Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis
Ferroptosis is a form of nonapoptotic cell death characterized by the unchecked accumulation of lipid peroxides. Ferrostatin-1 and its analogs (ferrostatins) specifically prevent ferroptosis in multiple contexts, but many aspects of their molecular mechanism of action remain poorly described. Here,...
Saved in:
| Published in | ACS chemical biology Vol. 13; no. 4; pp. 1013 - 1020 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Chemical Society
20.04.2018
|
| Online Access | Get full text |
| ISSN | 1554-8929 1554-8937 1554-8937 |
| DOI | 10.1021/acschembio.8b00199 |
Cover
| Abstract | Ferroptosis is a form of nonapoptotic cell death characterized by the unchecked accumulation of lipid peroxides. Ferrostatin-1 and its analogs (ferrostatins) specifically prevent ferroptosis in multiple contexts, but many aspects of their molecular mechanism of action remain poorly described. Here, we employed stimulated Raman scattering (SRS) microscopy coupled with small vibrational tags to image the distribution of ferrostatins in cells and found that they accumulate in lysosomes, mitochondria, and the endoplasmic reticulum. We then evaluated the functional relevance of lysosomes and mitochondria to ferroptosis suppression by ferrostatins and found that neither is required for effective ferroptosis suppression. |
|---|---|
| AbstractList | Ferroptosis is a form of nonapoptotic cell death characterized by the unchecked accumulation of lipid peroxides. Ferrostatin-1 and its analogs (ferrostatins) specifically prevent ferroptosis in multiple contexts, but many aspects of their molecular mechanism of action remain poorly described. Here, we employed stimulated Raman scattering (SRS) microscopy coupled with small vibrational tags to image the distribution of ferrostatins in cells and found that they accumulate in lysosomes, mitochondria, and the endoplasmic reticulum. We then evaluated the functional relevance of lysosomes and mitochondria to ferroptosis suppression by ferrostatins and found that neither is required for effective ferroptosis suppression.Ferroptosis is a form of nonapoptotic cell death characterized by the unchecked accumulation of lipid peroxides. Ferrostatin-1 and its analogs (ferrostatins) specifically prevent ferroptosis in multiple contexts, but many aspects of their molecular mechanism of action remain poorly described. Here, we employed stimulated Raman scattering (SRS) microscopy coupled with small vibrational tags to image the distribution of ferrostatins in cells and found that they accumulate in lysosomes, mitochondria, and the endoplasmic reticulum. We then evaluated the functional relevance of lysosomes and mitochondria to ferroptosis suppression by ferrostatins and found that neither is required for effective ferroptosis suppression. Ferroptosis is a form of nonapoptotic cell death characterized by the unchecked accumulation of lipid peroxides. Ferrostatin-1 and its analogs (ferrostatins) specifically prevent ferroptosis in multiple contexts, but many aspects of their molecular mechanism of action remain poorly described. Here, we employed stimulated Raman scattering (SRS) microscopy coupled with small vibrational tags to image the distribution of ferrostatins in cells and found that they accumulate in lysosomes, mitochondria, and the endoplasmic reticulum. We then evaluated the functional relevance of lysosomes and mitochondria to ferroptosis suppression by ferrostatins and found that neither is required for effective ferroptosis suppression. Ferroptosis is a form of non-apoptotic cell death characterized by the unchecked accumulation of lipid peroxides. Ferrostatin-1 and its analogs (ferrostatins) specifically prevent ferroptosis in multiple contexts, but many aspects of their molecular mechanism of action remain poorly described. Here, we employed stimulated Raman scattering (SRS) microscopy coupled with small vibrational tags to image the distribution of ferrostatins in cells, and found that they accumulate in lysosomes, mitochondria, and endoplasmic reticulum. We then evaluated the functional relevance of lysosomes and mitochondria to ferroptosis suppression by ferrostatins, and found that neither is required for effective ferroptosis suppression. |
| Author | Gaschler, Michael M Stockwell, Brent R Min, Wei Hu, Fanghao Feng, Huizhong Linkermann, Andreas |
| AuthorAffiliation | Department of Chemistry Medical Clinic III, Division of Nephrology Columbia University Department of Biological Sciences |
| AuthorAffiliation_xml | – name: Department of Chemistry – name: Medical Clinic III, Division of Nephrology – name: Columbia University – name: Department of Biological Sciences – name: a Department of Chemistry, Columbia University, New York, NY 10027 – name: c Medical Clinic III, Division of Nephrology, Carl Gustav Carus University Hospital at the Technical University Dresden, Dresden 01309, Germany – name: b Department of Biological Sciences, Columbia University, New York, NY 10027 |
| Author_xml | – sequence: 1 givenname: Michael M surname: Gaschler fullname: Gaschler, Michael M organization: Columbia University – sequence: 2 givenname: Fanghao orcidid: 0000-0002-8659-4027 surname: Hu fullname: Hu, Fanghao organization: Columbia University – sequence: 3 givenname: Huizhong surname: Feng fullname: Feng, Huizhong organization: Columbia University – sequence: 4 givenname: Andreas surname: Linkermann fullname: Linkermann, Andreas organization: Medical Clinic III, Division of Nephrology – sequence: 5 givenname: Wei orcidid: 0000-0003-2570-3557 surname: Min fullname: Min, Wei email: wm2256@columbia.edu organization: Columbia University – sequence: 6 givenname: Brent R orcidid: 0000-0002-3532-3868 surname: Stockwell fullname: Stockwell, Brent R email: bstockwell@columbia.edu organization: Columbia University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29512999$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kU1v1DAYhC1URD_gD3BAOXLZrV8nduwLUlUoIC3iAJwtx_um6yqxg-0gwa_HS7ZL4dCTLc08Y2vmnJz44JGQl0DXQBlcGpvsDsfOhbXsKAWlnpAz4LxZSVW3J8c7U6fkPKU7SptaSPWMnDLFgSmlzsj0FjPG0XmTXfBV6Ku8w-rL3FkchnkwsdoEawb3a9GN31af0O6Md2ncu6_sPXeDMYaUi8-nyvmSMU0RU3L-dtGmHJJLz8nT3gwJXxzOC_Lt5t3X6w-rzef3H6-vNivDaZtX3DDTcmxb0daq7jmVoukk9KAYq1uJagtb4E3dCotCQgeNpAiWKcmNFEzUF-TNkjvN3Yhbiz5HM-gputHEnzoYp_9VvNvp2_BDcyWopKwEvD4ExPB9xpT16NK-FeMxzEkzCiCAlqqL9dXDt46P3NdcDGwx2FJRitgfLUD1fkv9d0t92LJA8j_IuvxnhvJfNzyOrhe0aPouzNGXqh8DfgPrGrlf |
| CitedBy_id | crossref_primary_10_1016_j_mcn_2019_103413 crossref_primary_10_1038_s41419_022_05430_3 crossref_primary_10_1016_j_molstruc_2020_129485 crossref_primary_10_1002_smo_20240048 crossref_primary_10_1038_s41418_020_00728_1 crossref_primary_10_1002_advs_202003136 crossref_primary_10_3389_fphar_2020_00239 crossref_primary_10_1016_j_ccell_2019_04_002 crossref_primary_10_1002_1878_0261_13649 crossref_primary_10_1016_j_isci_2024_109774 crossref_primary_10_62347_SIGP9279 crossref_primary_10_1002_jnr_25033 crossref_primary_10_1038_s41422_020_00441_1 crossref_primary_10_1038_s41580_024_00703_5 crossref_primary_10_1021_acs_inorgchem_4c02534 crossref_primary_10_3389_fmolb_2023_1203269 crossref_primary_10_1038_s41416_023_02149_6 crossref_primary_10_14336_AD_2023_0717 crossref_primary_10_2147_JMDH_S382643 crossref_primary_10_1021_acscentsci_3c01438 crossref_primary_10_3390_biom14101270 crossref_primary_10_1007_s12672_024_01573_1 crossref_primary_10_3390_ijms23031124 crossref_primary_10_1016_j_cophys_2022_100483 crossref_primary_10_1016_j_freeradbiomed_2023_06_023 crossref_primary_10_1186_s40001_023_01215_2 crossref_primary_10_1002_agm2_12074 crossref_primary_10_1016_j_msard_2025_106378 crossref_primary_10_1155_2022_8402568 crossref_primary_10_2139_ssrn_4102638 crossref_primary_10_1007_s11684_023_0992_z crossref_primary_10_3389_fendo_2020_628079 crossref_primary_10_1038_s41592_019_0538_0 crossref_primary_10_1002_jcp_30928 crossref_primary_10_1186_s13041_019_0501_0 crossref_primary_10_1016_j_chembiol_2019_11_003 crossref_primary_10_1039_D1OB01479J crossref_primary_10_3390_cells12040611 crossref_primary_10_1007_s00204_020_02722_5 crossref_primary_10_1021_acs_analchem_9b02095 crossref_primary_10_1080_01480545_2023_2295230 crossref_primary_10_1016_j_phrs_2024_107114 crossref_primary_10_1155_2021_5537330 crossref_primary_10_1155_2024_9943747 crossref_primary_10_1097_MD_0000000000039567 crossref_primary_10_1021_acs_biomac_3c01106 crossref_primary_10_3389_fnins_2018_00466 crossref_primary_10_3389_fphar_2022_905501 crossref_primary_10_1002_pmic_201800311 crossref_primary_10_1021_jacs_2c05359 crossref_primary_10_1002_smll_202406809 crossref_primary_10_1080_19490976_2023_2263210 crossref_primary_10_1002_ejoc_202200393 crossref_primary_10_1016_j_freeradbiomed_2019_01_008 crossref_primary_10_1038_s41467_024_49159_3 crossref_primary_10_3389_fphar_2024_1390798 crossref_primary_10_1016_j_jconrel_2022_08_004 crossref_primary_10_3390_md23040138 crossref_primary_10_3390_ijms23169395 crossref_primary_10_1021_acs_jmedchem_9b01546 crossref_primary_10_1186_s13062_024_00530_w crossref_primary_10_1158_0008_5472_CAN_21_3914 crossref_primary_10_1186_s12964_023_01422_8 crossref_primary_10_3389_fonc_2022_858480 crossref_primary_10_34133_research_0159 crossref_primary_10_1007_s11010_024_05009_w crossref_primary_10_1016_j_freeradbiomed_2021_08_015 crossref_primary_10_1016_j_heliyon_2023_e19801 crossref_primary_10_3892_ijo_2024_5714 crossref_primary_10_3390_antiox11081504 crossref_primary_10_1016_j_molcel_2018_10_042 crossref_primary_10_3389_fcell_2021_698679 crossref_primary_10_1111_ajt_16108 crossref_primary_10_1152_ajpregu_00117_2023 crossref_primary_10_1038_s41580_019_0173_8 crossref_primary_10_1016_j_ejmech_2024_117152 crossref_primary_10_3390_antiox13030298 crossref_primary_10_1021_acschembio_2c00200 crossref_primary_10_1016_j_freeradbiomed_2018_09_043 crossref_primary_10_1016_j_mito_2024_101974 crossref_primary_10_1186_s12943_024_02088_7 crossref_primary_10_1002_chem_202404323 crossref_primary_10_1038_s41598_023_42760_4 crossref_primary_10_1016_j_brainresbull_2019_08_013 crossref_primary_10_3390_ijms21144908 crossref_primary_10_3389_fcell_2022_832356 crossref_primary_10_1038_s41392_024_01769_5 crossref_primary_10_1002_admt_202100660 crossref_primary_10_1089_ars_2022_0106 crossref_primary_10_1152_ajpheart_00237_2020 crossref_primary_10_1016_j_freeradbiomed_2023_07_025 crossref_primary_10_1038_s41569_022_00735_4 crossref_primary_10_1002_adma_202309711 crossref_primary_10_1016_j_cmet_2020_10_011 crossref_primary_10_1016_j_tranon_2024_102251 crossref_primary_10_1159_000496922 crossref_primary_10_1111_jnc_15807 crossref_primary_10_1016_j_lfs_2023_122113 crossref_primary_10_3389_fimmu_2025_1531577 crossref_primary_10_1016_j_intimp_2024_113188 crossref_primary_10_1016_j_isci_2020_100953 crossref_primary_10_3390_nu13082751 crossref_primary_10_1016_j_ejcb_2019_151058 crossref_primary_10_1016_j_lfs_2021_119958 crossref_primary_10_1038_s41419_019_2061_8 crossref_primary_10_1016_j_jbc_2022_101617 crossref_primary_10_1038_s41556_024_01373_3 crossref_primary_10_1080_15384101_2020_1838781 crossref_primary_10_1016_j_cell_2024_01_030 crossref_primary_10_1117_1_JBO_25_1_014507 crossref_primary_10_1038_s41589_019_0408_1 crossref_primary_10_1016_j_freeradbiomed_2020_02_027 crossref_primary_10_1083_jcb_202105043 crossref_primary_10_1021_acs_est_4c08685 crossref_primary_10_1016_j_cell_2022_06_003 crossref_primary_10_1039_D1CB00116G crossref_primary_10_1021_acschemneuro_2c00308 crossref_primary_10_1016_j_ccell_2021_12_001 crossref_primary_10_1016_j_cmet_2020_12_007 crossref_primary_10_2147_IJN_S435087 crossref_primary_10_1002_anie_202502195 crossref_primary_10_1038_s41419_022_04770_4 crossref_primary_10_1016_j_cstres_2023_12_003 crossref_primary_10_1016_j_freeradbiomed_2020_09_027 crossref_primary_10_1039_D3CB00217A crossref_primary_10_1186_s13008_024_00127_9 crossref_primary_10_1038_s41589_022_01250_w crossref_primary_10_3390_cancers12051119 crossref_primary_10_3390_ijms22010066 crossref_primary_10_1016_j_tcb_2023_05_003 crossref_primary_10_1155_2023_3400147 crossref_primary_10_1016_j_freeradbiomed_2021_04_024 crossref_primary_10_1002_ange_202016802 crossref_primary_10_1016_j_saa_2023_123545 crossref_primary_10_1038_s41418_021_00859_z crossref_primary_10_1039_C9CC03051D crossref_primary_10_1038_s41586_023_06983_9 crossref_primary_10_1021_acscentsci_3c00052 crossref_primary_10_1021_acs_analchem_4c01413 crossref_primary_10_1146_annurev_biophys_052118_115500 crossref_primary_10_1016_j_devcel_2024_09_004 crossref_primary_10_1080_15548627_2020_1810918 crossref_primary_10_3389_fnut_2022_844757 crossref_primary_10_1038_s41420_023_01606_8 crossref_primary_10_1002_chem_202401285 crossref_primary_10_7554_eLife_37503 crossref_primary_10_1016_j_lfs_2024_123045 crossref_primary_10_1039_D0CC05939K crossref_primary_10_1038_s41422_019_0150_y crossref_primary_10_1007_s10571_021_01092_5 crossref_primary_10_1016_j_immuni_2024_03_019 crossref_primary_10_1073_pnas_1821022116 crossref_primary_10_3389_fimmu_2025_1534926 crossref_primary_10_1016_j_bbamcr_2020_118928 crossref_primary_10_1016_j_devcel_2021_03_033 crossref_primary_10_1016_j_chemosphere_2020_128413 crossref_primary_10_1002_anie_202016802 crossref_primary_10_1146_annurev_nutr_062320_114541 crossref_primary_10_3389_fcell_2021_774957 crossref_primary_10_1155_2022_2353115 crossref_primary_10_3389_fmolb_2022_938677 crossref_primary_10_1002_ctm2_752 crossref_primary_10_3390_life11030222 crossref_primary_10_1038_s41467_021_25377_x crossref_primary_10_1039_C8MT00212F crossref_primary_10_1093_lifemeta_loac035 crossref_primary_10_1055_a_2190_2803 crossref_primary_10_1038_s41598_025_90803_9 crossref_primary_10_1016_j_microc_2024_110570 crossref_primary_10_1016_j_bbcan_2024_189258 crossref_primary_10_1093_cvr_cvae270 crossref_primary_10_3389_fphar_2025_1570069 crossref_primary_10_1039_D2BM02087D crossref_primary_10_1038_s41419_024_06691_w crossref_primary_10_1210_endocr_bqac094 crossref_primary_10_3390_ijms25147544 crossref_primary_10_1002_path_5248 crossref_primary_10_1016_j_aca_2023_341571 crossref_primary_10_1038_s41419_021_04490_1 crossref_primary_10_1021_acs_inorgchem_9b01029 crossref_primary_10_1002_anie_202204788 crossref_primary_10_1186_s12943_020_01157_x crossref_primary_10_3389_fimmu_2023_1294317 crossref_primary_10_1158_2159_8290_CD_22_0976 crossref_primary_10_3389_fcell_2023_1179245 crossref_primary_10_1002_adbi_202000184 crossref_primary_10_1021_acs_analchem_1c03075 crossref_primary_10_1016_j_apsb_2020_07_003 crossref_primary_10_1016_j_brainresbull_2021_04_023 crossref_primary_10_3390_cells11203301 crossref_primary_10_1002_jbio_202000129 crossref_primary_10_1142_S1793545822300105 crossref_primary_10_1007_s10565_024_09853_w crossref_primary_10_1016_j_neuropharm_2024_110210 crossref_primary_10_1007_s10495_022_01785_2 crossref_primary_10_1016_j_chembiol_2024_06_004 crossref_primary_10_1007_s11010_022_04644_5 crossref_primary_10_1073_pnas_1912700116 crossref_primary_10_1155_2022_3568597 crossref_primary_10_1038_s41419_020_2334_2 crossref_primary_10_1007_s43032_025_01827_5 crossref_primary_10_1007_s12551_023_01126_w crossref_primary_10_3390_cells10092462 crossref_primary_10_3389_fcell_2022_982606 crossref_primary_10_3389_fphar_2021_630167 crossref_primary_10_1002_ange_202502195 crossref_primary_10_1016_j_freeradbiomed_2021_12_007 crossref_primary_10_1016_j_cub_2023_02_060 crossref_primary_10_3389_fcell_2021_675617 crossref_primary_10_3390_cancers12010164 crossref_primary_10_1007_s13577_023_00896_5 crossref_primary_10_1038_s41589_022_01249_3 crossref_primary_10_1016_j_xcrp_2023_101683 crossref_primary_10_1016_j_phrs_2024_107383 crossref_primary_10_1002_chem_202300953 crossref_primary_10_1016_j_chembiol_2020_03_014 crossref_primary_10_1016_j_ccr_2022_214875 crossref_primary_10_3390_ijms25010075 crossref_primary_10_1016_j_biopha_2024_117555 crossref_primary_10_1016_j_foodres_2025_115900 crossref_primary_10_1039_D1CS01167G crossref_primary_10_3390_cells11091399 crossref_primary_10_3390_cells11172726 crossref_primary_10_1016_j_pneurobio_2019_101716 crossref_primary_10_1039_D2CB00160H crossref_primary_10_1016_j_freeradbiomed_2021_02_045 crossref_primary_10_1007_s10238_023_01047_8 crossref_primary_10_3389_fphys_2019_00139 crossref_primary_10_3389_fcvm_2021_710963 crossref_primary_10_1016_j_biopha_2022_113280 crossref_primary_10_3389_fcell_2021_634690 crossref_primary_10_1016_j_foodchem_2022_132051 crossref_primary_10_1016_j_molcel_2023_03_005 crossref_primary_10_1038_s41420_023_01597_6 crossref_primary_10_1016_j_chembiol_2020_03_005 crossref_primary_10_1021_acs_analchem_2c05708 crossref_primary_10_1002_ange_202204788 crossref_primary_10_1007_s12272_020_01273_8 crossref_primary_10_3390_nano9030341 crossref_primary_10_1016_j_chembiol_2018_11_016 crossref_primary_10_3390_antiox12081590 crossref_primary_10_1002_med_21933 crossref_primary_10_1089_ars_2023_0278 |
| Cites_doi | 10.1021/ja308529n 10.1021/acs.jmedchem.5b01641 10.7554/eLife.02523 10.1016/j.molcel.2015.06.011 10.1021/acs.accounts.6b00210 10.1038/ncb3064 10.1016/j.cell.2012.03.042 10.1021/ja411006a 10.1172/jci.insight.90777 10.1038/nchembio.2239 10.1038/srep07930 10.1042/BJ20150658 10.1073/pnas.1415518111 10.1681/ASN.2015121376 10.1038/nchem.1961 10.1083/jcb.200809125 10.1038/nmeth.2878 10.1021/acs.analchem.6b00422 10.1016/j.cell.2013.12.010 10.1021/acscentsci.7b00028 10.1021/acscentsci.6b00199 10.1016/0006-2952(74)90174-9 10.1007/s00018-016-2194-1 10.1007/s10930-015-9629-7 10.1016/j.celrep.2013.10.034 |
| ContentType | Journal Article |
| DBID | AAYXX CITATION NPM 7X8 5PM |
| DOI | 10.1021/acschembio.8b00199 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry |
| EISSN | 1554-8937 |
| EndPage | 1020 |
| ExternalDocumentID | PMC5960802 29512999 10_1021_acschembio_8b00199 b245813606 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIBIB NIH HHS grantid: R01 EB020892 – fundername: NIGMS NIH HHS grantid: T32 GM008281 – fundername: NCI NIH HHS grantid: P01 CA087497 – fundername: NCI NIH HHS grantid: R35 CA209896 |
| GroupedDBID | - 23M 53G 55A 5GY 5VS 7~N AABXI ABMVS ABUCX ACGFS ACS AEESW AENEX AFEFF ALMA_UNASSIGNED_HOLDINGS AQSVZ CS3 D0L EBS ED ED~ EJD F5P GNL GX1 IH9 IHE JG JG~ P2P RNS ROL UI2 VF5 VG9 W1F --- 4.4 5ZA 6J9 AAYXX ABBLG ABJNI ABLBI ABQRX ACGFO ADHLV AHGAQ BAANH CITATION CUPRZ GGK NPM 7X8 5PM |
| ID | FETCH-LOGICAL-a507t-5a2a75e7767393f50864b81f1922378e9d1d154376ce681b1480e1c2985a86263 |
| IEDL.DBID | ACS |
| ISSN | 1554-8929 1554-8937 |
| IngestDate | Thu Aug 21 17:13:43 EDT 2025 Fri Jul 11 05:50:34 EDT 2025 Wed Feb 19 02:35:45 EST 2025 Tue Jul 01 03:43:58 EDT 2025 Thu Apr 24 22:51:16 EDT 2025 Fri Feb 05 20:53:46 EST 2021 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-a507t-5a2a75e7767393f50864b81f1922378e9d1d154376ce681b1480e1c2985a86263 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0002-3532-3868 0000-0002-8659-4027 0000-0003-2570-3557 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/5960802 |
| PMID | 29512999 |
| PQID | 2011610893 |
| PQPubID | 23479 |
| PageCount | 8 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_5960802 proquest_miscellaneous_2011610893 pubmed_primary_29512999 crossref_primary_10_1021_acschembio_8b00199 crossref_citationtrail_10_1021_acschembio_8b00199 acs_journals_10_1021_acschembio_8b00199 |
| ProviderPackageCode | JG~ 55A AABXI GNL VF5 7~N VG9 W1F ACS AEESW AFEFF ABMVS ABUCX IH9 AQSVZ ED~ UI2 CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2018-04-20 |
| PublicationDateYYYYMMDD | 2018-04-20 |
| PublicationDate_xml | – month: 04 year: 2018 text: 2018-04-20 day: 20 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | ACS chemical biology |
| PublicationTitleAlternate | ACS Chem. Biol |
| PublicationYear | 2018 |
| Publisher | American Chemical Society |
| Publisher_xml | – name: American Chemical Society |
| References | ref9/cit9 ref6/cit6 ref3/cit3 ref18/cit18 ref11/cit11 ref16/cit16 ref23/cit23 ref14/cit14 ref8/cit8 ref5/cit5 ref2/cit2 ref20/cit20 ref17/cit17 ref10/cit10 ref26/cit26 ref19/cit19 ref21/cit21 ref12/cit12 ref15/cit15 ref22/cit22 ref13/cit13 ref4/cit4 ref1/cit1 ref24/cit24 Alberts B. (ref25/cit25) 2002 ref7/cit7 |
| References_xml | – ident: ref11/cit11 doi: 10.1021/ja308529n – ident: ref7/cit7 doi: 10.1021/acs.jmedchem.5b01641 – volume-title: Molecular Biology of the Cell year: 2002 ident: ref25/cit25 – ident: ref13/cit13 doi: 10.7554/eLife.02523 – ident: ref15/cit15 doi: 10.1016/j.molcel.2015.06.011 – ident: ref9/cit9 doi: 10.1021/acs.accounts.6b00210 – ident: ref20/cit20 doi: 10.1038/ncb3064 – ident: ref1/cit1 doi: 10.1016/j.cell.2012.03.042 – ident: ref2/cit2 doi: 10.1021/ja411006a – ident: ref6/cit6 doi: 10.1172/jci.insight.90777 – ident: ref21/cit21 doi: 10.1038/nchembio.2239 – ident: ref12/cit12 doi: 10.1038/srep07930 – ident: ref14/cit14 doi: 10.1042/BJ20150658 – ident: ref4/cit4 doi: 10.1073/pnas.1415518111 – ident: ref5/cit5 doi: 10.1681/ASN.2015121376 – ident: ref18/cit18 doi: 10.1038/nchem.1961 – ident: ref24/cit24 doi: 10.1083/jcb.200809125 – ident: ref10/cit10 doi: 10.1038/nmeth.2878 – ident: ref19/cit19 doi: 10.1021/acs.analchem.6b00422 – ident: ref26/cit26 doi: 10.1016/j.cell.2013.12.010 – ident: ref8/cit8 doi: 10.1021/acscentsci.7b00028 – ident: ref22/cit22 doi: 10.1021/acscentsci.6b00199 – ident: ref17/cit17 doi: 10.1016/0006-2952(74)90174-9 – ident: ref16/cit16 doi: 10.1007/s00018-016-2194-1 – ident: ref3/cit3 doi: 10.1007/s10930-015-9629-7 – ident: ref23/cit23 doi: 10.1016/j.celrep.2013.10.034 |
| SSID | ssj0043689 |
| Score | 2.6176944 |
| Snippet | Ferroptosis is a form of nonapoptotic cell death characterized by the unchecked accumulation of lipid peroxides. Ferrostatin-1 and its analogs (ferrostatins)... Ferroptosis is a form of non-apoptotic cell death characterized by the unchecked accumulation of lipid peroxides. Ferrostatin-1 and its analogs (ferrostatins)... |
| SourceID | pubmedcentral proquest pubmed crossref acs |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1013 |
| Title | Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis |
| URI | http://dx.doi.org/10.1021/acschembio.8b00199 https://www.ncbi.nlm.nih.gov/pubmed/29512999 https://www.proquest.com/docview/2011610893 https://pubmed.ncbi.nlm.nih.gov/PMC5960802 |
| Volume | 13 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVABC databaseName: American Chemical Society Journals customDbUrl: eissn: 1554-8937 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0043689 issn: 1554-8929 databaseCode: ACS dateStart: 20150220 isFulltext: true titleUrlDefault: https://pubs.acs.org/action/showPublications?display=journals providerName: American Chemical Society – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 1554-8937 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0043689 issn: 1554-8929 databaseCode: GX1 dateStart: 0 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwEB6VcoBLedOlgIyExAGyrJ1kbR9XW5YKsVyg0t4i23EggjqrJnvh1zOTx7ZLoeolF3ucZDz2fGPPA-C1tlZKR9fqcZpEiS1kZLiyUZpIl7tp7PKcYoeXX6Ynp8mnVbrag3f_ucEX_L1xaOb5M1tWY0UqXutbcFtMFSdTazb_Ouy7lEpdt9lR8aUKtX4fIvPvMUgZuXpXGV1BmH87Sl7SPIt7sBzidzqHk5_jTWPH7vfVdI43-qn7cNBDUDbrZOYB7PnwEO7Mh8pvj2B9PPjI0KyxqmCIEhluMXTKT26r7DNpwD6Ck5mQs6WnCOKyPqPeMzfQLfw5RZVgv1CzMjCqIdo63obvXdu6qeqyfgyniw_f5idRX5khMogfmyg1wsjUUyagWMcFgrxpYhUvEC6KWCqvc54jNsPNy3mcKYs218RzJ7RKDZlQ8RPYD1Xwh8BsbuhMJdauSJPEcu2tQ60prRAuKbgcwRtkVtavrDprL80Fzy44mPUcHAEfJjNzfYJzqrPx61qat1uadZfe49rerwYZyXBKiOkm-GpTZwSjEIgi-BvB005mtuMJTaCKqOWONG07UIbv3ZZQ_mgzfadoX6qJeHZjHhzBXfwURdddYvIc9pvzjX-BqKmxL9vFgs-PK_4HMbAXig |
| linkProvider | American Chemical Society |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3Pb9MwFH6CcRgXYAxG2diMhMQBpdROUsfHqVB1o92FTtotih2HRTCnmtMLfz3vpUlHxzSxa-zn2M8_3mf7vc8AH5TWUhq6Vg_jKIh0IYOMJzqII2lyMwxNnlPs8OxsODmPTi_iizaOm2JhsBIeS_LNJf4NuwD_jN-wFVe6rPoJWXqlHsOThgqF8NDoe7f8EqO6akhS8d8JGv82UubuMsgmGb9pk_4Bmrf9Jf8yQOPnMF9XvfE7-dlf1rpvft9idXxg217AsxaQsuPVCNqBR9a9hO1R9w7cLiy-dB4z1IesKhhiRoYLDp35kxMrm5I9bOM5WeZyNrMUT1z6K8p9bDq5sb2mGBPM5zwrHaMXRRs3XPdjlbaoK1_6V3A-_jofTYL2nYYgQzRZB3EmMhlb4gUKVVgg5BtGOuEFgkcRysSqnOeI1HApM3aIMBl3YAPLjVBJnNGGKnwNW65y9g0wnWd0whIqU8RRpLmy2qANlVoIExVc9uAjKitt55lPmyt0wdMbDaatBnvAuz5NTUt3Tq9u_LpX5tNaZrEi-7g39_tuqKTYJaT0zNlq6VMCVQhLEQr2YG81dNblCUUQi6TlxqBaZyC-780UV142vN8x7jaTgXj73zo4gu3JfDZNpydn3_bhKVYroYswMTiArfp6ad8hnqr1YTN__gD9mh8E |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB5BkYALb8ryNBISB5Rl7cTr-FhtWRVoKySotLcodhyISp1Vnb3w65nJOgtbUIW4xh7HHj_msz3zGeCVNkYpS9fqqcySzNQqKXluEpkpW9lpaquKYoePjqcHJ9mHhVzEowuKhcFKBCwp9Jf4NKuXVR0ZBvhb_I4tOTNNO87J2mt9Fa5J4oAjTDT7PCzBxKque6JU_H-OACBGy_y9DLJLNmzbpT_A5kWfyd-M0Pw2LDbV731PTserzoztjwvMjv_RvjtwKwJTtrceSXfhivP34MZseA_uPiz3B88Z6kvW1gyxI8OFh87-yZmVHZJdjHGdrPQVO3IUV9yEM8q9Zwe5uTunWBPM5wNrPKOXRXt3XP91nbbs2tCEB3Ayf_dldpDE9xqSElFll8hSlEo64gdKdVoj9JtmJuc1gkiRqtzpileI2HBJs26KcBl3YhPHrdC5LGljlT6EHd969wiYqUo6aUm1rWWWGa6dsWhLlRHCZjVXI3iNyirifAtFf5UuePFLg0XU4Aj40K-FjbTn9PrG90tl3mxklmvSj0tzvxyGS4FdQkovvWtXoSBwhfAUIeEIdtfDZ1Oe0AS1SFptDaxNBuL93k7xzbee_1virjOfiMf_rIMXcP3T_rw4fH_88QncxFrldB8mJk9hpztfuWcIqzrzvJ9CPwH26iF- |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Determination+of+the+Subcellular+Localization+and+Mechanism+of+Action+of+Ferrostatins+in+Suppressing+Ferroptosis&rft.jtitle=ACS+chemical+biology&rft.au=Gaschler%2C+Michael+M&rft.au=Hu%2C+Fanghao&rft.au=Feng%2C+Huizhong&rft.au=Linkermann%2C+Andreas&rft.date=2018-04-20&rft.issn=1554-8937&rft.eissn=1554-8937&rft.volume=13&rft.issue=4&rft.spage=1013&rft_id=info:doi/10.1021%2Facschembio.8b00199&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1554-8929&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1554-8929&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1554-8929&client=summon |