Thalamic control of sensory enhancement and sleep spindle properties in a biophysical model of thalamoreticular microcircuitry

Thalamoreticular circuitry is known to play a key role in attention, cognition and the generation of sleep spindles, and is implicated in numerous brain disorders, but the cellular and synaptic mechanisms remain intractable. Therefore, we developed the first detailed computational model of mouse tha...

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Main Authors Iavarone, Elisabetta, Simko, Jane, Shi, Ying, Bertschy, Marine, María Garcia Amado, Litvak, Polina, Anna-Kristin Kaufmann, O'reilly, Christian, Amsalem, Oren, Abdellah, Marwan, Chevtchenko, Grigori, Coste, Benoît, Jean-Denis Courcol, Ecker, András, Favreau, Cyrille, Fleury, Adrien Christian, Werner Van Geit, Gevaert, Michael, Nadir Román Guerrero, Herttuainen, Joni, Genrich Ivaska, Kerrien, Samuel, King, James G, Kumbhar, Pramod, Lurie, Patrycja, Magkanaris, Ioannis, Muddapu, Vignayanandam R, Nair, Jayakrishnan, Pereira, Fernando L, Perin, Rodrigo, Petitjean, Fabien, Ranjan, Rajnish, Reimann, Michael, Soltuzu, Liviu, Mohameth, François Sy, Ulbrich, Alexander, Tuncel, M Anıl, Wolf, Matthias, Clascá, Francisco, Markram, Henry, Hill, Sean L
Format Paper
LanguageEnglish
Published Cold Spring Harbor Cold Spring Harbor Laboratory Press 14.04.2022
Cold Spring Harbor Laboratory
Edition1.2
Subjects
Activity patterns
Attention
Cortex (somatosensory)
Gap junctions
Information processing
Mathematical models
Neural networks
Neuromodulation
Neuroscience
Sensory integration
Sleep
Sleep and wakefulness
Synaptic plasticity
Thalamic reticular nucleus
Thalamus
Online AccessGet full text
ISSN2692-8205
2692-8205
DOI10.1101/2022.02.28.482273

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Abstract Thalamoreticular circuitry is known to play a key role in attention, cognition and the generation of sleep spindles, and is implicated in numerous brain disorders, but the cellular and synaptic mechanisms remain intractable. Therefore, we developed the first detailed computational model of mouse thalamus and thalamic reticular nucleus microcircuitry that captures morphological and biophysical properties of ~14,000 neurons connected via ~6M synapses, and recreates biological synaptic and gap junction connectivity. Simulations recapitulate multiple independent network-level experimental findings across different brain states, providing a novel unifying cellular and synaptic account of spontaneous and evoked activity in both wakefulness and sleep. Furthermore, we found that: 1.) inhibitory rebound produces frequency-selective enhancement of thalamic responses during wakefulness, in addition to its role in spindle generation; 2.) thalamic interactions generate the characteristic waxing and waning of spindle oscillations; and 3.) changes in thalamic excitability (e.g. due to neuromodulation) control spindle frequency and occurrence. The model is openly available and provides a new tool to interpret spindle oscillations and test hypotheses of thalamoreticular circuit function and dysfunction across different network states in health and disease. Competing Interest Statement The authors have declared no competing interest. Footnotes * We revised the title, abstract, and introduction to highlight some of the primary findings on thalamic control of sensory responses and spindle properties. * https://identifiers.org/bbkg:thalamus/studios/e9ceee28-b2c2-4c4d-bff9-d16f43c3eb0f
AbstractList Thalamoreticular circuitry is known to play a key role in attention, cognition and the generation of sleep spindles, and is implicated in numerous brain disorders, but the cellular and synaptic mechanisms remain intractable. Therefore, we developed the first detailed computational model of mouse thalamus and thalamic reticular nucleus microcircuitry that captures morphological and biophysical properties of ~14,000 neurons connected via ~6M synapses, and recreates biological synaptic and gap junction connectivity. Simulations recapitulate multiple independent network-level experimental findings across different brain states, providing a novel unifying cellular and synaptic account of spontaneous and evoked activity in both wakefulness and sleep. Furthermore, we found that: 1.) inhibitory rebound produces frequency-selective enhancement of thalamic responses during wakefulness, in addition to its role in spindle generation; 2.) thalamic interactions generate the characteristic waxing and waning of spindle oscillations; and 3.) changes in thalamic excitability (e.g. due to neuromodulation) control spindle frequency and occurrence. The model is openly available and provides a new tool to interpret spindle oscillations and test hypotheses of thalamoreticular circuit function and dysfunction across different network states in health and disease. Competing Interest Statement The authors have declared no competing interest. Footnotes * We revised the title, abstract, and introduction to highlight some of the primary findings on thalamic control of sensory responses and spindle properties. * https://identifiers.org/bbkg:thalamus/studios/e9ceee28-b2c2-4c4d-bff9-d16f43c3eb0f
Thalamoreticular circuitry is known to play a key role in attention, cognition and the generation of sleep spindles, and is implicated in numerous brain disorders, but the cellular and synaptic mechanisms remain intractable. Therefore, we developed the first detailed computational model of mouse thalamus and thalamic reticular nucleus microcircuitry that captures morphological and biophysical properties of ∼14,000 neurons connected via ∼6M synapses, and recreates biological synaptic and gap junction connectivity. Simulations recapitulate multiple independent network-level experimental findings across different brain states, providing a novel unifying cellular and synaptic account of spontaneous and evoked activity in both wakefulness and sleep. Furthermore, we found that: 1.) inhibitory rebound produces frequency-selective enhancement of thalamic responses during wakefulness, in addition to its role in spindle generation; 2.) thalamic interactions generate the characteristic waxing and waning of spindle oscillations; and 3.) changes in thalamic excitability (e.g. due to neuromodulation) control spindle frequency and occurrence. The model is openly available and provides a new tool to interpret spindle oscillations and test hypotheses of thalamoreticular circuit function and dysfunction across different network states in health and disease.
Author O'reilly, Christian
María Garcia Amado
Coste, Benoît
Ranjan, Rajnish
Tuncel, M Anıl
Nair, Jayakrishnan
Simko, Jane
Chevtchenko, Grigori
Petitjean, Fabien
Nadir Román Guerrero
Pereira, Fernando L
Abdellah, Marwan
Hill, Sean L
Kerrien, Samuel
Muddapu, Vignayanandam R
Genrich Ivaska
Mohameth, François Sy
Jean-Denis Courcol
Lurie, Patrycja
Gevaert, Michael
Favreau, Cyrille
Herttuainen, Joni
Magkanaris, Ioannis
Wolf, Matthias
Amsalem, Oren
Kumbhar, Pramod
Soltuzu, Liviu
Iavarone, Elisabetta
Shi, Ying
Ecker, András
Reimann, Michael
Perin, Rodrigo
Markram, Henry
Anna-Kristin Kaufmann
Clascá, Francisco
Bertschy, Marine
Litvak, Polina
Werner Van Geit
Fleury, Adrien Christian
King, James G
Ulbrich, Alexander
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References Ferrarelli, Huber, Peterson, Massimini, Murphy, Riedner, Watson, Bria, Tononi (2022.02.28.482273v2.78) 2007; 164
Jones (2022.02.28.482273v2.117) 2007
Sohal, Pangratz-Fuehrer, Rudolph, Huguenard (2022.02.28.482273v2.211) 2006; 26
Clawson, Durkin, Aton (2022.02.28.482273v2.39) 2016; 2016
Pellegrini, Lecci, Lüthi, Astori (2022.02.28.482273v2.179) 2016; 39
McCormick (2022.02.28.482273v2.162) 1992; 39
Harris, Hirokawa, Sorensen, Gu, Mills, Ng, Bohn, Mortrud, Ouellette, Kidney, Smith, Dang, Sunkin, Bernard, Oh, Madisen, Zeng (2022.02.28.482273v2.96) 2014; 8
Druckmann, Banitt, Gidon, Schürmann, Markram, Segev (2022.02.28.482273v2.70) 2007; 1
Häusser, Roth (2022.02.28.482273v2.99) 1997; 17
Kandel, Buzsáki (2022.02.28.482273v2.120) 1997; 17
Golomb, Wang, Rinzel (2022.02.28.482273v2.90) 1996; 75
Kubota, Sohn, Kawaguchi (2022.02.28.482273v2.134) 2018; 12
Nestvogel, McCormick (2022.02.28.482273v2.174) 2021
Morgan, Lichtman (2022.02.28.482273v2.173) 2020
Parri, Crunelli (2022.02.28.482273v2.178) 1998; 18
Furuta, Tomioka, Taki, Nakamura, Tamamaki, Kaneko (2022.02.28.482273v2.87) 2001; 49
Castro-Alamancos (2022.02.28.482273v2.32) 2002; 539
Shu, Ju, Fan (2022.02.28.482273v2.206) 1988; 85
Hay, Hill, Schürmann, Markram, Segev (2022.02.28.482273v2.101) 2011b; 7
del Castillo, Katz (2022.02.28.482273v2.58) 1954; 124
Li, Lopez-Huerta, Adiconis, Levandowski, Choi, Simmons, Arias-Garcia, Guo, Yao, Blosser, Wimmer, Aida, Atamian, Naik, Sun, Bi, Malhotra, Hession, Shema, Gomes, Li, Hwang, Krol, Kowalczyk, Peça, Pan, Halassa, Levin, Fu, Feng (2022.02.28.482273v2.147) 2020
Brown, Taheri, Kenyon, Berger-Wolf, Llano (2022.02.28.482273v2.28) 2020; 7
Gruber, Wise (2022.02.28.482273v2.92) 2016; 2016
Castelnovo, Graziano, Ferrarelli, D’Agostino (2022.02.28.482273v2.31) 2018; 48
McAlonan, Cavanaugh, Wurtz (2022.02.28.482273v2.161) 2006; 26
Sarid, Bruno, Sakmann, Segev, Feldmeyer (2022.02.28.482273v2.197) 2007; 104
Monconduit, Lopez-Avila, Molat, Chalus, Villanueva (2022.02.28.482273v2.172) 2006; 26
Avanzini, de Curtis, Panzica, Spreafico (2022.02.28.482273v2.12) 1989; 416
Jaeger (2022.02.28.482273v2.111) 2000
Saito, Kaga, Nakagawa, Okubo, Kohashi, Omori, Fukuda, Inagaki (2022.02.28.482273v2.195) 2019; 41
Tsodyks, Markram (2022.02.28.482273v2.225) 1997; 94
Fogerson, Huguenard (2022.02.28.482273v2.80) 2016; 92
Reimann, King, Muller, Ramaswamy, Markram (2022.02.28.482273v2.188) 2015; 9
Saalmann, Pinsk, Wang, Li, Kastner (2022.02.28.482273v2.194) 2012; 337
Zhu, Lytton, Xue, Uhlrich (2022.02.28.482273v2.241) 1999; 81
Kozloski, Sfyrakis, Hill, Schurmann, Peck, Markram (2022.02.28.482273v2.131) 2008; 52
Crabtree (2022.02.28.482273v2.51) 2018; 12
Landisman, Connors (2022.02.28.482273v2.138) 2007; 17
Slézia, Hangya, Ulbert, Acsády (2022.02.28.482273v2.209) 2011; 31
Timofeev, Bazhenov, Sejnowski, Steriade (2022.02.28.482273v2.223) 2001; 1
Dai, Hernando, Billeh, Gratiy, Planas, Davison, Dura-Bernal, Gleeson, Devresse, Dichter, Gevaert, King, Van Geit, Povolotsky, Muller, Courcol, Arkhipov (2022.02.28.482273v2.55) 2020; 16
Destexhe, Sejnowski (2022.02.28.482273v2.68) 1995; 92
Miyata (2022.02.28.482273v2.169) 2007; 59
Landisman, Long, Beierlein, Deans, Paul, Connors (2022.02.28.482273v2.139) 2002; 22
Martin-Cortecero, Nuñez (2022.02.28.482273v2.158) 2014; 1591
Federhen (2022.02.28.482273v2.75) 2012; 40
Soto-Sánchez, Wang, Vaingankar, Sommer, Hirsch (2022.02.28.482273v2.212) 2017; 8
Huguenard, McCormick (2022.02.28.482273v2.108) 1992; 68
Martinez-Garcia, Voelcker, Zaltsman, Patrick, Stevens, Connors, Cruikshank (2022.02.28.482273v2.159) 2020; 583
McCormick, Pape (2022.02.28.482273v2.165) 1990; 431
Daigle, Madisen, Hage, Valley, Knoblich, Larsen, Takeno, Huang, Gu, Larsen, Mills, Bosma-Moody, Siverts, Walker, Graybuck, Yao, Fong, Nguyen, Garren, Lenz, Chavarha, Pendergraft, Harrington, Hirokawa, Harris, Nicovich, McGraw, Ollerenshaw, Smith, Baker, Ting, Sunkin, Lecoq, Lin, Boyden, Murphy, da Costa, Waters, Li, Tasic, Zeng (2022.02.28.482273v2.56) 2018; 174
Lüthi (2022.02.28.482273v2.150) 2014; 20
Bridson (2022.02.28.482273v2.27) 2007
Bús, Antal, Emri (2022.02.28.482273v2.30) 2018; 69
Lee, Patrick, Richardson, Connors (2022.02.28.482273v2.142) 2014; 34
Bazhenov, Timofeev, Steriade, Sejnowski (2022.02.28.482273v2.19) 2000; 84
Li, Henriquez, Fröhlich (2022.02.28.482273v2.146) 2017; 13
Sherman, Guillery (2022.02.28.482273v2.200) 1998; 95
Makinson, Huguenard (2022.02.28.482273v2.153) 2015; 18
Goldowitz (2022.02.28.482273v2.89) 2010; 9
Diamond, Armstrong-James, Ebner (2022.02.28.482273v2.69) 1992; 318
Castro-Alamancos (2022.02.28.482273v2.33) 2002; 87
Reuveni, Friedman, Amitai, Gutnick (2022.02.28.482273v2.190) 1993; 13
Connelly, Crunelli, Errington (2022.02.28.482273v2.42) 2017
Boucetta, Cissé, Mainville, Morales, Jones (2022.02.28.482273v2.26) 2014; 34
Hughes, Crunelli (2022.02.28.482273v2.106) 2005; 11
Warren, Agmon, Jones (2022.02.28.482273v2.235) 1994; 72
Destexhe, Contreras, Steriade (2022.02.28.482273v2.64) 1998; 79
Shosaku, Kayama, Sumitomo, Sugitani, Iwama (2022.02.28.482273v2.205) 1989; 32
Bal, von Krosigk, McCormick (2022.02.28.482273v2.15) 1995; 483
von Krosigk, Bal, McCormick (2022.02.28.482273v2.231) 1993; 261
Shishido, Toda (2022.02.28.482273v2.202) 2017; 243
Fernandez, Vantomme, Osorio-Forero, Cardis, Béard, Lüthi (2022.02.28.482273v2.76) 2018; 7
McAlonan, Cavanaugh, Wurtz (2022.02.28.482273v2.160) 2008; 456
Winnubst, Bas, Ferreira, Wu, Economo, Edson, Arthur, Bruns, Rokicki, Schauder, Olbris, Murphy, Ackerman, Arshadi, Baldwin, Blake, Elsayed, Hasan, Ramirez, Dos Santos, Weldon, Zafar, Dudman, Gerfen, Hantman, Korff, Sternson, Spruston, Svoboda, Chandrashekar (2022.02.28.482273v2.238) 2019; 179
Hill, Wang, Schürmann, Markram, Riachi (2022.02.28.482273v2.103) 2012; 109
Erö, Gewaltig, Keller, Markram (2022.02.28.482273v2.73) 2018; 12
Lüthi, McCormick (2022.02.28.482273v2.151) 1998; 20
Steriade, McCormick, Sejnowski (2022.02.28.482273v2.220) 1993; 262
Magistretti, Alonso (2022.02.28.482273v2.152) 1999; 114
Thankachan, Katsuki, McKenna, Yang, Shukla, Deisseroth, Uygun, Strecker, Brown, McNally, Basheer (2022.02.28.482273v2.222) 2019; 9
Krahe, El-Danaf, Dilger, Henderson, Guido (2022.02.28.482273v2.132) 2011; 31
Kim, Bal, McCormick (2022.02.28.482273v2.122) 1995
Cox, Sherman (2022.02.28.482273v2.49) 2000; 27
Reichova, Sherman (2022.02.28.482273v2.187) 2004; 92
Jahr, Stevens (2022.02.28.482273v2.114) 1990; 10
Cox, Schapiro, Manoach, Stickgold (2022.02.28.482273v2.50) 2017; 11
Budde, Biella, Munsch, Pape (2022.02.28.482273v2.29) 1997; 503
Ulrich, Huguenard (2022.02.28.482273v2.227) 1997; 17
Fuhrmann, Segev, Markram, Tsodyks (2022.02.28.482273v2.86) 2002; 87
Hines, Carnevale (2022.02.28.482273v2.104) 1997; 9
Kumbhar, Hines, Fouriaux, Ovcharenko, King, Delalondre, Schürmann (2022.02.28.482273v2.135) 2019; 13
Christensen, Kempfner, Zoetmulder, Leonthin, Arvastson, Christensen, Sorensen, Jennum (2022.02.28.482273v2.37) 2014; 125
Destexhe, Hughes, Rudolph, Crunelli (2022.02.28.482273v2.65) 2007; 30
Gentet, Ulrich (2022.02.28.482273v2.88) 2003; 546
Anwar, Riachi, Hill, Schürmann, Markram (2022.02.28.482273v2.7) 2009
Sholl (2022.02.28.482273v2.203) 1953; 87
Ohara, Lieberman (2022.02.28.482273v2.175) 1985; 14
Jurgens, Bell, McQuiston, Guido (2022.02.28.482273v2.118) 2012; 7
Rovó, Mátyás, Barthó, Slézia, Lecci, Pellegrini, Astori, Dávid, Hangya, Lüthi, Acsády (2022.02.28.482273v2.193) 2014; 34
Connelly, Crunelli, Errington (2022.02.28.482273v2.43) 2016; 36
Wang, Ding, Li, Royall, Feng, Lesnar, Graddis, Naeemi, Facer, Ho, Dolbeare, Blanchard, Dee, Wakeman, Hirokawa, Szafer, Sunkin, Oh, Bernard, Phillips, Hawrylycz, Koch, Zeng, Harris, Ng (2022.02.28.482273v2.233) 2020; 181
Clascá, Rubio-Garrido, Jabaudon (2022.02.28.482273v2.38) 2012; 35
Cruikshank, Urabe, Nurmikko, Connors (2022.02.28.482273v2.53) 2010; 65
Destexhe, McCormick, Sejnowski (2022.02.28.482273v2.66) 1993; 65
Cavdar, Bay, Kirazli, Cakmak, Onat (2022.02.28.482273v2.34) 2013; 34
Abdellah, Hernando, Eilemann, Lapere, Antille, Markram, Schürmann (2022.02.28.482273v2.1) 2018; 34
Miyata, Imoto (2022.02.28.482273v2.170) 2006; 575
Huguenard, Prince (2022.02.28.482273v2.109) 1992; 12
Lam, Sherman (2022.02.28.482273v2.137) 2011; 31
Crandall, Cruikshank, Connors (2022.02.28.482273v2.52) 2015; 86
Kirchgessner, Franklin, Callaway (2022.02.28.482273v2.126) 2020; 117
Anwar, Riachi, Hill, Schürmann, Markram (2022.02.28.482273v2.6) 2009
Wimmer, Schmitt, Davidson, Nakajima, Deisseroth, Halassa (2022.02.28.482273v2.237) 2015
Bazhenov, Timofeev, Steriade, Sejnowski (2022.02.28.482273v2.20) 1998; 79
Evangelio, García-Amado, Clascá (2022.02.28.482273v2.74) 2018; 12
Ecker, Romani, Sáray, Káli, Migliore, Falck, Lange, Mercer, Thomson, Muller, Reimann, Ramaswamy (2022.02.28.482273v2.71) 2020; 30
Manoach, Pan, Purcell, Stickgold (2022.02.28.482273v2.156) 2016; 80
Timofeev, Chauvette (2022.02.28.482273v2.224) 2013; 36
Ferrarelli, Peterson, Sarasso, Riedner, Murphy, Benca, Bria, Kalin, Tononi (2022.02.28.482273v2.79) 2010; 167
Aston-Jones, Bloom (2022.02.28.482273v2.10) 1981; 1
Markram, Muller, Ramaswamy, Reimann, Abdellah, Sanchez, Ailamaki, Alonso-Nanclares, Antille, Arsever, Kahou, Berger, Bilgili, Buncic, Chalimourda, Chindemi, Courcol, Delalondre, Delattre, Druckmann, Dumusc, Dynes, Eilemann, Gal, Gevaert, Ghobril, Gidon, Graham, Gupta, Haenel, Hay, Heinis, Hernando, Hines, Kanari, Keller, Kenyon, Khazen, Kim, King, Kisvarday, Kumbhar, Lasserre, Le Bé, Magalhães, Merchán-Pérez, Meystre, Morrice, Muller, Muñoz-Céspedes, Muralidhar, Muthurasa, Nachbaur, Newton, Nolte, Ovcharenko, Palacios, Pastor, Perin, Ranjan, Riachi, Rodríguez, Riquelme, Rössert, Sfyrakis, Shi, Shillcock, Silberberg, Silva, Tauheed, Telefont, Toledo-Rodriguez, Tränkler, Van Geit, Díaz, Walker, Wang, Zaninetta, DeFelipe, Hill, Segev, Schürmann (2022.02.28.482273v2.157) 2015; 163
Rikhye, Wimmer, Halassa (2022.02.28.482273v2.191) 2018; 41
Houser, Vaughn, Barber, Roberts (2022.02.28.482273v2.105) 1980; 200
Kim, Sanchez-Vives, McCormick (2022.02.28.482273v2.124) 1997; 278
Mineff, Weinberg (2022.02.28.482273v2.168) 2000; 101
Shosaku (2022.02.28.482273v2.204) 1986; 55
Ktonas, Golemati, Xa
References_xml – volume: 258
  start-page: 397
  year: 1987
  end-page: 406
  ident: 2022.02.28.482273v2.97
  article-title: Axon collaterals in the thalamic reticular nucleus from thalamocortical neurons of the rat ventrobasal thalamus
  publication-title: J. Comp. Neurol
– volume: 27
  start-page: 597
  year: 2000
  end-page: 610
  ident: 2022.02.28.482273v2.49
  article-title: Control of Dendritic Outputs of Inhibitory Interneurons in the Lateral Geniculate Nucleus
  publication-title: Neuron
– volume: 31
  start-page: 17437
  year: 2011
  end-page: 17448
  ident: 2022.02.28.482273v2.132
  article-title: Morphologically distinct classes of relay cells exhibit regional preferences in the dorsal lateral geniculate nucleus of the mouse
  publication-title: J. Neurosci. Off. J. Soc. Neurosci
– volume: 11
  start-page: 4949
  year: 2020
  ident: 2022.02.28.482273v2.239
  article-title: A petascale automated imaging pipeline for mapping neuronal circuits with high-throughput transmission electron microscopy
  publication-title: Nat. Commun
– volume: 19
  start-page: 2130
  year: 2017
  end-page: 2142
  ident: 2022.02.28.482273v2.40
  article-title: Distinct thalamic reticular cell types differentially modulate normal and pathological cortical rhythms
  publication-title: Cell Rep
– volume: 101
  start-page: 969
  year: 2000
  end-page: 982
  ident: 2022.02.28.482273v2.168
  article-title: Differential synaptic distribution of AMPA receptor subunits in the ventral posterior and reticular thalamic nuclei of the rat
  publication-title: Neuroscience
– volume: 87
  start-page: 946
  year: 2002
  end-page: 953
  ident: 2022.02.28.482273v2.33
  article-title: Properties of primary sensory (lemniscal) synapses in the ventrobasal thalamus and the relay of high-frequency sensory inputs
  publication-title: J. Neurophysiol
– volume: 12
  year: 2018
  ident: 2022.02.28.482273v2.134
  article-title: Large Volume Electron Microscopy and Neural Microcircuit Analysis
  publication-title: Front. Neural Circuits
– volume: 4
  year: 2017
  ident: 2022.02.28.482273v2.221
  article-title: Afferent Fiber Remodeling in the Somatosensory Thalamus of Mice as a Neural Basis of Somatotopic Reorganization in the Brain and Ectopic Mechanical Hypersensitivity after Peripheral Sensory Nerve Injury
  publication-title: eNeuro
– volume: 31
  start-page: 9124
  year: 2011
  end-page: 9134
  ident: 2022.02.28.482273v2.24
  article-title: Corticothalamic Feedback Controls Sleep Spindle Duration In Vivo
  publication-title: J. Neurosci
– volume: 40
  start-page: D136
  year: 2012
  end-page: 143
  ident: 2022.02.28.482273v2.75
  article-title: The NCBI Taxonomy database
  publication-title: Nucleic Acids Res
– volume: 26
  start-page: 1677
  year: 2006
  end-page: 1687
  ident: 2022.02.28.482273v2.128
  article-title: Single Ih channels in pyramidal neuron dendrites: properties, distribution, and impact on action potential output
  publication-title: J. Neurosci
– volume: 318
  start-page: 462
  year: 1992
  end-page: 476
  ident: 2022.02.28.482273v2.69
  article-title: Somatic sensory responses in the rostral sector of the posterior group (POm) and in the ventral posterior medial nucleus (VPM) of the rat thalamus
  publication-title: J. Comp. Neurol
– volume: 174
  start-page: 465
  year: 2018
  end-page: 480
  ident: 2022.02.28.482273v2.56
  article-title: A Suite of Transgenic Driver and Reporter Mouse Lines with Enhanced Brain-Cell-Type Targeting and Functionality
  publication-title: Cell
– volume: 117
  start-page: 13066
  year: 2020
  end-page: 13077
  ident: 2022.02.28.482273v2.126
  article-title: Context-dependent and dynamic functional influence of corticothalamic pathways to first- and higher-order visual thalamus
  publication-title: Proc. Natl. Acad. Sci
– volume: 5
  start-page: 2217
  year: 1994a
  end-page: 2220
  ident: 2022.02.28.482273v2.62
  article-title: Modeling the control of reticular thalamic oscillations by neuromodulators
  publication-title: Neuroreport
– volume: 10
  start-page: 3178
  year: 1990
  end-page: 3182
  ident: 2022.02.28.482273v2.114
  article-title: Voltage dependence of NMDA-activated macroscopic conductances predicted by single-channel kinetics
  publication-title: J. Neurosci. Off. J. Soc. Neurosci
– volume: 11
  start-page: 683
  year: 2008
  end-page: 692
  ident: 2022.02.28.482273v2.54
  article-title: T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites
  publication-title: Nat. Neurosci.
– volume: 31
  start-page: 5009
  year: 2021
  end-page: 5023
  ident: 2022.02.28.482273v2.177
  article-title: Noradrenergic circuit control of non-REM sleep substates
  publication-title: Curr. Biol
– volume: 17
  start-page: 8880
  year: 1997
  end-page: 8893
  ident: 2022.02.28.482273v2.196
  article-title: Functional properties of perigeniculate inhibition of dorsal lateral geniculate nucleus thalamocortical neurons in vitro
  publication-title: J. Neurosci. Off. J. Soc. Neurosci
– volume: 9
  year: 2016
  ident: 2022.02.28.482273v2.36
  article-title: Thalamic Circuit Mechanisms Link Sensory Processing in Sleep and Attention
  publication-title: Front. Neural Circuits
– volume: 40
  start-page: 2663
  year: 2020
  end-page: 2679
  ident: 2022.02.28.482273v2.192
  article-title: Area-Specific Synapse Structure in Branched Posterior Nucleus Axons Reveals a New Level of Complexity in Thalamocortical Networks
  publication-title: J. Neurosci
– volume: 75
  start-page: 125
  year: 2005
  end-page: 141
  ident: 2022.02.28.482273v2.83
  article-title: The reticular nucleus revisited: Intrinsic and network properties of a thalamic pacemaker
  publication-title: Prog. Neurobiol
– volume: 57
  start-page: 260
  year: 1987
  end-page: 273
  ident: 2022.02.28.482273v2.218
  article-title: The deafferented reticular thalamic nucleus generates spindle rhythmicity
  publication-title: J. Neurophysiol
– year: 2009
  ident: 2022.02.28.482273v2.226
– volume: 20
  start-page: 553
  year: 1998
  end-page: 563
  ident: 2022.02.28.482273v2.151
  article-title: Periodicity of thalamic synchronized oscillations: the role of Ca2+-mediated upregulation of Ih
  publication-title: Neuron
– volume: 84
  start-page: 1076
  year: 2000
  end-page: 1087
  ident: 2022.02.28.482273v2.19
  article-title: Spiking-bursting activity in the thalamic reticular nucleus initiates sequences of spindle oscillations in thalamic networks
  publication-title: J. Neurophysiol
– volume: 46
  start-page: 1
  year: 2004
  end-page: 31
  ident: 2022.02.28.482273v2.181
  article-title: The thalamic reticular nucleus: structure, function and concept
  publication-title: Brain Res. Rev
– volume: 93
  start-page: 294
  year: 2005
  end-page: 304
  ident: 2022.02.28.482273v2.84
  article-title: Membrane bistability in thalamic reticular neurons during spindle oscillations
  publication-title: J. Neurophysiol
– volume: 36
  start-page: 825
  year: 2013
  end-page: 826
  ident: 2022.02.28.482273v2.224
  article-title: The Spindles: Are They Still Thalamic?
  publication-title: Sleep
– volume: 10
  start-page: 17
  year: 2016
  ident: 2022.02.28.482273v2.230
  article-title: BluePyOpt: leveraging open source software and cloud infrastructure to optimise model parameters in neuroscience. Front
  publication-title: Neuroinformatics
– volume: 79
  start-page: 999
  year: 1998
  end-page: 1016
  ident: 2022.02.28.482273v2.64
  article-title: Mechanisms underlying the synchronizing action of corticothalamic feedback through inhibition of thalamic relay cells
  publication-title: J. Neurophysiol
– volume: 582
  start-page: 195
  year: 2007
  end-page: 208
  ident: 2022.02.28.482273v2.144
  article-title: Heterogeneity of firing properties among rat thalamic reticular nucleus neurons: Electrophysiological heterogeneity of TRN neurons
  publication-title: J. Physiol
– volume: 26
  start-page: 8633
  year: 2006
  end-page: 8645
  ident: 2022.02.28.482273v2.60
  article-title: Distinct Electrical and Chemical Connectivity Maps in the Thalamic Reticular Nucleus: Potential Roles in Synchronization and Sensation
  publication-title: J. Neurosci
– volume: 94
  start-page: 8854
  year: 1997
  end-page: 8859
  ident: 2022.02.28.482273v2.47
  article-title: Nucleus reticularis neurons mediate diverse inhibitory effects in thalamus
  publication-title: Proc. Natl. Acad. Sci. U. S. A
– volume: 92
  start-page: 9515
  year: 1995
  end-page: 9519
  ident: 2022.02.28.482273v2.68
  article-title: G protein activation kinetics and spillover of gamma-aminobutyric acid may account for differences between inhibitory responses in the hippocampus and thalamus
  publication-title: Proc. Natl. Acad. Sci. U. S. A
– volume: 111
  start-page: 11828
  year: 2014
  end-page: 11833
  ident: 2022.02.28.482273v2.143
  article-title: Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice
  publication-title: Proc. Natl. Acad. Sci. U. S. A
– volume: 63
  start-page: 1
  year: 1986
  end-page: 20
  ident: 2022.02.28.482273v2.201
  article-title: The control of retinogeniculate transmission in the mammalian lateral geniculate nucleus
  publication-title: Exp. Brain Res
– volume: 17
  start-page: 2853
  year: 2007
  end-page: 2865
  ident: 2022.02.28.482273v2.138
  article-title: VPM and PoM Nuclei of the Rat Somatosensory Thalamus: Intrinsic Neuronal Properties and Corticothalamic Feedback
  publication-title: Cereb. Cortex
– volume: 26
  start-page: 1443
  year: 2019
  end-page: 1457
  ident: 2022.02.28.482273v2.228
  article-title: Brain-State-Dependent Modulation of Neuronal Firing and Membrane Potential Dynamics in the Somatosensory Thalamus during Natural Sleep
  publication-title: Cell Rep
– volume: 34
  start-page: 7137
  year: 2014
  end-page: 7147
  ident: 2022.02.28.482273v2.193
  article-title: Phasic, Nonsynaptic GABA-A Receptor-Mediated Inhibition Entrains Thalamocortical Oscillations
  publication-title: J. Neurosci
– volume: 104
  start-page: 16353
  year: 2007
  end-page: 16358
  ident: 2022.02.28.482273v2.197
  article-title: Modeling a layer 4-to-layer 2/3 module of a single column in rat neocortex: Interweaving in vitro and in vivo experimental observations
  publication-title: Proc. Natl. Acad. Sci
– volume: 1157
  start-page: 10
  year: 2009
  end-page: 23
  ident: 2022.02.28.482273v2.115
  article-title: Synchrony in the Interconnected Circuitry of the Thalamus and Cerebral Cortex
  publication-title: Ann. N. Y. Acad. Sci
– volume: 142
  start-page: 511
  year: 2004
  end-page: 523
  ident: 2022.02.28.482273v2.232
  article-title: The dynamics of spindles and EEG slow-wave activity in NREM sleep in mice
  publication-title: Arch. Ital. Biol
– volume: 108
  start-page: 13823
  year: 2011
  end-page: 13828
  ident: 2022.02.28.482273v2.11
  article-title: The Ca(V)3.3 calcium channel is the major sleep spindle pacemaker in thalamus
  publication-title: Proc. Natl. Acad. Sci. U. S. A
– year: 2007
  ident: 2022.02.28.482273v2.27
  publication-title: Fast Poisson disk sampling in arbitrary dimensions. SIGGRAPH Sketches 10, 1278780.1278807
– volume: 2016
  start-page: e6936381
  year: 2016
  ident: 2022.02.28.482273v2.39
  article-title: Form and Function of Sleep Spindles across the Lifespan
  publication-title: Neural Plast
– volume: 17
  start-page: 297
  year: 1996
  end-page: 308
  ident: 2022.02.28.482273v2.14
  article-title: What Stops Synchronized Thalamocortical Oscillations?
  publication-title: Neuron
– volume: 261
  start-page: 361
  year: 1993
  end-page: 364
  ident: 2022.02.28.482273v2.231
  article-title: Cellular mechanisms of a synchronized oscillation in the thalamus
  publication-title: Science
– volume: 72
  start-page: 1993
  year: 1994
  end-page: 2003
  ident: 2022.02.28.482273v2.235
  article-title: Oscillatory synaptic interactions between ventroposterior and reticular neurons in mouse thalamus in vitro
  publication-title: J. Neurophysiol
– volume: 16
  start-page: 5567
  year: 1996
  end-page: 5582
  ident: 2022.02.28.482273v2.13
  article-title: Multiple channel types contribute to the low-voltage-activated calcium current in hippocampal CA3 pyramidal neurons
  publication-title: J. Neurosci. Off. J. Soc. Neurosci
– volume: 18
  start-page: 104
  year: 2015
  end-page: 111
  ident: 2022.02.28.482273v2.3
  article-title: ErbB4 regulation of a thalamic reticular nucleus circuit for sensory selection
  publication-title: Nat. Neurosci
– volume: 18
  start-page: 2
  year: 2015
  end-page: 4
  ident: 2022.02.28.482273v2.153
  article-title: Attentional flexibility in the thalamus: now we’re getting soMwhere
  publication-title: Nat. Neurosci
– volume: 35
  start-page: 1524
  year: 2012
  end-page: 1532
  ident: 2022.02.28.482273v2.38
  article-title: Unveiling the diversity of thalamocortical neuron subtypes: Thalamocortical neuron diversity
  publication-title: Eur. J. Neurosci
– volume: 39
  start-page: 337
  year: 1992
  end-page: 388
  ident: 2022.02.28.482273v2.162
  article-title: Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity
  publication-title: Prog. Neurobiol
– volume: 503
  start-page: 79
  year: 1997
  end-page: 85
  ident: 2022.02.28.482273v2.29
  article-title: Lack of regulation by intracellular Ca2+ of the hyperpolarization-activated cation current in rat thalamic neurones
  publication-title: J. Physiol
– volume: 262
  start-page: 679
  year: 1993
  end-page: 685
  ident: 2022.02.28.482273v2.220
  article-title: Thalamocortical oscillations in the sleeping and aroused brain
  publication-title: Science
– volume: 17
  start-page: 7606
  year: 1997
  end-page: 7625
  ident: 2022.02.28.482273v2.99
  article-title: Estimating the time course of the excitatory synaptic conductance in neocortical pyramidal cells using a novel voltage jump method
  publication-title: J. Neurosci. Off. J. Soc. Neurosci
– volume: 31
  start-page: 6791
  year: 2011
  end-page: 6799
  ident: 2022.02.28.482273v2.137
  article-title: Functional organization of the thalamic input to the thalamic reticular nucleus
  publication-title: J. Neurosci. Off. J. Soc. Neurosci
– volume: 41
  start-page: 751
  year: 2019
  end-page: 759
  ident: 2022.02.28.482273v2.195
  article-title: Association of inattention with slow-spindle density in sleep EEG of children with attention deficit-hyperactivity disorder
  publication-title: Brain Dev
– volume: 99
  start-page: 2291
  year: 2008
  end-page: 2304
  ident: 2022.02.28.482273v2.82
  article-title: Proprioceptive and cutaneous representations in the rat ventral posterolateral thalamus
  publication-title: J. Neurophysiol
– volume: 93
  start-page: 1165
  year: 2017
  end-page: 1179
  ident: 2022.02.28.482273v2.154
  article-title: Regulation of Thalamic and Cortical Network Synchrony by Scn8a
  publication-title: Neuron
– volume: 1661
  start-page: 49
  year: 2017
  end-page: 66
  ident: 2022.02.28.482273v2.125
  article-title: Robust interactions between the effects of auditory and cutaneous electrical stimulations on cell activities in the thalamic reticular nucleus
  publication-title: Brain Res
– volume: 94
  start-page: 719
  year: 1997
  end-page: 723
  ident: 2022.02.28.482273v2.225
  article-title: The neural code between neocortical pyramidal neurons depends on neurotransmitter release probability
  publication-title: Proc. Natl. Acad. Sci
– volume: 1
  start-page: 1
  year: 2007
  ident: 2022.02.28.482273v2.70
  article-title: A novel multiple objective optimization framework for constraining conductance-based neuron models by experimental data
  publication-title: Front. Neurosci
– volume: 109
  start-page: 20673
  year: 2012
  end-page: 20678
  ident: 2022.02.28.482273v2.121
  article-title: Optogenetically induced sleep spindle rhythms alter sleep architectures in mice
  publication-title: Proc. Natl. Acad. Sci. U. S. A
– start-page: 13
  year: 1966
  end-page: 46
  ident: 2022.02.28.482273v2.198
  publication-title: Patterns of organization in specific and nonspecific thalamic fields, in: The Thalamus. Columbia University Press, New York, pp.
– volume: 12
  start-page: 3804
  year: 1992
  end-page: 3817
  ident: 2022.02.28.482273v2.109
  article-title: A novel T-type current underlies prolonged Ca(2+)-dependent burst firing in GABAergic neurons of rat thalamic reticular nucleus
  publication-title: J. Neurosci. Off. J. Soc. Neurosci
– volume: 79
  start-page: 2730
  year: 1998
  end-page: 2748
  ident: 2022.02.28.482273v2.20
  article-title: Cellular and network models for intrathalamic augmenting responses during 10-Hz stimulation
  publication-title: J. Neurophysiol
– volume: 1
  start-page: 53
  year: 2001
  end-page: 69
  ident: 2022.02.28.482273v2.223
  article-title: Contribution of intrinsic and synaptic factors in the desynchronization of thalamic oscillatory activity
  publication-title: Thalamus Relat. Syst
– volume: 112
  start-page: 393
  year: 2014
  end-page: 410
  ident: 2022.02.28.482273v2.4
  article-title: The interplay of seven subthreshold conductances controls the resting membrane potential and the oscillatory behavior of thalamocortical neurons
  publication-title: J. Neurophysiol
– volume: 55
  start-page: 1030
  year: 1986
  end-page: 1043
  ident: 2022.02.28.482273v2.204
  article-title: Cross-correlation analysis of a recurrent inhibitory circuit in the rat thalamus
  publication-title: J. Neurophysiol
– volume: 588
  start-page: 2403
  year: 2010
  end-page: 2415
  ident: 2022.02.28.482273v2.141
  article-title: Electrical and chemical synapses between relay neurons in developing thalamus
  publication-title: J. Physiol
– volume: 7
  year: 2020
  ident: 2022.02.28.482273v2.28
  article-title: Signal Propagation via Open-Loop Intrathalamic Architectures: A Computational Model
  publication-title: eNeuro
– volume: 163
  start-page: 456
  year: 2015
  end-page: 492
  ident: 2022.02.28.482273v2.157
  article-title: Reconstruction and Simulation of Neocortical Microcircuitry
  publication-title: Cell
– volume: 5
  start-page: 533
  year: 2002
  end-page: 538
  ident: 2022.02.28.482273v2.41
  article-title: Ion channel properties underlying axonal action potential initiation in pyramidal neurons
  publication-title: Nat. Neurosci
– volume: 12
  year: 2018
  ident: 2022.02.28.482273v2.51
  article-title: Functional Diversity of Thalamic Reticular Subnetworks
  publication-title: Front. Syst. Neurosci
– volume: 7
  start-page: e39111
  year: 2018
  ident: 2022.02.28.482273v2.76
  article-title: Thalamic reticular control of local sleep in mouse sensory cortex
  publication-title: eLife
– year: 2007
  ident: 2022.02.28.482273v2.117
  publication-title: The thalamus.
– volume: 200
  start-page: 341
  year: 1980
  end-page: 354
  ident: 2022.02.28.482273v2.105
  article-title: GABA neurons are the major cell type of the nucleus reticularis thalami
  publication-title: Brain Res
– volume: 456
  start-page: 391
  year: 2008
  end-page: 394
  ident: 2022.02.28.482273v2.160
  article-title: Guarding the gateway to cortex with attention in visual thalamus
  publication-title: Nature
– volume: 92
  start-page: 5577
  year: 1995
  end-page: 5581
  ident: 2022.02.28.482273v2.234
  article-title: Emergent spindle oscillations and intermittent burst firing in a thalamic model: specific neuronal mechanisms
  publication-title: Proc. Natl. Acad. Sci
– volume: 7
  start-page: 31
  year: 1995
  end-page: 40
  ident: 2022.02.28.482273v2.182
  article-title: The axonal arborization of single thalamic reticular neurons in the somatosensory thalamus of the rat
  publication-title: Eur. J. Neurosci
– volume: 22
  start-page: 1002
  year: 2002
  end-page: 1009
  ident: 2022.02.28.482273v2.139
  article-title: Electrical synapses in the thalamic reticular nucleus
  publication-title: J. Neurosci. Off. J. Soc. Neurosci
– volume: 41
  start-page: 163
  year: 2018
  end-page: 183
  ident: 2022.02.28.482273v2.191
  article-title: Toward an Integrative Theory of Thalamic Function
  publication-title: Annu. Rev. Neurosci
– volume: 111
  start-page: 6798
  year: 2014
  end-page: 6803
  ident: 2022.02.28.482273v2.167
  article-title: Cortical control of adaptation and sensory relay mode in the thalamus
  publication-title: Proc. Natl. Acad. Sci
– volume: 391
  start-page: 180
  year: 1998
  end-page: 203
  ident: 2022.02.28.482273v2.183
  article-title: Projection and innervation patterns of individual thalamic reticular axons in the thalamus of the adult rat: a three-dimensional, graphic, and morphometric analysis
  publication-title: J. Comp. Neurol
– volume: 92
  start-page: 687
  year: 2016
  end-page: 704
  ident: 2022.02.28.482273v2.80
  article-title: Tapping the Brakes: Cellular and Synaptic Mechanisms that Regulate Thalamic Oscillations
  publication-title: Neuron
– volume: 62
  start-page: 612
  year: 2009
  end-page: 632
  ident: 2022.02.28.482273v2.21
  article-title: Neurons that Fire Together Also Conspire Together: Is Normal Sleep Circuitry Hijacked to Generate Epilepsy?
  publication-title: Neuron
– volume: 416
  start-page: 111
  year: 1989
  end-page: 122
  ident: 2022.02.28.482273v2.12
  article-title: Intrinsic properties of nucleus reticularis thalami neurones of the rat studied in vitro
  publication-title: J. Physiol
– volume: 30
  start-page: 334
  year: 2007
  end-page: 342
  ident: 2022.02.28.482273v2.65
  article-title: Are corticothalamic “up” states fragments of wakefulness?
  publication-title: Trends Neurosci
– volume: 81
  start-page: 702
  year: 1999
  end-page: 711
  ident: 2022.02.28.482273v2.241
  article-title: An intrinsic oscillation in interneurons of the rat lateral geniculate nucleus
  publication-title: J. Neurophysiol
– volume: 10
  year: 2016
  ident: 2022.02.28.482273v2.184
  article-title: A Simple and Efficient In Vivo Non-viral RNA Transfection Method for Labeling the Whole Axonal Tree of Individual Adult Long-Range Projection Neurons
  publication-title: Front. Neuroanat
– volume: 599
  start-page: 5085
  year: 2021
  end-page: 5101
  ident: 2022.02.28.482273v2.207
  article-title: Morphology, physiology and synaptic connectivity of local interneurons in the mouse somatosensory thalamus
  publication-title: J. Physiol
– volume: 0
  year: 2020
  ident: 2022.02.28.482273v2.23
  article-title: Systematic Integration of Structural and Functional Data into Multi-scale Models of Mouse Primary Visual Cortex
  publication-title: Neuron
– volume: 65
  start-page: 2473
  year: 1993
  end-page: 2477
  ident: 2022.02.28.482273v2.66
  article-title: A model for 8-10 Hz spindling in interconnected thalamic relay and reticularis neurons
  publication-title: Biophys. J
– volume: 31
  start-page: 607
  year: 2011
  end-page: 617
  ident: 2022.02.28.482273v2.209
  article-title: Phase advancement and nucleus-specific timing of thalamocortical activity during slow cortical oscillation
  publication-title: J. Neurosci. Off. J. Soc. Neurosci
– volume: 82
  start-page: 1367
  year: 2014
  end-page: 1379
  ident: 2022.02.28.482273v2.18
  article-title: Ongoing Network State Controls the Length of Sleep Spindles via Inhibitory Activity
  publication-title: Neuron
– volume: 32
  start-page: 77
  year: 1989
  end-page: 102
  ident: 2022.02.28.482273v2.205
  article-title: Analysis of recurrent inhibitory circuit in rat thalamus: Neurophysiology of the thalamic reticular nucleus
  publication-title: Prog. Neurobiol
– volume: 20
  start-page: 185
  year: 1997
  end-page: 215
  ident: 2022.02.28.482273v2.163
  article-title: SLEEP AND AROUSAL: Thalamocortical Mechanisms
  publication-title: Annu. Rev. Neurosci
– volume: 137
  start-page: 1087
  year: 2006
  end-page: 1106
  ident: 2022.02.28.482273v2.214
  article-title: Grouping of brain rhythms in corticothalamic systems
  publication-title: Neuroscience
– volume: 15
  start-page: 604
  year: 1995
  end-page: 622
  ident: 2022.02.28.482273v2.46
  article-title: Cellular basis of EEG slow rhythms: a study of dynamic corticothalamic relationships
  publication-title: J. Neurosci. Off. J. Soc. Neurosci
– volume: 30
  start-page: 350
  year: 2007
  end-page: 356
  ident: 2022.02.28.482273v2.107
  article-title: Thalamic synchrony and dynamic regulation of global forebrain oscillations
  publication-title: Trends Neurosci
– volume: 114
  start-page: 491
  year: 1999
  end-page: 509
  ident: 2022.02.28.482273v2.152
  article-title: Biophysical properties and slow voltage-dependent inactivation of a sustained sodium current in entorhinal cortex layer-II principal neurons: a whole-cell and single-channel study
  publication-title: J. Gen. Physiol
– volume: 483
  start-page: 665
  year: 1995
  end-page: 685
  ident: 2022.02.28.482273v2.16
  article-title: Role of the ferret perigeniculate nucleus in the generation of synchronized oscillations in vitro
  publication-title: J. Physiol
– volume: 126
  start-page: 213
  year: 2021
  end-page: 235
  ident: 2022.02.28.482273v2.176
  article-title: Rodent somatosensory thalamocortical circuitry: Neurons, synapses, and connectivity
  publication-title: Neurosci. Biobehav. Rev
– volume: 304
  start-page: 478
  year: 1991
  end-page: 490
  ident: 2022.02.28.482273v2.213
  article-title: The reticular thalamic nucleus (RTN) of the rat: Cytoarchitectural, Golgi, immunocytochemical, and horseradish peroxidase study
  publication-title: J. Comp. Neurol
– year: 2019
  ident: 2022.02.28.482273v2.17
  publication-title: Estimating the Readily-Releasable Vesicle Pool Size at Synaptic Connections in the Neocortex. Front. Synaptic Neurosci. 11
– volume: 18
  start-page: 214
  year: 2012
  end-page: 227
  ident: 2022.02.28.482273v2.102
  article-title: A Neuron Membrane Mesh Representation for Visualization of Electrophysiological Simulations
  publication-title: IEEE Trans. Vis. Comput. Graph
– volume: 65
  start-page: 230
  year: 2010
  end-page: 245
  ident: 2022.02.28.482273v2.53
  article-title: Pathway-Specific Feedforward Circuits between Thalamus and Neocortex Revealed by Selective Optical Stimulation of Axons
  publication-title: Neuron
– volume: 12
  start-page: 27
  year: 2018
  ident: 2022.02.28.482273v2.74
  article-title: Thalamocortical Projection Neuron and Interneuron Numbers in the Visual Thalamic Nuclei of the Adult C57BL/6 Mouse
  publication-title: Front. Neuroanat
– volume: 349
  start-page: 205
  year: 1984
  end-page: 226
  ident: 2022.02.28.482273v2.113
  article-title: Electrophysiological properties of guinea-pig thalamic neurones: an in vitro study
  publication-title: J. Physiol
– volume: 431
  start-page: 291
  year: 1990
  end-page: 318
  ident: 2022.02.28.482273v2.165
  article-title: Properties of a hyperpolarization-activated cation current and its role in rhythmic oscillation in thalamic relay neurones
  publication-title: J. Physiol
– volume: 26
  start-page: 8441
  year: 2006
  end-page: 8450
  ident: 2022.02.28.482273v2.172
  article-title: Corticofugal output from the primary somatosensory cortex selectively modulates innocuous and noxious inputs in the rat spinothalamic system
  publication-title: J. Neurosci. Off. J. Soc. Neurosci
– volume: 278
  start-page: 130
  year: 1997
  end-page: 134
  ident: 2022.02.28.482273v2.124
  article-title: Functional dynamics of GABAergic inhibition in the thalamus
  publication-title: Science
– volume: 164
  start-page: 483
  year: 2007
  end-page: 492
  ident: 2022.02.28.482273v2.78
  article-title: Reduced sleep spindle activity in schizophrenia patients
  publication-title: Am. J. Psychiatry
– year: 1995
  ident: 2022.02.28.482273v2.122
  article-title: Spindle waves are propagating synchronized oscillations in the ferret LGNd in vitro
  publication-title: J. Neurophysiol
– volume: 85
  start-page: 169
  year: 1988
  end-page: 171
  ident: 2022.02.28.482273v2.206
  article-title: The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system
  publication-title: Neurosci. Lett
– volume: 357
  start-page: 1659
  year: 2002
  end-page: 1673
  ident: 2022.02.28.482273v2.116
  article-title: Thalamic circuitry and thalamocortical synchrony
  publication-title: Philos. Trans. R. Soc. B Biol. Sci
– volume: 1991
  start-page: 3655
  issue: 26
  year: 2016
  end-page: 3668
  ident: 2022.02.28.482273v2.5
  article-title: From Neuron Biophysics to Orientation Selectivity in Electrically Coupled Networks of Neocortical L2/3 Large Basket Cells
  publication-title: Cereb. Cortex N. Y. N
– volume: 20
  start-page: 243
  year: 2014
  end-page: 256
  ident: 2022.02.28.482273v2.150
  article-title: Sleep Spindles Where They Come From, What They Do
  publication-title: The Neuroscientist
– volume: 28
  start-page: 317
  year: 2005
  end-page: 324
  ident: 2022.02.28.482273v2.215
  article-title: Sleep, epilepsy and thalamic reticular inhibitory neurons
  publication-title: Trends Neurosci
– volume: 414
  start-page: 67
  year: 1999
  end-page: 79
  ident: 2022.02.28.482273v2.148
  article-title: Predominance of corticothalamic synaptic inputs to thalamic reticular nucleus neurons in the rat
  publication-title: J. Comp. Neurol
– volume: 69
  start-page: 16
  year: 2018
  end-page: 28
  ident: 2022.02.28.482273v2.30
  article-title: Intrathalamic connections shape spindle activity - a modelling study
  publication-title: Acta Biol. Hung
– volume: 7
  start-page: e1002107
  year: 2011a
  ident: 2022.02.28.482273v2.100
  article-title: Models of Neocortical Layer 5b Pyramidal Cells Capturing a Wide Range of Dendritic and Perisomatic Active Properties
  publication-title: PLoS Comput. Biol
– volume: 125
  start-page: 512
  year: 2014
  end-page: 519
  ident: 2022.02.28.482273v2.37
  article-title: Decreased sleep spindle density in patients with idiopathic REM sleep behavior disorder and patients with Parkinson’s disease
  publication-title: Clin. Neurophysiol
– volume: 14
  start-page: 439
  year: 1991
  end-page: 445
  ident: 2022.02.28.482273v2.129
  article-title: Quantal analysis and synaptic efficacy in the CNS
  publication-title: Trends Neurosci
– volume: 167
  start-page: 1339
  year: 2010
  end-page: 1348
  ident: 2022.02.28.482273v2.79
  article-title: Thalamic dysfunction in schizophrenia suggested by whole-night deficits in slow and fast spindles
  publication-title: Am. J. Psychiatry
– volume: 17
  start-page: 309
  year: 1996
  end-page: 321
  ident: 2022.02.28.482273v2.140
  article-title: Abolition of Spindle Oscillations by Serotonin and Norepinephrine in the Ferret Lateral Geniculate and Perigeniculate Nuclei In Vitro
  publication-title: Neuron
– volume: 13
  start-page: 4609
  year: 1993
  end-page: 4621
  ident: 2022.02.28.482273v2.190
  article-title: Stepwise repolarization from Ca2+ plateaus in neocortical pyramidal cells: evidence for nonhomogeneous distribution of HVA Ca2+ channels in dendrites
  publication-title: J. Neurosci. Off. J. Soc. Neurosci
– volume: 573
  start-page: 121
  year: 2006
  end-page: 132
  ident: 2022.02.28.482273v2.9
  article-title: Developmental remodelling of the lemniscal synapse in the ventral basal thalamus of the mouse
  publication-title: J. Physiol
– volume: 101
  start-page: 9816
  year: 2004
  end-page: 9821
  ident: 2022.02.28.482273v2.85
  article-title: Prolonged hyperpolarizing potentials precede spindle oscillations in the thalamic reticular nucleus
  publication-title: Proc Natl Acad Sci U A
– volume: 334
  start-page: 389
  year: 2011
  end-page: 393
  ident: 2022.02.28.482273v2.94
  article-title: Activity-dependent long-term depression of electrical synapses
  publication-title: Science
– volume: 61
  start-page: 311
  year: 1989
  end-page: 330
  ident: 2022.02.28.482273v2.208
  article-title: Thalamocortical response transformation in the rat vibrissa/barrel system
  publication-title: J. Neurophysiol
– volume: 21
  start-page: 1148
  year: 2001
  end-page: 1159
  ident: 2022.02.28.482273v2.240
  article-title: Muscarinic regulation of dendritic and axonal outputs of rat thalamic interneurons: a new cellular mechanism for uncoupling distal dendrites
  publication-title: J. Neurosci. Off. J. Soc. Neurosci
– volume: 72
  start-page: 803
  year: 1994b
  end-page: 818
  ident: 2022.02.28.482273v2.63
  article-title: A model of spindle rhythmicity in the isolated thalamic reticular nucleus
  publication-title: J. Neurophysiol
– volume: 86
  start-page: 768
  year: 2015
  end-page: 782
  ident: 2022.02.28.482273v2.52
  article-title: A Corticothalamic Switch: Controlling the Thalamus with Dynamic Synapses
  publication-title: Neuron
– volume: 114
  start-page: E6212
  year: 2017
  end-page: E6221
  ident: 2022.02.28.482273v2.171
  article-title: Synaptic properties of the lemniscal and paralemniscal pathways to the mouse somatosensory thalamus
  publication-title: Proc. Natl. Acad. Sci
– start-page: 393
  year: 1997
  end-page: 533
  ident: 2022.02.28.482273v2.219
  publication-title: Thalamic organization and chemical neuroanatomy, in: Thalamus. Vol. 1. Elsevier, pp.
– volume: 7
  start-page: 1
  year: 2016
  end-page: 12
  ident: 2022.02.28.482273v2.91
  article-title: High-throughput dual-colour precision imaging for brain-wide connectome with cytoarchitectonic landmarks at the cellular level
  publication-title: Nat. Commun
– volume: 10
  start-page: e59272
  year: 2021
  ident: 2022.02.28.482273v2.112
  article-title: Dual midbrain and forebrain origins of thalamic inhibitory interneurons
  publication-title: eLife
– volume: 34
  start-page: 13170
  year: 2014
  end-page: 13182
  ident: 2022.02.28.482273v2.142
  article-title: Two Functionally Distinct Networks of Gap Junction-Coupled Inhibitory Neurons in the Thalamic Reticular Nucleus
  publication-title: J. Neurosci
– year: 2019
  ident: 2022.02.28.482273v2.77
  article-title: Sleep Spindles: Mechanisms and Functions
  publication-title: Physiol. Rev
– volume: 54
  start-page: 1473
  year: 1985
  end-page: 1497
  ident: 2022.02.28.482273v2.217
  article-title: Abolition of spindle oscillations in thalamic neurons disconnected from nucleus reticularis thalami
  publication-title: J. Neurophysiol
– volume: 34
  start-page: 4708
  year: 2014
  end-page: 4727
  ident: 2022.02.28.482273v2.26
  article-title: Discharge Profiles across the Sleep–Waking Cycle of Identified Cholinergic, GABAergic, and Glutamatergic Neurons in the Pontomesencephalic Tegmentum of the Rat
  publication-title: J. Neurosci
– year: 1996
  ident: 2022.02.28.482273v2.45
  article-title: Spindle oscillation in cats: the role of corticothalamic feedback in a thalamically generated rhythm
  publication-title: J. Physiol
– year: 2021
  ident: 2022.02.28.482273v2.93
  article-title: Computational Circuit Mechanisms Underlying Thalamic Control of Attention
– volume: 8
  start-page: d878
  year: 2003
  end-page: 899
  ident: 2022.02.28.482273v2.216
  article-title: The corticothalamic system in sleep
  publication-title: Front. Biosci. J. Virtual Libr
– volume: 8
  start-page: 76
  year: 2014
  ident: 2022.02.28.482273v2.96
  article-title: Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation
  publication-title: Front. Neural Circuits
– volume: 48
  start-page: 2738
  year: 2018
  end-page: 2758
  ident: 2022.02.28.482273v2.31
  article-title: Sleep spindles and slow waves in schizophrenia and related disorders: main findings, challenges and future perspectives
  publication-title: Eur. J. Neurosci
– volume: 59
  start-page: 377
  year: 2007
  end-page: 382
  ident: 2022.02.28.482273v2.169
  article-title: Distinct properties of corticothalamic and primary sensory synapses to thalamic neurons
  publication-title: Neurosci. Res
– volume: 399
  start-page: 143
  year: 1986
  end-page: 147
  ident: 2022.02.28.482273v2.57
  article-title: GABA immunoreactivity in the thalamic reticular nucleus of the rat. A light and electron microscopical study
  publication-title: Brain Res
– volume: 9
  year: 2015
  ident: 2022.02.28.482273v2.188
  article-title: An algorithm to predict the connectome of neural microcircuits
  publication-title: Front. Comput. Neurosci
– volume: 109
  start-page: E2885
  year: 2012
  end-page: E2894
  ident: 2022.02.28.482273v2.103
  article-title: Statistical connectivity provides a sufficient foundation for specific functional connectivity in neocortical neural microcircuits
  publication-title: Proc. Natl. Acad. Sci
– volume: 392
  start-page: 147
  year: 1987
  end-page: 165
  ident: 2022.02.28.482273v2.166
  article-title: Actions of acetylcholine in the guinea-pig and cat medial and lateral geniculate nuclei, in vitro
  publication-title: J. Physiol
– year: 2015
  ident: 2022.02.28.482273v2.237
  article-title: Thalamic control of sensory selection in divided attention
  publication-title: Nature
– volume: 76
  start-page: 2049
  year: 1996
  end-page: 2070
  ident: 2022.02.28.482273v2.61
  article-title: Ionic mechanisms underlying synchronized oscillations and propagating waves in a model of ferret thalamic slices
  publication-title: J. Neurophysiol
– volume: 57
  start-page: 420
  year: 2008
  end-page: 431
  ident: 2022.02.28.482273v2.2
  article-title: Active dendritic conductances dynamically regulate GABA release from thalamic interneurons
  publication-title: Neuron
– volume: 124
  start-page: 560
  year: 1954
  end-page: 573
  ident: 2022.02.28.482273v2.58
  article-title: Quantal components of the end-plate potential
  publication-title: J. Physiol
– volume: 273
  start-page: 1709
  year: 1996
  end-page: 1714
  ident: 2022.02.28.482273v2.127
  article-title: Small-conductance, calcium-activated potassium channels from mammalian brain
  publication-title: Science
– volume: 8
  start-page: 800
  year: 2017
  ident: 2022.02.28.482273v2.212
  article-title: Spatial scale of receptive fields in the visual sector of the cat thalamic reticular nucleus
  publication-title: Nat. Commun
– volume: 8
  start-page: 762
  year: 2014
  ident: 2022.02.28.482273v2.155
  article-title: Sleep spindle deficits in antipsychotic-naïve early course schizophrenia and in non-psychotic first-degree relatives
  publication-title: Front. Hum. Neurosci
– volume: 26
  start-page: 4444
  year: 2006
  end-page: 4450
  ident: 2022.02.28.482273v2.161
  article-title: Attentional modulation of thalamic reticular neurons
  publication-title: J. Neurosci. Off. J. Soc. Neurosci
– volume: 24
  start-page: 1711
  year: 2021
  end-page: 1720
  ident: 2022.02.28.482273v2.25
  article-title: Corticothalamic feedback sculpts visual spatial integration in mouse thalamus
  publication-title: Nat. Neurosci
– volume: 546
  start-page: 801
  year: 2003
  end-page: 811
  ident: 2022.02.28.482273v2.88
  article-title: Strong, reliable and precise synaptic connections between thalamic relay cells and neurones of the nucleus reticularis in juvenile rats
  publication-title: J. Physiol
– volume: 1
  start-page: 876
  year: 1981
  end-page: 886
  ident: 2022.02.28.482273v2.10
  article-title: Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle
  publication-title: J. Neurosci. Off. J. Soc. Neurosci
– volume: 17
  start-page: 6783
  year: 1997
  end-page: 6797
  ident: 2022.02.28.482273v2.120
  article-title: Cellular-synaptic generation of sleep spindles, spike-and-wave discharges, and evoked thalamocortical responses in the neocortex of the rat
  publication-title: J. Neurosci. Off. J. Soc. Neurosci
– start-page: 0015
  year: 2017
  end-page: 0017
  ident: 2022.02.28.482273v2.42
  article-title: Variable action potential backpropagation during tonic firing and low-threshold spike bursts in thalamocortical but not thalamic reticular nucleus neurons
  publication-title: J. Neurosci
– volume: 24
  start-page: 341
  year: 2004
  end-page: 349
  ident: 2022.02.28.482273v2.149
  article-title: Small clusters of electrically coupled neurons generate synchronous rhythms in the thalamic reticular nucleus
  publication-title: J. Neurosci. Off. J. Soc. Neurosci
– volume: 539
  start-page: 567
  year: 2002
  end-page: 578
  ident: 2022.02.28.482273v2.32
  article-title: Different temporal processing of sensory inputs in the rat thalamus during quiescent and information processing states in vivo
  publication-title: J. Physiol
– volume: 32
  start-page: 1047
  year: 2011
  end-page: 1056
  ident: 2022.02.28.482273v2.35
  article-title: Synaptic organization of the rat thalamus: a quantitative study
  publication-title: Neurol. Sci
– volume: 366
  start-page: 416
  year: 1996
  end-page: 430
  ident: 2022.02.28.482273v2.48
  article-title: Heterogeneous axonal arborizations of rat thalamic reticular neurons in the ventrobasal nucleus
  publication-title: J. Comp. Neurol
– volume: 83
  start-page: 2791
  year: 2000
  end-page: 2801
  ident: 2022.02.28.482273v2.98
  article-title: High Responsiveness and Direction Sensitivity of Neurons in the Rat Thalamic Reticular Nucleus to Vibrissa Deflections
  publication-title: J. Neurophysiol
– volume: 9
  start-page: 557
  year: 2015
  ident: 2022.02.28.482273v2.186
  article-title: The neocortical microcircuit collaboration portal: a resource for rat somatosensory cortex
  publication-title: Front. Neural Circuits
– volume: 9
  start-page: 1179
  year: 1997
  end-page: 1209
  ident: 2022.02.28.482273v2.104
  article-title: The NEURON simulation environment
  publication-title: Neural Comput
– volume: 18
  start-page: 854
  year: 1998
  end-page: 867
  ident: 2022.02.28.482273v2.178
  article-title: Sodium current in rat and cat thalamocortical neurons: role of a non-inactivating component in tonic and burst firing
  publication-title: J. Neurosci. Off. J. Soc. Neurosci
– volume: 80
  start-page: 599
  year: 2016
  end-page: 608
  ident: 2022.02.28.482273v2.156
  article-title: Reduced Sleep Spindles in Schizophrenia: A Treatable Endophenotype That Links Risk Genes to Impaired Cognition?
  publication-title: Biol. Psychiatry
– volume: 9
  start-page: 128
  year: 2010
  end-page: 128
  ident: 2022.02.28.482273v2.89
  article-title: Allen Reference Atlas
  publication-title: A Digital Color Bra in Atlas of the C57BL/6J Male Mouse - by H. W. Dong. Genes Brain Behav.
– volume: 2016
  start-page: 4724792
  year: 2016
  ident: 2022.02.28.482273v2.92
  article-title: Sleep Spindle Characteristics in Children with Neurodevelopmental Disorders and Their Relation to Cognition
  publication-title: Neural Plast
– volume: 26
  start-page: 4247
  year: 2006
  end-page: 4255
  ident: 2022.02.28.482273v2.211
  article-title: Intrinsic and synaptic dynamics interact to generate emergent patterns of rhythmic bursting in thalamocortical neurons
  publication-title: J. Neurosci. Off. J. Soc. Neurosci
– volume: 87
  start-page: 140
  year: 2002
  end-page: 148
  ident: 2022.02.28.482273v2.86
  article-title: Coding of temporal information by activity-dependent synapses
  publication-title: J. Neurophysiol
– volume: 42
  start-page: 27
  year: 1997
  end-page: 37
  ident: 2022.02.28.482273v2.8
  article-title: GABAergic neurons in mammalian thalamus: a marker of thalamic complexity?
  publication-title: Brain Res. Bull
– volume: 96
  start-page: 2593
  year: 2006
  end-page: 2600
  ident: 2022.02.28.482273v2.136
  article-title: Mapping of the functional interconnections between thalamic reticular neurons using photostimulation
  publication-title: J. Neurophysiol
– volume: 39
  start-page: 875
  year: 2016
  end-page: 885
  ident: 2022.02.28.482273v2.179
  article-title: Suppression of Sleep Spindle Rhythmogenesis in Mice with Deletion of CaV3.2 and CaV3.3 T-type Ca(2+) Channels
  publication-title: Sleep
– volume: 11
  start-page: 357
  year: 2005
  end-page: 372
  ident: 2022.02.28.482273v2.106
  article-title: Thalamic mechanisms of EEG alpha rhythms and their pathological implications
  publication-title: Neurosci. Rev. J. Bringing Neurobiol. Neurol. Psychiatry
– volume: 12
  year: 2018
  ident: 2022.02.28.482273v2.73
  article-title: A Cell Atlas for the Mouse Brain
  publication-title: Front.Neuroinformatics
– volume: 592
  start-page: 4137
  year: 2014
  end-page: 4145
  ident: 2022.02.28.482273v2.22
  article-title: Synaptic mechanisms underlying cholinergic control of thalamic reticular nucleus neurons
  publication-title: J. Physiol
– volume: 68
  start-page: 1373
  year: 1992
  end-page: 1383
  ident: 2022.02.28.482273v2.108
  article-title: Simulation of the currents involved in rhythmic oscillations in thalamic relay neurons
  publication-title: J. Neurophysiol
– year: 2009
  ident: 2022.02.28.482273v2.6
  publication-title: An Approach to Capturing Neuron Morphological Diversity, in: Computational Modeling Methods for Neuroscientists. The MIT Press.
– volume: 17
  start-page: 2348
  year: 1997
  end-page: 2354
  ident: 2022.02.28.482273v2.227
  article-title: Nucleus-Specific Chloride Homeostasis in Rat Thalamus
  publication-title: J. Neurosci
– year: 2020
  ident: 2022.02.28.482273v2.173
  article-title: An Individual Interneuron Participates in Many Kinds of Inhibition and Innervates Much of the Mouse Visual Thalamus
  publication-title: Neuron
– year: 2021
  ident: 2022.02.28.482273v2.174
  article-title: Visual thalamocortical mechanisms of waking state-dependent activity and alpha oscillations
  publication-title: Neuron
– volume: 11
  start-page: 433
  year: 2017
  ident: 2022.02.28.482273v2.50
  article-title: Individual Differences in Frequency and Topography of Slow and Fast Sleep Spindles
  publication-title: Front. Hum. Neurosci
– volume: 575
  start-page: 161
  year: 2006
  end-page: 174
  ident: 2022.02.28.482273v2.170
  article-title: Different composition of glutamate receptors in corticothalamic and lemniscal synaptic responses and their roles in the firing responses of ventrobasal thalamic neurons in juvenile mice
  publication-title: J. Physiol
– volume: 75
  start-page: 37
  year: 2020
  end-page: 44
  ident: 2022.02.28.482273v2.236
  article-title: Sleep spindle abnormalities related to Alzheimer’s disease: a systematic mini-review
  publication-title: Sleep Med
– volume: 185
  start-page: 133
  year: 2009
  end-page: 142
  ident: 2022.02.28.482273v2.133
  article-title: Time–frequency analysis methods to quantify the time-varying microstructure of sleep EEG spindles: Possibility for dementia biomarkers?
  publication-title: J. Neurosci. Methods
– volume: 13
  year: 2019
  ident: 2022.02.28.482273v2.135
  article-title: CoreNEURON : An Optimized Compute Engine for the NEURON Simulator. Front
  publication-title: Neuroinformatics
– volume: 337
  start-page: 753
  year: 2012
  end-page: 756
  ident: 2022.02.28.482273v2.194
  article-title: The pulvinar regulates information transmission between cortical areas based on attention demands
  publication-title: Science
– volume: 1591
  start-page: 27
  year: 2014
  end-page: 37
  ident: 2022.02.28.482273v2.158
  article-title: Tactile response adaptation to whisker stimulation in the lemniscal somatosensory pathway of rats
  publication-title: Brain Res
– volume: 483
  start-page: 641
  issue: Pt 3
  year: 1995
  end-page: 663
  ident: 2022.02.28.482273v2.15
  article-title: Synaptic and membrane mechanisms underlying synchronized oscillations in the ferret lateral geniculate nucleus in vitro
  publication-title: J. Physiol
– volume: 598
  start-page: 174
  year: 2021
  end-page: 181
  ident: 2022.02.28.482273v2.180
  article-title: Morphological diversity of single neurons in molecularly defined cell types
  publication-title: Nature
– volume: 116
  start-page: 995
  year: 2016
  end-page: 1011
  ident: 2022.02.28.482273v2.59
  article-title: Two classes of excitatory synaptic responses in rat thalamic reticular neurons
  publication-title: J. Neurophysiol
– volume: 14
  start-page: 365
  year: 1985
  end-page: 411
  ident: 2022.02.28.482273v2.175
  article-title: The thalamic reticular nucleus of the adult rat: experimental anatomical studies
  publication-title: J. Neurocytol
– volume: 16
  start-page: e1007696
  year: 2020
  ident: 2022.02.28.482273v2.55
  article-title: The SONATA data format for efficient description of large-scale network models
  publication-title: PLoS Comput. Biol
– volume: 17
  start-page: 1179
  year: 1997
  end-page: 1196
  ident: 2022.02.28.482273v2.44
  article-title: Spatiotemporal patterns of spindle oscillations in cortex and thalamus
  publication-title: J. Neurosci. Off. J. Soc. Neurosci
– volume: 49
  start-page: 1497
  year: 2001
  end-page: 1508
  ident: 2022.02.28.482273v2.87
  article-title: In vivo transduction of central neurons using recombinant Sindbis virus: Golgi-like labeling of dendrites and axons with membrane-targeted fluorescent proteins
  publication-title: J. Histochem. Cytochem. Off. J. Histochem. Soc
– volume: 14
  start-page: 1118
  year: 2011
  end-page: 1120
  ident: 2022.02.28.482273v2.95
  article-title: Selective optical drive of thalamic reticular nucleus generates thalamic bursts and cortical spindles
  publication-title: Nat. Publ. Group
– volume: 525
  start-page: 621
  year: 2000
  end-page: 639
  ident: 2022.02.28.482273v2.130
  article-title: Voltage-gated K+ channels in layer 5 neocortical pyramidal neurones from young rats: subtypes and gradients
  publication-title: J. Physiol
– volume: 71
  start-page: 1702
  year: 1994
  end-page: 1715
  ident: 2022.02.28.482273v2.145
  article-title: The role of GABA-mediated inhibition in the rat ventral posterior medial thalamus
  publication-title: I. Assessment of receptive field changes following thalamic reticular nucleus lesions. J. Neurophysiol
– volume: 590
  start-page: 737
  year: 2012
  end-page: 752
  ident: 2022.02.28.482273v2.185
  article-title: Intrinsic morphological diversity of thick-tufted layer 5 pyramidal neurons ensures robust and invariant properties of in silico synaptic connections: Comparison of in vitro and in silico TTL5 synaptic connections
  publication-title: J. Physiol
– start-page: 159
  year: 2000
  end-page: 178
  ident: 2022.02.28.482273v2.111
  article-title: Accurate reconstruction of neuronal morphology
  publication-title: Computational Neuroscience: Realistic Modeling for Experimentalists
– volume: 30
  start-page: 1129
  year: 2020
  end-page: 1145
  ident: 2022.02.28.482273v2.71
  article-title: Data-driven integration of hippocampal CA1 synaptic physiology in silico
  publication-title: Hippocampus
– volume: 18
  start-page: 3574
  year: 1998
  end-page: 3588
  ident: 2022.02.28.482273v2.67
  article-title: Dendritic Low-Threshold Calcium Currents in Thalamic Relay Cells
  publication-title: J. Neurosci
– volume: 75
  start-page: 750
  year: 1996
  end-page: 769
  ident: 2022.02.28.482273v2.90
  article-title: Propagation of spindle waves in a thalamic slice model
  publication-title: J. Neurophysiol
– volume: 23
  start-page: 8978
  year: 2003
  end-page: 8988
  ident: 2022.02.28.482273v2.210
  article-title: Inhibitory interconnections control burst pattern and emergent network synchrony in reticular thalamus
  publication-title: J. Neurosci. Off. J. Soc. Neurosci
– volume: 80
  start-page: 1222
  year: 1998
  end-page: 1235
  ident: 2022.02.28.482273v2.123
  article-title: Functional and ionic properties of a slow afterhyperpolarization in ferret perigeniculate neurons in vitro
  publication-title: J. Neurophysiol
– volume: 13
  start-page: 647
  year: 2015
  end-page: 656
  ident: 2022.02.28.482273v2.229
  article-title: Whisking-Related Changes in Neuronal Firing and Membrane Potential Dynamics in the Somatosensory Thalamus of Awake Mice
  publication-title: Cell Rep
– volume: 68
  start-page: 1384
  year: 1992
  end-page: 1400
  ident: 2022.02.28.482273v2.164
  article-title: A model of the electrophysiological properties of thalamocortical relay neurons
  publication-title: J. Neurophysiol
– volume: 181
  start-page: 936
  year: 2020
  end-page: 953
  ident: 2022.02.28.482273v2.233
  article-title: The Allen Mouse Brain Common Coordinate Framework: A 3D Reference Atlas
  publication-title: Cell
– start-page: 1
  year: 2020
  end-page: 6
  ident: 2022.02.28.482273v2.147
  article-title: Distinct subnetworks of the thalamic reticular nucleus
  publication-title: Nature
– volume: 27
  start-page: 670
  year: 2004
  end-page: 675
  ident: 2022.02.28.482273v2.199
  article-title: Interneurons and triadic circuitry of the thalamus
  publication-title: Trends Neurosci
– volume: 11
  start-page: 2473
  year: 1992
  end-page: 2486
  ident: 2022.02.28.482273v2.189
  article-title: Characterization of a Shaw-related potassium channel family in rat brain
  publication-title: EMBO J
– volume: 34
  start-page: i574
  year: 2018
  end-page: i582
  ident: 2022.02.28.482273v2.1
  article-title: NeuroMorphoVis: a collaborative framework for analysis and visualization of neuronal morphology skeletons reconstructed from microscopy stacks
  publication-title: Bioinformatics
– volume: 583
  start-page: 813
  year: 2020
  end-page: 818
  ident: 2022.02.28.482273v2.159
  article-title: Two dynamically distinct circuits drive inhibition in the sensory thalamus
  publication-title: Nature
– volume: 102
  start-page: 735
  year: 2019
  end-page: 744
  ident: 2022.02.28.482273v2.72
  article-title: The Scientific Case for Brain Simulations
  publication-title: Neuron
– volume: 34
  start-page: 1991
  year: 2013
  end-page: 2000
  ident: 2022.02.28.482273v2.34
  article-title: Comparing GABAergic cell populations in the thalamic reticular nucleus of normal and genetic absence epilepsy rats from Strasbourg (GAERS)
  publication-title: Neurol. Sci. Off. J. Ital. Neurol. Soc. Ital. Soc. Clin. Neurophysiol
– volume: 15
  start-page: e1006753
  year: 2019
  ident: 2022.02.28.482273v2.110
  article-title: Experimentally-constrained biophysical models of tonic and burst firing modes in thalamocortical neurons
  publication-title: PLOS Comput. Biol.
– volume: 52
  start-page: 43
  year: 2008
  end-page: 55
  ident: 2022.02.28.482273v2.131
  article-title: Identifying, tabulating, and analyzing contacts between branched neuron morphologies
  publication-title: IBM J. Res. Dev
– volume: 7
  start-page: e45717
  year: 2012
  ident: 2022.02.28.482273v2.118
  article-title: Optogenetic stimulation of the corticothalamic pathway affects relay cells and GABAergic neurons differently in the mouse visual thalamus
  publication-title: PloS One
– volume: 7
  start-page: e1002107
  year: 2011b
  ident: 2022.02.28.482273v2.101
  article-title: Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties
  publication-title: PLoS Comput. Biol
– volume: 9
  start-page: 1
  year: 2019
  end-page: 16
  ident: 2022.02.28.482273v2.222
  article-title: Thalamic Reticular Nucleus Parvalbumin Neurons Regulate Sleep Spindles and Electrophysiological Aspects of Schizophrenia in Mice
  publication-title: Sci. Rep
– start-page: 211
  year: 2009
  end-page: 232
  ident: 2022.02.28.482273v2.7
  publication-title: Computational Neuroscience. Realistic Modeling for Experimentalists. MIT Press, Cambridge, Mass
– volume: 92
  start-page: 2185
  year: 2004
  end-page: 2197
  ident: 2022.02.28.482273v2.187
  article-title: Somatosensory corticothalamic projections: distinguishing drivers from modulators
  publication-title: J. Neurophysiol
– volume: 99
  start-page: 2291
  year: 2008
  end-page: 2304
  ident: 2022.02.28.482273v2.81
  article-title: Proprioceptive and cutaneous representations in the rat ventral posterolateral thalamus
  publication-title: J. Neurophysiol.
– volume: 179
  start-page: 268
  year: 2019
  end-page: 281
  ident: 2022.02.28.482273v2.238
  article-title: Reconstruction of 1,000 Projection Neurons Reveals New Cell Types and Organization of Long-Range Connectivity in the Mouse Brain
  publication-title: Cell
– volume: 13
  start-page: e1005797
  year: 2017
  ident: 2022.02.28.482273v2.146
  article-title: Unified thalamic model generates multiple distinct oscillations with state-dependent entrainment by stimulation
  publication-title: PLOS Comput. Biol
– volume: 14
  start-page: 10
  year: 2019
  ident: 2022.02.28.482273v2.119
  article-title: Sleep oscillation-specific associations with Alzheimer’s disease CSF biomarkers: novel roles for sleep spindles and tau
  publication-title: Mol. Neurodegener
– volume: 95
  start-page: 7121
  year: 1998
  end-page: 7126
  ident: 2022.02.28.482273v2.200
  article-title: On the actions that one nerve cell can have on another: Distinguishing “drivers” from “modulators.”
  publication-title: Proc. Natl. Acad. Sci
– volume: 36
  start-page: 3735
  year: 2016
  end-page: 3754
  ident: 2022.02.28.482273v2.43
  article-title: Passive synaptic normalization and input synchrony-dependent amplification of cortical feedback in thalamocortical neuron dendrites
  publication-title: J. Neurosci
– volume: 243
  start-page: 115
  year: 2017
  end-page: 126
  ident: 2022.02.28.482273v2.202
  article-title: Temporal Patterns of Individual Neuronal Firing in Rat Dorsal Column Nuclei Provide Information Required for Somatosensory Discrimination
  publication-title: Tohoku J. Exp. Med
– volume: 87
  start-page: 387
  year: 1953
  ident: 2022.02.28.482273v2.203
  article-title: Dendritic organization in the neurons of the visual and motor cortices of the cat
  publication-title: J. Anat
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SecondaryResourceType preprint
Snippet Thalamoreticular circuitry is known to play a key role in attention, cognition and the generation of sleep spindles, and is implicated in numerous brain...
SourceID biorxiv
proquest
SourceType Open Access Repository
Aggregation Database
SubjectTerms Activity patterns
Attention
Cortex (somatosensory)
Gap junctions
Information processing
Mathematical models
Neural networks
Neuromodulation
Neuroscience
Sensory integration
Sleep
Sleep and wakefulness
Synaptic plasticity
Thalamic reticular nucleus
Thalamus
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Title Thalamic control of sensory enhancement and sleep spindle properties in a biophysical model of thalamoreticular microcircuitry
URI https://www.proquest.com/docview/2635110952
https://www.biorxiv.org/content/10.1101/2022.02.28.482273
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