The Holy Grail of Orthopedic Surgery: Mesenchymal Stem Cells-Their Current Uses and Potential Applications

Only select tissues and organs are able to spontaneously regenerate after disease or trauma, and this regenerative capacity diminishes over time. Human stem cell research explores therapeutic regenerative approaches to treat various conditions. Mesenchymal stem cells (MSCs) are derived from adult st...

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Published inStem Cells International Vol. 2017; no. 2017; pp. 1 - 14-050
Main Authors Ibarra, Clemente, Granados, Julio, Olivos-Meza, Anell, Berebichez-Fastlicht, Enrique, Granados-Montiel, Julio, Gómez-García, R., Berebichez-Fridman, Roberto, Velasquillo, Cristina
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Limiteds 01.01.2017
Hindawi Publishing Corporation
Hindawi
John Wiley & Sons, Inc
Wiley
Subjects
Bone diseases
Bone marrow
Bone surgery
Care and treatment
Fibroblasts
Gene expression
Granulocytes
Human subjects
Injuries
Medicine
Orthopedic surgery
Orthopedics
Osteoarthritis
Review
Stem cells
Tissue engineering
Online AccessGet full text
ISSN1687-966X
1687-9678
1687-9678
DOI10.1155/2017/2638305

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Abstract Only select tissues and organs are able to spontaneously regenerate after disease or trauma, and this regenerative capacity diminishes over time. Human stem cell research explores therapeutic regenerative approaches to treat various conditions. Mesenchymal stem cells (MSCs) are derived from adult stem cells; they are multipotent and exert anti-inflammatory and immunomodulatory effects. They can differentiate into multiple cell types of the mesenchyme, for example, endothelial cells, osteoblasts, chondrocytes, fibroblasts, tenocytes, vascular smooth muscle cells, and sarcomere muscular cells. MSCs are easily obtained and can be cultivated and expanded in vitro; thus, they represent a promising and encouraging treatment approach in orthopedic surgery. Here, we review the application of MSCs to various orthopedic conditions, namely, orthopedic trauma; muscle injury; articular cartilage defects and osteoarthritis; meniscal injuries; bone disease; nerve, tendon, and ligament injuries; spinal cord injuries; intervertebral disc problems; pediatrics; and rotator cuff repair. The use of MSCs in orthopedics may transition the practice in the field from predominately surgical replacement and reconstruction to bioregeneration and prevention. However, additional research is necessary to explore the safety and effectiveness of MSC treatment in orthopedics, as well as applications in other medical specialties.
AbstractList Only select tissues and organs are able to spontaneously regenerate after disease or trauma, and this regenerative capacity diminishes over time. Human stem cell research explores therapeutic regenerative approaches to treat various conditions. Mesenchymal stem cells (MSCs) are derived from adult stem cells; they are multipotent and exert anti-inflammatory and immunomodulatory effects. They can differentiate into multiple cell types of the mesenchyme, for example, endothelial cells, osteoblasts, chondrocytes, fibroblasts, tenocytes, vascular smooth muscle cells, and sarcomere muscular cells. MSCs are easily obtained and can be cultivated and expanded in vitro; thus, they represent a promising and encouraging treatment approach in orthopedic surgery. Here, we review the application of MSCs to various orthopedic conditions, namely, orthopedic trauma; muscle injury; articular cartilage defects and osteoarthritis; meniscal injuries; bone disease; nerve, tendon, and ligament injuries; spinal cord injuries; intervertebral disc problems; pediatrics; and rotator cuff repair. The use of MSCs in orthopedics may transition the practice in the field from predominately surgical replacement and reconstruction to bioregeneration and prevention. However, additional research is necessary to explore the safety and effectiveness of MSC treatment in orthopedics, as well as applications in other medical specialties.
Only select tissues and organs are able to spontaneously regenerate after disease or trauma, and this regenerative capacity diminishes over time. Human stem cell research explores therapeutic regenerative approaches to treat various conditions. Mesenchymal stem cells (MSCs) are derived from adult stem cells; they are multipotent and exert anti-inflammatory and immunomodulatory effects. They can differentiate into multiple cell types of the mesenchyme, for example, endothelial cells, osteoblasts, chondrocytes, fibroblasts, tenocytes, vascular smooth muscle cells, and sarcomere muscular cells. MSCs are easily obtained and can be cultivated and expanded in vitro; thus, they represent a promising and encouraging treatment approach in orthopedic surgery. Here, we review the application of MSCs to various orthopedic conditions, namely, orthopedic trauma; muscle injury; articular cartilage defects and osteoarthritis; meniscal injuries; bone disease; nerve, tendon, and ligament injuries; spinal cord injuries; intervertebral disc problems; pediatrics; and rotator cuff repair. The use of MSCs in orthopedics may transition the practice in the field from predominately surgical replacement and reconstruction to bioregeneration and prevention. However, additional research is necessary to explore the safety and effectiveness of MSC treatment in orthopedics, as well as applications in other medical specialties.Only select tissues and organs are able to spontaneously regenerate after disease or trauma, and this regenerative capacity diminishes over time. Human stem cell research explores therapeutic regenerative approaches to treat various conditions. Mesenchymal stem cells (MSCs) are derived from adult stem cells; they are multipotent and exert anti-inflammatory and immunomodulatory effects. They can differentiate into multiple cell types of the mesenchyme, for example, endothelial cells, osteoblasts, chondrocytes, fibroblasts, tenocytes, vascular smooth muscle cells, and sarcomere muscular cells. MSCs are easily obtained and can be cultivated and expanded in vitro; thus, they represent a promising and encouraging treatment approach in orthopedic surgery. Here, we review the application of MSCs to various orthopedic conditions, namely, orthopedic trauma; muscle injury; articular cartilage defects and osteoarthritis; meniscal injuries; bone disease; nerve, tendon, and ligament injuries; spinal cord injuries; intervertebral disc problems; pediatrics; and rotator cuff repair. The use of MSCs in orthopedics may transition the practice in the field from predominately surgical replacement and reconstruction to bioregeneration and prevention. However, additional research is necessary to explore the safety and effectiveness of MSC treatment in orthopedics, as well as applications in other medical specialties.
Audience Academic
Author Anell Olivos-Meza
Julio Granados
Enrique Berebichez-Fastlicht
Cristina Velasquillo
Roberto Berebichez-Pridman
Julio Granados-Mentiel
Clemente Ibarra
Ricardo Gómez-García
AuthorAffiliation 2 School of Medicine, Faculty of Health Sciences, Anáhuac University, Av. Universidad Anáhuac 46, Lomas Anahuac, 52786 Huixquilucan, MEX, Mexico
5 Department of Transplantation, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Av. Vasco de Quiroga, No. 15, Tlalpan, Belisario Domínguez Sección XVI, 14080 Mexico City, Mexico
1 Tissue Engineering, Cell Therapy and Regenerative Medicine Unit, Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”, Calzada México Xochimilco, No. 289, Col. Arenal de Guadalupe, 14389 Mexico City, Mexico
7 General Direction, Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”, Calzada México Xochimilco, No. 289, Col. Arenal de Guadalupe, 14389 Mexico City, Mexico
3 Department of Orthopedic Surgery, American British Cowdray Medical Center, Av. Carlos Graef Fernández, No. 154, Col. Santa Fe, Cuajimalpa, 05300 Mexico City, Mexico
6 Direction of Research, Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibar
AuthorAffiliation_xml – name: 1 Tissue Engineering, Cell Therapy and Regenerative Medicine Unit, Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”, Calzada México Xochimilco, No. 289, Col. Arenal de Guadalupe, 14389 Mexico City, Mexico
– name: 7 General Direction, Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”, Calzada México Xochimilco, No. 289, Col. Arenal de Guadalupe, 14389 Mexico City, Mexico
– name: 4 Orthopedic Sports Medicine and Arthroscopy Division, Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”, Calzada México Xochimilco, No. 289, Col. Arenal de Guadalupe, 14389 Mexico City, Mexico
– name: 3 Department of Orthopedic Surgery, American British Cowdray Medical Center, Av. Carlos Graef Fernández, No. 154, Col. Santa Fe, Cuajimalpa, 05300 Mexico City, Mexico
– name: 6 Direction of Research, Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”, Calzada México Xochimilco, No. 289, Col. Arenal de Guadalupe, 14389 Mexico City, Mexico
– name: 2 School of Medicine, Faculty of Health Sciences, Anáhuac University, Av. Universidad Anáhuac 46, Lomas Anahuac, 52786 Huixquilucan, MEX, Mexico
– name: 5 Department of Transplantation, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Av. Vasco de Quiroga, No. 15, Tlalpan, Belisario Domínguez Sección XVI, 14080 Mexico City, Mexico
Author_xml – sequence: 1
  fullname: Ibarra, Clemente
– sequence: 2
  fullname: Granados, Julio
– sequence: 3
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  fullname: Granados-Montiel, Julio
– sequence: 6
  fullname: Gómez-García, R.
– sequence: 7
  fullname: Berebichez-Fridman, Roberto
– sequence: 8
  fullname: Velasquillo, Cristina
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28698718$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright Copyright © 2017 Roberto Berebichez-Fridman et al.
COPYRIGHT 2017 John Wiley & Sons, Inc.
Copyright © 2017 Roberto Berebichez-Fridman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © 2017 Roberto Berebichez-Fridman et al. 2017
Copyright_xml – notice: Copyright © 2017 Roberto Berebichez-Fridman et al.
– notice: COPYRIGHT 2017 John Wiley & Sons, Inc.
– notice: Copyright © 2017 Roberto Berebichez-Fridman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
– notice: Copyright © 2017 Roberto Berebichez-Fridman et al. 2017
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Issue 2017
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Snippet Only select tissues and organs are able to spontaneously regenerate after disease or trauma, and this regenerative capacity diminishes over time. Human stem...
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SubjectTerms Bone diseases
Bone marrow
Bone surgery
Care and treatment
Fibroblasts
Gene expression
Granulocytes
Human subjects
Injuries
Medicine
Orthopedic surgery
Orthopedics
Osteoarthritis
Review
Stem cells
Tissue engineering
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Title The Holy Grail of Orthopedic Surgery: Mesenchymal Stem Cells-Their Current Uses and Potential Applications
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https://search.emarefa.net/detail/BIM-1201022
https://dx.doi.org/10.1155/2017/2638305
https://www.ncbi.nlm.nih.gov/pubmed/28698718
https://www.proquest.com/docview/1915328544
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https://pubmed.ncbi.nlm.nih.gov/PMC5494105
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Volume 2017
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