Structure and IgE Cross-Reactivity among Cashew, Pistachio, Walnut, and Peanut Vicilin-Buried Peptides

Peanut and tree-nut allergies are frequently comorbid for reasons not completely understood. Vicilin-buried peptides (VBPs) are an emerging family of food allergens whose conserved structural fold could mediate peanut/tree-nut co-allergy. Peptide microarrays were used to identify immunoglobulin E (I...

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Published inJournal of agricultural and food chemistry Vol. 71; no. 6; pp. 2990 - 2998
Main Authors Foo, Alexander C. Y., Nesbit, Jacqueline B., Gipson, Stephen A. Y., DeRose, Eugene F., Cheng, Hsiaopo, Hurlburt, Barry K., Kulis, Michael D., Kim, Edwin H., Dreskin, Stephen C., Mustafa, Shahzad, Maleki, Soheila J., Mueller, Geoffrey A.
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 15.02.2023
Subjects
Allergens - chemistry
Allergens - immunology
Anacardium - chemistry
Arachis - chemistry
blood serum
comorbidity
cross reaction
Cross Reactions
epitopes
food chemistry
Food Safety and Toxicology
Humans
immunoglobulin E
Immunoglobulin E - immunology
Juglans - chemistry
Nut Hypersensitivity - diagnosis
Nuts - chemistry
patients
peanuts
peptide microarrays
peptides
Peptides - chemistry
Peptides - immunology
pistachios
Pistacia - chemistry
vicilin
walnuts
vicilin-buried peptide
allergen
peanut
tree-nut
Online AccessGet full text
ISSN0021-8561
1520-5118
1520-5118
DOI10.1021/acs.jafc.2c07061

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Abstract Peanut and tree-nut allergies are frequently comorbid for reasons not completely understood. Vicilin-buried peptides (VBPs) are an emerging family of food allergens whose conserved structural fold could mediate peanut/tree-nut co-allergy. Peptide microarrays were used to identify immunoglobulin E (IgE) epitopes from the N-terminus of the vicilin allergens Ara h 1, Ana o 1, Jug r 2, and Pis v 3 using serum from three patient diagnosis groups: monoallergic to either peanuts or cashew/pistachio, or dual allergic. IgE binding peptides were highly prevalent in the VBP domains AH1.1, AO1.1, JR2.1, and PV3.1, but not in AO1.2, JR2.2, JR2.3, and PV3.2 nor the unstructured regions. The IgE profiles did not correlate with diagnosis group. The structure of the VBPs from cashew and pistachio was solved using solution-NMR. Comparisons of structural features suggest that the VBP scaffold from peanuts and tree-nuts can support cross-reactivity. This may help understand comorbidity and cross-reactivity despite a distant evolutionary origin.
AbstractList Peanut and tree-nut allergies are frequently comorbid for reasons not completely understood. Vicilin-buried peptides (VBPs) are an emerging family of food allergens whose conserved structural fold could mediate peanut/tree-nut co-allergy. Peptide microarrays were used to identify immunoglobulin E (IgE) epitopes from the N-terminus of the vicilin allergens Ara h 1, Ana o 1, Jug r 2, and Pis v 3 using serum from three patient diagnosis groups: monoallergic to either peanuts or cashew/pistachio, or dual allergic. IgE binding peptides were highly prevalent in the VBP domains AH1.1, AO1.1, JR2.1, and PV3.1, but not in AO1.2, JR2.2, JR2.3, and PV3.2 nor the unstructured regions. The IgE profiles did not correlate with diagnosis group. The structure of the VBPs from cashew and pistachio was solved using solution-NMR. Comparisons of structural features suggest that the VBP scaffold from peanuts and tree-nuts can support cross-reactivity. This may help understand comorbidity and cross-reactivity despite a distant evolutionary origin.
Peanut and tree-nut allergies are frequently comorbid for reasons not completely understood. Vicilin-buried peptides (VBPs) are an emerging family of food allergens whose conserved structural fold could mediate peanut/tree-nut co-allergy. Peptide microarrays were used to identify immunoglobulin E (IgE) epitopes from the N-terminus of the vicilin allergens Ara h 1, Ana o 1, Jug r 2, and Pis v 3 using serum from three patient diagnosis groups: monoallergic to either peanuts or cashew/pistachio, or dual allergic. IgE binding peptides were highly prevalent in the VBP domains AH1.1, AO1.1, JR2.1, and PV3.1, but not in AO1.2, JR2.2, JR2.3, and PV3.2 nor the unstructured regions. The IgE profiles did not correlate with diagnosis group. The structure of the VBPs from cashew and pistachio was solved using solution-NMR. Comparisons of structural features suggest that the VBP scaffold from peanuts and tree-nuts can support cross-reactivity. This may help understand comorbidity and cross-reactivity despite a distant evolutionary origin.Peanut and tree-nut allergies are frequently comorbid for reasons not completely understood. Vicilin-buried peptides (VBPs) are an emerging family of food allergens whose conserved structural fold could mediate peanut/tree-nut co-allergy. Peptide microarrays were used to identify immunoglobulin E (IgE) epitopes from the N-terminus of the vicilin allergens Ara h 1, Ana o 1, Jug r 2, and Pis v 3 using serum from three patient diagnosis groups: monoallergic to either peanuts or cashew/pistachio, or dual allergic. IgE binding peptides were highly prevalent in the VBP domains AH1.1, AO1.1, JR2.1, and PV3.1, but not in AO1.2, JR2.2, JR2.3, and PV3.2 nor the unstructured regions. The IgE profiles did not correlate with diagnosis group. The structure of the VBPs from cashew and pistachio was solved using solution-NMR. Comparisons of structural features suggest that the VBP scaffold from peanuts and tree-nuts can support cross-reactivity. This may help understand comorbidity and cross-reactivity despite a distant evolutionary origin.
Author Nesbit, Jacqueline B.
Maleki, Soheila J.
Mustafa, Shahzad
Cheng, Hsiaopo
Kim, Edwin H.
Gipson, Stephen A. Y.
Dreskin, Stephen C.
Mueller, Geoffrey A.
Hurlburt, Barry K.
Foo, Alexander C. Y.
Kulis, Michael D.
DeRose, Eugene F.
AuthorAffiliation National Institute of Environmental Health Sciences
Department of Pediatrics
Genome Integrity and Structural Biology Laboratory
Agricultural Research Service
Rochester Regional Health
Division of Allergy and Clinical Immunology
United States Department of Agriculture
University of North Carolina School of Medicine
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Cites_doi 10.1038/nmeth.2019
10.1111/cea.14202
10.1007/s10858-015-9924-9
10.1093/bioinformatics/btr200
10.1002/prot.21165
10.1007/s40629-016-0115-3
10.1021/acs.jnatprod.0c00594
10.1016/j.jaci.2020.11.046
10.3389/falgy.2021.769728
10.1007/s10858-009-9333-z
10.1056/NEJMcp1611971
10.1021/acs.jafc.1c07225
10.1016/j.jaci.2020.11.004
10.1111/cea.13554
10.1067/mai.2002.125208
10.1016/j.waojou.2022.100641
10.1006/jmbi.2000.4474
10.1074/jbc.M114.559971
10.1016/j.foodchem.2021.131028
10.1093/nar/gkz331
10.1016/j.pep.2014.11.012
10.1111/j.1398-9995.2010.02346.x
10.1007/s00894-001-0058-5
10.1002/anie.201100370
10.1371/journal.pone.0208276
10.1159/000493100
10.1016/j.jaci.2011.07.007
10.1097/MOP.0000000000000509
10.1111/all.13948
10.1021/acschembio.9b00167
10.1021/acs.jafc.9b02781
10.1073/pnas.1500851112
10.1021/jf504672m
10.1007/s10858-010-9461-5
10.3390/allergies1010006
10.1067/mai.2000.108434
10.1016/j.jaip.2018.04.036
10.1016/j.foodres.2015.12.006
10.1093/nar/gky497
10.1016/j.jaci.2015.03.015
10.1111/pai.13141
10.1016/j.jmb.2008.12.049
10.1039/C3FO60702J
10.1016/j.jaci.2015.09.026
10.4049/jimmunol.1600072
10.1021/bi049555n
10.1016/j.jaci.2014.12.1545
10.1007/s12016-020-08810-9
10.1016/j.jaci.2017.11.003
10.1021/acs.jafc.1c00390
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References ref9/cit9
ref45/cit45
ref3/cit3
ref27/cit27
ref16/cit16
ref23/cit23
ref8/cit8
ref31/cit31
ref2/cit2
ref34/cit34
ref20/cit20
ref48/cit48
ref17/cit17
ref10/cit10
ref35/cit35
ref19/cit19
ref21/cit21
ref42/cit42
ref46/cit46
ref49/cit49
ref13/cit13
ref24/cit24
ref38/cit38
ref50/cit50
ref6/cit6
ref36/cit36
ref18/cit18
ref11/cit11
ref25/cit25
ref29/cit29
ref32/cit32
ref39/cit39
ref14/cit14
ref5/cit5
ref51/cit51
ref43/cit43
ref28/cit28
Guar R. K. (ref37/cit37) 2014; 5
ref40/cit40
ref26/cit26
ref12/cit12
ref15/cit15
ref41/cit41
ref22/cit22
ref33/cit33
ref4/cit4
ref30/cit30
ref47/cit47
ref1/cit1
ref44/cit44
ref7/cit7
References_xml – ident: ref32/cit32
  doi: 10.1038/nmeth.2019
– ident: ref10/cit10
  doi: 10.1111/cea.14202
– ident: ref26/cit26
  doi: 10.1007/s10858-015-9924-9
– ident: ref27/cit27
  doi: 10.1093/bioinformatics/btr200
– ident: ref25/cit25
  doi: 10.1002/prot.21165
– ident: ref49/cit49
  doi: 10.1007/s40629-016-0115-3
– ident: ref12/cit12
  doi: 10.1021/acs.jnatprod.0c00594
– ident: ref3/cit3
  doi: 10.1016/j.jaci.2020.11.046
– ident: ref39/cit39
  doi: 10.3389/falgy.2021.769728
– ident: ref24/cit24
  doi: 10.1007/s10858-009-9333-z
– ident: ref2/cit2
  doi: 10.1056/NEJMcp1611971
– ident: ref8/cit8
  doi: 10.1021/acs.jafc.1c07225
– ident: ref14/cit14
  doi: 10.1016/j.jaci.2020.11.004
– ident: ref11/cit11
  doi: 10.1111/cea.13554
– ident: ref16/cit16
  doi: 10.1067/mai.2002.125208
– ident: ref18/cit18
  doi: 10.1016/j.waojou.2022.100641
– ident: ref34/cit34
  doi: 10.1006/jmbi.2000.4474
– ident: ref48/cit48
  doi: 10.1074/jbc.M114.559971
– ident: ref51/cit51
  doi: 10.1016/j.foodchem.2021.131028
– ident: ref45/cit45
  doi: 10.1093/nar/gkz331
– ident: ref20/cit20
  doi: 10.1016/j.pep.2014.11.012
– ident: ref1/cit1
  doi: 10.1111/j.1398-9995.2010.02346.x
– ident: ref33/cit33
  doi: 10.1007/s00894-001-0058-5
– ident: ref22/cit22
  doi: 10.1002/anie.201100370
– ident: ref43/cit43
  doi: 10.1371/journal.pone.0208276
– ident: ref17/cit17
  doi: 10.1159/000493100
– ident: ref44/cit44
  doi: 10.1016/j.jaci.2011.07.007
– ident: ref5/cit5
  doi: 10.1097/MOP.0000000000000509
– volume: 5
  start-page: 6
  year: 2014
  ident: ref37/cit37
  publication-title: IIOAB J.
– ident: ref41/cit41
  doi: 10.1111/all.13948
– ident: ref13/cit13
  doi: 10.1021/acschembio.9b00167
– ident: ref15/cit15
  doi: 10.1021/acs.jafc.9b02781
– ident: ref29/cit29
  doi: 10.1073/pnas.1500851112
– ident: ref6/cit6
  doi: 10.1021/jf504672m
– ident: ref21/cit21
  doi: 10.1007/s10858-010-9461-5
– ident: ref7/cit7
  doi: 10.3390/allergies1010006
– ident: ref42/cit42
  doi: 10.1067/mai.2000.108434
– ident: ref4/cit4
  doi: 10.1016/j.jaip.2018.04.036
– ident: ref31/cit31
  doi: 10.1016/j.foodres.2015.12.006
– ident: ref28/cit28
  doi: 10.1093/nar/gky497
– ident: ref35/cit35
  doi: 10.1016/j.jaci.2015.03.015
– ident: ref19/cit19
  doi: 10.1111/pai.13141
– ident: ref46/cit46
  doi: 10.1016/j.jmb.2008.12.049
– ident: ref30/cit30
  doi: 10.1039/C3FO60702J
– ident: ref40/cit40
  doi: 10.1016/j.jaci.2015.09.026
– ident: ref47/cit47
  doi: 10.4049/jimmunol.1600072
– ident: ref23/cit23
  doi: 10.1021/bi049555n
– ident: ref36/cit36
  doi: 10.1016/j.jaci.2014.12.1545
– ident: ref38/cit38
  doi: 10.1007/s12016-020-08810-9
– ident: ref50/cit50
  doi: 10.1016/j.jaci.2017.11.003
– ident: ref9/cit9
  doi: 10.1021/acs.jafc.1c00390
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Snippet Peanut and tree-nut allergies are frequently comorbid for reasons not completely understood. Vicilin-buried peptides (VBPs) are an emerging family of food...
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SubjectTerms Allergens - chemistry
Allergens - immunology
Anacardium - chemistry
Arachis - chemistry
blood serum
comorbidity
cross reaction
Cross Reactions
epitopes
food chemistry
Food Safety and Toxicology
Humans
immunoglobulin E
Immunoglobulin E - immunology
Juglans - chemistry
Nut Hypersensitivity - diagnosis
Nuts - chemistry
patients
peanuts
peptide microarrays
peptides
Peptides - chemistry
Peptides - immunology
pistachios
Pistacia - chemistry
vicilin
walnuts
Title Structure and IgE Cross-Reactivity among Cashew, Pistachio, Walnut, and Peanut Vicilin-Buried Peptides
URI http://dx.doi.org/10.1021/acs.jafc.2c07061
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