Targeting a Cryptic Allosteric Site for Selective Inhibition of the Oncogenic Protein Tyrosine Phosphatase Shp2 - Chio, Cynthia M; Lim, Christopher S; Bishop, Anthony C (Biochemistry (Easton), 2015)
Keywords: active sites; Allosteric Site - drug effects; Amino Acid Sequence; crystal structure; cysteine; Drug Design; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - pharmacology; human diseases; Humans; Models, Molecular; Molecular Sequence Data; Neoplasms - drug therapy; Neoplasms - enzymology; proline; Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 11 - chemistry; Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism; protein-tyrosine-phosphatase; solvents