Identification of Effector Metabolites Using Exometabolite Profiling of Diverse Microalgae
Microalgae are responsible for nearly half of primary production on earth and play an important role in global biogeochemical cycling as well as in a range of industrial applications. Algal exometabolites are important mediators of algal-algal and algal-bacterial interactions that ultimately affect...
Saved in:
| Published in | mSystems Vol. 6; no. 6; p. e0083521 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Society for Microbiology
21.12.2021
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 2379-5077 2379-5077 |
| DOI | 10.1128/mSystems.00835-21 |
Cover
| Abstract | Microalgae are responsible for nearly half of primary production on earth and play an important role in global biogeochemical cycling as well as in a range of industrial applications. Algal exometabolites are important mediators of algal-algal and algal-bacterial interactions that ultimately affect algal growth and physiology.
Dissolved exometabolites mediate algal interactions in aquatic ecosystems, but microalgal exometabolomes remain understudied. We conducted an untargeted metabolomic analysis of nonpolar exometabolites exuded from four phylogenetically and ecologically diverse eukaryotic microalgal strains grown in the laboratory, freshwater
Chlamydomonas reinhardtii
, brackish
Desmodesmus
sp., marine
Phaeodactylum tricornutum
, and marine
Microchloropsis salina
, to identify released metabolites based on relative enrichment in the exometabolomes compared to cell pellet metabolomes. Exudates from the different taxa were distinct, but we did not observe clear phylogenetic patterns. We used feature-based molecular networking to explore the identities of these metabolites, revealing several distinct di- and tripeptides secreted by each of the algae, lumichrome, a compound that is known to be involved in plant growth and bacterial quorum sensing, and novel prostaglandin-like compounds. We further investigated the impacts of exogenous additions of eight compounds selected based on exometabolome enrichment on algal growth. Of these compounds, five (lumichrome, 5′-
S
-methyl-5′-thioadenosine, 17-phenyl trinor prostaglandin A2, dodecanedioic acid, and aleuritic acid) impacted growth in at least one of the algal cultures. Two of these compounds (dodecanedioic acid and aleuritic acid) produced contrasting results, increasing growth in some algae and decreasing growth in others. Together, our results reveal new groups of microalgal exometabolites, some of which could alter algal growth when provided exogenously, suggesting potential roles in allelopathy and algal interactions.
IMPORTANCE
Microalgae are responsible for nearly half of primary production on earth and play an important role in global biogeochemical cycling as well as in a range of industrial applications. Algal exometabolites are important mediators of algal-algal and algal-bacterial interactions that ultimately affect algal growth and physiology. In this study, we characterize exometabolomes across marine and freshwater algae to gain insights into the diverse metabolites they release into their environments (“exudates”). We observe that while phylogeny can play a role in exometabolome content, environmental conditions or habitat origin (freshwater versus marine) are also important. We also find that several of these compounds can influence algal growth (as measured by chlorophyll production) when provided exogenously, highlighting the importance of characterization of these novel compounds and their role in microalgal ecophysiology. |
|---|---|
| AbstractList | Microalgae are responsible for nearly half of primary production on earth and play an important role in global biogeochemical cycling as well as in a range of industrial applications. Algal exometabolites are important mediators of algal-algal and algal-bacterial interactions that ultimately affect algal growth and physiology.
Dissolved exometabolites mediate algal interactions in aquatic ecosystems, but microalgal exometabolomes remain understudied. We conducted an untargeted metabolomic analysis of nonpolar exometabolites exuded from four phylogenetically and ecologically diverse eukaryotic microalgal strains grown in the laboratory, freshwater
Chlamydomonas reinhardtii
, brackish
Desmodesmus
sp., marine
Phaeodactylum tricornutum
, and marine
Microchloropsis salina
, to identify released metabolites based on relative enrichment in the exometabolomes compared to cell pellet metabolomes. Exudates from the different taxa were distinct, but we did not observe clear phylogenetic patterns. We used feature-based molecular networking to explore the identities of these metabolites, revealing several distinct di- and tripeptides secreted by each of the algae, lumichrome, a compound that is known to be involved in plant growth and bacterial quorum sensing, and novel prostaglandin-like compounds. We further investigated the impacts of exogenous additions of eight compounds selected based on exometabolome enrichment on algal growth. Of these compounds, five (lumichrome, 5′-
S
-methyl-5′-thioadenosine, 17-phenyl trinor prostaglandin A2, dodecanedioic acid, and aleuritic acid) impacted growth in at least one of the algal cultures. Two of these compounds (dodecanedioic acid and aleuritic acid) produced contrasting results, increasing growth in some algae and decreasing growth in others. Together, our results reveal new groups of microalgal exometabolites, some of which could alter algal growth when provided exogenously, suggesting potential roles in allelopathy and algal interactions.
IMPORTANCE
Microalgae are responsible for nearly half of primary production on earth and play an important role in global biogeochemical cycling as well as in a range of industrial applications. Algal exometabolites are important mediators of algal-algal and algal-bacterial interactions that ultimately affect algal growth and physiology. In this study, we characterize exometabolomes across marine and freshwater algae to gain insights into the diverse metabolites they release into their environments (“exudates”). We observe that while phylogeny can play a role in exometabolome content, environmental conditions or habitat origin (freshwater versus marine) are also important. We also find that several of these compounds can influence algal growth (as measured by chlorophyll production) when provided exogenously, highlighting the importance of characterization of these novel compounds and their role in microalgal ecophysiology. Dissolved exometabolites mediate algal interactions in aquatic ecosystems, but microalgal exometabolomes remain understudied. We conducted an untargeted metabolomic analysis of nonpolar exometabolites exuded from four phylogenetically and ecologically diverse eukaryotic microalgal strains grown in the laboratory, freshwater Chlamydomonas reinhardtii, brackish Desmodesmus sp., marine Phaeodactylum tricornutum, and marine Microchloropsis salina, to identify released metabolites based on relative enrichment in the exometabolomes compared to cell pellet metabolomes. Exudates from the different taxa were distinct, but we did not observe clear phylogenetic patterns. We used feature-based molecular networking to explore the identities of these metabolites, revealing several distinct di- and tripeptides secreted by each of the algae, lumichrome, a compound that is known to be involved in plant growth and bacterial quorum sensing, and novel prostaglandin-like compounds. We further investigated the impacts of exogenous additions of eight compounds selected based on exometabolome enrichment on algal growth. Of these compounds, five (lumichrome, 5′-S-methyl-5′-thioadenosine, 17-phenyl trinor prostaglandin A2, dodecanedioic acid, and aleuritic acid) impacted growth in at least one of the algal cultures. Two of these compounds (dodecanedioic acid and aleuritic acid) produced contrasting results, increasing growth in some algae and decreasing growth in others. Together, our results reveal new groups of microalgal exometabolites, some of which could alter algal growth when provided exogenously, suggesting potential roles in allelopathy and algal interactions. IMPORTANCE Microalgae are responsible for nearly half of primary production on earth and play an important role in global biogeochemical cycling as well as in a range of industrial applications. Algal exometabolites are important mediators of algal-algal and algal-bacterial interactions that ultimately affect algal growth and physiology. In this study, we characterize exometabolomes across marine and freshwater algae to gain insights into the diverse metabolites they release into their environments (“exudates”). We observe that while phylogeny can play a role in exometabolome content, environmental conditions or habitat origin (freshwater versus marine) are also important. We also find that several of these compounds can influence algal growth (as measured by chlorophyll production) when provided exogenously, highlighting the importance of characterization of these novel compounds and their role in microalgal ecophysiology. Dissolved exometabolites mediate algal interactions in aquatic ecosystems, but microalgal exometabolomes remain understudied. We conducted an untargeted metabolomic analysis of nonpolar exometabolites exuded from four phylogenetically and ecologically diverse eukaryotic microalgal strains grown in the laboratory, freshwater Chlamydomonas reinhardtii , brackish Desmodesmus sp., marine Phaeodactylum tricornutum , and marine Microchloropsis salina , to identify released metabolites based on relative enrichment in the exometabolomes compared to cell pellet metabolomes. Exudates from the different taxa were distinct, but we did not observe clear phylogenetic patterns. We used feature-based molecular networking to explore the identities of these metabolites, revealing several distinct di- and tripeptides secreted by each of the algae, lumichrome, a compound that is known to be involved in plant growth and bacterial quorum sensing, and novel prostaglandin-like compounds. We further investigated the impacts of exogenous additions of eight compounds selected based on exometabolome enrichment on algal growth. Of these compounds, five (lumichrome, 5′- S -methyl-5′-thioadenosine, 17-phenyl trinor prostaglandin A2, dodecanedioic acid, and aleuritic acid) impacted growth in at least one of the algal cultures. Two of these compounds (dodecanedioic acid and aleuritic acid) produced contrasting results, increasing growth in some algae and decreasing growth in others. Together, our results reveal new groups of microalgal exometabolites, some of which could alter algal growth when provided exogenously, suggesting potential roles in allelopathy and algal interactions. IMPORTANCE Microalgae are responsible for nearly half of primary production on earth and play an important role in global biogeochemical cycling as well as in a range of industrial applications. Algal exometabolites are important mediators of algal-algal and algal-bacterial interactions that ultimately affect algal growth and physiology. In this study, we characterize exometabolomes across marine and freshwater algae to gain insights into the diverse metabolites they release into their environments (“exudates”). We observe that while phylogeny can play a role in exometabolome content, environmental conditions or habitat origin (freshwater versus marine) are also important. We also find that several of these compounds can influence algal growth (as measured by chlorophyll production) when provided exogenously, highlighting the importance of characterization of these novel compounds and their role in microalgal ecophysiology. ABSTRACT Dissolved exometabolites mediate algal interactions in aquatic ecosystems, but microalgal exometabolomes remain understudied. We conducted an untargeted metabolomic analysis of nonpolar exometabolites exuded from four phylogenetically and ecologically diverse eukaryotic microalgal strains grown in the laboratory, freshwater Chlamydomonas reinhardtii, brackish Desmodesmus sp., marine Phaeodactylum tricornutum, and marine Microchloropsis salina, to identify released metabolites based on relative enrichment in the exometabolomes compared to cell pellet metabolomes. Exudates from the different taxa were distinct, but we did not observe clear phylogenetic patterns. We used feature-based molecular networking to explore the identities of these metabolites, revealing several distinct di- and tripeptides secreted by each of the algae, lumichrome, a compound that is known to be involved in plant growth and bacterial quorum sensing, and novel prostaglandin-like compounds. We further investigated the impacts of exogenous additions of eight compounds selected based on exometabolome enrichment on algal growth. Of these compounds, five (lumichrome, 5′-S-methyl-5′-thioadenosine, 17-phenyl trinor prostaglandin A2, dodecanedioic acid, and aleuritic acid) impacted growth in at least one of the algal cultures. Two of these compounds (dodecanedioic acid and aleuritic acid) produced contrasting results, increasing growth in some algae and decreasing growth in others. Together, our results reveal new groups of microalgal exometabolites, some of which could alter algal growth when provided exogenously, suggesting potential roles in allelopathy and algal interactions. IMPORTANCE Microalgae are responsible for nearly half of primary production on earth and play an important role in global biogeochemical cycling as well as in a range of industrial applications. Algal exometabolites are important mediators of algal-algal and algal-bacterial interactions that ultimately affect algal growth and physiology. In this study, we characterize exometabolomes across marine and freshwater algae to gain insights into the diverse metabolites they release into their environments (“exudates”). We observe that while phylogeny can play a role in exometabolome content, environmental conditions or habitat origin (freshwater versus marine) are also important. We also find that several of these compounds can influence algal growth (as measured by chlorophyll production) when provided exogenously, highlighting the importance of characterization of these novel compounds and their role in microalgal ecophysiology. Dissolved exometabolites mediate algal interactions in aquatic ecosystems, but microalgal exometabolomes remain understudied. We conducted an untargeted metabolomic analysis of nonpolar exometabolites exuded from four phylogenetically and ecologically diverse eukaryotic microalgal strains grown in the laboratory, freshwater Chlamydomonas reinhardtii, brackish Desmodesmus sp., marine Phaeodactylum tricornutum, and marine Microchloropsis salina, to identify released metabolites based on relative enrichment in the exometabolomes compared to cell pellet metabolomes. Exudates from the different taxa were distinct, but we did not observe clear phylogenetic patterns. We used feature-based molecular networking to explore the identities of these metabolites, revealing several distinct di- and tripeptides secreted by each of the algae, lumichrome, a compound that is known to be involved in plant growth and bacterial quorum sensing, and novel prostaglandin-like compounds. We further investigated the impacts of exogenous additions of eight compounds selected based on exometabolome enrichment on algal growth. Of these compounds, five (lumichrome, 5'-S-methyl-5'-thioadenosine, 17-phenyl trinor prostaglandin A2, dodecanedioic acid, and aleuritic acid) impacted growth in at least one of the algal cultures. Two of these compounds (dodecanedioic acid and aleuritic acid) produced contrasting results, increasing growth in some algae and decreasing growth in others. Together, our results reveal new groups of microalgal exometabolites, some of which could alter algal growth when provided exogenously, suggesting potential roles in allelopathy and algal interactions. Dissolved exometabolites mediate algal interactions in aquatic ecosystems, but microalgal exometabolomes remain understudied. We conducted an untargeted metabolomic analysis of nonpolar exometabolites exuded from four phylogenetically and ecologically diverse eukaryotic microalgal strains grown in the laboratory, freshwater Chlamydomonas reinhardtii, brackish sp., marine Phaeodactylum tricornutum, and marine Microchloropsis salina, to identify released metabolites based on relative enrichment in the exometabolomes compared to cell pellet metabolomes. Exudates from the different taxa were distinct, but we did not observe clear phylogenetic patterns. We used feature-based molecular networking to explore the identities of these metabolites, revealing several distinct di- and tripeptides secreted by each of the algae, lumichrome, a compound that is known to be involved in plant growth and bacterial quorum sensing, and novel prostaglandin-like compounds. We further investigated the impacts of exogenous additions of eight compounds selected based on exometabolome enrichment on algal growth. Of these compounds, five (lumichrome, 5'- -methyl-5'-thioadenosine, 17-phenyl trinor prostaglandin A2, dodecanedioic acid, and aleuritic acid) impacted growth in at least one of the algal cultures. Two of these compounds (dodecanedioic acid and aleuritic acid) produced contrasting results, increasing growth in some algae and decreasing growth in others. Together, our results reveal new groups of microalgal exometabolites, some of which could alter algal growth when provided exogenously, suggesting potential roles in allelopathy and algal interactions. Microalgae are responsible for nearly half of primary production on earth and play an important role in global biogeochemical cycling as well as in a range of industrial applications. Algal exometabolites are important mediators of algal-algal and algal-bacterial interactions that ultimately affect algal growth and physiology. In this study, we characterize exometabolomes across marine and freshwater algae to gain insights into the diverse metabolites they release into their environments ("exudates"). We observe that while phylogeny can play a role in exometabolome content, environmental conditions or habitat origin (freshwater versus marine) are also important. We also find that several of these compounds can influence algal growth (as measured by chlorophyll production) when provided exogenously, highlighting the importance of characterization of these novel compounds and their role in microalgal ecophysiology. Dissolved exometabolites mediate algal interactions in aquatic ecosystems, but microalgal exometabolomes remain understudied. We conducted an untargeted metabolomic analysis of nonpolar exometabolites exuded from four phylogenetically and ecologically diverse eukaryotic microalgal strains grown in the laboratory, freshwater Chlamydomonas reinhardtii, brackish Desmodesmus sp., marine Phaeodactylum tricornutum, and marine Microchloropsis salina, to identify released metabolites based on relative enrichment in the exometabolomes compared to cell pellet metabolomes. Exudates from the different taxa were distinct, but we did not observe clear phylogenetic patterns. We used feature-based molecular networking to explore the identities of these metabolites, revealing several distinct di- and tripeptides secreted by each of the algae, lumichrome, a compound that is known to be involved in plant growth and bacterial quorum sensing, and novel prostaglandin-like compounds. We further investigated the impacts of exogenous additions of eight compounds selected based on exometabolome enrichment on algal growth. Of these compounds, five (lumichrome, 5'-S-methyl-5'-thioadenosine, 17-phenyl trinor prostaglandin A2, dodecanedioic acid, and aleuritic acid) impacted growth in at least one of the algal cultures. Two of these compounds (dodecanedioic acid and aleuritic acid) produced contrasting results, increasing growth in some algae and decreasing growth in others. Together, our results reveal new groups of microalgal exometabolites, some of which could alter algal growth when provided exogenously, suggesting potential roles in allelopathy and algal interactions. IMPORTANCE Microalgae are responsible for nearly half of primary production on earth and play an important role in global biogeochemical cycling as well as in a range of industrial applications. Algal exometabolites are important mediators of algal-algal and algal-bacterial interactions that ultimately affect algal growth and physiology. In this study, we characterize exometabolomes across marine and freshwater algae to gain insights into the diverse metabolites they release into their environments ("exudates"). We observe that while phylogeny can play a role in exometabolome content, environmental conditions or habitat origin (freshwater versus marine) are also important. We also find that several of these compounds can influence algal growth (as measured by chlorophyll production) when provided exogenously, highlighting the importance of characterization of these novel compounds and their role in microalgal ecophysiology.Dissolved exometabolites mediate algal interactions in aquatic ecosystems, but microalgal exometabolomes remain understudied. We conducted an untargeted metabolomic analysis of nonpolar exometabolites exuded from four phylogenetically and ecologically diverse eukaryotic microalgal strains grown in the laboratory, freshwater Chlamydomonas reinhardtii, brackish Desmodesmus sp., marine Phaeodactylum tricornutum, and marine Microchloropsis salina, to identify released metabolites based on relative enrichment in the exometabolomes compared to cell pellet metabolomes. Exudates from the different taxa were distinct, but we did not observe clear phylogenetic patterns. We used feature-based molecular networking to explore the identities of these metabolites, revealing several distinct di- and tripeptides secreted by each of the algae, lumichrome, a compound that is known to be involved in plant growth and bacterial quorum sensing, and novel prostaglandin-like compounds. We further investigated the impacts of exogenous additions of eight compounds selected based on exometabolome enrichment on algal growth. Of these compounds, five (lumichrome, 5'-S-methyl-5'-thioadenosine, 17-phenyl trinor prostaglandin A2, dodecanedioic acid, and aleuritic acid) impacted growth in at least one of the algal cultures. Two of these compounds (dodecanedioic acid and aleuritic acid) produced contrasting results, increasing growth in some algae and decreasing growth in others. Together, our results reveal new groups of microalgal exometabolites, some of which could alter algal growth when provided exogenously, suggesting potential roles in allelopathy and algal interactions. IMPORTANCE Microalgae are responsible for nearly half of primary production on earth and play an important role in global biogeochemical cycling as well as in a range of industrial applications. Algal exometabolites are important mediators of algal-algal and algal-bacterial interactions that ultimately affect algal growth and physiology. In this study, we characterize exometabolomes across marine and freshwater algae to gain insights into the diverse metabolites they release into their environments ("exudates"). We observe that while phylogeny can play a role in exometabolome content, environmental conditions or habitat origin (freshwater versus marine) are also important. We also find that several of these compounds can influence algal growth (as measured by chlorophyll production) when provided exogenously, highlighting the importance of characterization of these novel compounds and their role in microalgal ecophysiology. |
| Author | Bowen, Benjamin Golini, Amber Thelen, Michael Stuart, Rhona K. Mayali, Xavier Brisson, Vanessa Northen, Trent R. |
| Author_xml | – sequence: 1 givenname: Vanessa surname: Brisson fullname: Brisson, Vanessa organization: Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California, USA – sequence: 2 givenname: Xavier orcidid: 0000-0002-2170-0773 surname: Mayali fullname: Mayali, Xavier organization: Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California, USA – sequence: 3 givenname: Benjamin surname: Bowen fullname: Bowen, Benjamin organization: Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA – sequence: 4 givenname: Amber surname: Golini fullname: Golini, Amber organization: Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA – sequence: 5 givenname: Michael orcidid: 0000-0002-2479-5480 surname: Thelen fullname: Thelen, Michael organization: Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California, USA – sequence: 6 givenname: Rhona K. surname: Stuart fullname: Stuart, Rhona K. organization: Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California, USA – sequence: 7 givenname: Trent R. surname: Northen fullname: Northen, Trent R. organization: Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA, The DOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, California, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34726483$$D View this record in MEDLINE/PubMed https://www.osti.gov/servlets/purl/1842430$$D View this record in Osti.gov |
| BookMark | eNp9Uk1vEzEUtFARLaU_gAtaceKS4M_1-oKE2gCRWoEEvXCxHO9z6mjXLrZT0X-Pm22jlkNPtp5n5vnNm9foIMQACL0leE4I7T6OP29zgTHPMe6YmFHyAh1RJtVMYCkPHt0P0UnOG4wxaZkkVL1Ch4xL2vKOHaHfyx5C8c5bU3wMTXTNwjmwJabmAopZxcEXyM1l9mHdLP7GcV9sfqTo_HBXr6wzfwMpQ3PhbYpmWBt4g146M2Q4uT-P0eWXxa_Tb7Pz71-Xp5_PZ0YwUmayo9JBC7xvDTCiRKu46rDgloK0quVUKIl76RSVUlkhiGldJ6XkQgGVnB2j5aTbR7PR18mPJt3qaLzeFWJaa5OKtwNogOoBF8QR63jLQHHprGGKrFbG9ExUrU-T1vV2NUJvqzfJDE9En74Ef6XX8UZ3oqVcqirwfhKIuXidbfXJXtkYQrVUk45TznAFfbjvkuKfLeSiR58tDIMJELdZ14kpI5gJWaHzCWrySPUmblOoXmqC9V0I9EMI9C4EmpJKePd4gv3XH1ZeAWQC1D3lnMDtIc-Jyv84dbBdYKoJfniG-Q_xNdRc |
| CitedBy_id | crossref_primary_10_1016_j_envres_2024_119439 crossref_primary_10_1016_j_biteb_2022_101321 crossref_primary_10_1038_s42003_025_07608_9 crossref_primary_10_1080_10408398_2024_2431208 crossref_primary_10_1111_nph_19051 crossref_primary_10_1016_j_envres_2024_118135 crossref_primary_10_1007_s10811_024_03330_x crossref_primary_10_1016_j_algal_2025_103904 crossref_primary_10_3390_plants13233415 crossref_primary_10_1016_j_plaphy_2023_03_012 crossref_primary_10_3390_microorganisms11082003 crossref_primary_10_3390_fermentation10070341 crossref_primary_10_1128_msphere_00231_22 crossref_primary_10_1016_j_orggeochem_2024_104880 crossref_primary_10_3389_fmicb_2022_914472 |
| Cites_doi | 10.3390/microorganisms9020311 10.3389/fmicb.2014.00111 10.3389/fnins.2017.00183 10.1016/0304-4203(87)90065-X 10.1038/nmicrobiol.2017.65 10.1038/nature07410 10.1038/483S17a 10.1007/s10811-015-0666-6 10.3389/fpls.2014.00436 10.1046/j.1365-2958.1999.01577.x 10.1111/j.1529-8817.1980.tb00724.x 10.1104/pp.105.071589 10.1002/lom3.10181 10.1016/j.algal.2019.101696 10.1038/s41396-020-00811-y 10.3389/fpls.2015.00700 10.1038/s41592-020-0933-6 10.1038/nbt.3597 10.1021/acs.analchem.0c04795 10.1016/j.algal.2018.08.012 10.3389/fmicb.2016.00828 10.1038/s41598-018-28627-z 10.1093/bioinformatics/bts252 10.1094/MPMI-21-9-1184 10.1016/j.trac.2009.12.004 10.1104/pp.18.00925 10.1111/nph.15765 10.1038/s41564-018-0129-3 10.1016/j.biortech.2016.07.022 10.1021/acs.analchem.7b04400 10.1186/1471-2105-11-395 10.1073/pnas.2012088117 10.1007/s11306-007-0082-2 10.1111/lam.12034 10.1007/BF02857948 10.4319/lom.2008.6.230 10.1016/j.algal.2020.102156 10.1016/j.biotechadv.2007.02.001 10.1007/s11306-007-0070-6 10.1021/ja508782y 10.1046/j.1529-8817.2001.01052.x 10.3390/md17070428 10.1126/sciadv.abd4210 10.1007/s12010-013-0386-9 10.1016/j.algal.2018.12.003 10.1139/m62-029 10.1016/j.rser.2009.07.020 10.1186/s13068-018-1343-1 10.1016/j.algal.2018.101390 10.1038/ismej.2017.27 10.1039/c1mb05196b 10.1016/j.ijpharm.2004.05.020 10.1073/pnas.2019855118 10.1038/s41396-020-0683-6 10.1126/science.1143609 10.1093/bioinformatics/btk039 10.1038/s41598-020-79320-z 10.1111/j.1462-2920.2008.01569.x 10.1073/pnas.1917265117 |
| ContentType | Journal Article |
| CorporateAuthor | Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States) Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States) |
| CorporateAuthor_xml | – sequence: 0 name: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States) – sequence: 0 name: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States) |
| DBID | AAYXX CITATION NPM 7X8 OIOZB OTOTI 5PM DOA |
| DOI | 10.1128/mSystems.00835-21 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic OSTI.GOV - Hybrid OSTI.GOV PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | CrossRef PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology Environmental Sciences |
| EISSN | 2379-5077 |
| Editor | Alegado, Rosie |
| Editor_xml | – sequence: 1 givenname: Rosie surname: Alegado fullname: Alegado, Rosie |
| ExternalDocumentID | oai_doaj_org_article_ee163451f1cf463e947fca391bbaad35 PMC8562479 1842430 mSystems00835-21 34726483 10_1128_mSystems_00835_21 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: U.S. Department of Energy (DOE) grantid: FWP SCW1039 – fundername: U.S. Department of Energy (DOE) grantid: DE-AC52-07NA27344 – fundername: U.S. Department of Energy (DOE) grantid: DE-AC52-07NA27344 funderid: https://doi.org/10.13039/100000015 – fundername: U.S. Department of Energy (DOE) grantid: FWP SCW1039 funderid: https://doi.org/10.13039/100000015 – fundername: ; grantid: FWP SCW1039 – fundername: ; grantid: DE-AC52-07NA27344 |
| GroupedDBID | 0R~ 53G 5VS 7X7 8FE 8FH 8FI 8FJ AAFWJ AAGFI AAUOK AAYXX ABUWG ACPRK ADBBV AFKRA AFPKN AHMBA ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI CCPQU CITATION EBS FRP FYUFA GROUPED_DOAJ H13 HCIFZ HMCUK HYE KQ8 LK8 M48 M7P M~E O9- OK1 PHGZM PHGZT PIMPY PQQKQ PROAC RHI RPM RSF UKHRP NPM PQGLB 0R 3V. ADACO BBAFP BXI PQEST PQUKI PRINS 7X8 PUEGO OIOZB OTOTI 5PM |
| ID | FETCH-LOGICAL-a531t-7827fe6e4d6ae319569498054c2e7c96425970d7f92779c551a6f8777459e2743 |
| IEDL.DBID | M48 |
| ISSN | 2379-5077 |
| IngestDate | Wed Aug 27 01:26:05 EDT 2025 Thu Aug 21 14:05:21 EDT 2025 Thu Dec 05 06:26:23 EST 2024 Fri Sep 05 02:45:03 EDT 2025 Tue Dec 28 13:57:58 EST 2021 Mon Jul 21 05:58:19 EDT 2025 Tue Jul 01 02:58:58 EDT 2025 Thu Apr 24 23:02:39 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Keywords | lumichrome Microchloropsis salina Chlamydomonas reinhardtii Phaeodactylum tricornutum microalgae Desmodesmus effector metabolites Chlamydononas reinhardtii exometabolome |
| Language | English |
| License | This is a work of the U.S. Government and is not subject to copyright protection in the United States. Foreign copyrights may apply. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-a531t-7827fe6e4d6ae319569498054c2e7c96425970d7f92779c551a6f8777459e2743 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 AC52-07NA27344; AC02-05CH11231 LLNL-JRNL-823908 USDOE Office of Science (SC), Biological and Environmental Research (BER) Citation Brisson V, Mayali X, Bowen B, Golini A, Thelen M, Stuart RK, Northen TR. 2021. Identification of effector metabolites using exometabolite profiling of diverse microalgae. mSystems 6:e00835-21. https://doi.org/10.1128/mSystems.00835-21. |
| ORCID | 0000-0002-2170-0773 0000-0002-2479-5480 0000000224795480 0000000221700773 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1128/mSystems.00835-21 |
| PMID | 34726483 |
| PQID | 2592310357 |
| PQPubID | 23479 |
| PageCount | 16 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_ee163451f1cf463e947fca391bbaad35 pubmedcentral_primary_oai_pubmedcentral_nih_gov_8562479 osti_scitechconnect_1842430 proquest_miscellaneous_2592310357 asm2_journals_10_1128_mSystems_00835_21 pubmed_primary_34726483 crossref_primary_10_1128_mSystems_00835_21 crossref_citationtrail_10_1128_mSystems_00835_21 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2021-Dec-21 |
| PublicationDateYYYYMMDD | 2021-12-21 |
| PublicationDate_xml | – month: 12 year: 2021 text: 2021-Dec-21 day: 21 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: 1752 N St., N.W., Washington, DC |
| PublicationTitle | mSystems |
| PublicationTitleAbbrev | mSystems |
| PublicationTitleAlternate | mSystems |
| PublicationYear | 2021 |
| Publisher | American Society for Microbiology |
| Publisher_xml | – sequence: 0 name: American Society for Microbiology – name: American Society for Microbiology |
| References | e_1_3_2_26_2 e_1_3_2_49_2 e_1_3_2_28_2 e_1_3_2_41_2 e_1_3_2_20_2 e_1_3_2_43_2 e_1_3_2_22_2 e_1_3_2_45_2 e_1_3_2_24_2 e_1_3_2_47_2 e_1_3_2_60_2 e_1_3_2_9_2 e_1_3_2_16_2 e_1_3_2_37_2 e_1_3_2_7_2 e_1_3_2_18_2 e_1_3_2_39_2 e_1_3_2_54_2 e_1_3_2_10_2 e_1_3_2_31_2 e_1_3_2_52_2 e_1_3_2_5_2 e_1_3_2_12_2 e_1_3_2_33_2 e_1_3_2_58_2 e_1_3_2_3_2 e_1_3_2_14_2 e_1_3_2_35_2 e_1_3_2_56_2 e_1_3_2_50_2 e_1_3_2_27_2 e_1_3_2_48_2 e_1_3_2_29_2 e_1_3_2_40_2 e_1_3_2_21_2 e_1_3_2_42_2 e_1_3_2_23_2 e_1_3_2_44_2 e_1_3_2_25_2 e_1_3_2_46_2 e_1_3_2_15_2 e_1_3_2_38_2 e_1_3_2_8_2 e_1_3_2_17_2 e_1_3_2_59_2 e_1_3_2_6_2 e_1_3_2_19_2 e_1_3_2_30_2 e_1_3_2_53_2 e_1_3_2_32_2 e_1_3_2_51_2 e_1_3_2_11_2 e_1_3_2_34_2 e_1_3_2_57_2 e_1_3_2_4_2 e_1_3_2_13_2 e_1_3_2_36_2 e_1_3_2_55_2 e_1_3_2_2_2 Katajamaa, M, Miettinen, J, Oresic, M (B57) 2006; 22 Pluskal, T, Castillo, S, Villar-Briones, A, Oresic, M (B58) 2010; 11 Cirri, E, Pohnert, G (B4) 2019; 223 Dakora, FD, Matiru, VN, Kanu, A (B32) 2015; 6 Pruesse, E, Peplies, J, Glockner, FO (B59) 2012; 28 Chung, TY, Kuo, CY, Lin, WJ, Wang, WL, Chou, JY (B46) 2018; 8 Seymour, JR, Amin, SA, Raina, JB, Stocker, R (B8) 2017; 2 Verbeke, F, De Craemer, S, Debunne, N, Janssens, Y, Wynendaele, E, Van de Wiele, C, De Spiegeleer, B (B42) 2017; 11 Mills, GL, McFadden, E, Quinn, JG (B47) 1987; 20 Remmers, IM, D’Adamo, S, Martens, DE, de Vos, RCH, Mumm, R, America, AHP, Cordewener, JHG, Bakker, LV, Peters, SA, Wijffels, RH, Lamers, PP (B13) 2018; 35 Bolling, C, Fiehn, O (B14) 2005; 139 Groenewald, EG, van der Westhuizen, AJ (B39) 1997; 63 Sumner, LW, Amberg, A, Barrett, D, Beale, MH, Beger, R, Daykin, CA, Fan, TWM, Fiehn, O, Goodacre, R, Griffin, JL, Hankemeier, T, Hardy, N, Harnly, J, Higashi, R, Kopka, J, Lane, AN, Lindon, JC, Marriott, P, Nicholls, AW, Reily, MD, Thaden, JJ, Viant, MR (B23) 2007; 3 Nothias, LF, Petras, D, Schmid, R, Duhrkop, K, Rainer, J, Sarvepalli, A, Protsyuk, I, Ernst, M, Tsugawa, H, Fleischauer, M, Aicheler, F, Aksenov, AA, Alka, O, Allard, PM, Barsch, A, Cachet, X, Caraballo-Rodriguez, AM, Da Silva, RR, Dang, T, Garg, N, Gauglitz, JM, Gurevich, A, Isaac, G, Jarmusch, AK, Kamenik, Z, Kang, KB, Kessler, N, Koester, I, Korf, A, Le Gouellec, A, Ludwig, M, Martin, HC, McCall, LI, McSayles, J, Meyer, SW, Mohimani, H, Morsy, M, Moyne, O, Neumann, S, Neuweger, H, Nguyen, NH, Nothias-Esposito, M, Paolini, J, Phelan, VV, Pluskal, T, Quinn, RA, Rogers, S, Shrestha, B, Tripathi, A, van der Hooft, JJJ (B20) 2020; 17 Ahmad, I, Fasihullah, Q, Noor, A, Ansari, IA, Ali, QNM (B36) 2004; 280 Murphy, KM, Edwards, J, Louie, KB, Bowen, BP, Sundaresan, V, Northen, TR, Zerbe, P (B56) 2021; 11 Mata, TM, Martins, AA, Caetano, NS (B3) 2010; 14 Leflaive, J, Lacroix, G, Nicaise, Y, Ten-Hage, L (B7) 2008; 10 Lupette, J, Jaussaud, A, Vigor, C, Oger, C, Galano, JM, Reversat, G, Vercauteren, J, Jouhet, J, Durand, T, Marechal, E (B40) 2018; 178 Fu, H, Uchimiya, M, Gore, J, Moran, MA (B10) 2020; 117 Di Dato, V, Orefice, I, Amato, A, Fontanarosa, C, Amoresano, A, Cutignano, A, Ianora, A, Romano, G (B38) 2017; 11 Naik, DN, Wahidullah, S, Meena, RM (B45) 2013; 56 Malik, AA, Swenson, T, Weihe, C, Morrison, EW, Martiny, JBH, Brodie, EL, Northen, TR, Allison, SD (B54) 2020; 14 Baran, R, Bowen, BP, Northen, TR (B17) 2011; 7 BenMoussa-Dahmen, I, Chtourou, H, Rezgui, F, Sayadi, S, Dhouib, A (B29) 2016; 218 Wang, M, Carver, JJ, Phelan, VV, Sanchez, LM, Garg, N, Peng, Y, Nguyen, DD, Watrous, J, Kapono, CA, Luzzatto-Knaan, T, Porto, C, Bouslimani, A, Melnik, AV, Meehan, MJ, Liu, W-T, Crüsemann, M, Boudreau, PD, Esquenazi, E, Sandoval-Calderón, M, Kersten, RD, Pace, LA, Quinn, RA, Duncan, KR, Hsu, C-C, Floros, DJ, Gavilan, RG, Kleigrewe, K, Northen, T, Dutton, RJ, Parrot, D, Carlson, EE, Aigle, B, Michelsen, CF, Jelsbak, L, Sohlenkamp, C, Pevzner, P, Edlund, A, McLean, J, Piel, J, Murphy, BT, Gerwick, L, Liaw, C-C, Yang, Y-L, Humpf, H-U, Maansson, M, Keyzers, RA, Sims, AC, Johnson, AR, Sidebottom, AM, Sedio, BE (B21) 2016; 34 Boysen, AK, Heal, KR, Carlson, LT, Ingalls, AE (B55) 2018; 90 Ferrer-González, FX, Widner, B, Holderman, NR, Glushka, J, Edison, AS, Kujawinski, EB, Moran, MA (B15) 2021; 15 Di Costanzo, F, Di Dato, V, Ianora, A, Romano, G (B37) 2019; 17 Johnson, WM, Soule, MCK, Kujawinski, EB (B49) 2017; 15 Park, WK, Yoo, G, Moon, M, Kim, C, Choi, YE, Yang, JW (B5) 2013; 171 Alvarez-Sanchez, B, Priego-Capote, F, de Castro, MDL (B24) 2010; 29 Belmondo, S, Fiorilli, V, Perez-Tienda, J, Ferrol, N, Marmeisse, R, Lanfranco, L (B43) 2014; 5 Hughes, AH, Magot, F, Tawfike, AF, Rad-Menendez, C, Thomas, N, Young, LC, Stucchi, L, Carettoni, D, Stanley, MS, Edrada-Ebel, R, Duncan, KR (B26) 2021; 9 Zhalnina, K, Louie, KB, Hao, Z, Mansoori, N, da Rocha, UN, Shi, SJ, Cho, HJ, Karaoz, U, Loque, D, Bowen, BP, Firestone, MK, Northen, TR, Brodie, EL (B9) 2018; 3 Seyedsayamdost, MR, Wang, RR, Kolter, R, Clardy, J (B12) 2014; 136 Fiehn, O, Robertson, D, Griffin, J, van der Werf, M, Nikolau, B, Morrison, N, Sumner, LW, Goodacre, R, Hardy, NW, Taylor, C, Fostel, J, Kristal, B, Kaddurah-Daouk, R, Mendes, P, van Ommen, B, Lindon, JC, Sansone, SA (B22) 2007; 3 Becker, JW, Berube, PM, Follett, CL, Waterbury, JB, Chisholm, SW, DeLong, EF, Repeta, DJ (B16) 2014; 5 Labeeuw, L, Khey, J, Bramucci, AR, Atwal, H, de la Mata, AP, Harynuk, J, Case, RJ (B6) 2016; 7 Arora, N, Laurens, LML, Sweeney, N, Pruthi, V, Poluri, KM, Pienkos, PT (B28) 2019; 37 Lopez, BR, Palacios, OA, Bashan, Y, Hernandez-Sandoval, FE, de-Bashan, LE (B33) 2019; 44 Dittmar, T, Koch, B, Hertkorn, N, Kattner, G (B48) 2008; 6 B50 Heo, J, Kim, S, Cho, DH, Song, GC, Kim, HS, Ryu, CM (B35) 2019; 38 Williams, A, Chiles, EN, Conetta, D, Pathmanathan, JS, Cleves, PA, Putnam, HM, Su, XY, Bhattacharya, D (B41) 2021; 7 B51 Peng, HX, de-Bashan, LE, Higgins, BT (B34) 2021; 53 von Alvensleben, N, Magnusson, M, Heimann, K (B30) 2016; 28 Bowler, C, Allen, AE, Badger, JH, Grimwood, J, Jabbari, K, Kuo, A, Maheswari, U, Martens, C, Maumus, F, Otillar, RP, Rayko, E, Salamov, A, Vandepoele, K, Beszteri, B, Gruber, A, Heijde, M, Katinka, M, Mock, T, Valentin, K, Verret, F, Berges, JA, Brownlee, C, Cadoret, JP, Chiovitti, A, Choi, CJ, Coesel, S, De Martino, A, Detter, JC, Durkin, C, Falciatore, A, Fournet, J, Haruta, M, Huysman, MJJ, Jenkins, BD, Jiroutova, K, Jorgensen, RE, Joubert, Y, Kaplan, A, Kroger, N, Kroth, PG, La Roche, J, Lindquist, E, Lommer, M, Martin-Jezequel, V, Lopez, PJ, Lucas, S, Mangogna, M, McGinnis, K, Medlin, LK, Montsant, A (B19) 2008; 456 Shibl, AA, Isaac, A, Ochsenkuhn, MA, Cardenas, A, Fei, C, Behringer, G, Arnoux, M, Drou, N, Santos, MP, Gunsalus, KC, Voolstra, CR, Amin, SA (B11) 2020; 117 Swift, CL, Louie, KB, Bowen, BP, Olson, HM, Purvine, SO, Salamov, A, Mondo, SJ, Solomon, KV, Wright, AT, Northen, TR, Grigoriev, IV, Keller, NP, O’Malley, MA (B53) 2021; 118 Pontrelli, S, Sauer, U (B25) 2021; 93 Rajamani, S, Bauer, WD, Robinson, JB, Farrow, JM, Pesci, EC, Teplitski, M, Gao, MS, Sayre, RT, Phillips, DA (B31) 2008; 21 Chisti, Y (B2) 2007; 25 Guillard, RR, Ryther, JH (B52) 1962; 8 Falkowski, P (B1) 2012; 483 Merchant, SS, Prochnik, SE, Vallon, O, Harris, EH, Karpowicz, SJ, Witman, GB, Terry, A, Salamov, A, Fritz-Laylin, LK, Marechal-Drouard, L, Marshall, WF, Qu, LH, Nelson, DR, Sanderfoot, AA, Spalding, MH, Kapitonov, VV, Ren, QH, Ferris, P, Lindquist, E, Shapiro, H, Lucas, SM, Grimwood, J, Schmutz, J, Cardol, P, Cerutti, H, Chanfreau, G, Chen, CL, Cognat, V, Croft, MT, Dent, R, Dutcher, S, Fernandez, E, Fukuzawa, H, Gonzalez-Ballester, D, Gonzalez-Halphen, D, Hallmann, A, Hanikenne, M, Hippler, M, Inwood, W, Jabbari, K, Kalanon, M, Kuras, R, Lefebvre, PA, Lemaire, SD, Lobanov, AV, Lohr, M, Manuell, A, Meir, I, Mets, L, Mittag, M (B18) 2007; 318 Holden, MTG, Chhabra, SR, de Nys, R, Stead, P, Bainton, NJ, Hill, PJ, Manefield, M, Kumar, N, Labatte, M, England, D, Rice, S, Givskov, M, Salmond, GPC, Stewart, G, Bycroft, BW, Kjelleberg, SA, Williams, P (B44) 1999; 33 Arora, N, Kumari, P, Kumar, A, Gangwar, R, Gulati, K, Pruthi, PA, Prasad, R, Kumar, D, Pruthi, V, Poluri, KM (B27) 2019; 12 |
| References_xml | – ident: e_1_3_2_27_2 doi: 10.3390/microorganisms9020311 – ident: e_1_3_2_17_2 doi: 10.3389/fmicb.2014.00111 – ident: e_1_3_2_43_2 doi: 10.3389/fnins.2017.00183 – ident: e_1_3_2_48_2 doi: 10.1016/0304-4203(87)90065-X – ident: e_1_3_2_9_2 doi: 10.1038/nmicrobiol.2017.65 – ident: e_1_3_2_20_2 doi: 10.1038/nature07410 – ident: e_1_3_2_2_2 doi: 10.1038/483S17a – ident: e_1_3_2_31_2 doi: 10.1007/s10811-015-0666-6 – ident: e_1_3_2_44_2 doi: 10.3389/fpls.2014.00436 – ident: e_1_3_2_45_2 doi: 10.1046/j.1365-2958.1999.01577.x – ident: e_1_3_2_52_2 doi: 10.1111/j.1529-8817.1980.tb00724.x – ident: e_1_3_2_15_2 doi: 10.1104/pp.105.071589 – ident: e_1_3_2_50_2 doi: 10.1002/lom3.10181 – ident: e_1_3_2_34_2 doi: 10.1016/j.algal.2019.101696 – ident: e_1_3_2_16_2 doi: 10.1038/s41396-020-00811-y – ident: e_1_3_2_33_2 doi: 10.3389/fpls.2015.00700 – ident: e_1_3_2_21_2 doi: 10.1038/s41592-020-0933-6 – ident: e_1_3_2_22_2 doi: 10.1038/nbt.3597 – ident: e_1_3_2_26_2 doi: 10.1021/acs.analchem.0c04795 – ident: e_1_3_2_14_2 doi: 10.1016/j.algal.2018.08.012 – ident: e_1_3_2_7_2 doi: 10.3389/fmicb.2016.00828 – ident: e_1_3_2_47_2 doi: 10.1038/s41598-018-28627-z – ident: e_1_3_2_60_2 doi: 10.1093/bioinformatics/bts252 – ident: e_1_3_2_32_2 doi: 10.1094/MPMI-21-9-1184 – ident: e_1_3_2_25_2 doi: 10.1016/j.trac.2009.12.004 – ident: e_1_3_2_41_2 doi: 10.1104/pp.18.00925 – ident: e_1_3_2_5_2 doi: 10.1111/nph.15765 – ident: e_1_3_2_10_2 doi: 10.1038/s41564-018-0129-3 – ident: e_1_3_2_30_2 doi: 10.1016/j.biortech.2016.07.022 – ident: e_1_3_2_56_2 doi: 10.1021/acs.analchem.7b04400 – ident: e_1_3_2_59_2 doi: 10.1186/1471-2105-11-395 – ident: e_1_3_2_12_2 doi: 10.1073/pnas.2012088117 – ident: e_1_3_2_24_2 doi: 10.1007/s11306-007-0082-2 – ident: e_1_3_2_46_2 doi: 10.1111/lam.12034 – ident: e_1_3_2_40_2 doi: 10.1007/BF02857948 – ident: e_1_3_2_49_2 doi: 10.4319/lom.2008.6.230 – ident: e_1_3_2_35_2 doi: 10.1016/j.algal.2020.102156 – ident: e_1_3_2_3_2 doi: 10.1016/j.biotechadv.2007.02.001 – ident: e_1_3_2_23_2 doi: 10.1007/s11306-007-0070-6 – ident: e_1_3_2_13_2 doi: 10.1021/ja508782y – ident: e_1_3_2_51_2 doi: 10.1046/j.1529-8817.2001.01052.x – ident: e_1_3_2_38_2 doi: 10.3390/md17070428 – ident: e_1_3_2_42_2 doi: 10.1126/sciadv.abd4210 – ident: e_1_3_2_6_2 doi: 10.1007/s12010-013-0386-9 – ident: e_1_3_2_29_2 doi: 10.1016/j.algal.2018.12.003 – ident: e_1_3_2_53_2 doi: 10.1139/m62-029 – ident: e_1_3_2_4_2 doi: 10.1016/j.rser.2009.07.020 – ident: e_1_3_2_28_2 doi: 10.1186/s13068-018-1343-1 – ident: e_1_3_2_36_2 doi: 10.1016/j.algal.2018.101390 – ident: e_1_3_2_39_2 doi: 10.1038/ismej.2017.27 – ident: e_1_3_2_18_2 doi: 10.1039/c1mb05196b – ident: e_1_3_2_37_2 doi: 10.1016/j.ijpharm.2004.05.020 – ident: e_1_3_2_54_2 doi: 10.1073/pnas.2019855118 – ident: e_1_3_2_55_2 doi: 10.1038/s41396-020-0683-6 – ident: e_1_3_2_19_2 doi: 10.1126/science.1143609 – ident: e_1_3_2_58_2 doi: 10.1093/bioinformatics/btk039 – ident: e_1_3_2_57_2 doi: 10.1038/s41598-020-79320-z – ident: e_1_3_2_8_2 doi: 10.1111/j.1462-2920.2008.01569.x – ident: e_1_3_2_11_2 doi: 10.1073/pnas.1917265117 – volume: 178 start-page: 1344 year: 2018 end-page: 1357 ident: B40 article-title: Non-enzymatic synthesis of bioactive isoprostanoids in the diatom Phaeodactylum following oxidative stress publication-title: Plant Physiol doi: 10.1104/pp.18.00925 – volume: 8 start-page: 229 year: 1962 end-page: 239 ident: B52 article-title: Studies of marine planktonic diatoms.1. Cyclotella nana Hustedt, and Detonula confervacea (Cleve) Gran publication-title: Can J Microbiol doi: 10.1139/m62-029 – volume: 21 start-page: 1184 year: 2008 end-page: 1192 ident: B31 article-title: The vitamin riboflavin and its derivative lumichrome activate the LasR bacterial quorum-sensing receptor publication-title: Mol Plant Microbe Interact doi: 10.1094/MPMI-21-9-1184 – volume: 12 start-page: 2 year: 2019 ident: B27 article-title: Delineating the molecular responses of a halotolerant microalga using integrated omics approach to identify genetic engineering targets for enhanced TAG production publication-title: Biotechnol Biofuels doi: 10.1186/s13068-018-1343-1 – volume: 33 start-page: 1254 year: 1999 end-page: 1266 ident: B44 article-title: Quorum-sensing cross talk: isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other Gram-negative bacteria publication-title: Mol Microbiol doi: 10.1046/j.1365-2958.1999.01577.x – volume: 22 start-page: 634 year: 2006 end-page: 636 ident: B57 article-title: MZmine: toolbox for processing and visualization of mass spectrometry based molecular profile data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btk039 – volume: 90 start-page: 1363 year: 2018 end-page: 1369 ident: B55 article-title: Best-matched internal standard normalization in liquid chromatography-mass spectrometry metabolomics applied to environmental samples publication-title: Anal Chem doi: 10.1021/acs.analchem.7b04400 – volume: 14 start-page: 217 year: 2010 end-page: 232 ident: B3 article-title: Microalgae for biodiesel production and other applications: a review publication-title: Renew Sustain Energy Rev doi: 10.1016/j.rser.2009.07.020 – volume: 5 start-page: 111 year: 2014 ident: B16 article-title: Closely related phytoplankton species produce similar suites of dissolved organic matter publication-title: Front Microbiol doi: 10.3389/fmicb.2014.00111 – volume: 9 start-page: 311 year: 2021 ident: B26 article-title: Exploring the chemical space of macro- and micro-algae using comparative metabolomics publication-title: Microorganisms doi: 10.3390/microorganisms9020311 – volume: 7 start-page: 828 year: 2016 ident: B6 article-title: Indole-3-acetic acid is produced by Emiliania huxleyi coccolith-bearing cells and triggers a physiological response in bald cells publication-title: Front Microbiol doi: 10.3389/fmicb.2016.00828 – volume: 7 start-page: 3200 year: 2011 end-page: 3206 ident: B17 article-title: Untargeted metabolic footprinting reveals a surprising breadth of metabolite uptake and release by Synechococcus sp. PCC 7002 publication-title: Mol Biosyst doi: 10.1039/c1mb05196b – volume: 11 start-page: 395 year: 2010 ident: B58 article-title: MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-11-395 – volume: 117 start-page: 27445 year: 2020 end-page: 27455 ident: B11 article-title: Diatom modulation of select bacteria through use of two unique secondary metabolites publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.2012088117 – volume: 15 start-page: 417 year: 2017 end-page: 428 ident: B49 article-title: Extraction efficiency and quantification of dissolved metabolites in targeted marine metabolomics publication-title: Limnol Oceanogr Methods doi: 10.1002/lom3.10181 – volume: 118 year: 2021 ident: B53 article-title: Anaerobic gut fungi are an untapped reservoir of natural products publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.2019855118 – volume: 17 start-page: 428 year: 2019 ident: B37 article-title: Prostaglandins in marine organisms: a review publication-title: Marine Drugs doi: 10.3390/md17070428 – volume: 11 start-page: 1722 year: 2017 end-page: 1726 ident: B38 article-title: Animal-like prostaglandins in marine microalgae publication-title: ISME J doi: 10.1038/ismej.2017.27 – ident: B50 article-title: Berges JA, Franklin DJ, Harrison PJ. 2001. Evolution of an artificial seawater medium: improvements in enriched seawater, artificial water over the last two decades. J Phycol 37:1138–1145. doi: 10.1046/j.1529-8817.2001.01052.x . – volume: 53 start-page: 102156 year: 2021 ident: B34 article-title: Comparison of algae growth and symbiotic mechanisms in the presence of plant growth promoting bacteria and non-plant growth promoting bacteria publication-title: Algal Res doi: 10.1016/j.algal.2020.102156 – volume: 63 start-page: 199 year: 1997 end-page: 220 ident: B39 article-title: Prostaglandins and related substances in plants publication-title: Bot Rev doi: 10.1007/BF02857948 – volume: 223 start-page: 100 year: 2019 end-page: 106 ident: B4 article-title: Algae-bacteria interactions that balance the planktonic microbiome publication-title: New Phytol doi: 10.1111/nph.15765 – volume: 15 start-page: 762 year: 2021 end-page: 773 ident: B15 article-title: Resource partitioning of phytoplankton metabolites that support bacterial heterotrophy publication-title: ISME J doi: 10.1038/s41396-020-00811-y – volume: 3 start-page: 175 year: 2007 end-page: 178 ident: B22 article-title: The metabolomics standards initiative (MSI) publication-title: Metabolomics doi: 10.1007/s11306-007-0070-6 – volume: 17 start-page: 905 year: 2020 end-page: 908 ident: B20 article-title: Feature-based molecular networking in the GNPS analysis environment publication-title: Nat Methods doi: 10.1038/s41592-020-0933-6 – volume: 11 start-page: 183 year: 2017 end-page: 118 ident: B42 article-title: Peptides as quorum sensing molecules: measurement techniques and obtained levels in vitro and in vivo publication-title: Front Neurosci doi: 10.3389/fnins.2017.00183 – volume: 5 start-page: 436 year: 2014 ident: B43 article-title: A dipeptide transporter from the arbuscular mycorrhizal fungus Rhizophagus irregularis is upregulated in the intraradical phase publication-title: Front Plant Sci doi: 10.3389/fpls.2014.00436 – ident: B51 article-title: Harrison PJ, Waters RE, Taylor FJR. 1980. A broad-spectrum artificial seawater medium for coastal and open ocean phytoplankton. J Phycol 16:28–35. doi: 10.1111/j.0022-3646.1980.00028.x . – volume: 38 start-page: 101390 year: 2019 ident: B35 article-title: Genome-wide exploration of Escherichia coli genes to promote Chlorella vulgaris growth publication-title: Algal Res doi: 10.1016/j.algal.2018.101390 – volume: 280 start-page: 199 year: 2004 end-page: 208 ident: B36 article-title: Photolysis of riboflavin in aqueous solution: a kinetic study publication-title: Int J Pharm doi: 10.1016/j.ijpharm.2004.05.020 – volume: 3 start-page: 470 year: 2018 end-page: 480 ident: B9 article-title: Dynamic root exudate chemistry and microbial substrate preferences drive patterns in rhizosphere microbial community assembly publication-title: Nat Microbiol doi: 10.1038/s41564-018-0129-3 – volume: 29 start-page: 120 year: 2010 end-page: 127 ident: B24 article-title: Metabolomics analysis II. Preparation of biological samples prior to detection publication-title: TrAC Trends Anal Chem doi: 10.1016/j.trac.2009.12.004 – volume: 37 start-page: 260 year: 2019 end-page: 268 ident: B28 article-title: Elucidating the unique physiological responses of halotolerant Scenedesmus sp. cultivated in sea water for biofuel production publication-title: Algal Res doi: 10.1016/j.algal.2018.12.003 – volume: 318 start-page: 245 year: 2007 end-page: 251 ident: B18 article-title: The Chlamydomonas genome reveals the evolution of key animal and plant functions publication-title: Science doi: 10.1126/science.1143609 – volume: 483 start-page: S17 year: 2012 end-page: S20 ident: B1 article-title: Ocean science: the power of plankton publication-title: Nature doi: 10.1038/483S17a – volume: 28 start-page: 1823 year: 2012 end-page: 1829 ident: B59 article-title: SINA: accurate high-throughput multiple sequence alignment of ribosomal RNA genes publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts252 – volume: 2 start-page: 12 year: 2017 ident: B8 article-title: Zooming in on the phycosphere: the ecological interface for phytoplankton-bacteria relationships publication-title: Nat Microbiol doi: 10.1038/nmicrobiol.2017.65 – volume: 171 start-page: 1128 year: 2013 end-page: 1142 ident: B5 article-title: Phytohormone supplementation significantly increases growth of Chlamydomonas reinhardtii cultivated for biodiesel production publication-title: Appl Biochem Biotechnol doi: 10.1007/s12010-013-0386-9 – volume: 218 start-page: 816 year: 2016 end-page: 825 ident: B29 article-title: Salinity stress increases lipid, secondary metabolites and enzyme activity in Amphora subtropica and Dunaliella sp. for biodiesel production publication-title: Bioresour Technol doi: 10.1016/j.biortech.2016.07.022 – volume: 136 start-page: 15150 year: 2014 end-page: 15153 ident: B12 article-title: Hybrid biosynthesis of roseobacticides from algal and bacterial precursor molecules publication-title: J Am Chem Soc doi: 10.1021/ja508782y – volume: 56 start-page: 197 year: 2013 end-page: 207 ident: B45 article-title: Attenuation of Pseudomonas aeruginosa virulence by marine invertebrate derived Streptomyces sp publication-title: Lett Appl Microbiol doi: 10.1111/lam.12034 – volume: 25 start-page: 294 year: 2007 end-page: 306 ident: B2 article-title: Biodiesel from microalgae publication-title: Biotechnol Adv doi: 10.1016/j.biotechadv.2007.02.001 – volume: 34 start-page: 828 year: 2016 end-page: 837 ident: B21 article-title: Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking publication-title: Nat Biotechnol doi: 10.1038/nbt.3597 – volume: 28 start-page: 861 year: 2016 end-page: 876 ident: B30 article-title: Salinity tolerance of four freshwater microalgal species and the effects of salinity and nutrient limitation on biochemical profiles publication-title: J Appl Phycol doi: 10.1007/s10811-015-0666-6 – volume: 93 start-page: 7164 year: 2021 end-page: 7171 ident: B25 article-title: Salt-tolerant metabolomics for exometabolomic measurements of marine bacterial isolates publication-title: Anal Chem doi: 10.1021/acs.analchem.0c04795 – volume: 139 start-page: 1995 year: 2005 end-page: 2005 ident: B14 article-title: Metabolite profiling of Chlamydomonas reinhardtii under nutrient deprivation publication-title: Plant Physiol doi: 10.1104/pp.105.071589 – volume: 35 start-page: 33 year: 2018 end-page: 49 ident: B13 article-title: Orchestration of transcriptome, proteome and metabolome in the diatom Phaeodactylum tricornutum during nitrogen limitation publication-title: Algal Res doi: 10.1016/j.algal.2018.08.012 – volume: 44 start-page: 101696 year: 2019 ident: B33 article-title: Riboflavin and lumichrome exuded by the bacterium Azospirillum brasilense promote growth and changes in metabolites in Chlorella sorokiniana under autotrophic conditions publication-title: Algal Res doi: 10.1016/j.algal.2019.101696 – volume: 10 start-page: 1536 year: 2008 end-page: 1546 ident: B7 article-title: Colony induction and growth inhibition in Desmodesmus quadrispina (Chlorococcales) by allelochemicals released from the filamentous alga Uronema confervicolum (Ulotrichales) publication-title: Environ Microbiol doi: 10.1111/j.1462-2920.2008.01569.x – volume: 8 start-page: 13 year: 2018 ident: B46 article-title: Indole-3-acetic-acid-induced phenotypic plasticity in Desmodesmus algae publication-title: Sci Rep doi: 10.1038/s41598-018-28627-z – volume: 7 start-page: 9 year: 2021 ident: B41 article-title: Metabolomic shifts associated with heat stress in coral holobionts publication-title: Sci Adv doi: 10.1126/sciadv.abd4210 – volume: 6 start-page: 11 year: 2015 ident: B32 article-title: Rhizosphere ecology of lumichrome and riboflavin, two bacterial signal molecules eliciting developmental changes in plants publication-title: Front Plant Sci doi: 10.3389/fpls.2015.00700 – volume: 14 start-page: 2236 year: 2020 end-page: 2247 ident: B54 article-title: Drought and plant litter chemistry alter microbial gene expression and metabolite production publication-title: ISME J doi: 10.1038/s41396-020-0683-6 – volume: 11 start-page: 13 year: 2021 ident: B56 article-title: Bioactive diterpenoids impact the composition of the root-associated microbiome in maize (Zea mays) publication-title: Sci Rep doi: 10.1038/s41598-020-79320-z – volume: 117 start-page: 3656 year: 2020 end-page: 3662 ident: B10 article-title: Ecological drivers of bacterial community assembly in synthetic phycospheres publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1917265117 – volume: 3 start-page: 211 year: 2007 end-page: 221 ident: B23 article-title: Proposed minimum reporting standards for chemical analysis publication-title: Metabolomics doi: 10.1007/s11306-007-0082-2 – volume: 20 start-page: 313 year: 1987 end-page: 325 ident: B47 article-title: Chromatographic studies of dissolved organic-matter and copper organic-complexes isolated from estuarine waters publication-title: Marine Chem doi: 10.1016/0304-4203(87)90065-X – volume: 456 start-page: 239 year: 2008 end-page: 244 ident: B19 article-title: The Phaeodactylum genome reveals the evolutionary history of diatom genomes publication-title: Nature doi: 10.1038/nature07410 – volume: 6 start-page: 230 year: 2008 end-page: 235 ident: B48 article-title: A simple and efficient method for the solid-phase extraction of dissolved organic matter (SPE-DOM) from seawater publication-title: Limnol Oceanogr Methods doi: 10.4319/lom.2008.6.230 |
| SSID | ssj0001637129 |
| Score | 2.3369565 |
| Snippet | Microalgae are responsible for nearly half of primary production on earth and play an important role in global biogeochemical cycling as well as in a range of... Dissolved exometabolites mediate algal interactions in aquatic ecosystems, but microalgal exometabolomes remain understudied. We conducted an untargeted... ABSTRACT Dissolved exometabolites mediate algal interactions in aquatic ecosystems, but microalgal exometabolomes remain understudied. We conducted an... |
| SourceID | doaj pubmedcentral osti proquest asm2 pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e0083521 |
| SubjectTerms | BASIC BIOLOGICAL SCIENCES biological and medical sciences biomass Chlamydomonas reinhardtii Desmodesmus effector metabolites energy Environmental Microbiology environmental sciences exometabolome lumichrome microalgae Research Article |
| SummonAdditionalLinks | – databaseName: American Society for Microbiology Open Access dbid: AAUOK link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3da9UwFA9jQ_BF3PyqmyOCIAidbT6a5vGqG0O56oMXhi8hTRMmeFvZ7UD_e89J0-qVMXwqTRMaTs5Jfic55xdCXhShbm3byNxZmAKFVSzX3mKMWFuFoHRdWExwXn6szlfi_YW82CHVlAuTJLg5sZt1PMifLZvVr9eJxfskAocc88f3JEB-cLr2FovVpw9_dlcqrmAlS8eYN7aFORj-wbbWo0jbD48ezOsmyPlv5ORfS9HZfXIvYUi6GAd9n-z47oDcGW-V_PWAfB2Tb0PajaN9oCNHcX9Fl36AUce84w2N0QL09Ge_ngvp53iFN5ZDq3cxZsPTJQbtYc6Hf0hWZ6df3p7n6QqF3IJxDTms_yr4you2sp5jbqAWIH8pHPPKaXA-wKEoWhU0U0o7gE-2CkgRKKT24LDyR2S36zv_hFDtFJO25q1HVrNW27q2yAVTNpwreM_IS5SnmUbQRPeC1WaSvImSN6zMSDGJ3LjERI4XYny_rcmrucmPkYbjtspvcBznisigHQtAn0wySOM96IiQZShdEBX3WqjgLNdl01jbcpmRQ9QCA0AE2XQdhh25wYBDzAQvMvJ8Ug4D9oiHLLbz_fXGgEARMnOpMvJ4VJa5I1woDCjkGVFbarTV0-0v3bfLyPldA04VSj_9byEfkrsMw29KBrp-RHaHq2v_DPDT0BwnY_kNbKcZUg priority: 102 providerName: American Society for Microbiology – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3fi9QwEB5kQfBF_G29UyIIglCvTdKmefTHHYew4oMHhy8hTScouO1x2wP9728m7S67IueLT6XZBrLTmeab9ptvAF4Vsel811Z58PQI1N7I3KJnjlhXx2hsU3gucF5-rk_P9Kfz6nyn1RdzwiZ54MlwR4iEGHRVxjJEXSu02sTglS3b1vtOJfXSwhY7yVR6u1IrQzvZ_BmTnsFHq1kB_G0CHTlrgy78eiX39qMk20-HgcLrb5DzT-bkzlZ0cg_uzhhSvJvWfh9uYf8Abk9dJX8_hG9T8W2c38aJIYpJo3i4FEsc6a5z3fFaJLaAOP41rLaD4ktq4c3jNOtj4mygWDJpj2s-8BGcnRx__XCazy0Uck_BNea0_5uINequ9qi4NtBqsn-lg0QTLCUflFAUnYlWGmMDwSdfR5YI1JVFSljVY1j0Q49PQdhgZOUb1SGrmnXWN41nLZiyVcrQeQav2Z5ujoG1S-mFbNzG8i5Z3skyg2JjchdmJXJuiPHzpilvtlMuJhmOmy5-z_dxeyEraKcB8is3-5X7l19lcMBe4AiIsJpuYNpRGB0lxFKrIoOXG-dwFI_8kcX3OFytHRmUIbOqTAZPJmfZLkRpw4RClYHZc6O9le7_0v_4njS_G8Kp2thn_-OvHcAdycycUlIYHMJivLzC5wStxvZFiqJrIHUitA priority: 102 providerName: Directory of Open Access Journals |
| Title | Identification of Effector Metabolites Using Exometabolite Profiling of Diverse Microalgae |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/34726483 https://journals.asm.org/doi/10.1128/mSystems.00835-21 https://www.proquest.com/docview/2592310357 https://www.osti.gov/servlets/purl/1842430 https://pubmed.ncbi.nlm.nih.gov/PMC8562479 https://doaj.org/article/ee163451f1cf463e947fca391bbaad35 |
| Volume | 6 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3fa9RAEB5qi-CL-LuxekQQBCE12d1ksw8i13qlKFeLeHD4smySXRV6id6l0P73zmySoydHwaeQTTaE2Zndb3ZnvgF4Hbu8MlWRRqXBKVAYySJlDcWIVZlzUuWxoQTn6Vl2OhOf5ul8B4byVr0AV1tdO6onNVteHF79uf6ABv--S4DJ3y16cu9DjyciSivf88dFFMnXo32_5ZJxmfi6ZYxLFSESkv0559av4CRtVgu2sWB5Xn-8NGh_2zDpv6GVN9aqkwdwvweZ4bjTioewY-tHcLcrO3n9GL532bmu364LGxd2JMbNMpzaFtWCEpNXoQ8nCCdXzWLdGJ77Gt_Ujr0--qAOG04pqo-SQuwTmJ1Mvh2fRn2Nhcig9bURAgTpbGZFlRnLKXlQCRygVJTMylKhd4IeR1xJp5iUqkR8ZTJHHIIiVRY9Wv4UduumtvsQqlKy1OS8skR7VimT54bIYpKCc4n3AbwheephjLX3P1iuB8lrL3nNkgDiQeS67KnKqWLGxW1d3q67_O54Om57-YjGcf0iUWz7hmb5Q_cWq61FfRFp4pLSiYxbJaQrDVdJURhT8TSAA9ICjUiF6HZLiksqW40eMxM8DuDVoBwaDZZOYUxtm8uVRoESpuapDOBZpyzrH-FCUsQhD0BuqNHGn24-qX_99KTgOQJZIdXz_5HDAdxjFKKTMFT3F7DbLi_tS8RYbTGCO3IuR7A3Hs--fMbr0eTs_OvI71iMvFX9BYM3KcA |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3da9UwFA-yIfoynJ91fkQQBKGzTdKmebzOjavbnT7swvAlpGmCym471g62_95z0tyrV8bwqTRtaDg5p_md5JzfIeRt5qvGNHWRWgO_QGEkS5UzGCPWlN5LVWUGE5xnx-V0Lr6cFqcxqhJzYX5hXd6zftf0i3COj4aNG9GxHmH1YRGZvHcDeEgxh3yzYCoDHd-cTOZfD__ssJRcwmoWjzJv7Av_YfgQW1uTAnU_XDowsZtg57_Rk38tRwcPyFbEkXQyTvw2uePah-TuWFny-hH5Pibg-rgjRztPR57i7oLO3AAzj7nHPQ0RA3T_qlusGum3UMYb26HXpxC34egMA_cw78M9JvOD_ZO9aRrLKKQGDGxIAQNI70onmtI4jvmBSsAcFMIyJ60CBwSciqyRXjEplQUIZUqPNIGiUA6cVv6EbLRd654Rqqxkhal445DZrFGmqgzyweQ15xLuE_IO5amjHfQ6uBis0kvJ6yB5zfKEZEuRaxvZyLEoxtltXd6vupyPVBy3vfwR53H1IrJohwZQKh2NUjsHOiKK3OfWi5I7JaS3hqu8ro1peJGQHdQCDWAEGXUthh7ZQYNTzATPEvJmqRwabBIPWkzrusteg0ARNvNCJuTpqCyrgXAhMaiQJ0SuqdHaSNeftD9_BN7vCrCqkOr5fwv5Nbk3PZkd6aPPx4c75D7DcJycgd6_IBvDxaV7CXhqqF9Fw_kN3u0dow |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3di9QwEB9kD8UX8fvq-VFBEISebZI2zePq3XJ67nkPLhy-hDRNUHDb47YH-t87k2ZXV47Dp9K0oWU-mpnmN78BeJX7ujVtU2bW4CdQGMky5QxhxNrKe6nq3FCB8_ykOlqIj2flWURVUi1MlOBq36yWYSOfPPu89bEfYf12GZm890PwkFEN-U5Ju2UT2JlOF5-P__xhqbjE1SxuZV45F7_D-By2tSYF6n489OhiV4Wd_6In_1qOZnfhTowj0-mo-Htww3X34ebYWfLXA_g6FuD6-Ecu7X068hT3F-ncDah5qj1epQExkB7-7JebwfQ0tPGmcZx1EHAbLp0TcI_qPtxDWMwOv7w_ymIbhcyggw0ZxgDSu8qJtjKOU32gEqiDUljmpFWYgGBSkbfSKyalshhCmcoTTaAolcOklT-CSdd3bhdSZSUrTc1bR8xmrTJ1bYgPpmg4l3iewGuSp15rUYcUg9V6LXkdJK9ZkUC-Frm2kY2cmmL8uG7Km82U85GK47qb35EeNzcSi3YYQJvS0Sm1c2gjoix8Yb2ouFNCemu4KprGmJaXCeyRFWgMRohR1xL0yA4ak2ImeJ7Ay7VxaPRJ2mgxnesvVxoFSmEzL2UCj0dj2bwIF5JAhTwBuWVGW2-6faX7_i3wftcYqwqpnvy3kF_ArdODmf704eR4D24zQuMUDM3-KUyGi0v3DMOpoXke_eY3wB8dSA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Identification+of+Effector+Metabolites+Using+Exometabolite+Profiling+of+Diverse+Microalgae&rft.jtitle=mSystems&rft.au=Brisson%2C+Vanessa&rft.au=Mayali%2C+Xavier&rft.au=Bowen%2C+Benjamin&rft.au=Golini%2C+Amber&rft.date=2021-12-21&rft.issn=2379-5077&rft.eissn=2379-5077&rft.volume=6&rft.issue=6&rft_id=info:doi/10.1128%2FmSystems.00835-21&rft.externalDBID=n%2Fa&rft.externalDocID=10_1128_mSystems_00835_21 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2379-5077&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2379-5077&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2379-5077&client=summon |