: 2004 end-page: 350 article-title: El factor de crecimiento transformante β como blanco terapéutico – volume: 125 start-page: 117 year: 2003 end-page: 125 article-title: Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II – volume: 31 start-page: 828 issue: 4 year: 2000 end-page: 833 article-title: Host genetic factors influence disease progression in chronic hepatitis C – volume: 12 start-page: 36 issue: 1 year: 2013 end-page: 43 article-title: Long-term follow-up of hepatitis C virus-positive patients with persistently normal serum transaminases – volume: 289 start-page: 236 issue: 6 year: 1985 end-page: 239 article-title: Drugs affecting bilirubin uptake by human erythrocyte ghosts – volume: 271 start-page: 13050 year: 1996 end-page: 13060 article-title: Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression – volume: 28 start-page: 592 issue: 5 year: 2008 end-page: 605 article-title: Bilirubin in clinical practice: a review – volume: 168 start-page: 431 year: 2003 end-page: 435 article-title: Transforming growth factor b1 gene polymorphisms are associated with disease progression in idiopathic pulmonary fibrosis – volume: 118 start-page: 1149 year: 2000 end-page: 1156 article-title: Angiotensin II induces contraction and proliferation of human hepatic stellate cells – volume: 11 start-page: 1929 issue: 13 year: 2005 end-page: 1936 article-title: Transforming growth factor-β1 gene polymorphisms are associated with progression of liver fibrosis in Caucasians with chronic hepatitis C infection – volume: 120 start-page: 287 year: 2011 end-page: 296 article-title: Swiss Hepatitis C Cohort Study Group. A common polymorphism in the ABCBII gene is associated with advanced fibrosis in hepatitis C but not in non-alcoholic fatty liver disease – volume: 84 start-page: 747 year: 2012 end-page: 755 article-title: The interleukin 28B rs12979860 C/T polymorphism and serum cholesterol as predictors of fibrosis progression in patients with chronic hepatitis C and persistently normal transaminases – volume: 74 start-page: 842 year: 1995 end-page: 847 article-title: Environmental and genetic factors in relation to elevated circulating levels of plasminogen activator inhibitor-1 in Caucasian patients with non insulin-dependent diabetes mellitus – volume: 37 start-page: 493 year: 2003 end-page: 503 article-title: Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal – start-page: 409 year: 2003 end-page: 427 article-title: Hepatic fibrosis publication-title: Schiff& die;s Diseases of the Liver – volume: 274 start-page: 21491 year: 1999 end-page: 21494 article-title: Matrix metalloproteinase – volume: 22 start-page: 696 year: 1995 end-page: 699 article-title: Histological grading and staging of chronic hepatitis – volume: 19 start-page: 229 year: 2012 end-page: 235 article-title: Should we treat HCV carriers with normal ALT levels? The ‘5Ws’ dilemma – volume: 99 start-page: 1786 year: 1997 end-page: 1797 article-title: A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and effects basal transcription in vitro – volume: 18 start-page: 562 year: 1998 end-page: 567 article-title: PAI-1 plasma levels in a general population without clinical evidence of atherosclerosis: relation to environmental and genetic determinants arteriosclerosis – volume: 56 start-page: 944 year: 2008 end-page: 953 article-title: Fibrogenic polymorphisms (TGF-beta, PAI-1, AT) in Mexican patients with established liver fibrosis. Potential correlation with pirfenidone treatment – volume: 70 start-page: 16 issue: 1 year: 2013 end-page: 22 article-title: Controlled clinical trial with pirfenidone in the treatment of breast capsular contracture – volume: 87 start-page: 1969 year: 1993 end-page: 1973 article-title: Stimulation of plasminogen activator inhibitor by infusion of angiotensin II. Evidence of a potential interaction between the rennin- angiotensin system and fibrinolytic function – volume: 331 start-page: 1286 year: 1994 end-page: 1292 article-title: Mechanisms of disease: transforming growth factor-beta in tissue fibrosis – volume: 16 start-page: 1215 year: 1988 article-title: A simple salting out procedure for extracting DNA from human nucleated cells – volume: 11 start-page: 172 year: 2010 article-title: Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of non-alcoholic fatty liver disease – volume: 21 start-page: 851 year: 2011 end-page: 860 article-title: Predicting cirrhosis and clinical outcomes in patients with advanced chronic C with a panel of genetic markers (CRS7) – volume: 58 start-page: 5321 year: 1998 end-page: 5355 article-title: Single nucleotide polymorphism in the matrix metalloproteinase-1 promoter creates and Ets binding site and augments transcription – volume: 39 start-page: 967 year: 2003 end-page: 971 article-title: Pro fibrotic polymorphisms predictive of advanced liver fibrosis in the severely obese – volume: 5 start-page: 681 year: 2011 end-page: 687 article-title: Combined effect of pro and anti-inflammatory cytokine gene polymorphisms on susceptibility to liver cirrhosis in Tunisian HCV-infected patients – ident: bibr33-JIM.0b013e3182a32e24 doi: 10.1097/00007890-199810270-00009 – ident: bibr12-JIM.0b013e3182a32e24 doi: 10.1590/S0036-36342004000400009 – ident: bibr40-JIM.0b013e3182a32e24 doi: 10.1111/j.1365-2893.2011.01485.x – ident: bibr19-JIM.0b013e3182a32e24 doi: 10.1172/JCI119343 – ident: bibr4-JIM.0b013e3182a32e24 doi: 10.1136/jmg.2005.032557 – ident: bibr7-JIM.0b013e3182a32e24 doi: 10.1042/CS20100246 – ident: bibr14-JIM.0b013e3182a32e24 doi: 10.1016/j.cyto.2003.08.007 – ident: bibr15-JIM.0b013e3182a32e24 doi: 10.1016/S0009-8981(01)00738-0 – ident: bibr37-JIM.0b013e3182a32e24 doi: 10.1007/s10620-007-9937-7 – start-page: 409 year: 2003 ident: bibr20-JIM.0b013e3182a32e24 publication-title: Schiff& die;s Diseases of the Liver – ident: bibr43-JIM.0b013e3182a32e24 doi: 10.1111/j.1478-3231.2008.01716.x – ident: bibr9-JIM.0b013e3182a32e24 doi: 10.1007/s12072-010-9232-0 – ident: bibr38-JIM.0b013e3182a32e24 doi: 10.1111/j.1440-1746.2005.03860.x – ident: bibr1-JIM.0b013e3182a32e24 doi: 10.1053/he.2000.6253 – ident: bibr26-JIM.0b013e3182a32e24 doi: 10.1161/01.ATV.18.4.562 – ident: bibr21-JIM.0b013e3182a32e24 doi: 10.1074/jbc.274.31.21491 – ident: bibr24-JIM.0b013e3182a32e24 doi: 10.1161/01.CIR.87.6.1969 – ident: bibr32-JIM.0b013e3182a32e24 doi: 10.1002/lt.22190 – volume: 6 start-page: 39 year: 2001 ident: bibr34-JIM.0b013e3182a32e24 publication-title: Ann Transplant – ident: bibr2-JIM.0b013e3182a32e24 doi: 10.1053/jhep.2003.50127 – ident: bibr16-JIM.0b013e3182a32e24 doi: 10.1164/rccm.200210-1165OC – ident: bibr35-JIM.0b013e3182a32e24 doi: 10.1097/SAP.0b013e31822284f4 – ident: bibr8-JIM.0b013e3182a32e24 doi: 10.1097/FPC.0b013e32834c3e74 – ident: bibr11-JIM.0b013e3182a32e24 doi: 10.1016/S1286-4579(99)00250-6 – ident: bibr18-JIM.0b013e3182a32e24 doi: 10.1016/S0016-5085(03)00695-4 – ident: bibr27-JIM.0b013e3182a32e24 doi: 10.1016/0168-8278(95)80226-6 – ident: bibr41-JIM.0b013e3182a32e24 doi: 10.1002/jmv.23259 – ident: bibr5-JIM.0b013e3182a32e24 doi: 10.3748/wjg.15.6023 – ident: bibr13-JIM.0b013e3182a32e24 doi: 10.1093/nar/15.7.3188 – ident: bibr25-JIM.0b013e3182a32e24 doi: 10.1055/s-0038-1649834 – volume: 58 start-page: 5321 year: 1998 ident: bibr22-JIM.0b013e3182a32e24 publication-title: Cancer Res – ident: bibr10-JIM.0b013e3182a32e24 doi: 10.1056/NEJM199411103311907 – ident: bibr29-JIM.0b013e3182a32e24 doi: 10.2310/JIM.0b013e3181891512 – ident: bibr17-JIM.0b013e3182a32e24 doi: 10.1016/S0016-5085(00)70368-4 – ident: bibr6-JIM.0b013e3182a32e24 doi: 10.1186/1471-2350-11-172 – ident: bibr23-JIM.0b013e3182a32e24 doi: 10.1074/jbc.271.22.13055 – ident: bibr39-JIM.0b013e3182a32e24 doi: 10.1016/S1665-2681(19)31383-3 – ident: bibr28-JIM.0b013e3182a32e24 doi: 10.1093/nar/16.3.1215 – ident: bibr30-JIM.0b013e3182a32e24 doi: 10.3748/wjg.v11.i13.1929 – ident: bibr31-JIM.0b013e3182a32e24 doi: 10.1016/0006-291X(91)91056-I – ident: bibr3-JIM.0b013e3182a32e24 doi: 10.1016/S0168-8278(03)00459-8 – ident: bibr36-JIM.0b013e3182a32e24 doi: 10.1016/j.recesp.2011.09.022 – ident: bibr42-JIM.0b013e3182a32e24 doi: 10.1097/00000441-198506000-00005 |
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| Snippet | Background/AimThe aim of this work was to establish an association between the single-nucleotide polymorphisms (SNPs) of TGFB1 (rs1800471), AT (rs3789679),... Background/Aim The aim of this work was to establish an association between the single-nucleotide polymorphisms (SNPs) of TGFB1 (rs1800471), AT (rs3789679),... The aim of this work was to establish an association between the single-nucleotide polymorphisms (SNPs) of TGFB1 (rs1800471), AT (rs3789679), MMP-1... Background/Aim The aim of this work was to establish an association between the single-nucleotide polymorphisms (SNPs) of TGFB1 (rs1800471), AT (rs3789679),... |
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| SubjectTerms | Aged Alleles Female Genetic Association Studies - methods Genotype Hepatitis C, Chronic - diagnosis Hepatitis C, Chronic - ethnology Hepatitis C, Chronic - genetics Humans Liver Cirrhosis - diagnosis Liver Cirrhosis - ethnology Liver Cirrhosis - genetics Liver Function Tests - methods Male Matrix Metalloproteinase 3 - genetics Mexico - ethnology Middle Aged Necrosis - diagnosis Necrosis - ethnology Necrosis - genetics Polymorphism, Single Nucleotide - genetics Serum Albumin - genetics Serum Globulins - genetics Transforming Growth Factor beta1 - genetics |
| Title | Association of Genetic Polymorphisms With Histological Grading of Necroinflammation, Staging of Fibrosis, and Liver Function in Mexicans With Chronic Hepatitis C Virus Infection |
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