The diagnostic performance of urinary free cortisol is better than the cortisol:cortisone ratio in detecting de novo Cushing's syndrome: the use of a LC–MS/MS method in routine clinical practice - Ceccato, Filippo; Antonelli, Giorgia; Barbot, Mattia; Zilio, Marialuisa; Mazzai, Linda; Gatti, Rosalba; Zaninotto, Martina; Mantero, Franco; Boscaro, Marco; Plebani, Mario; Scaroni, Carla (European journal of endocrinology, 2014)
Keywords: Adrenals. Adrenal axis. Renin-angiotensin system (diseases); Adult; Biological and medical sciences; Chromatography, Liquid - methods; Clinical Study; Cortisone - urine; Endocrinopathies; Female; Fundamental and applied biological sciences. Psychology; Glucocorticoids - urine; Humans; Hydrocortisone - urine; Male; Medical sciences; Middle Aged; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Pituitary ACTH Hypersecretion - diagnosis; Pituitary ACTH Hypersecretion - urine; Prevention and actions; Public health. Hygiene; Public health. Hygiene-occupational medicine; Tandem Mass Spectrometry - methods; Vertebrates: endocrinology; Endocrinopathy; Performance evaluation; Adrenal cortex diseases; Methodology; Hyperadrenocorticism; Cortisol; Hydrocortisone; Glucocorticoid; Adrenal gland diseases; Ratio; Diagnosis; Urine; Corticosteroid; Steroid hormone; Use; Antiinflammatory agent; Cushing syndrome; Liquid chromatography; Medical screening; De novo; Cortisone; Professional practice; Mass spectrometry MS/MS; Adrenal hormone; Performance; Endocrinology