Thrombolysis in acute ischaemic stroke: time for a rethink?
As the UK regulator reviews alteplase in ischaemic stroke, Brian Alper and colleagues interpret the evidence to suggest increased mortality with uncertain benefit for its use beyond three hours
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| Published in | BMJ (Online) Vol. 350; no. mar17 3; p. h1075 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
British Medical Journal Publishing Group
17.03.2015
BMJ Publishing Group LTD |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0959-8138 1756-1833 1756-1833 |
| DOI | 10.1136/bmj.h1075 |
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| Abstract | As the UK regulator reviews alteplase in ischaemic stroke, Brian Alper and colleagues interpret the evidence to suggest increased mortality with uncertain benefit for its use beyond three hours |
|---|---|
| AbstractList | As the UK regulator reviews alteplase in ischaemic stroke, Brian Alper and colleagues interpret the evidence to suggest increased mortality with uncertain benefit for its use beyond three hours |
| Author | Prasad, Kameshwar Manheimer, Eric McLellan, James S Alper, Brian S Malone-Moses, Meghan |
| Author_xml | – sequence: 1 givenname: Brian S surname: Alper fullname: Alper, Brian S email: balper@EBSCO.com organization: Bahrain Branch of the Cochrane Collaboration, Awali, Bahrain – sequence: 2 givenname: Meghan surname: Malone-Moses fullname: Malone-Moses, Meghan email: balper@EBSCO.com organization: Bahrain Branch of the Cochrane Collaboration, Awali, Bahrain – sequence: 3 givenname: James S surname: McLellan fullname: McLellan, James S email: balper@EBSCO.com organization: Bahrain Branch of the Cochrane Collaboration, Awali, Bahrain – sequence: 4 givenname: Kameshwar surname: Prasad fullname: Prasad, Kameshwar email: balper@EBSCO.com organization: Bahrain Branch of the Cochrane Collaboration, Awali, Bahrain – sequence: 5 givenname: Eric surname: Manheimer fullname: Manheimer, Eric email: balper@EBSCO.com organization: Bahrain Branch of the Cochrane Collaboration, Awali, Bahrain |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25786912$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | ANALYSIS Associations Clinical medicine Disability Drug Administration Schedule Emergency medical care Evidence-Based Medicine Fibrinolytic Agents - therapeutic use Humans Ischemia Medicine Meta-Analysis as Topic Patients Physicians Practice Guidelines as Topic Review Literature as Topic Stroke Stroke - drug therapy Thrombolytic Therapy Tissue Plasminogen Activator - therapeutic use |
| Title | Thrombolysis in acute ischaemic stroke: time for a rethink? |
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