Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent - Capparelli, Edmund V.; Bricker-Ford, Robin; Rogers, M. John; McKerrow, James H.; Reed, Sharon L. (Antimicrobial agents and chemotherapy, 2017)
Keywords: Administration, Oral; Adult; Antiparasitic Agents; Antiparasitic Agents - blood; Antiparasitic Agents - pharmacokinetics; Antirheumatic Agents; Antirheumatic Agents - blood; Antirheumatic Agents - pharmacokinetics; Auranofin; Auranofin - blood; Auranofin - pharmacokinetics; Computer Simulation; Drug Administration Schedule; Drug Dosage Calculations; Drug Repositioning; Entamoeba histolytica; Entamoeba histolytica - drug effects; Entamoeba histolytica - growth & development; Experimental Therapeutics; Female; Giardia; Giardia intestinalis; Giardia lamblia; Giardia lamblia - drug effects; Giardia lamblia - growth & development; Gold - blood; Half-Life; Healthy Volunteers; High-Throughput Screening Assays; Humans; Inhibitory Concentration 50; Male; Metronidazole - pharmacology; Models, Statistical; Tissue Distribution; antiparasitic agents; auranofin; phase I trial