Multifaceted Bioanalytical Methods for the Comprehensive Pharmacokinetic and Catabolic Assessment of MEDI3726, an Anti-Prostate-Specific Membrane Antigen Pyrrolobenzodiazepine Antibody–Drug Conjugate - Huang, Yue; Del Nagro, Christopher J; Balic, Kemal; Ismaiel, Omnia A; Ma, Eric; Faria, Morse; Wheeler, Aaron M; Yuan, Moucun; Waldron, Michael P; Peay, Marlking G; Cortes, Diego F; Roskos, Lorin; et al. (Analytical chemistry (Washington), 2020)
Keywords: analytical chemistry; Antibodies; Antigens; Antineoplastic Agents - blood; Antineoplastic Agents - metabolism; Antineoplastic Agents - pharmacokinetics; Benzodiazepines - blood; Benzodiazepines - metabolism; Benzodiazepines - pharmacokinetics; Catabolism; Chains; Chemistry; clinical trials; Conjugates; dissociation; Disulfide bonds; disulfides; Humans; Immunoconjugates - blood; Immunoconjugates - metabolism; Immunoconjugates - pharmacokinetics; Immunoglobulin G; Immunoglobulin G - blood; Immunoglobulin G - metabolism; Membranes; Pharmacokinetics; Pharmacology; Prostate; prostate-specific antigen; Prostate-Specific Antigen - immunology; Proteins; Pyrroles - blood; Pyrroles - metabolism; Pyrroles - pharmacokinetics; scaffolding proteins; Scaffolds; Structural members; Warheads