An Activator Locks Kv7.1 Channels Open by Electro-Mechanical Uncoupling and Allosterically Modulates its Pore - Möller, Melina; Schreiber, Julian A; Zaydman, Mark; Beller, Zachary; Becker, Sebastian; Ritter, Nadine; Wrobel, Eva; Strutz-Seebohm, Nathalie; Decher, Niels; Cui, Jianmin; Schmitt, Nicole; Düfer, Martina; et al. (bioRxiv, 2021)
Keywords: Action potential; Alanine; Allosteric properties; Amino acids; Arrhythmia; Benzodiazepines; Biophysics; Cardiac arrhythmia; Drug development; Drug therapy; Electrophysiology; Fluorometry; Heart; Long QT syndrome; Molecular modelling; Potassium channels (voltage-gated); Scanning mutagenesis; Structure-function relationships; L3; (; gating; 7.1; agonist; activator; K; structure