Pharmacokinetics of Aztreonam in Healthy Subjects and Patients with Cystic Fibrosis and Evaluation of Dose-Exposure Relationships Using Monte Carlo Simulation - Vinks, Alexander A.; van Rossem, Ronald N.; Mathôt, Ron A. A.; Heijerman, Harry G. M.; Mouton, Johan W. (Antimicrobial Agents and Chemotherapy, 2007)
Keywords: Adult; Algorithms; Anti-Bacterial Agents; Anti-Bacterial Agents - cerebrospinal fluid; Anti-Bacterial Agents - pharmacokinetics; Antibiotics. Antiinfectious agents. Antiparasitic agents; Aztreonam; Aztreonam - cerebrospinal fluid; Aztreonam - pharmacokinetics; Biological and medical sciences; Cystic Fibrosis; Cystic Fibrosis - metabolism; Dose-Response Relationship, Drug; Errors of metabolism; Female; Half-Life; Humans; Male; Medical sciences; Metabolic diseases; Miscellaneous hereditary metabolic disorders; Models, Statistical; Monte Carlo Method; Pharmacology; Pharmacology. Drug treatments; Pseudomonas aeruginosa; Human; Evaluation; Healthy subject; Respiratory disease; β-Lactams; Metabolic diseases; Cystic fibrosis; Exposure; Monobactam derivatives; Genetic disease; Antibiotic; Simulation; Azetidine derivatives; Aztreonam; Digestive diseases; Antibacterial agent; Pharmacokinetics; Dose; Pancreatic disease