Prediction of Volume of Distribution Values in Humans for Neutral and Basic Drugs Using Physicochemical Measurements and Plasma Protein Binding Data - Lombardo, Franco; Obach, R. Scott; Shalaeva, Marina Y; Gao, Feng (Journal of medicinal chemistry, 2002)
Keywords: Biological and medical sciences; Blood Proteins - metabolism; Chemical Phenomena; Chemistry, Physical; General pharmacology; Half-Life; Humans; Hydrogen-Ion Concentration; Medical sciences; Models, Biological; Pharmaceutical Preparations - chemistry; Pharmaceutical Preparations - metabolism; Pharmacokinetics; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions; Pharmacology. Drug treatments; Protein Binding; Human; Drug; Binding protein; Basic compound; Neutral compound; Prediction; Bioavailability; Pharmacokinetics; Serum protein; Physicochemical properties