Parent-reported health outcomes at preschool age in preterm survivors: a population-based cohort study

• Published in: Archives of disease in childhood. Fetal and neonatal edition Vol. 109; no. 4; pp. 436 - 442
• Main Authors: MacDonald, Sydney, Stratas, Alexandra, Synnes, Anne R, Sandila, Navjot, Campbell-Yeo, Marsha, Shah, Prakesh S, Ghotra, Satvinder
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health 01.07.2024; BMJ Publishing Group LTD
• Subjects: Activities of daily living; Age; Cerebral palsy; Child Development; Child Health; Children & youth; Clinics; Cohort analysis; Families & family life; Infants; Intensive care; Neonatology; Newborn babies; Original research; Patients; Pregnancy; Premature babies; Quality of life; Sociodemographics; Survivor; Traumatic brain injury; Visual impairment; Neonatology; Child Development; Child Health
• ISSN: 1359-2998; 1468-2052; 1468-2052
• DOI: 10.1136/archdischild-2023-326136

ObjectiveLiterature on health status (HS) and health-related quality of life of preterm survivors at preschool age is sparse. Further, little is known about the relationship between parent-reported HS outcomes and standardised neurodevelopmental outcomes measured in preterm survivors at preschool age. Our objective was to evaluate parent-reported child HS outcomes and their relationship to neurodevelopmental outcomes at 36 months of age in very preterm survivors.DesignProspective population-based cohort study.SettingPerinatal follow-up programme.PatientsInfants <31 weeks’ gestational age born from 2014 to 2016.Outcome measuresParents completed the Health Status Classification System for Pre-School Children questionnaire at 36 months. At the same age, neurodevelopmental assessments were completed to determine neurodevelopmental impairment (NDI). NDI was categorised as none, ‘mild’ or ‘significant’ (moderate or severe cerebral palsy, Bayley Scales of Infant and Toddler Development - Third Edition <70, blind or required hearing aid).ResultsOf 118 children, 87 (73.7%) parents reported their child had an HS concern (mild: 61 (51%); moderate: 16 (13.6%); and severe: 10 (8.5%)). Mild and significant NDIs were observed in 17 (14.4%) and 14 (11.9%) children, respectively. For the 14 (12%) children with significant NDI, 7 (50.0%) parents reported severe and 4 (28.6%) reported moderate concerns. Conversely, for 26 (22%) children with parent-reported moderate to severe concerns, 11 (42.3%) met the criteria for significant NDI. There was a moderate positive correlation between parental concern and NDI status (Spearman correlation=0.46, p<0.0001).ConclusionsParental HS concerns only moderately correlated with the NDI status. Of the 12% of children with significant NDI, only half of the parents reported severe HS concerns.