High-Affinity, Non-Peptide Agonists for the ORL1 (Orphanin FQ/Nociceptin) Receptor - Röver, Stephan; Adam, Geo; Cesura, Andrea M; Galley, Guido; Jenck, François; Monsma, Frederick J; Wichmann, Jürgen; Dautzenberg, Frank M (Journal of medicinal chemistry, 2000)
Keywords: Binding, Competitive; Biological and medical sciences; Cell Line; Chemistry, Medicinal; Humans; Imidazoles - chemical synthesis; Imidazoles - chemistry; Imidazoles - pharmacology; Life Sciences & Biomedicine; Ligands; Medical sciences; Neuropharmacology; Neurotransmitters. Neurotransmission. Receptors; Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Radioligand Assay; Receptors, Opioid - agonists; Science & Technology; Spiro Compounds - chemical synthesis; Spiro Compounds - chemistry; Spiro Compounds - pharmacology; Structure-Activity Relationship; ENDOGENOUS LIGAND; ORL RECEPTOR; KAPPA-OPIOID RECEPTORS; PROTEIN-COUPLED RECEPTOR; TISSUE DISTRIBUTION; GENE FAMILY; MOLECULAR-CLONING; LONG-TERM POTENTIATION; CDNA CLONING; NOCICEPTIN/ORPHANIN FQ; Agonist; Nitrogen heterocycle; Opioid receptor; Lactam; Non peptide compound; Tricyclic compound; In vitro; Spiran; Biological fixation; Structure activity relation; Bicyclic compound; Aromatic compound; Chemical synthesis; Acenaphthylene derivatives