Biochemical Gas Sensors (Biosniffers) Using Forward and Reverse Reactions of Secondary Alcohol Dehydrogenase for Breath Isopropanol and Acetone as Potential Volatile Biomarkers of Diabetes Mellitus
This study describes two biosniffers to determine breath acetone and isopropanol (IPA) levels and applies them for breath measurement in healthy subjects and diabetic patients. Secondary alcohol dehydrogenase (S-ADH) can reduce acetone and oxidize nicotinamide adenine dinucleotide (NADH to NAD+) in...
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| Published in | Analytical chemistry (Washington) Vol. 89; no. 22; pp. 12261 - 12268 |
|---|---|
| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Chemical Society
21.11.2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0003-2700 1520-6882 1520-6882 |
| DOI | 10.1021/acs.analchem.7b03191 |
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| Abstract | This study describes two biosniffers to determine breath acetone and isopropanol (IPA) levels and applies them for breath measurement in healthy subjects and diabetic patients. Secondary alcohol dehydrogenase (S-ADH) can reduce acetone and oxidize nicotinamide adenine dinucleotide (NADH to NAD+) in a weak acid environment. NADH can be excited by 340 nm excitation lights and subsequently emit 490 nm fluorescence. Therefore, acetone can be measured by the decrease in NADH fluorescence intensity. S-ADH can also oxidize IPA and reduce NAD+ to NADH when it is in an alkaline environment. Thus, IPA can be detected by the increase of fluorescence. The developed biosniffers show rapid response, high sensitivity and high selectivity. The breath acetone and IPA analysis in healthy subjects shows that the mean values were 750.0 ± 434.4 ppb and 15.4 ± 11.3 ppb. Both acetone and IPA did not show a statistical difference among different genders and ages. The breath acetone analysis for diabetic patients shows a mean value of 1207.7 ± 689.5 ppb, which was higher than that of healthy subjects (p < 1 × 10–6). In particularly, type-1 diabetic (T1D) patients exhaled a much higher concentration of acetone than type-2 diabetic (T2D) patients (p < 0.01). The breath IPA also had a higher concentration in diabetic patients (23.1 ± 20.1 ppb, p < 0.01), but only T2D patients presented a statistical difference (23.9 ± 21.3 ppb, p < 0.01). These findings are worthwhile in the study of breath biomarkers for diabetes mellitus diagnosis. Additionally, the developed biosniffers provide a new technique for volatolomics research. |
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| AbstractList | This study describes two biosniffers to determine breath acetone and isopropanol (IPA) levels and applies them for breath measurement in healthy subjects and diabetic patients. Secondary alcohol dehydrogenase (S-ADH) can reduce acetone and oxidize nicotinamide adenine dinucleotide (NADH to NAD+) in a weak acid environment. NADH can be excited by 340 nm excitation lights and subsequently emit 490 nm fluorescence. Therefore, acetone can be measured by the decrease in NADH fluorescence intensity. S-ADH can also oxidize IPA and reduce NAD+ to NADH when it is in an alkaline environment. Thus, IPA can be detected by the increase of fluorescence. The developed biosniffers show rapid response, high sensitivity and high selectivity. The breath acetone and IPA analysis in healthy subjects shows that the mean values were 750.0 ± 434.4 ppb and 15.4 ± 11.3 ppb. Both acetone and IPA did not show a statistical difference among different genders and ages. The breath acetone analysis for diabetic patients shows a mean value of 1207.7 ± 689.5 ppb, which was higher than that of healthy subjects (p < 1 × 10–6). In particularly, type-1 diabetic (T1D) patients exhaled a much higher concentration of acetone than type-2 diabetic (T2D) patients (p < 0.01). The breath IPA also had a higher concentration in diabetic patients (23.1 ± 20.1 ppb, p < 0.01), but only T2D patients presented a statistical difference (23.9 ± 21.3 ppb, p < 0.01). These findings are worthwhile in the study of breath biomarkers for diabetes mellitus diagnosis. Additionally, the developed biosniffers provide a new technique for volatolomics research. This study describes two biosniffers to determine breath acetone and isopropanol (IPA) levels and applies them for breath measurement in healthy subjects and diabetic patients. Secondary alcohol dehydrogenase (S-ADH) can reduce acetone and oxidize nicotinamide adenine dinucleotide (NADH to NAD+) in a weak acid environment. NADH can be excited by 340 nm excitation lights and subsequently emit 490 nm fluorescence. Therefore, acetone can be measured by the decrease in NADH fluorescence intensity. S-ADH can also oxidize IPA and reduce NAD+ to NADH when it is in an alkaline environment. Thus, IPA can be detected by the increase of fluorescence. The developed biosniffers show rapid response, high sensitivity and high selectivity. The breath acetone and IPA analysis in healthy subjects shows that the mean values were 750.0 ± 434.4 ppb and 15.4 ± 11.3 ppb. Both acetone and IPA did not show a statistical difference among different genders and ages. The breath acetone analysis for diabetic patients shows a mean value of 1207.7 ± 689.5 ppb, which was higher than that of healthy subjects (p < 1 × 10-6). In particularly, type-1 diabetic (T1D) patients exhaled a much higher concentration of acetone than type-2 diabetic (T2D) patients (p < 0.01). The breath IPA also had a higher concentration in diabetic patients (23.1 ± 20.1 ppb, p < 0.01), but only T2D patients presented a statistical difference (23.9 ± 21.3 ppb, p < 0.01). These findings are worthwhile in the study of breath biomarkers for diabetes mellitus diagnosis. Additionally, the developed biosniffers provide a new technique for volatolomics research.This study describes two biosniffers to determine breath acetone and isopropanol (IPA) levels and applies them for breath measurement in healthy subjects and diabetic patients. Secondary alcohol dehydrogenase (S-ADH) can reduce acetone and oxidize nicotinamide adenine dinucleotide (NADH to NAD+) in a weak acid environment. NADH can be excited by 340 nm excitation lights and subsequently emit 490 nm fluorescence. Therefore, acetone can be measured by the decrease in NADH fluorescence intensity. S-ADH can also oxidize IPA and reduce NAD+ to NADH when it is in an alkaline environment. Thus, IPA can be detected by the increase of fluorescence. The developed biosniffers show rapid response, high sensitivity and high selectivity. The breath acetone and IPA analysis in healthy subjects shows that the mean values were 750.0 ± 434.4 ppb and 15.4 ± 11.3 ppb. Both acetone and IPA did not show a statistical difference among different genders and ages. The breath acetone analysis for diabetic patients shows a mean value of 1207.7 ± 689.5 ppb, which was higher than that of healthy subjects (p < 1 × 10-6). In particularly, type-1 diabetic (T1D) patients exhaled a much higher concentration of acetone than type-2 diabetic (T2D) patients (p < 0.01). The breath IPA also had a higher concentration in diabetic patients (23.1 ± 20.1 ppb, p < 0.01), but only T2D patients presented a statistical difference (23.9 ± 21.3 ppb, p < 0.01). These findings are worthwhile in the study of breath biomarkers for diabetes mellitus diagnosis. Additionally, the developed biosniffers provide a new technique for volatolomics research. This study describes two biosniffers to determine breath acetone and isopropanol (IPA) levels and applies them for breath measurement in healthy subjects and diabetic patients. Secondary alcohol dehydrogenase (S-ADH) can reduce acetone and oxidize nicotinamide adenine dinucleotide (NADH to NAD+) in a weak acid environment. NADH can be excited by 340 nm excitation lights and subsequently emit 490 nm fluorescence. Therefore, acetone can be measured by the decrease in NADH fluorescence intensity. S-ADH can also oxidize IPA and reduce NAD+ to NADH when it is in an alkaline environment. Thus, IPA can be detected by the increase of fluorescence. The developed biosniffers show rapid response, high sensitivity and high selectivity. The breath acetone and IPA analysis in healthy subjects shows that the mean values were 750.0 ± 434.4 ppb and 15.4 ± 11.3 ppb. Both acetone and IPA did not show a statistical difference among different genders and ages. The breath acetone analysis for diabetic patients shows a mean value of 1207.7 ± 689.5 ppb, which was higher than that of healthy subjects (p < 1 x 10-6). In particularly, type-1 diabetic (T1D) patients exhaled a much higher concentration of acetone than type-2 diabetic (T2D) patients (p < 0.01). The breath IPA also had a higher concentration in diabetic patients (23.1 ± 20.1 ppb, p < 0.01), but only T2D patients presented a statistical difference (23.9 ± 21.3 ppb, p < 0.01). These findings are worthwhile in the study of breath biomarkers for diabetes mellitus diagnosis. Additionally, the developed biosniffers provide a new technique for volatolomics research. This study describes two biosniffers to determine breath acetone and isopropanol (IPA) levels and applies them for breath measurement in healthy subjects and diabetic patients. Secondary alcohol dehydrogenase (S-ADH) can reduce acetone and oxidize nicotinamide adenine dinucleotide (NADH to NAD⁺) in a weak acid environment. NADH can be excited by 340 nm excitation lights and subsequently emit 490 nm fluorescence. Therefore, acetone can be measured by the decrease in NADH fluorescence intensity. S-ADH can also oxidize IPA and reduce NAD⁺ to NADH when it is in an alkaline environment. Thus, IPA can be detected by the increase of fluorescence. The developed biosniffers show rapid response, high sensitivity and high selectivity. The breath acetone and IPA analysis in healthy subjects shows that the mean values were 750.0 ± 434.4 ppb and 15.4 ± 11.3 ppb. Both acetone and IPA did not show a statistical difference among different genders and ages. The breath acetone analysis for diabetic patients shows a mean value of 1207.7 ± 689.5 ppb, which was higher than that of healthy subjects (p < 1 × 10–⁶). In particularly, type-1 diabetic (T1D) patients exhaled a much higher concentration of acetone than type-2 diabetic (T2D) patients (p < 0.01). The breath IPA also had a higher concentration in diabetic patients (23.1 ± 20.1 ppb, p < 0.01), but only T2D patients presented a statistical difference (23.9 ± 21.3 ppb, p < 0.01). These findings are worthwhile in the study of breath biomarkers for diabetes mellitus diagnosis. Additionally, the developed biosniffers provide a new technique for volatolomics research. This study describes two biosniffers to determine breath acetone and isopropanol (IPA) levels and applies them for breath measurement in healthy subjects and diabetic patients. Secondary alcohol dehydrogenase (S-ADH) can reduce acetone and oxidize nicotinamide adenine dinucleotide (NADH to NAD ) in a weak acid environment. NADH can be excited by 340 nm excitation lights and subsequently emit 490 nm fluorescence. Therefore, acetone can be measured by the decrease in NADH fluorescence intensity. S-ADH can also oxidize IPA and reduce NAD to NADH when it is in an alkaline environment. Thus, IPA can be detected by the increase of fluorescence. The developed biosniffers show rapid response, high sensitivity and high selectivity. The breath acetone and IPA analysis in healthy subjects shows that the mean values were 750.0 ± 434.4 ppb and 15.4 ± 11.3 ppb. Both acetone and IPA did not show a statistical difference among different genders and ages. The breath acetone analysis for diabetic patients shows a mean value of 1207.7 ± 689.5 ppb, which was higher than that of healthy subjects (p < 1 × 10 ). In particularly, type-1 diabetic (T1D) patients exhaled a much higher concentration of acetone than type-2 diabetic (T2D) patients (p < 0.01). The breath IPA also had a higher concentration in diabetic patients (23.1 ± 20.1 ppb, p < 0.01), but only T2D patients presented a statistical difference (23.9 ± 21.3 ppb, p < 0.01). These findings are worthwhile in the study of breath biomarkers for diabetes mellitus diagnosis. Additionally, the developed biosniffers provide a new technique for volatolomics research. |
| Author | Suzuki, Takuma Iwasaki, Yasuhiko Ogawa, Yoshihiro Tsujii, Masato Toda, Kanako Mitsubayashi, Kohji Ye, Ming Araki, Kouji Chien, Po-Jen Otsuka, Hiromi Shinada, Kayoko Minami, Isao Toma, Koji Arakawa, Takahiro |
| AuthorAffiliation | Department of Biomedical Devices and Instrumentation, Institute of Biomaterials and Bioengineering Preventive Oral Health Care Science, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Department of Medical and Bioregulatory Science, Graduate School of Medical Sciences Faculty of Chemistry, Materials and Bioengineering Department of Molecular and Cellular Metabolism, Graduate School of Medical and Dental Sciences Graduate School of Medical and Dental Sciences Educational System in Dentistry, Graduate School of Medical and Dental Sciences Kansai University Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences Kyushu University |
| AuthorAffiliation_xml | – name: Tokyo Medical and Dental University – name: Department of Biomedical Devices and Instrumentation, Institute of Biomaterials and Bioengineering – name: Kyushu University – name: Faculty of Chemistry, Materials and Bioengineering – name: Department of Molecular and Cellular Metabolism, Graduate School of Medical and Dental Sciences – name: Preventive Oral Health Care Science, Graduate School of Medical and Dental Sciences – name: Graduate School of Medical and Dental Sciences – name: Educational System in Dentistry, Graduate School of Medical and Dental Sciences – name: Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences – name: Kansai University – name: Department of Medical and Bioregulatory Science, Graduate School of Medical Sciences |
| Author_xml | – sequence: 1 givenname: Po-Jen surname: Chien fullname: Chien, Po-Jen organization: Tokyo Medical and Dental University – sequence: 2 givenname: Takuma surname: Suzuki fullname: Suzuki, Takuma organization: Tokyo Medical and Dental University – sequence: 3 givenname: Masato surname: Tsujii fullname: Tsujii, Masato organization: Tokyo Medical and Dental University – sequence: 4 givenname: Ming surname: Ye fullname: Ye, Ming organization: Tokyo Medical and Dental University – sequence: 5 givenname: Isao surname: Minami fullname: Minami, Isao organization: Tokyo Medical and Dental University – sequence: 6 givenname: Kanako surname: Toda fullname: Toda, Kanako organization: Tokyo Medical and Dental University – sequence: 7 givenname: Hiromi surname: Otsuka fullname: Otsuka, Hiromi organization: Tokyo Medical and Dental University – sequence: 8 givenname: Koji surname: Toma fullname: Toma, Koji organization: Tokyo Medical and Dental University – sequence: 9 givenname: Takahiro surname: Arakawa fullname: Arakawa, Takahiro organization: Tokyo Medical and Dental University – sequence: 10 givenname: Kouji surname: Araki fullname: Araki, Kouji organization: Tokyo Medical and Dental University – sequence: 11 givenname: Yasuhiko surname: Iwasaki fullname: Iwasaki, Yasuhiko organization: Kansai University – sequence: 12 givenname: Kayoko surname: Shinada fullname: Shinada, Kayoko organization: Tokyo Medical and Dental University – sequence: 13 givenname: Yoshihiro surname: Ogawa fullname: Ogawa, Yoshihiro organization: Tokyo Medical and Dental University – sequence: 14 givenname: Kohji orcidid: 0000-0002-1555-1281 surname: Mitsubayashi fullname: Mitsubayashi, Kohji email: m.bdi@tmd.ac.jp organization: Tokyo Medical and Dental University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29120608$$D View this record in MEDLINE/PubMed |
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| Snippet | This study describes two biosniffers to determine breath acetone and isopropanol (IPA) levels and applies them for breath measurement in healthy subjects and... |
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| SubjectTerms | 2-Propanol - chemistry 2-Propanol - metabolism Acetone Acetone - chemistry Acetone - metabolism Adenine Adult Aged Alcohol dehydrogenase Alcohol Dehydrogenase - metabolism Alcohols Biochemistry Biomarkers Biomarkers - analysis Breath Tests Chemistry Dehydrogenase Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - diagnosis Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - metabolism Female Fluorescence Gas sensors Gases Gases - chemistry Healthy Volunteers Humans Isopropanol isopropyl alcohol Male methodology Middle Aged NAD NAD (coenzyme) NADH Nicotinamide Nicotinamide adenine dinucleotide noninsulin-dependent diabetes mellitus Patients Selectivity Sensitivity analysis Sensors Statistics Volatile Organic Compounds - analysis |
| Title | Biochemical Gas Sensors (Biosniffers) Using Forward and Reverse Reactions of Secondary Alcohol Dehydrogenase for Breath Isopropanol and Acetone as Potential Volatile Biomarkers of Diabetes Mellitus |
| URI | http://dx.doi.org/10.1021/acs.analchem.7b03191 https://www.ncbi.nlm.nih.gov/pubmed/29120608 https://www.proquest.com/docview/1982174201 https://www.proquest.com/docview/1963278189 https://www.proquest.com/docview/2020908445 |
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