Macrolides and β-Lactam Antibiotics Enhance C3b Deposition on the Surface of Multidrug-Resistant Streptococcus pneumoniae Strains by a LytA Autolysin-Dependent Mechanism - RAMOS-SEVILLANO, Elisa; RODRIGUEZ-SOSA, Cinthya; DIEZ-MARTINEZ, Roberto; GIMENEZ, María-José; OLMEDILLAS, Eduardo; GARCIA, Pedro; GARCIA, Ernesto; AGUILAR, Lorenzo; YUSTE, Jose (Antimicrobial Agents and Chemotherapy, 2012)
Keywords: Animals; Anti-Bacterial Agents; Anti-Bacterial Agents - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacterial diseases; Bacterial Proteins; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; beta-Lactams; beta-Lactams - pharmacology; Biological and medical sciences; Cell Wall - drug effects; Cell Wall - enzymology; Complement C3b; Complement C3b - immunology; Complement C3b - pharmacology; Culture Media; Drug Resistance, Multiple, Bacterial - drug effects; Drug Resistance, Multiple, Bacterial - genetics; Human bacterial diseases; Immune Sera - chemistry; Immune Sera - immunology; Infectious diseases; Macrolides; Macrolides - pharmacology; Mechanisms of Action: Physiological Effects; Medical sciences; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mutation; N-Acetylmuramoyl-L-alanine Amidase; N-Acetylmuramoyl-L-alanine Amidase - genetics; N-Acetylmuramoyl-L-alanine Amidase - metabolism; Pharmacology. Drug treatments; Staphylococcal infections, streptococcal infections, pneumococcal infections; Streptococcus pneumoniae; Streptococcus pneumoniae - drug effects; Streptococcus pneumoniae - enzymology; Streptococcus pneumoniae - genetics; Enzyme; β-Lactams; Metalloendopeptidases; Autolysin; Macrolide; Strain; Streptococcus pneumoniae; Surface; Infection; Peptidases; Streptococcaceae; Antibiotic; Streptococcal infection; Multiple resistance; Bacteriosis; Bacteria; Hydrolases; Micrococcales; Protein synthesis inhibitor; Antibacterial agent; Mechanism of action; Complement C3b; Pneumococcal infection; Deposition