N‑(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6‑Diazo-5-oxo‑l‑norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders - Nedelcovych, Michael T; Tenora, Lukáš; Kim, Boe-Hyun; Kelschenbach, Jennifer; Chao, Wei; Hadas, Eran; Jančařík, Andrej; Prchalová, Eva; Zimmermann, Sarah C; Dash, Ranjeet P; Gadiano, Alexandra J; Garrett, Caroline; et al. (Journal of medicinal chemistry, 2017)
Keywords: Aminocaproates - administration & dosage; Aminocaproates - chemical synthesis; Aminocaproates - pharmacology; Animals; Azo Compounds - administration & dosage; Azo Compounds - chemical synthesis; Azo Compounds - pharmacology; Blood - metabolism; Brain - metabolism; Chemistry, Medicinal; Diazooxonorleucine - administration & dosage; Diazooxonorleucine - pharmacology; Drug Stability; Female; Glutamic Acid - metabolism; Glutaminase - antagonists & inhibitors; HIV Infections - complications; Humans; Life Sciences & Biomedicine; Male; Mice, Inbred C57BL; Neurocognitive Disorders - drug therapy; Neurocognitive Disorders - etiology; Nootropic Agents - administration & dosage; Nootropic Agents - chemical synthesis; Nootropic Agents - pharmacology; Pharmacology & Pharmacy; Prodrugs - administration & dosage; Prodrugs - chemical synthesis; Prodrugs - pharmacology; Science & Technology; Swine; Viral Load - drug effects; MURINE MODEL; IN-VITRO; MAGNETIC-RESONANCE-SPECTROSCOPY; SYNAPTIC DYSFUNCTION; INDUCE NEUROTOXICITY; COGNITIVE IMPAIRMENT; LONG-TERM POTENTIATION; VIRUS TYPE-1 ENCEPHALITIS; MITOCHONDRIAL GLUTAMINASE; HIV-1-INFECTED MACROPHAGES