Molecular Design and Biomedical Application of AIEgens with Photochemical Activity

Photochemical reaction is expected to become a promising type of green chemistry with merits of operational flexibility, excellent regioselectivity, high yield, and mild reaction condition. Recently, aggregation-induced emission (AIE)-based fluorescent molecules with photoresponsivity have been quic...

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Bibliographic Details
Published inChemical & biomedical imaging Vol. 1; no. 9; pp. 785 - 795
Main Authors Li, Jianqing, Zhuang, Zeyan, Lou, Xiaoding, Zhao, Zujin, Tang, Ben Zhong
Format Journal Article
LanguageEnglish
Published United States Nanjing University and American Chemical Society 25.12.2023
American Chemical Society
Subjects
Review
diphenylethene
fluorescence imaging
aggregation-induced emission
photoisomerization
antitumor/antibacterial therapy
photoreactions
photodimerization
photocyclization
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ISSN2832-3637
2832-3637
DOI10.1021/cbmi.3c00038

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Summary:Photochemical reaction is expected to become a promising type of green chemistry with merits of operational flexibility, excellent regioselectivity, high yield, and mild reaction condition. Recently, aggregation-induced emission (AIE)-based fluorescent molecules with photoresponsivity have been quickly developed and employed in the biomedical field. In this Review, photoresponsive AIE materials based on the inherent photochemical reactions are highlighted according to the photochemical pathways: photoisomerization, photocyclization, photodimerization, and multiple photoreactions. Following this, their biomedical applications are summarized and discussed, including photoactivatable bioimaging, diagnosis, and therapy. Finally, the challenges and future perspectives are presented.
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ISSN:2832-3637
2832-3637
DOI:10.1021/cbmi.3c00038