Collagen binding adhesin restricts Staphylococcus aureus skin infection

Staphylococcus aureus causes approximately 80% of skin and soft tissue infections (SSTIs). Collagen is the most abundant human extracellular matrix protein with critical roles in wound healing, and S. aureus encodes a collagen binding adhesin (Cna). The role of this protein during skin infections is...

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Main Authors Bhattacharya, Mohini, Spencer, Brady L, Kwiecinski, Jakub M, Podkowik, Magdalena, Putzel, Gregory, Pironti, Alejandro, Shopsin, Bo, Doran, Kelly S, Horswill, Alexander R
Format Journal Article Paper
LanguageEnglish
Published United States Cold Spring Harbor Laboratory 02.11.2024
Edition1.1
Subjects
Microbiology
skin
C1q
inflammation
Collagen
MRSA
Online AccessGet full text
ISSN2692-8205
2692-8205
DOI10.1101/2024.11.01.621145

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Abstract Staphylococcus aureus causes approximately 80% of skin and soft tissue infections (SSTIs). Collagen is the most abundant human extracellular matrix protein with critical roles in wound healing, and S. aureus encodes a collagen binding adhesin (Cna). The role of this protein during skin infections is unknown. Here we report that inability to bind collagen results in worsened pathology of intradermal δcna S. aureus infection. WT/Cna+ S. aureus showed reduced infection severity, aggregate formation, and significantly improved clearance of bacteria. Cna binds to the collagen-like domain of serum C1q protein to reduce its opsonophagocytic functions. We demonstrate that infection of C1qKO mice with WT bacteria show results similar to the δcna group. Conversely, inability to bind collagen resulted in an amplified inflammatory response caused in part by macrophage and neutrophil small molecule mediators released at the infection site (MMP-9, MMP-12, LTB4), resulting in increased immune cell infiltration and death.
AbstractList Staphylococcus aureus causes approximately 80% of skin and soft tissue infections (SSTIs). Collagen is the most abundant human extracellular matrix protein with critical roles in wound healing, and S. aureus encodes a collagen binding adhesin (Cna). The role of this protein during skin infections is unknown. Here we report that inability to bind collagen results in worsened pathology of intradermal Δcna S. aureus infection. WT/Cna+ S. aureus showed reduced infection severity, aggregate formation, and significantly improved clearance of bacteria. Cna binds to the collagen-like domain of serum C1q protein to reduce its opsonophagocytic functions. We demonstrate that infection of C1qKO mice with WT bacteria show results similar to the Δcna group. Conversely, inability to bind collagen resulted in an amplified inflammatory response caused in part by macrophage and neutrophil small molecule mediators released at the infection site (MMP-9, MMP-12, LTB4), resulting in increased immune cell infiltration and death.Staphylococcus aureus causes approximately 80% of skin and soft tissue infections (SSTIs). Collagen is the most abundant human extracellular matrix protein with critical roles in wound healing, and S. aureus encodes a collagen binding adhesin (Cna). The role of this protein during skin infections is unknown. Here we report that inability to bind collagen results in worsened pathology of intradermal Δcna S. aureus infection. WT/Cna+ S. aureus showed reduced infection severity, aggregate formation, and significantly improved clearance of bacteria. Cna binds to the collagen-like domain of serum C1q protein to reduce its opsonophagocytic functions. We demonstrate that infection of C1qKO mice with WT bacteria show results similar to the Δcna group. Conversely, inability to bind collagen resulted in an amplified inflammatory response caused in part by macrophage and neutrophil small molecule mediators released at the infection site (MMP-9, MMP-12, LTB4), resulting in increased immune cell infiltration and death.
Staphylococcus aureus causes approximately 80% of skin and soft tissue infections (SSTIs). Collagen is the most abundant human extracellular matrix protein with critical roles in wound healing, and S. aureus encodes a collagen binding adhesin (Cna). The role of this protein during skin infections is unknown. Here we report that inability to bind collagen results in worsened pathology of intradermal δcna S. aureus infection. WT/Cna+ S. aureus showed reduced infection severity, aggregate formation, and significantly improved clearance of bacteria. Cna binds to the collagen-like domain of serum C1q protein to reduce its opsonophagocytic functions. We demonstrate that infection of C1qKO mice with WT bacteria show results similar to the δcna group. Conversely, inability to bind collagen resulted in an amplified inflammatory response caused in part by macrophage and neutrophil small molecule mediators released at the infection site (MMP-9, MMP-12, LTB4), resulting in increased immune cell infiltration and death.
Author Horswill, Alexander R
Bhattacharya, Mohini
Kwiecinski, Jakub M
Pironti, Alejandro
Putzel, Gregory
Shopsin, Bo
Podkowik, Magdalena
Spencer, Brady L
Doran, Kelly S
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Cites_doi 10.1038/nrmicro.2015.3
10.1073/PNAS.2114478119/SUPPL_FILE/PNAS.2114478119.SAPP.PDF
10.1016/J.IMMUNI.2010.07.018
10.1371/JOURNAL.PCBI.1005595
10.1046/J.0022-202X.2001.01331.X
10.1073/pnas.1305121110
10.1093/BIOINFORMATICS/BTY560
10.4049/JIMMUNOL.178.2.1013
10.1016/J.BBAMCR.2017.08.003
10.3390/TOXINS5061140
10.4049/JIMMUNOL.2400185
10.1126/science.1092385
10.1155/2019/3205072
10.1007/978-1-59745-467-4_2
10.1371/journal.ppat.1007800
10.31838/ijpr/2020.SP2.087
10.1038/ni.1923
10.1093/CID/CIZ002
10.1128/AAC.00172-20
10.1371/JOURNAL.PONE.0235115
10.1086/314576
10.1128/IAI.68.6.3776-3779.2000
10.1128/IAI.02048-05/SUPPL_FILE/AI_TB_32ZYMOG.DOC
10.1038/s41598-017-17318-w
10.1172/JCI1823
10.3201/EID2111.150452
10.3389/fcimb.2012.00012
10.1146/annurev-pathol-012615-044351
10.1159/000324044
10.3201/EID1506.081632
10.3389/FIMMU.2020.620339/BIBTEX
10.1126/science.1242255
10.3201/EID1704.100482
10.1086/676872
10.1038/nrmicro.2017.27
10.1128/IAI.00095-13
10.1001/jama.286.10.1201
10.1016/S8756-3282(01)00632-9
10.1074/JBC.M113.454462
10.1128/CMR.00134-14
10.1038/ni.2769
10.1097/QCO.0000000000000239
10.1186/1471-2334-13-252
10.1083/jcb.200606027
10.1126/SCIENCE.285.5428.760
10.1111/IMR.12223
10.1073/PNAS.1402136111/SUPPL_FILE/PNAS.201402136SI.PDF
10.1016/S0022-2836(05)80360-2
10.1038/s41564-024-01769-9
10.26502/FCCM.92920302
10.1002/jlb.66.3.416
10.1007/S00281-021-00892-7
10.1038/NRM3043
10.7717/PEERJ.6995
10.1038/s41598-022-27279-4
10.1038/SJ.EMBOJ.7600888
10.1101/CSHPERSPECT.A004978
10.1128/MBIO.02125-17/ASSET/882A0284-3A6D-4893-91C3-9005C71C09A9/ASSETS/GRAPHIC/MBO0021837730005.JPEG
10.1128/MBIO.01137-19/SUPPL_FILE/MBIO.01137-19-ST002.DOCX
10.1093/NAR/28.1.27
10.1021/ACSNANO.6B08404
10.1080/22221751.2024.2316809
10.1016/J.CMI.2020.06.029
10.1016/s0021-9258(18)42898-0
10.1128/AAC.02288-17
10.1128/MBIO.02125-17
10.3389/FCELL.2021.624025
10.1038/S41467-018-03208-W
10.2340/00015555-3466
10.4049/JIMMUNOL.1701574
10.1093/BIOINFORMATICS/BTZ848
10.1111/J.1365-2249.2005.02840.X
10.1016/j.mib.2013.01.012
10.1016/j.mib.2013.11.004
10.1093/INFDIS/JIT288
10.1371/JOURNAL.PONE.0150606
10.1093/femsre/fuae002
10.1067/MAI.2001.117455
10.3389/fimmu.2018.00639
10.1038/NATURE08181
10.1126/SCIIMMUNOL.ADG3517/SUPPL_FILE/SCIIMMUNOL.ADG3517_MDAR_REPRODUCIBILITY_CHECKLIST.PDF
10.1016/j.chom.2013.04.006
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Keywords skin
C1q
inflammation
Collagen
MRSA
Language English
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References Vandendriessche, Cambier, Proost, Marques (2024.11.01.621145v1.59) 2021; 9
Kavanaugh, Flack, Lister, Ricker, Ibberson, Jenul, Moormeier, Delmain, Bayles, Horswill (2024.11.01.621145v1.83) 2019; 10
Brown, Kwiecinski, Cruz, Shahbandi, Todd, Cech, Horswill (2024.11.01.621145v1.34) 2020; 64
Mazmanian, Liu, Ton-That, Schneewind (2024.11.01.621145v1.15) 1999; 285
Houghton, Hartzell, Robbins, Gomis-Rüth, Shapiro (2024.11.01.621145v1.32) 2009; 460
Bidula, Sexton, Schelenz (2024.11.01.621145v1.73) 2019; 2019
Giang, Seelen, van Doorn, Rissmann, Prens, Damman (2024.11.01.621145v1.23) 2018; 9
Jin, Zhou, Ge, Shen, Xiao (2024.11.01.621145v1.58) 2024; 13
Groom, Wolsey, Naimi, Smith, Johnson, Boxrud, Moore, Cheek (2024.11.01.621145v1.12) 2001; 286
Malik, Bakshi, McCabe, Catlett, Shah, Singh, Jackson, Gaggar, Metzger, Melendez (2024.11.01.621145v1.29) 2007; 178
Mathew-Steiner, Roy, Sen (2024.11.01.621145v1.2) 2021
Brandt, Putnam, Cassat, Serezani (2024.11.01.621145v1.39) 2018; 200
Low, Koziol, Manninger, Blais, Carrillo (2024.11.01.621145v1.85) 2019; 7
Kaye, Petty, Shorr, Zilberberg (2024.11.01.621145v1.6) 2019; 68
Forde, Kolter, Zwicky, Baasch, Lohrmann, Eckert, Gres, Lagies, Gorka, Rambold (2024.11.01.621145v1.66) 2023; 8
Pelzek, Shopsin, Radke, Tam, Ueberheide, Fenyö, Brown, Li, Rubin, Fulmer (2024.11.01.621145v1.36) 2018; 9
Ruiz, Tenner, Ruiz, Henschen-Edman, Nagase, Tenner (2024.11.01.621145v1.68) 1999; 66
Rosbjerg, Plchová, Bayarri-Olmos, Holm, Pedersen, Skjoedt, Garred (2024.11.01.621145v1.75) 2024; 213
Boero, Gorham, Francis, Brand, Teng, Doorduijn, Ruyken, Muts, Lehmann, Verschoor (2024.11.01.621145v1.60) 2023; 13
Patti, Jonsson, Guss, Switalski, Wiberg, Lindberg, Höök (2024.11.01.621145v1.19) 1992; 267
Urso, Monk, Cheng, Predella, Wong Fok Lung, Theiller, Boylan, Perelman, Baskota, Moustafa (2024.11.01.621145v1.70) 2024; 2024
Ray, Suaya, Baxter (2024.11.01.621145v1.53) 2013; 13
Nauseef (2024.11.01.621145v1.46) 2007
Thomas, Peacock, Daenke, Berendt (2024.11.01.621145v1.17) 1999; 179
Rhem, Lech, Patti, McDevitt, Höök, Jones, Wilhelmus (2024.11.01.621145v1.21) 2000; 68
Pidwill, Gibson, Cole, Renshaw, Foster (2024.11.01.621145v1.31) 2021; 11
Valotteau, Prystopiuk, Pietrocola, Rindi, Peterle, De Filippis, Foster, Speziale, Dufrêne (2024.11.01.621145v1.3) 2017; 11
Chen, Schneewind, Missiakas (2024.11.01.621145v1.43) 2022; 119
Cho, Strickland, Tomkinson, Fehringer, Gelfand, Leung (2024.11.01.621145v1.54) 2001; 116
Sinha, Sen, Singh, Das, Ghatak, Rhea, Blackstone, Powell, Khanna, Roy (2024.11.01.621145v1.69) 2018; 9
Ortines, Liu, Cheng, Cohen, Lawlor, Gami, Wang, Dillen, Archer, Miller (2024.11.01.621145v1.41) 2018; 62
Kwiecinski Id, Crosby, Valotteau, Id, Nayak, Chauhanid, Schmidt, Dufrêne, Horswill (2024.11.01.621145v1.35) 2019
Abtin, Jain, Mitchell, Roediger, Brzoska, Tikoo, Cheng, Ng, Cavanagh, Von Andrian (2024.11.01.621145v1.67) 2013; 15
Fuchs, Abed, Goosmann, Hurwitz, Schulze, Wahn, Weinrauch, Brinkmann, Zychlinsky (2024.11.01.621145v1.25) 2007; 176
Altschul, Gish, Miller, Myers, Lipman (2024.11.01.621145v1.88) 1990; 215
Zong, Xu, Liang, Keene, Höök, Gurusiddappa, Höök, Narayana (2024.11.01.621145v1.16) 2005; 24
Jopling, Boue, Belmonte (2024.11.01.621145v1.72) 2011; 12
Cho, Strickland, Boguniewicz, Leung (2024.11.01.621145v1.55) 2001; 108
Yu, O’Koren, Hotten, Kan, Kopin, Nelson, Que, Gunn (2024.11.01.621145v1.42) 2016; 11
Del Giudice (2024.11.01.621145v1.4) 2020; 100
Stsiapanava, Olsson, Wan, Kleinschmidt, Rutishauser, Zubarev, Samuelsson, Rinaldo-Matthis, Haeggström (2024.11.01.621145v1.33) 2014; 111
Thammavongsa, Missiakas, Schneewind (2024.11.01.621145v1.45) 2013; 342
Spaan, Henry, van Rooijen, Perret, Badiou, Aerts, Kemmink, de Haas, van Kessel, Vandenesch (2024.11.01.621145v1.61) 2013; 13
Nilsson, Patti, Bremell, Höök, Tarkowski (2024.11.01.621145v1.18) 1998; 101
Kang, Ko, Liang, Ross, Liu, Murray, Höök (2024.11.01.621145v1.22) 2013; 288
Esposito, Noviello, Leone (2024.11.01.621145v1.5) 2016; 29
Tong, Davis, Eichenberger, Holland, Fowler (2024.11.01.621145v1.77) 2015; 28
Chen, Zhou, Chen, Gu (2024.11.01.621145v1.84) 2018; 34
Chou, Kim, Sadik, Seung, Lan, Byrne, Haribabu, Iwakura, Luster (2024.11.01.621145v1.49) 2010; 33
Thammavongsa, Kim, Missiakas, Schneewind (2024.11.01.621145v1.82) 2015; 13
Elkington, O’Kane, Friedland (2024.11.01.621145v1.30) 2005; 142
Thomer, Schneewind, Missiakas (2024.11.01.621145v1.78) 2016; 11
Rhem, Lech, Patti, McDevitt, Höök, Jones, Wilhelmus (2024.11.01.621145v1.50) 2000; 68
Ricklin, Hajishengallis, Yang, Lambris (2024.11.01.621145v1.44) 2010; 11
Kwiecinski, Jacobsson, Karlsson, Zhu, Wang, Bremell, Josefsson, Jin (2024.11.01.621145v1.79) 2013; 208
Yoong, Torres (2024.11.01.621145v1.63) 2013; 16
Spaan, van Strijp, Torres (2024.11.01.621145v1.62) 2017; 15
2024.11.01.621145v1.11
Foster, Kok, Flores, Minard, Luna, Lamberth, Kaplan, Hulten (2024.11.01.621145v1.38) 2020; 15
Hienz, Schennings, Heimdahl, Flock (2024.11.01.621145v1.51) 1996; 174
Friesen, Neuber, Fuhrmann, Kietzmann, Wenzel, Schaumburg, Müller, Ignatius (2024.11.01.621145v1.57) 2020; 26
Elasri, Thomas, Skinner, Blevins, Beenken, Nelson, Smelter (2024.11.01.621145v1.20) 2002; 30
Krishnaswamy, Mintz, Sagi (2024.11.01.621145v1.48) 2017; 1864
Singh, Rai, Agrawal (2024.11.01.621145v1.76) 2023; 7
Wick, Judd, Gorrie, Holt (2024.11.01.621145v1.86) 2017; 13
Chaumeil, Mussig, Hugenholtz, Parks (2024.11.01.621145v1.87) 2020; 36
Golding, Levett, McDonald, Irvine, Quinn, Nsungu, Woods, Khan, Ofner-Agostini, Mulvey (2024.11.01.621145v1.14) 2011; 17
Taylor, Hattle, Dreitz, Troudt, Izzo, Basaraba, Orme, Matrisian, Izzo (2024.11.01.621145v1.28) 2006; 74
Bhattacharya, Berends, Zheng, Hill, Chan, Torres, Wozniak (2024.11.01.621145v1.47) 2020
Pelzek, Shopsin, Radke, Tam, Ueberheide, Fenyö, Brown, Li, Rubin, Fulmer (2024.11.01.621145v1.52) 2018; 9
Brinkmann, Reichard, Goosmann, Fauler, Uhlemann, Weiss, Weinrauch, Zychlinsky (2024.11.01.621145v1.26) 2004; 303
DuMont, Yoong, Surewaard, Benson, Nijland, van Strijp, Torres (2024.11.01.621145v1.64) 2013; 81
Vandenesch, Lina, Henry (2024.11.01.621145v1.81) 2012; 2
Dal Peraro, van der Goot (2024.11.01.621145v1.9) 2016; 14
Kandhwal, Behl, Singh, Sharma, Arora, Bhatia, Al-Harrasi, Sachdeva, Bungau (2024.11.01.621145v1.27) 2022; 14
Pouw, Ricklin (2024.11.01.621145v1.24) 2021; 43
Otto (2024.11.01.621145v1.8) 2014; 17
DuMont, Yoong, Day, Alonzo, McDonald, Jennings, Torres (2024.11.01.621145v1.65) 2013; 110
Kanehisa, Goto (2024.11.01.621145v1.89) 2000; 28
Ricard-Blum (2024.11.01.621145v1.1) 2011; 3
Vignaroli, Varaldo, Camporese (2024.11.01.621145v1.13) 2009; 15
Del Giudice, Bes, Hubiche, Blanc, Roudière, Lina, Vandenesch, Etienne (2024.11.01.621145v1.56) 2011; 222
Bhattacharya, Horswill (2024.11.01.621145v1.10) 2024; 48
Berube, Wardenburg (2024.11.01.621145v1.40) 2013; 5
Lacroix, Tessier, Dumestre-Pérard, Vadon-Le Goff, Gout, Bruckner-Tuderman, Kiritsi, Nyström, Ricard-Blum, Moali (2024.11.01.621145v1.74) 2017; 7
Gordon, Plüddemann, Martinez Estrada (2024.11.01.621145v1.71) 2014; 262
Phillips, Rosenberg, Shopsin, Cuff, Skeete, Foti, Kraemer, Inglima, Press, Bosco (2024.11.01.621145v1.37) 2014; 35
Bhattacharya, Berends, Chan, Schwab, Roy, Sen, Torres, Wozniak (2024.11.01.621145v1.80) 2018
Carrel, Perencevich, David (2024.11.01.621145v1.7) 2015; 21
References_xml – volume: 14
  start-page: 77
  year: 2016
  end-page: 92
  ident: 2024.11.01.621145v1.9
  article-title: Pore-forming toxins: ancient, but never really out of fashion
  publication-title: Nat Rev Microbiol
  doi: 10.1038/nrmicro.2015.3
– volume: 119
  start-page: e2114478119
  year: 2022
  ident: 2024.11.01.621145v1.43
  article-title: Engineered human antibodies for the opsonization and killing of Staphylococcus aureus
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/PNAS.2114478119/SUPPL_FILE/PNAS.2114478119.SAPP.PDF
– volume: 33
  start-page: 266
  year: 2010
  ident: 2024.11.01.621145v1.49
  article-title: Lipid-Cytokine-Chemokine Cascade Drives Neutrophil Recruitment in a Murine Model of Inflammatory Arthritis
  publication-title: Immunity
  doi: 10.1016/J.IMMUNI.2010.07.018
– volume: 13
  year: 2017
  ident: 2024.11.01.621145v1.86
  article-title: Unicycler: Resolving bacterial genome assemblies from short and long sequencing reads
  publication-title: PLoS Comput Biol
  doi: 10.1371/JOURNAL.PCBI.1005595
– volume: 116
  start-page: 658
  year: 2001
  end-page: 663
  ident: 2024.11.01.621145v1.54
  article-title: Preferential Binding of Staphylococcus aureus to Skin Sites of Th2-Mediated Inflammation in a Murine Model
  publication-title: Journal of Investigative Dermatology
  doi: 10.1046/J.0022-202X.2001.01331.X
– volume: 110
  start-page: 10794
  year: 2013
  end-page: 10799
  ident: 2024.11.01.621145v1.65
  article-title: Staphylococcus aureus LukAB cytotoxin kills human neutrophils by targeting the CD11b subunit of the integrin Mac-1
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1305121110
– volume: 34
  start-page: i884
  year: 2018
  end-page: i890
  ident: 2024.11.01.621145v1.84
  article-title: fastp: an ultra-fast all-in-one FASTQ preprocessor
  publication-title: Bioinformatics
  doi: 10.1093/BIOINFORMATICS/BTY560
– volume: 178
  start-page: 1013
  year: 2007
  end-page: 1020
  ident: 2024.11.01.621145v1.29
  article-title: Matrix Metalloproteinase 9 Activity Enhances Host Susceptibility to Pulmonary Infection with Type A and B Strains of Francisella tularensis
  publication-title: The Journal of Immunology
  doi: 10.4049/JIMMUNOL.178.2.1013
– volume: 1864
  start-page: 2220
  year: 2017
  end-page: 2227
  ident: 2024.11.01.621145v1.48
  article-title: Matrix metalloproteinases: The sculptors of chronic cutaneous wounds
  publication-title: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  doi: 10.1016/J.BBAMCR.2017.08.003
– year: 2021
  ident: 2024.11.01.621145v1.2
  article-title: Collagen in Wound Healing
– volume: 5
  start-page: 1140
  year: 2013
  ident: 2024.11.01.621145v1.40
  article-title: Staphylococcus aureus α-Toxin: Nearly a Century of Intrigue
  publication-title: Toxins (Basel
  doi: 10.3390/TOXINS5061140
– volume: 213
  start-page: 998
  year: 2024
  end-page: 1007
  ident: 2024.11.01.621145v1.75
  article-title: C1q/MASP Complexes—Hybrid Complexes of Classical and Lectin Pathway Proteins Are Found in the Circulation
  publication-title: The Journal of Immunology
  doi: 10.4049/JIMMUNOL.2400185
– volume: 303
  start-page: 1532
  year: 2004
  end-page: 1535
  ident: 2024.11.01.621145v1.26
  article-title: Neutrophil extracellular traps kill bacteria
  publication-title: Science
  doi: 10.1126/science.1092385
– volume: 2019
  year: 2019
  ident: 2024.11.01.621145v1.73
  article-title: Ficolins and the Recognition of Pathogenic Microorganisms: An Overview of the Innate Immune Response and Contribution of Single Nucleotide Polymorphisms
  publication-title: J Immunol Res
  doi: 10.1155/2019/3205072
– start-page: 15
  year: 2007
  end-page: 20
  ident: 2024.11.01.621145v1.46
  article-title: Isolation of Human Neutrophils From Venous Blood
  publication-title: Methods in molecular biology (Clifton, N.J.)
  doi: 10.1007/978-1-59745-467-4_2
– year: 2019
  ident: 2024.11.01.621145v1.35
  article-title: Staphylococcus aureus adhesion in endovascular infections is controlled by the ArlRS-MgrA signaling cascade
  doi: 10.1371/journal.ppat.1007800
– volume: 14
  start-page: 4391
  year: 2022
  ident: 2024.11.01.621145v1.27
  article-title: Role of matrix metalloproteinase in wound healing
  publication-title: Am J Transl Res
  doi: 10.31838/ijpr/2020.SP2.087
– volume: 11
  start-page: 785
  year: 2010
  end-page: 797
  ident: 2024.11.01.621145v1.44
  article-title: Complement: a key system for immune surveillance and homeostasis
  publication-title: Nature Immunology
  doi: 10.1038/ni.1923
– volume: 68
  start-page: S193
  year: 2019
  end-page: S199
  ident: 2024.11.01.621145v1.6
  article-title: Current Epidemiology, Etiology, and Burden of Acute Skin Infections in the United States
  publication-title: Clinical Infectious Diseases
  doi: 10.1093/CID/CIZ002
– volume: 64
  year: 2020
  ident: 2024.11.01.621145v1.34
  article-title: Novel Peptide from Commensal Staphylococcus simulans Blocks Methicillin-Resistant Staphylococcus aureus Quorum Sensing and Protects Host Skin from Damage
  publication-title: Antimicrob Agents Chemother
  doi: 10.1128/AAC.00172-20
– volume: 15
  year: 2020
  ident: 2024.11.01.621145v1.38
  article-title: Adhesin genes and biofilm formation among pediatric Staphylococcus aureus isolates from implant-associated infections
  publication-title: PLoS One
  doi: 10.1371/JOURNAL.PONE.0235115
– year: 2020
  ident: 2024.11.01.621145v1.47
  article-title: Leukocidins and the nuclease Nuc prevent neutrophil mediated killing of Staphylococcus aureus biofilms
  publication-title: Infect Immun
– volume: 179
  start-page: 291
  year: 1999
  end-page: 293
  ident: 2024.11.01.621145v1.17
  article-title: Adhesion of Staphylococcus aureus to Collagen Is Not a Major Virulence Determinant for Septic Arthritis, Osteomyelitis, or Endocarditis
  publication-title: J Infect Dis
  doi: 10.1086/314576
– volume: 68
  start-page: 3776
  year: 2000
  ident: 2024.11.01.621145v1.21
  article-title: The Collagen-Binding Adhesin Is a Virulence Factor in Staphylococcus aureus Keratitis
  publication-title: Infect Immun
  doi: 10.1128/IAI.68.6.3776-3779.2000
– volume: 74
  start-page: 6135
  year: 2006
  end-page: 6144
  ident: 2024.11.01.621145v1.28
  article-title: Role for matrix metalloproteinase 9 in granuloma formation during pulmonary Mycobacterium tuberculosis infection
  publication-title: Infect Immun
  doi: 10.1128/IAI.02048-05/SUPPL_FILE/AI_TB_32ZYMOG.DOC
– year: 2018
  ident: 2024.11.01.621145v1.80
  article-title: Staphylococcus aureus biofilms release leukocidins to elicit extracellular trap formation and evade neutrophil-mediated killing
  publication-title: Proceedings of the National Academy of Sciences
– volume: 7
  start-page: 1
  year: 2017
  end-page: 13
  ident: 2024.11.01.621145v1.74
  article-title: Interaction of Complement Defence Collagens C1q and Mannose-Binding Lectin with BMP-1/Tolloid-like Proteinases
  publication-title: Scientific Reports
  doi: 10.1038/s41598-017-17318-w
– volume: 101
  start-page: 2640
  year: 1998
  end-page: 2649
  ident: 2024.11.01.621145v1.18
  article-title: Vaccination with a recombinant fragment of collagen adhesin provides protection against Staphylococcus aureus-mediated septic death
  publication-title: Journal of Clinical Investigation
  doi: 10.1172/JCI1823
– volume: 21
  start-page: 1973
  year: 2015
  end-page: 1980
  ident: 2024.11.01.621145v1.7
  article-title: USA300 Methicillin-Resistant Staphylococcus aureus, United States, 2000-2013
  publication-title: Emerg Infect Dis
  doi: 10.3201/EID2111.150452
– volume: 2
  start-page: 12
  year: 2012
  ident: 2024.11.01.621145v1.81
  article-title: Staphylococcus aureus hemolysins, bi-component leukocidins, and cytolytic peptides: a redundant arsenal of membrane-damaging virulence factors?
  publication-title: Front Cell Infect Microbiol
  doi: 10.3389/fcimb.2012.00012
– volume: 11
  start-page: 343
  year: 2016
  end-page: 364
  ident: 2024.11.01.621145v1.78
  article-title: Pathogenesis of Staphylococcus aureus Bloodstream Infections
  publication-title: Annual Review of Pathology: Mechanisms of Disease
  doi: 10.1146/annurev-pathol-012615-044351
– volume: 222
  start-page: 167
  year: 2011
  end-page: 170
  ident: 2024.11.01.621145v1.56
  article-title: Panton-valentine leukocidin-positive Staphylococcus aureus strains are associated with follicular skin infections
  publication-title: Dermatology
  doi: 10.1159/000324044
– volume: 15
  start-page: 995
  year: 2009
  ident: 2024.11.01.621145v1.13
  article-title: Methicillin-Resistant Staphylococcus aureus USA400 Clone, Italy
  publication-title: Emerg Infect Dis
  doi: 10.3201/EID1506.081632
– volume: 11
  start-page: 620339
  year: 2021
  ident: 2024.11.01.621145v1.31
  article-title: The Role of Macrophages in Staphylococcus aureus Infection
  publication-title: Front Immunol
  doi: 10.3389/FIMMU.2020.620339/BIBTEX
– volume: 342
  start-page: 863
  year: 2013
  end-page: 866
  ident: 2024.11.01.621145v1.45
  article-title: Staphylococcus aureus Degrades Neutrophil Extracellular Traps to Promote Immune Cell Death
  publication-title: Science
  doi: 10.1126/science.1242255
– volume: 17
  start-page: 722
  year: 2011
  ident: 2024.11.01.621145v1.14
  article-title: High Rates of Staphylococcus aureus USA400 Infection, Northern Canada
  publication-title: Emerg Infect Dis
  doi: 10.3201/EID1704.100482
– volume: 35
  start-page: 826
  year: 2014
  end-page: 832
  ident: 2024.11.01.621145v1.37
  article-title: Preventing surgical site infections: a randomized, open-label trial of nasal mupirocin ointment and nasal povidone-iodine solution
  publication-title: Infect Control Hosp Epidemiol
  doi: 10.1086/676872
– volume: 15
  start-page: 435
  year: 2017
  end-page: 447
  ident: 2024.11.01.621145v1.62
  article-title: Leukocidins: staphylococcal bi-component pore-forming toxins find their receptors
  publication-title: Nat Rev Microbiol
  doi: 10.1038/nrmicro.2017.27
– volume: 81
  start-page: 1830
  year: 2013
  end-page: 1841
  ident: 2024.11.01.621145v1.64
  article-title: Staphylococcus aureus elaborates leukocidin AB to mediate escape from within human neutrophils
  publication-title: Infect Immun
  doi: 10.1128/IAI.00095-13
– volume: 286
  start-page: 1201
  year: 2001
  end-page: 1205
  ident: 2024.11.01.621145v1.12
  article-title: Community-acquired methicillin-resistant Staphylococcus aureus in a rural American Indian community
  publication-title: JAMA
  doi: 10.1001/jama.286.10.1201
– volume: 30
  start-page: 275
  year: 2002
  end-page: 280
  ident: 2024.11.01.621145v1.20
  article-title: Staphylococcus aureus collagen adhesin contributes to the pathogenesis of osteomyelitis
  publication-title: Bone
  doi: 10.1016/S8756-3282(01)00632-9
– volume: 288
  start-page: 20520
  year: 2013
  ident: 2024.11.01.621145v1.22
  article-title: Collagen-binding Microbial Surface Components Recognizing Adhesive Matrix Molecule (MSCRAMM) of Gram-positive Bacteria Inhibit Complement Activation via the Classical Pathway
  publication-title: J Biol Chem
  doi: 10.1074/JBC.M113.454462
– volume: 28
  start-page: 603
  year: 2015
  end-page: 661
  ident: 2024.11.01.621145v1.77
  article-title: Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management
  publication-title: Clin Microbiol Rev
  doi: 10.1128/CMR.00134-14
– volume: 15
  start-page: 45
  year: 2013
  end-page: 53
  ident: 2024.11.01.621145v1.67
  article-title: Perivascular macrophages mediate neutrophil recruitment during bacterial skin infection
  publication-title: Nature Immunology
  doi: 10.1038/ni.2769
– volume: 29
  start-page: 109
  year: 2016
  end-page: 115
  ident: 2024.11.01.621145v1.5
  article-title: Epidemiology and microbiology of skin and soft tissue infections
  publication-title: Curr Opin Infect Dis
  doi: 10.1097/QCO.0000000000000239
– volume: 13
  start-page: 252
  year: 2013
  ident: 2024.11.01.621145v1.53
  article-title: Incidence, microbiology, and patient characteristics of skin and soft-tissue infections in a U.S. population: a retrospective population-based study
  publication-title: BMC Infect Dis
  doi: 10.1186/1471-2334-13-252
– volume: 176
  start-page: 231
  year: 2007
  end-page: 241
  ident: 2024.11.01.621145v1.25
  article-title: Novel cell death program leads to neutrophil extracellular traps
  publication-title: J Cell Biol
  doi: 10.1083/jcb.200606027
– ident: 2024.11.01.621145v1.11
  article-title: Four pediatric deaths from community-acquired methicillin-resistant Staphylococcus aureus — Minnesota and North Dakota, 1997-1999
– volume: 285
  start-page: 760
  year: 1999
  end-page: 763
  ident: 2024.11.01.621145v1.15
  article-title: Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall
  publication-title: Science
  doi: 10.1126/SCIENCE.285.5428.760
– volume: 262
  start-page: 36
  year: 2014
  end-page: 55
  ident: 2024.11.01.621145v1.71
  article-title: Macrophage heterogeneity in tissues: Phenotypic diversity and functions
  publication-title: Immunol Rev
  doi: 10.1111/IMR.12223
– volume: 111
  start-page: 4227
  year: 2014
  end-page: 4232
  ident: 2024.11.01.621145v1.33
  article-title: Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/PNAS.1402136111/SUPPL_FILE/PNAS.201402136SI.PDF
– volume: 215
  start-page: 403
  year: 1990
  end-page: 410
  ident: 2024.11.01.621145v1.88
  article-title: Basic local alignment search tool
  publication-title: J Mol Biol
  doi: 10.1016/S0022-2836(05)80360-2
– volume: 2024
  start-page: 1
  year: 2024
  end-page: 16
  ident: 2024.11.01.621145v1.70
  article-title: Staphylococcus aureus adapts to exploit collagen-derived proline during chronic infection
  publication-title: Nature Microbiology
  doi: 10.1038/s41564-024-01769-9
– volume: 7
  start-page: 5
  year: 2023
  ident: 2024.11.01.621145v1.76
  article-title: Regulation of Collagen I and Collagen III in Tissue Injury and Regeneration
  publication-title: Cardiol Cardiovasc Med
  doi: 10.26502/FCCM.92920302
– volume: 66
  start-page: 416
  year: 1999
  end-page: 422
  ident: 2024.11.01.621145v1.68
  article-title: Digestion of C1q collagen-like domain with MMPs-1,-2,-3, and-9 further defines the sequence involved in the stimulation of neutrophil superoxide production
  publication-title: Article in Journal of Leukocyte Biology
  doi: 10.1002/jlb.66.3.416
– volume: 43
  start-page: 757
  year: 2021
  end-page: 771
  ident: 2024.11.01.621145v1.24
  article-title: Tipping the balance: intricate roles of the complement system in disease and therapy
  publication-title: Seminars in Immunopathology
  doi: 10.1007/S00281-021-00892-7
– volume: 12
  start-page: 79
  year: 2011
  end-page: 89
  ident: 2024.11.01.621145v1.72
  article-title: Dedifferentiation, transdifferentiation and reprogramming: Three routes to regeneration
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/NRM3043
– volume: 7
  year: 2019
  ident: 2024.11.01.621145v1.85
  article-title: ConFindr: rapid detection of intraspecies and cross-species contamination in bacterial whole-genome sequence data
  publication-title: PeerJ
  doi: 10.7717/PEERJ.6995
– volume: 13
  start-page: 1
  year: 2023
  end-page: 17
  ident: 2024.11.01.621145v1.60
  article-title: Purified complement C3b triggers phagocytosis and activation of human neutrophils via complement receptor 1
  publication-title: Scientific Reports
  doi: 10.1038/s41598-022-27279-4
– volume: 24
  start-page: 4224
  year: 2005
  end-page: 4236
  ident: 2024.11.01.621145v1.16
  article-title: A ‘Collagen Hug’ Model for Staphylococcus aureus CNA binding to collagen
  publication-title: EMBO J
  doi: 10.1038/SJ.EMBOJ.7600888
– volume: 3
  start-page: 1
  year: 2011
  end-page: 19
  ident: 2024.11.01.621145v1.1
  article-title: The Collagen Family
  publication-title: Cold Spring Harb Perspect Biol
  doi: 10.1101/CSHPERSPECT.A004978
– volume: 9
  year: 2018
  ident: 2024.11.01.621145v1.36
  article-title: Human memory B cells targeting Staphylococcus aureus exotoxins are prevalent with skin and soft tissue infection
  publication-title: mBio
  doi: 10.1128/MBIO.02125-17/ASSET/882A0284-3A6D-4893-91C3-9005C71C09A9/ASSETS/GRAPHIC/MBO0021837730005.JPEG
– volume: 10
  year: 2019
  ident: 2024.11.01.621145v1.83
  article-title: Identification of extracellular DNA-binding proteins in the biofilm matrix
  publication-title: mBio
  doi: 10.1128/MBIO.01137-19/SUPPL_FILE/MBIO.01137-19-ST002.DOCX
– volume: 28
  start-page: 27
  year: 2000
  end-page: 30
  ident: 2024.11.01.621145v1.89
  article-title: KEGG: kyoto encyclopedia of genes and genomes
  publication-title: Nucleic Acids Res
  doi: 10.1093/NAR/28.1.27
– volume: 11
  start-page: 2160
  year: 2017
  end-page: 2170
  ident: 2024.11.01.621145v1.3
  article-title: Single-Cell and Single-Molecule Analysis Unravels the Multifunctionality of the Staphylococcus aureus Collagen-Binding Protein Cna
  publication-title: ACS Nano
  doi: 10.1021/ACSNANO.6B08404
– volume: 174
  start-page: 83
  year: 1996
  end-page: 88
  ident: 2024.11.01.621145v1.51
  article-title: Collagen binding of Staphylococcus aureus is a virulence factor in experimental endocarditis
  publication-title: J Infect Dis
– volume: 13
  year: 2024
  ident: 2024.11.01.621145v1.58
  article-title: Epidemiology and clinical features of Skin and Soft Tissue Infections Caused by PVL-Positive and PVL-Negative Methicillin-Resistant Staphylococcus aureus Isolates in inpatients in China: a single-center retrospective 7-year study
  publication-title: Emerg Microbes Infect
  doi: 10.1080/22221751.2024.2316809
– volume: 26
  start-page: e1
  issue: 1416
  year: 2020
  end-page: 1416
  ident: 2024.11.01.621145v1.57
  article-title: Panton-Valentine leukocidin–positive Staphylococcus aureus in skin and soft tissue infections from primary care patients
  publication-title: Clinical Microbiology and Infection
  doi: 10.1016/J.CMI.2020.06.029
– volume: 267
  start-page: 4766
  year: 1992
  end-page: 4772
  ident: 2024.11.01.621145v1.19
  article-title: Molecular characterization and expression of a gene encoding a Staphylococcus aureus collagen adhesin
  publication-title: Journal of Biological Chemistry
  doi: 10.1016/s0021-9258(18)42898-0
– volume: 62
  year: 2018
  ident: 2024.11.01.621145v1.41
  article-title: Neutralizing Alpha-Toxin Accelerates Healing of Staphylococcus aureus-Infected Wounds in Nondiabetic and Diabetic Mice
  publication-title: Antimicrob Agents Chemother
  doi: 10.1128/AAC.02288-17
– volume: 9
  year: 2018
  ident: 2024.11.01.621145v1.52
  article-title: Human Memory B Cells Targeting Staphylococcus aureus Exotoxins Are Prevalent with Skin and Soft Tissue Infection
  publication-title: mBio
  doi: 10.1128/MBIO.02125-17
– volume: 9
  start-page: 624025
  year: 2021
  ident: 2024.11.01.621145v1.59
  article-title: Complement Receptors and Their Role in Leukocyte Recruitment and Phagocytosis
  publication-title: Front Cell Dev Biol
  doi: 10.3389/FCELL.2021.624025
– volume: 9
  year: 2018
  ident: 2024.11.01.621145v1.69
  article-title: Direct conversion of injury-site myeloid cells to fibroblast-like cells of granulation tissue
  publication-title: Nat Commun
  doi: 10.1038/S41467-018-03208-W
– volume: 68
  start-page: 3776
  year: 2000
  end-page: 3779
  ident: 2024.11.01.621145v1.50
  article-title: The collagen-binding adhesin is a virulence factor in Staphylococcus aureus keratitis
  publication-title: Infect Immun
  doi: 10.1128/IAI.68.6.3776-3779.2000
– volume: 100
  start-page: 208
  year: 2020
  end-page: 215
  ident: 2024.11.01.621145v1.4
  article-title: Skin Infections Caused by Staphylococcus aureus
  publication-title: Acta Derm Venereol
  doi: 10.2340/00015555-3466
– volume: 200
  start-page: 3871
  year: 2018
  end-page: 3880
  ident: 2024.11.01.621145v1.39
  article-title: Innate Immunity to Staphylococcus aureus : Evolving Paradigms in Soft Tissue and Invasive Infections
  publication-title: The Journal of Immunology
  doi: 10.4049/JIMMUNOL.1701574
– volume: 36
  start-page: 1925
  year: 2020
  end-page: 1927
  ident: 2024.11.01.621145v1.87
  article-title: GTDB-Tk: a toolkit to classify genomes with the Genome Taxonomy Database
  publication-title: Bioinformatics
  doi: 10.1093/BIOINFORMATICS/BTZ848
– volume: 142
  issue: 12
  year: 2005
  ident: 2024.11.01.621145v1.30
  article-title: The paradox of matrix metalloproteinases in infectious disease
  publication-title: Clin Exp Immunol
  doi: 10.1111/J.1365-2249.2005.02840.X
– volume: 16
  start-page: 63
  year: 2013
  end-page: 69
  ident: 2024.11.01.621145v1.63
  article-title: The effects of Staphylococcus aureus leukotoxins on the host: cell lysis and beyond
  publication-title: Curr Opin Microbiol
  doi: 10.1016/j.mib.2013.01.012
– volume: 17
  start-page: 32
  year: 2014
  end-page: 37
  ident: 2024.11.01.621145v1.8
  article-title: Staphylococcus aureus toxins
  publication-title: Curr Opin Microbiol
  doi: 10.1016/j.mib.2013.11.004
– volume: 208
  start-page: 990
  year: 2013
  end-page: 999
  ident: 2024.11.01.621145v1.79
  article-title: Staphylokinase promotes the establishment of Staphylococcus aureus skin infections while decreasing disease severity
  publication-title: J Infect Dis
  doi: 10.1093/INFDIS/JIT288
– volume: 11
  start-page: e0150606
  year: 2016
  ident: 2024.11.01.621145v1.42
  article-title: A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues
  publication-title: PLoS One
  doi: 10.1371/JOURNAL.PONE.0150606
– volume: 13
  start-page: 529
  year: 2015
  end-page: 543
  ident: 2024.11.01.621145v1.82
  article-title: Staphylococcal manipulation of host immune responses
  publication-title: Nat Rev Microbiol
– volume: 48
  start-page: 2
  year: 2024
  ident: 2024.11.01.621145v1.10
  article-title: The role of human extracellular matrix proteins in defining Staphylococcus aureus biofilm infections
  publication-title: FEMS Microbiol Rev
  doi: 10.1093/femsre/fuae002
– volume: 108
  start-page: 269
  year: 2001
  end-page: 274
  ident: 2024.11.01.621145v1.55
  article-title: Fibronectin and fibrinogen contribute to the enhanced binding of Staphylococcus aureus to atopic skin
  publication-title: J Allergy Clin Immunol
  doi: 10.1067/MAI.2001.117455
– volume: 9
  issue: 639
  year: 2018
  ident: 2024.11.01.621145v1.23
  article-title: Complement Activation in Inflammatory Skin Diseases
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2018.00639
– volume: 460
  start-page: 637
  year: 2009
  ident: 2024.11.01.621145v1.32
  article-title: Macrophage elastase kills bacteria within murine macrophages
  publication-title: Nature
  doi: 10.1038/NATURE08181
– volume: 8
  year: 2023
  ident: 2024.11.01.621145v1.66
  article-title: Metabolic rewiring tunes dermal macrophages in staphylococcal skin infection
  publication-title: Sci Immunol
  doi: 10.1126/SCIIMMUNOL.ADG3517/SUPPL_FILE/SCIIMMUNOL.ADG3517_MDAR_REPRODUCIBILITY_CHECKLIST.PDF
– volume: 13
  start-page: 584
  year: 2013
  end-page: 594
  ident: 2024.11.01.621145v1.61
  article-title: The Staphylococcal Toxin Panton-Valentine Leukocidin Targets Human C5a Receptors
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2013.04.006
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Snippet Staphylococcus aureus causes approximately 80% of skin and soft tissue infections (SSTIs). Collagen is the most abundant human extracellular matrix protein...
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Title Collagen binding adhesin restricts Staphylococcus aureus skin infection
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