Urine Proteome Biomarkers in Kidney Diseases. I. Limits, Perspectives, and First Focus on Normal Urine

Urine proteome is a potential source of information in renal diseases, and it is considered a natural area of investigation for biomarkers. Technology developments have markedly increased the power analysis on urinary proteins, and it is time to confront methodologies and results of major studies on...

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Published inBiomarker Insights Vol. 2016; no. 11; pp. 41 - 48
Main Authors Santucci, Laura, Bruschi, Maurizio, Candiano, Giovanni, Lugani, Francesca, Petretto, Andrea, Bonanni, Alice, Ghiggeri, Gian Marco
Format Journal Article
LanguageEnglish
Published London, England Libertas Academica 01.01.2016
SAGE Publishing
SAGE Publications
Sage Publications Ltd
Subjects
Biomarkers
Exosomes
Kidney diseases
Mass spectroscopy
Proteomes
Review
Urine
combinatorial peptide ligand libraries
mass spectrometry
urinary proteome
vesicles
Online AccessGet full text
ISSN1177-2719
1177-2719
DOI10.4137/BMI.S26229

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Abstract Urine proteome is a potential source of information in renal diseases, and it is considered a natural area of investigation for biomarkers. Technology developments have markedly increased the power analysis on urinary proteins, and it is time to confront methodologies and results of major studies on the topics. This is a first part of a series of reviews that will focus on the urine proteome as a site for detecting biomarkers of renal diseases; the theme of the first review concerns methodological aspects applied to normal urine. Main issues are techniques for urine pretreatment, separation of exosomes, use of combinatorial peptide ligand libraries, mass spectrometry approaches, and analysis of data sets. Available studies show important differences, suggesting a major confounding effect of the technologies utilized for analysis. The objective is to obtain consensus about which approaches should be utilized for studying urine proteome in renal diseases.
AbstractList Urine proteome is a potential source of information in renal diseases, and it is considered a natural area of investigation for biomarkers. Technology developments have markedly increased the power analysis on urinary proteins, and it is time to confront methodologies and results of major studies on the topics. This is a first part of a series of reviews that will focus on the urine proteome as a site for detecting biomarkers of renal diseases; the theme of the first review concerns methodological aspects applied to normal urine. Main issues are techniques for urine pretreatment, separation of exosomes, use of combinatorial peptide ligand libraries, mass spectrometry approaches, and analysis of data sets. Available studies show important differences, suggesting a major confounding effect of the technologies utilized for analysis. The objective is to obtain consensus about which approaches should be utilized for studying urine proteome in renal diseases.
Author Maurizio Bruschi
Giovanni Candiano
Andrea Petretto
Francesca Lugani
Alice Bonanni
Laura Santucci
Gian Marco Ghiggeri
AuthorAffiliation 3 Laboratory of Mass Spectrometry – Core Facility, Istituto Giannina Gaslini, Genova, Italy
1 Laboratory on Physiopathology of Uremia, Istituto Giannina Gaslini, Genova, Italy
2 Nephrology, Dialysis and Transplantation, Istituto Giannina Gaslini, Genova, Italy
AuthorAffiliation_xml – name: 2 Nephrology, Dialysis and Transplantation, Istituto Giannina Gaslini, Genova, Italy
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Cites_doi 10.1021/pr700800s
10.1073/pnas.0403453101
10.1093/nar/gkr828
10.1038/nrm1360
10.1016/j.chroma.2009.08.070
10.1021/acs.jproteome.5b00594
10.1038/nature08184
10.1038/ki.1987.173
10.1021/pr100835s
10.1038/nature07341
10.1038/nature10098
10.1002/mas.20178
10.1002/rcm.4441
10.1038/ki.1987.243
10.1038/nbt1300
10.1002/pmic.201100477
10.1038/ki.2012.256
10.1038/sj.ki.5000273
10.1083/jcb.201211138
10.1681/ASN.2006050486
10.1089/omi.2013.0010
10.1016/j.jprot.2013.01.012
10.1002/pmic.200800389
10.1007/978-1-60761-711-2_6
10.1093/nar/gkt1140
10.1056/NEJM197804132981507
10.1021/pr300830v
10.1186/gb-2006-7-9-r80
10.1016/j.ceb.2014.05.004
10.1074/mcp.M111.011015
10.1214/09-SS051
10.1038/nri855
10.1093/nar/gks1262
10.1016/j.jprot.2010.06.006
10.1021/pr4010037
10.1016/j.tcb.2008.11.003
10.1038/nbt.2839
10.1021/pr2003038
10.1681/ASN.2008040406
10.1021/pr8004887
10.1681/ASN.2013101066
10.1021/ac8001353
10.1002/pmic.201400302
10.1021/pr049882h
10.1093/ilar.43.4.207
10.1016/j.jprot.2008.05.002
10.1038/msb.2011.38
10.1681/ASN.2011101034
10.1038/ki.2009.550
10.1111/j.1523-1755.2004.00970.x
10.1016/j.bbagen.2013.04.026
10.1038/nbt.1661
10.1016/j.jprot.2014.07.021
10.1016/j.jprot.2011.09.018
10.1002/pmic.201100212
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Issue 11
Keywords combinatorial peptide ligand libraries
mass spectrometry
urinary proteome
vesicles
Language English
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References Thery, Zitvogel, Amigorena 2002; 2
Raposo, Stoorvogel 2013; 200
Santucci, Candiano, Petretto 2015; 112
Jensen, Jessen, Jorgensen 2008; 7
Adachi, Kumar, Zhang, Olsen, Mann 2006; 7
Candiano, Santucci, Bruschi 2012; 75
Ghiggeri, Candiano, Ginevri 1987; 32
de Godoy, Olsen, Cox 2008; 455
Prunotto, Farina, Lane 2013; 82
Marimuthu, O'Meally, Chaerkady 2011; 10
Maier, Schmidt, Guell 2011; 7
Norden, Sharratt, Cutillas, Cramer, Gardner, Unwin 2004; 66
Boschetti, Righetti 2008; 71
Brenner, Hostetter, Humes 1978; 298
Brunner, Ahrens, Mohanty 2007; 25
Ghiggeri, Ginevri, Candiano 1987; 32
Ejigu, Valkenborg, Baggerman 2013; 17
Candiano, Musante, Bruschi 2006; 17
Gruenberg, Stenmark 2004; 5
Cocucci, Racchetti, Meldolesi 2009; 19
Vizcaino, Deutsch, Wang 2014; 32
Domon, Aebersold 2010; 28
Righetti, Boschetti, Zanella, Fasoli, Citterio 2010; 1217
Alvarez, Khosroheidari, Kanchi Ravi, DiStefano 2012; 82
Righetti, Boschetti 2008; 27
Farrah, Deutsch, Omenn 2014; 13
Gaudet, Argoud-Puy, Cusin 2013; 12
Vizcaino, Cote, Csordas 2013; 41
Kowal, Tkach, Thery 2014; 29
Gonzales, Pisitkun, Hoffert 2009; 20
Khristenko, Larina, Domon 2016; 15
Schwanhausser, Busse, Li 2011; 473
Fay, Proschan 2010; 4
Li, Fan, Li 2010; 24
Conde-Vancells, Rodriguez-Suarez, Embade 2008; 7
Brenner, Hostetter, Humes 1978; 234
Gonzales, Zhou, Pisitkun 2010; 641
Malmstrom, Beck, Schmidt, Lange, Deutsch, Aebersold 2009; 460
Bachi, Simo, Restuccia 2008; 80
Nagaraj, Mann 2011; 10
Pisitkun, Shen, Knepper 2004; 101
2014; 42
Mathivanan, Ji, Simpson 2010; 73
Fernandez-Llama, Khositseth, Gonzales, Star, Pisitkun, Knepper 2010; 77
Boschetti, Righetti 2009; 9
Mathivanan, Fahner, Reid, Simpson 2012; 40
Hiemstra, Charles, Gracia 2014; 25
Michalski, Damoc, Hauschild 2011; 10
Bruschi, Santucci, Candiano, Ghiggeri 2013; 1830
Wang, Hill, Luther, Hachey, Schey 2012; 12
Dell, Holleran, Ramakrishnan 2002; 43
Perez-Riverol, Alpi, Wang, Hermjakob, Vizcaíno 2015; 15
Zerefos, Aivaliotis, Baumann, Vlahou 2012; 12
Keerthikumar, Chisanga, Ariyaratne 2015
Zhou, Yuen, Pisitkun 2006; 69
Weyer, Nielsen, Christensen, Birn 2012; 23
Craig, Cortens, Beavis 2004; 3
bibr10-BMI.S26229
bibr53-BMI.S26229
bibr30-BMI.S26229
bibr20-BMI.S26229
bibr23-BMI.S26229
bibr33-BMI.S26229
bibr43-BMI.S26229
bibr4-BMI.S26229
bibr18-BMI.S26229
bibr50-BMI.S26229
bibr1-BMI.S26229
bibr28-BMI.S26229
bibr48-BMI.S26229
bibr40-BMI.S26229
bibr38-BMI.S26229
bibr22-BMI.S26229
bibr19-BMI.S26229
bibr41-BMI.S26229
bibr29-BMI.S26229
bibr31-BMI.S26229
bibr51-BMI.S26229
bibr12-BMI.S26229
bibr39-BMI.S26229
bibr49-BMI.S26229
bibr52-BMI.S26229
bibr13-BMI.S26229
Brenner B.M. (bibr2-BMI.S26229) 1978; 234
bibr32-BMI.S26229
bibr42-BMI.S26229
bibr3-BMI.S26229
bibr27-BMI.S26229
bibr17-BMI.S26229
bibr47-BMI.S26229
bibr14-BMI.S26229
bibr37-BMI.S26229
bibr44-BMI.S26229
bibr11-BMI.S26229
bibr34-BMI.S26229
bibr54-BMI.S26229
bibr21-BMI.S26229
bibr24-BMI.S26229
bibr9-BMI.S26229
bibr57-BMI.S26229
bibr25-BMI.S26229
bibr35-BMI.S26229
bibr5-BMI.S26229
bibr8-BMI.S26229
bibr15-BMI.S26229
bibr55-BMI.S26229
bibr45-BMI.S26229
bibr16-BMI.S26229
bibr26-BMI.S26229
bibr6-BMI.S26229
bibr7-BMI.S26229
Keerthikumar S. (bibr56-BMI.S26229) 2015
bibr46-BMI.S26229
bibr36-BMI.S26229
665772 - Am J Physiol. 1978 Jun;234(6):F455-60
24253303 - Nucleic Acids Res. 2014 Jan;42(Database issue):D191-8
20601276 - J Proteomics. 2010 Sep 10;73(10):1907-20
24727771 - Nat Biotechnol. 2014 Mar;32(3):223-6
22282591 - J Am Soc Nephrol. 2012 Apr;23(4):591-6
21126025 - J Proteome Res. 2011 Feb 4;10(2):637-45
18481254 - Mass Spectrom Rev. 2008 Nov-Dec;27(6):596-608
26517171 - J Proteome Res. 2016 Jan 4;15(1):114-24
18410134 - Anal Chem. 2008 May 15;80(10):3557-65
12391396 - ILAR J. 2002;43(4):207-13
22106071 - Proteomics. 2012 Jan;12(2):329-38
22140069 - Proteomics. 2012 Feb;12(3):391-400
23808607 - OMICS. 2013 Sep;17(9):473-85
21989406 - Nucleic Acids Res. 2012 Jan;40(Database issue):D1241-4
19235170 - Proteomics. 2009 Mar;9(6):1492-510
15595733 - J Proteome Res. 2004 Nov-Dec;3(6):1234-42
19606093 - Nature. 2009 Aug 6;460(7256):762-5
18820680 - Nature. 2008 Oct 30;455(7217):1251-4
22785172 - Kidney Int. 2012 Nov;82(9):1024-32
20187088 - Rapid Commun Mass Spectrom. 2010 Mar;24(6):823-32
20130532 - Kidney Int. 2010 Apr;77(8):736-42
17005933 - J Am Soc Nephrol. 2006 Nov;17(11):3139-48
634317 - N Engl J Med. 1978 Apr 13;298(15):826-33
19056867 - J Am Soc Nephrol. 2009 Feb;20(2):363-79
18237110 - J Proteome Res. 2008 Mar;7(3):1288-96
12154376 - Nat Rev Immunol. 2002 Aug;2(8):569-79
18603494 - J Proteomics. 2008 Aug 21;71(3):255-64
16501490 - Kidney Int. 2006 Apr;69(8):1471-6
21772259 - Mol Syst Biol. 2011 Jul 19;7:511
23205526 - J Proteome Res. 2013 Jan 4;12(1):293-8
20414472 - Stat Surv. 2010;4:1-39
19367702 - J Proteome Res. 2008 Dec;7(12):5157-66
23628703 - Biochim Biophys Acta. 2013 Dec;1830(12):5503-8
26434508 - J Mol Biol. 2016 Feb 22;428(4):688-92
24700864 - J Am Soc Nephrol. 2014 Sep;25(9):2017-27
20407943 - Methods Mol Biol. 2010;641:89-99
23203882 - Nucleic Acids Res. 2013 Jan;41(Database issue):D1063-9
3306098 - Kidney Int. 1987 Jul;32(1):69-77
15071556 - Nat Rev Mol Cell Biol. 2004 Apr;5(4):317-23
25123350 - J Proteomics. 2015 Jan 1;112:53-62
25158685 - Proteomics. 2015 Mar;15(5-6):930-49
21593866 - Nature. 2011 May 19;473(7347):337-42
23376485 - J Proteomics. 2013 Apr 26;82:193-229
21642640 - Mol Cell Proteomics. 2011 Sep;10(9):M111.011015
20622845 - Nat Biotechnol. 2010 Jul;28(7):710-21
21500864 - J Proteome Res. 2011 Jun 3;10(6):2734-43
21982829 - J Proteomics. 2012 Jan 4;75(3):796-805
16948836 - Genome Biol. 2006;7(9):R80
24959705 - Curr Opin Cell Biol. 2014 Aug;29:116-25
24261998 - J Proteome Res. 2014 Jan 3;13(1):60-75
19144520 - Trends Cell Biol. 2009 Feb;19(2):43-51
19793586 - J Chromatogr A. 2010 Feb 5;1217(6):893-900
23420871 - J Cell Biol. 2013 Feb 18;200(4):373-83
3430951 - Kidney Int. 1987 Oct;32(4):547-53
15496171 - Kidney Int. 2004 Nov;66(5):1994-2003
17450130 - Nat Biotechnol. 2007 May;25(5):576-83
15326289 - Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13368-73
References_xml – volume: 234
  start-page: F455
  issue: 6
  year: 1978
  end-page: 60
  article-title: Glomerular permselectivity: barrier function based on discrimination of molecular size and charge
  publication-title: Am J Physiol.
– volume: 41
  start-page: D1063
  year: 2013
  end-page: 9
  article-title: The PRoteomics IDEntifications (PRIDE) database and associated tools: status in 2013
  publication-title: Nucleic Acids Res.
– volume: 32
  start-page: 547
  issue: 4
  year: 1987
  end-page: 53
  article-title: Characterization of cationic albumin in minimal change nephropathy
  publication-title: Kidney Int.
– volume: 66
  start-page: 1994
  issue: 5
  year: 2004
  end-page: 2003
  article-title: Quantitative amino acid and proteomic analysis: very low excretion of polypeptides >750 Da in normal urine
  publication-title: Kidney Int.
– volume: 77
  start-page: 736
  issue: 8
  year: 2010
  end-page: 42
  article-title: Tamm-Horsfall protein and urinary exosome isolation
  publication-title: Kidney Int.
– volume: 82
  start-page: 1024
  issue: 9
  year: 2012
  end-page: 32
  article-title: Comparison of protein, microRNA, and mRNA yields using different methods of urinary exosome isolation for the discovery of kidney disease biomarkers
  publication-title: Kidney Int.
– volume: 69
  start-page: 1471
  issue: 8
  year: 2006
  end-page: 6
  article-title: Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery
  publication-title: Kidney Int.
– volume: 43
  start-page: 207
  issue: 4
  year: 2002
  end-page: 13
  article-title: Sample size determination
  publication-title: ILAR J.
– volume: 1217
  start-page: 893
  issue: 6
  year: 2010
  end-page: 900
  article-title: Plucking, pillaging and plundering proteomes with combinatorial peptide ligand libraries
  publication-title: J Chromatogr A.
– volume: 17
  start-page: 473
  issue: 9
  year: 2013
  end-page: 85
  article-title: Evaluation of normalization methods to pave the way towards large-scale LC-MS-based metabolomics profiling experiments
  publication-title: OMICS.
– volume: 3
  start-page: 1234
  issue: 6
  year: 2004
  end-page: 42
  article-title: Open source system for analyzing, validating, and storing protein identification data
  publication-title: J Proteome Res.
– year: 2015
  article-title: ExoCarta: a web-based compendium of exosomal cargo
  publication-title: J Mol Biol.
– volume: 200
  start-page: 373
  issue: 4
  year: 2013
  end-page: 83
  article-title: Extracellular vesicles: exosomes, microvesicles, and friends
  publication-title: J Cell Biol.
– volume: 12
  start-page: 391
  issue: 3
  year: 2012
  end-page: 400
  article-title: Analysis of the urine proteome via a combination of multi-dimensional approaches
  publication-title: Proteomics.
– volume: 12
  start-page: 329
  issue: 2
  year: 2012
  end-page: 38
  article-title: Proteomic analysis of urine exosomes by multidimensional protein identification technology (MudPIT)
  publication-title: Proteomics.
– volume: 9
  start-page: 1492
  issue: 6
  year: 2009
  end-page: 510
  article-title: The art of observing rare protein species in proteomes with peptide ligand libraries
  publication-title: Proteomics.
– volume: 32
  start-page: 69
  issue: 1
  year: 1987
  end-page: 77
  article-title: Renal selectivity properties towards endogenous albumin in minimal change nephropathy
  publication-title: Kidney Int.
– volume: 15
  start-page: 930
  issue: 5-6
  year: 2015
  end-page: 49
  article-title: Making proteomics data accessible and reusable: current state of proteomics databases and repositories
  publication-title: Proteomics.
– volume: 19
  start-page: 43
  issue: 2
  year: 2009
  end-page: 51
  article-title: Shedding microvesicles: artefacts no more
  publication-title: Trends Cell Biol.
– volume: 71
  start-page: 255
  issue: 3
  year: 2008
  end-page: 64
  article-title: The ProteoMiner in the proteomic arena: a non-depleting tool for discovering low-abundance species
  publication-title: J Proteomics.
– volume: 80
  start-page: 3557
  issue: 10
  year: 2008
  end-page: 65
  article-title: Performance of combinatorial peptide libraries in capturing the low-abundance proteome of red blood cells. 2. Behavior of resins containing individual amino acids
  publication-title: Anal Chem.
– volume: 82
  start-page: 193
  year: 2013
  end-page: 229
  article-title: Proteomic analysis of podocyte exosomeenriched fraction from normal human urine
  publication-title: J Proteomics.
– volume: 5
  start-page: 317
  issue: 4
  year: 2004
  end-page: 23
  article-title: The biogenesis of multivesicular endosomes
  publication-title: Nat Rev Mol Cell Biol.
– volume: 40
  start-page: D1241
  year: 2012
  end-page: 4
  article-title: ExoCarta 2012: database of exosomal proteins, RNA and lipids
  publication-title: Nucleic Acids Res.
– volume: 298
  start-page: 826
  issue: 15
  year: 1978
  end-page: 33
  article-title: Molecular basis of proteinuria of glomerular origin
  publication-title: N Engl J Med.
– volume: 15
  start-page: 114
  issue: 1
  year: 2016
  end-page: 24
  article-title: Longitudinal urinary protein variability in participants of the space flight simulation program
  publication-title: J Proteome Res.
– volume: 13
  start-page: 60
  issue: 1
  year: 2014
  end-page: 75
  article-title: State of the human proteome in 2013 as viewed through PeptideAtlas: comparing the kidney, urine, and plasma proteomes for the biology- and disease-driven Human Proteome Project
  publication-title: J Proteome Res.
– volume: 23
  start-page: 591
  issue: 4
  year: 2012
  end-page: 6
  article-title: Generation of urinary albumin fragments does not require proximal tubular uptake
  publication-title: J Am Soc Nephrol.
– volume: 455
  start-page: 1251
  issue: 7217
  year: 2008
  end-page: 4
  article-title: Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast
  publication-title: Nature.
– volume: 20
  start-page: 363
  issue: 2
  year: 2009
  end-page: 79
  article-title: Large-scale proteomics and phosphoproteomics of urinary exosomes
  publication-title: J Am Soc Nephrol.
– volume: 12
  start-page: 293
  issue: 1
  year: 2013
  end-page: 8
  article-title: neXtProt: organizing protein knowledge in the context of human proteome projects
  publication-title: J Proteome Res.
– volume: 7
  start-page: 1288
  issue: 3
  year: 2008
  end-page: 96
  article-title: Multivariate data analysis of two-dimensional gel electrophoresis protein patterns from few samples
  publication-title: J Proteome Res.
– volume: 25
  start-page: 576
  issue: 5
  year: 2007
  end-page: 83
  article-title: A high-quality catalog of the proteome
  publication-title: Nat Biotechnol.
– volume: 28
  start-page: 710
  issue: 7
  year: 2010
  end-page: 21
  article-title: Options and considerations when selecting a quantitative proteomics strategy
  publication-title: Nat Biotechnol.
– volume: 7
  start-page: 5157
  issue: 12
  year: 2008
  end-page: 66
  article-title: Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes
  publication-title: J Proteome Res.
– volume: 29
  start-page: 116
  year: 2014
  end-page: 25
  article-title: Biogenesis and secretion of exosomes
  publication-title: Curr Opin Cell Biol.
– volume: 42
  start-page: D191
  year: 2014
  end-page: 8
  article-title: UniProt Consortium. Activities at the Universal Protein Resource (UniProt)
  publication-title: Nucleic Acids Res.
– volume: 10
  start-page: 2734
  issue: 6
  year: 2011
  end-page: 43
  article-title: A comprehensive map of the human urinary proteome
  publication-title: J Proteome Res.
– volume: 101
  start-page: 13368
  issue: 36
  year: 2004
  end-page: 73
  article-title: Identification and proteomic profling of exosomes in human urine
  publication-title: Proc Natl Acad Sci USA.
– volume: 4
  start-page: 1
  year: 2010
  end-page: 39
  article-title: Wilcoxon-Mann-Whitney or t-test? On assumptions for hypothesis tests and multiple interpretations of decision rules
  publication-title: Stat Surv.
– volume: 473
  start-page: 337
  issue: 7347
  year: 2011
  end-page: 42
  article-title: Global quantification of mammalian gene expression control
  publication-title: Nature.
– volume: 460
  start-page: 762
  issue: 7256
  year: 2009
  end-page: 5
  article-title: Proteome-wide cellular protein concentrations of the human pathogen
  publication-title: Nature.
– volume: 7
  start-page: R80
  issue: 9
  year: 2006
  article-title: The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins
  publication-title: Genome Biol.
– volume: 112
  start-page: 53
  year: 2015
  end-page: 62
  article-title: From hundreds to thousands: widening the normal human Urinome (1)
  publication-title: J Proteomics.
– volume: 25
  start-page: 2017
  issue: 9
  year: 2014
  end-page: 27
  article-title: Human urinary exosomes as innate immune effectors
  publication-title: J Am Soc Nephrol.
– volume: 75
  start-page: 796
  issue: 3
  year: 2012
  end-page: 805
  article-title: “Cheek-to-cheek” urinary proteome profiling via combinatorial peptide ligand libraries: a novel, unexpected elution system
  publication-title: J Proteomics.
– volume: 32
  start-page: 223
  issue: 3
  year: 2014
  end-page: 6
  article-title: ProteomeXchange provides globally coordinated proteomics data submission and dissemination
  publication-title: Nat Biotechnol.
– volume: 1830
  start-page: 5503
  issue: 12
  year: 2013
  end-page: 8
  article-title: Albumin heterogeneity in low-abundance fluids. The case of urine and cerebro-spinal fluid
  publication-title: Biochim Biophys Acta.
– volume: 2
  start-page: 569
  issue: 8
  year: 2002
  end-page: 79
  article-title: Exosomes: composition, biogenesis and function
  publication-title: Nat Rev Immunol.
– volume: 73
  start-page: 1907
  issue: 10
  year: 2010
  end-page: 20
  article-title: Exosomes: extracellular organelles important in intercellular communication
  publication-title: J Proteomics.
– volume: 10
  start-page: M111.011015
  issue: 9
  year: 2011
  article-title: Mass spectrometry-based proteomics using Q Exactive, a high-performance benchtop quadrupole Orbitrap mass spectrometer
  publication-title: Mol Cell Proteomics.
– volume: 10
  start-page: 637
  issue: 2
  year: 2011
  end-page: 45
  article-title: Quantitative analysis of the intra- and inter-individual variability of the normal urinary proteome
  publication-title: J Proteome Res.
– volume: 24
  start-page: 823
  issue: 6
  year: 2010
  end-page: 32
  article-title: A comprehensive and non-prefractionation on the protein level approach for the human urinary proteome: touching phosphorylation in urine
  publication-title: Rapid Commun Mass Spectrom.
– volume: 641
  start-page: 89
  year: 2010
  end-page: 99
  article-title: Isolation and purification of exosomes in urine
  publication-title: Methods Mol Biol.
– volume: 27
  start-page: 596
  issue: 6
  year: 2008
  end-page: 608
  article-title: The ProteoMiner and the FortyNiners: searching for gold nuggets in the proteomic arena
  publication-title: Mass Spectrom Rev.
– volume: 17
  start-page: 3139
  issue: 11
  year: 2006
  end-page: 48
  article-title: Repetitive fragmentation products of albumin and alpha1-antitrypsin in glomerular diseases associated with nephrotic syndrome
  publication-title: J Am Soc Nephrol
– volume: 7
  start-page: 511
  year: 2011
  article-title: Quantification of mRNA and protein and integration with protein turnover in a bacterium
  publication-title: Mol Syst Biol.
– ident: bibr41-BMI.S26229
  doi: 10.1021/pr700800s
– ident: bibr23-BMI.S26229
  doi: 10.1073/pnas.0403453101
– ident: bibr55-BMI.S26229
  doi: 10.1093/nar/gkr828
– ident: bibr12-BMI.S26229
  doi: 10.1038/nrm1360
– ident: bibr27-BMI.S26229
  doi: 10.1016/j.chroma.2009.08.070
– ident: bibr37-BMI.S26229
  doi: 10.1021/acs.jproteome.5b00594
– ident: bibr34-BMI.S26229
  doi: 10.1038/nature08184
– ident: bibr4-BMI.S26229
  doi: 10.1038/ki.1987.173
– volume: 234
  start-page: F455
  issue: 6
  year: 1978
  ident: bibr2-BMI.S26229
  publication-title: Am J Physiol.
– ident: bibr52-BMI.S26229
  doi: 10.1021/pr100835s
– ident: bibr31-BMI.S26229
  doi: 10.1038/nature07341
– ident: bibr36-BMI.S26229
  doi: 10.1038/nature10098
– ident: bibr26-BMI.S26229
  doi: 10.1002/mas.20178
– ident: bibr50-BMI.S26229
  doi: 10.1002/rcm.4441
– ident: bibr5-BMI.S26229
  doi: 10.1038/ki.1987.243
– ident: bibr30-BMI.S26229
  doi: 10.1038/nbt1300
– ident: bibr20-BMI.S26229
  doi: 10.1002/pmic.201100477
– ident: bibr18-BMI.S26229
  doi: 10.1038/ki.2012.256
– ident: bibr9-BMI.S26229
  doi: 10.1038/sj.ki.5000273
– ident: bibr10-BMI.S26229
  doi: 10.1083/jcb.201211138
– ident: bibr7-BMI.S26229
  doi: 10.1681/ASN.2006050486
– ident: bibr39-BMI.S26229
  doi: 10.1089/omi.2013.0010
– ident: bibr57-BMI.S26229
  doi: 10.1016/j.jprot.2013.01.012
– ident: bibr25-BMI.S26229
  doi: 10.1002/pmic.200800389
– ident: bibr22-BMI.S26229
  doi: 10.1007/978-1-60761-711-2_6
– ident: bibr47-BMI.S26229
  doi: 10.1093/nar/gkt1140
– year: 2015
  ident: bibr56-BMI.S26229
  publication-title: J Mol Biol.
– ident: bibr1-BMI.S26229
  doi: 10.1056/NEJM197804132981507
– ident: bibr48-BMI.S26229
  doi: 10.1021/pr300830v
– ident: bibr49-BMI.S26229
  doi: 10.1186/gb-2006-7-9-r80
– ident: bibr14-BMI.S26229
  doi: 10.1016/j.ceb.2014.05.004
– ident: bibr35-BMI.S26229
  doi: 10.1074/mcp.M111.011015
– ident: bibr40-BMI.S26229
  doi: 10.1214/09-SS051
– ident: bibr13-BMI.S26229
  doi: 10.1038/nri855
– ident: bibr43-BMI.S26229
  doi: 10.1093/nar/gks1262
– ident: bibr15-BMI.S26229
  doi: 10.1016/j.jprot.2010.06.006
– ident: bibr45-BMI.S26229
  doi: 10.1021/pr4010037
– ident: bibr16-BMI.S26229
  doi: 10.1016/j.tcb.2008.11.003
– ident: bibr42-BMI.S26229
  doi: 10.1038/nbt.2839
– ident: bibr51-BMI.S26229
  doi: 10.1021/pr2003038
– ident: bibr21-BMI.S26229
  doi: 10.1681/ASN.2008040406
– ident: bibr11-BMI.S26229
  doi: 10.1021/pr8004887
– ident: bibr17-BMI.S26229
  doi: 10.1681/ASN.2013101066
– ident: bibr28-BMI.S26229
  doi: 10.1021/ac8001353
– ident: bibr46-BMI.S26229
  doi: 10.1002/pmic.201400302
– ident: bibr44-BMI.S26229
  doi: 10.1021/pr049882h
– ident: bibr38-BMI.S26229
  doi: 10.1093/ilar.43.4.207
– ident: bibr24-BMI.S26229
  doi: 10.1016/j.jprot.2008.05.002
– ident: bibr33-BMI.S26229
  doi: 10.1038/msb.2011.38
– ident: bibr8-BMI.S26229
  doi: 10.1681/ASN.2011101034
– ident: bibr19-BMI.S26229
  doi: 10.1038/ki.2009.550
– ident: bibr6-BMI.S26229
  doi: 10.1111/j.1523-1755.2004.00970.x
– ident: bibr3-BMI.S26229
  doi: 10.1016/j.bbagen.2013.04.026
– ident: bibr32-BMI.S26229
  doi: 10.1038/nbt.1661
– ident: bibr53-BMI.S26229
  doi: 10.1016/j.jprot.2014.07.021
– ident: bibr29-BMI.S26229
  doi: 10.1016/j.jprot.2011.09.018
– ident: bibr54-BMI.S26229
  doi: 10.1002/pmic.201100212
– reference: 20414472 - Stat Surv. 2010;4:1-39
– reference: 15326289 - Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13368-73
– reference: 19606093 - Nature. 2009 Aug 6;460(7256):762-5
– reference: 25158685 - Proteomics. 2015 Mar;15(5-6):930-49
– reference: 17005933 - J Am Soc Nephrol. 2006 Nov;17(11):3139-48
– reference: 22106071 - Proteomics. 2012 Jan;12(2):329-38
– reference: 15496171 - Kidney Int. 2004 Nov;66(5):1994-2003
– reference: 665772 - Am J Physiol. 1978 Jun;234(6):F455-60
– reference: 26434508 - J Mol Biol. 2016 Feb 22;428(4):688-92
– reference: 23203882 - Nucleic Acids Res. 2013 Jan;41(Database issue):D1063-9
– reference: 23420871 - J Cell Biol. 2013 Feb 18;200(4):373-83
– reference: 21982829 - J Proteomics. 2012 Jan 4;75(3):796-805
– reference: 21126025 - J Proteome Res. 2011 Feb 4;10(2):637-45
– reference: 20130532 - Kidney Int. 2010 Apr;77(8):736-42
– reference: 16501490 - Kidney Int. 2006 Apr;69(8):1471-6
– reference: 20187088 - Rapid Commun Mass Spectrom. 2010 Mar;24(6):823-32
– reference: 634317 - N Engl J Med. 1978 Apr 13;298(15):826-33
– reference: 21593866 - Nature. 2011 May 19;473(7347):337-42
– reference: 19367702 - J Proteome Res. 2008 Dec;7(12):5157-66
– reference: 3306098 - Kidney Int. 1987 Jul;32(1):69-77
– reference: 24727771 - Nat Biotechnol. 2014 Mar;32(3):223-6
– reference: 25123350 - J Proteomics. 2015 Jan 1;112:53-62
– reference: 3430951 - Kidney Int. 1987 Oct;32(4):547-53
– reference: 21772259 - Mol Syst Biol. 2011 Jul 19;7:511
– reference: 19056867 - J Am Soc Nephrol. 2009 Feb;20(2):363-79
– reference: 20601276 - J Proteomics. 2010 Sep 10;73(10):1907-20
– reference: 20622845 - Nat Biotechnol. 2010 Jul;28(7):710-21
– reference: 22785172 - Kidney Int. 2012 Nov;82(9):1024-32
– reference: 15595733 - J Proteome Res. 2004 Nov-Dec;3(6):1234-42
– reference: 23808607 - OMICS. 2013 Sep;17(9):473-85
– reference: 20407943 - Methods Mol Biol. 2010;641:89-99
– reference: 24959705 - Curr Opin Cell Biol. 2014 Aug;29:116-25
– reference: 18481254 - Mass Spectrom Rev. 2008 Nov-Dec;27(6):596-608
– reference: 19235170 - Proteomics. 2009 Mar;9(6):1492-510
– reference: 16948836 - Genome Biol. 2006;7(9):R80
– reference: 22282591 - J Am Soc Nephrol. 2012 Apr;23(4):591-6
– reference: 18410134 - Anal Chem. 2008 May 15;80(10):3557-65
– reference: 23205526 - J Proteome Res. 2013 Jan 4;12(1):293-8
– reference: 21500864 - J Proteome Res. 2011 Jun 3;10(6):2734-43
– reference: 23628703 - Biochim Biophys Acta. 2013 Dec;1830(12):5503-8
– reference: 24261998 - J Proteome Res. 2014 Jan 3;13(1):60-75
– reference: 12154376 - Nat Rev Immunol. 2002 Aug;2(8):569-79
– reference: 12391396 - ILAR J. 2002;43(4):207-13
– reference: 18237110 - J Proteome Res. 2008 Mar;7(3):1288-96
– reference: 17450130 - Nat Biotechnol. 2007 May;25(5):576-83
– reference: 24700864 - J Am Soc Nephrol. 2014 Sep;25(9):2017-27
– reference: 26517171 - J Proteome Res. 2016 Jan 4;15(1):114-24
– reference: 21989406 - Nucleic Acids Res. 2012 Jan;40(Database issue):D1241-4
– reference: 18820680 - Nature. 2008 Oct 30;455(7217):1251-4
– reference: 22140069 - Proteomics. 2012 Feb;12(3):391-400
– reference: 15071556 - Nat Rev Mol Cell Biol. 2004 Apr;5(4):317-23
– reference: 24253303 - Nucleic Acids Res. 2014 Jan;42(Database issue):D191-8
– reference: 19144520 - Trends Cell Biol. 2009 Feb;19(2):43-51
– reference: 23376485 - J Proteomics. 2013 Apr 26;82:193-229
– reference: 21642640 - Mol Cell Proteomics. 2011 Sep;10(9):M111.011015
– reference: 18603494 - J Proteomics. 2008 Aug 21;71(3):255-64
– reference: 19793586 - J Chromatogr A. 2010 Feb 5;1217(6):893-900
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Snippet Urine proteome is a potential source of information in renal diseases, and it is considered a natural area of investigation for biomarkers. Technology...
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Publisher
StartPage 41
SubjectTerms Biomarkers
Exosomes
Kidney diseases
Mass spectroscopy
Proteomes
Review
Urine
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Title Urine Proteome Biomarkers in Kidney Diseases. I. Limits, Perspectives, and First Focus on Normal Urine
URI https://www.airitilibrary.com/Article/Detail/P20160527001-201612-201703160004-201703160004-41-48
http://insights.sagepub.com/urine-proteome-biomarkers-in-kidney-diseases-i-limits-perspectives-and-article-a5466
https://journals.sagepub.com/doi/full/10.4137/BMI.S26229
https://www.ncbi.nlm.nih.gov/pubmed/26997865
https://www.proquest.com/docview/1775979672
https://www.proquest.com/docview/2424769058
https://www.proquest.com/docview/1775178039
https://pubmed.ncbi.nlm.nih.gov/PMC4795486
https://doaj.org/article/12e0351bcbe54de9a446d715a5b071f1
Volume 2016
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