Dendrimers in medicine and biotechnology new molecular tools

• Main Authors: Boas, U, Christensen, J. B. (Jørn Bolstad), Heegaard, P. M. H
• Format: eBook Book
• Language: English
• Published: Cambridge RSC Pub 2006; NBN International; Royal Society of Chemistry; Royal Society of Chemistry, The; RSC Publishing
• Edition: 1
• Subjects: Biochemistry; Biotechnology; Chemistry; Dendrimers; Life Sciences; Molecular structure; SCIENCE
• ISBN: 0854048529; 9780854048526; 1847552676; 9781847552679
• DOI: 10.1039/9781847552679

Dendrimers are a new class of macromolecule increasingly used in the fields of synthetic organic chemistry, biology, medicine and biotechnology. Dendrimers in Medicine and Biotechnology: New Molecular Tools looks at this exciting and rapidly growing area of science. Using an interdisciplinary approa...

Table of Contents:

• Dendrimers in medicine and biotechnology: new molecular tools -- Preface -- Table of Contents -- Chapter 1: Dendrimers: Design, Synthesis and Chemical Properties -- Chapter 2: Properties of Dendrimers in Biological Systems -- Chapter 3: Dendrimers as Drug Delivery Devices -- Chapter 4: Dendrimer Drugs -- Chapter 5: Dendrimers in Diagnostics -- Chapter 6: Dendrimers as Biomimics -- Subject Index
• 5.1.2 Dendrimer-based Contrast Agents for MRI -- 5.1.3 Dendrimer-based Contrast Agents for Scintigraphy -- 5.2 Fluorescence Enhanced by Dendrimers -- 5.3 Dendrimers in Bioassays -- 5.3.1 Dendrimer-Enhanced Signal Generation -- 5.3.2 Dendrimers for Amplifying the Covalent Binding Capacity of Solid Phases -- 5.3.3 Microarray Application of Dendrimers -- 5.3.4 Fluorophore-Labelled Dendrimers for Visualisation Purposes -- 5.3.5 Using Dendrimers to Increase DNA Extraction Yields -- 5.3.6 Using Dendrimers for direct Detection of Live Bacteria -- 5.4 Summary -- References -- Chapter 6 Dendrimers as Biomimics -- 6.1 Introduction -- 6.2 Dendrimers as Protein Mimics -- 6.3 Dendrimers as Artificial Enzymes -- 6.4 Dendrimers as Artificial Antigens, Cell Surfaces and Antibodies -- 6.5 Summary -- References -- Subject Index
• Dendrimers In Medicine And Biotechnology -- Table of Contents -- Chapter 1 Dendrimers: Design, Synthesis and Chemical Properties -- 1.1 Introduction -- 1.2 Terms and Nomenclature in Dendrimer Chemistry -- 1.3 Dendrimer Design -- 1.4 Dendrimer Synthesis -- 1.5 Physicochemical Properties of Dendrimers -- 1.6 Summary -- References -- Chapter 2 Properties of Dendrimers in Biological Systems -- 2.1 Significance of Multivalent Binding in Biological Interactions -- 2.1.1 Dendritic Effect -- 2.1.2 Carbohydrate Ligands -- 2.2 Biocompatibility of Dendrimers -- 2.3 In Vitro Cytotoxicity of Dendrimers -- 2.4 In Vivo Cytotoxicity of Dendrimers -- 2.5 Biopermeability of Dendrimers -- 2.6 Biodistribution of Dendrimers -- 2.7 Immunogenicity of Dendrimers -- 2.8 Summary -- References -- Chapter 3 Dendrimers as Drug Delivery Devices -- 3.1 Introduction -- 3.2 Dendrimer Hosts -- 3.2.1 Dendrimer Hosts: Non-Specific Interactions with the Dendrimer Core -- 3.2.2 Dendritic Boxes or Topological Trapping of Guests -- 3.2.3 Dendrimer Hosts: Specific Interactions with the Dendrimer Core -- 3.2.4 Dendrimer Hosts: Non-Polar Interactions with the Dendrimer Surface Group -- 3.2.5 Dendrimer Hosts: Polar Interactions with the Dendrimer Surface Groups -- 3.3 Covalently Bound Drug-Dendrimer Conjugates -- 3.3.1 Self-Immolative Systems -- 3.4 Dendrimers as Gene Transfer Reagents -- 3.5 Summary -- References -- Chapter 4 Dendrimer Drugs -- 4.1 Introduction -- 4.2 Antiviral Dendrimers -- 4.3 Antibacterial Dendrimers -- 4.4 Dendrimers in Antitumour Therapy -- 4.5 Dendrimers in Therapy of Other Diseases -- 4.6 Dendrimer-Based Vaccines -- 4.7 Dendrimer Interactions with Proteins. Solublilisation of Protein Aggregates -- 4.8 Summary -- References -- Chapter 5 Dendrimers in Diagnostics -- 5.1 Contrast Agents based on Dendrimers -- 5.1.1 Dendrimer-based Contrast Agents for CT