Fluorescent Magnetic Nanoparticles for Magnetically Enhanced Cancer Imaging and Targeting in Living Subjects
Early detection and targeted therapy are two major challenges in the battle against cancer. Novel imaging contrast agents and targeting approaches are greatly needed to improve the sensitivity and specificity of cancer theranostic agents. Here, we implemented a novel approach using a magnetic microm...
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| Published in | ACS nano Vol. 6; no. 8; pp. 6862 - 6869 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Chemical Society
28.08.2012
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1936-0851 1936-086X 1936-086X |
| DOI | 10.1021/nn301670a |
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| Abstract | Early detection and targeted therapy are two major challenges in the battle against cancer. Novel imaging contrast agents and targeting approaches are greatly needed to improve the sensitivity and specificity of cancer theranostic agents. Here, we implemented a novel approach using a magnetic micromesh and biocompatible fluorescent magnetic nanoparticles (FMN) to magnetically enhance cancer targeting in living subjects. This approach enables magnetic targeting of systemically administered individual FMN, containing a single 8 nm superparamagnetic iron oxide core. Using a human glioblastoma mouse model, we show that nanoparticles can be magnetically retained in both the tumor neovasculature and surrounding tumor tissues. Magnetic accumulation of nanoparticles within the neovasculature was observable by fluorescence intravital microscopy in real time. Finally, we demonstrate that such magnetically enhanced cancer targeting augments the biological functions of molecules linked to the nanoparticle surface. |
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| AbstractList | Early detection and targeted therapy are two major challenges in the battle against cancer. Novel imaging contrast agents and targeting approaches are greatly needed to improve the sensitivity and specificity of cancer theranostic agents. Here, we implemented a novel approach using a magnetic micromesh and biocompatible fluorescent magnetic nanoparticles (FMN) to magnetically enhance cancer targeting in living subjects. This approach enables magnetic targeting of systemically administered individual FMN, containing a single 8 nm superparamagnetic iron oxide core. Using a human glioblastoma mouse model, we show that nanoparticles can be magnetically retained in both the tumor neovasculature and surrounding tumor tissues. Magnetic accumulation of nanoparticles within the neovasculature was observable by fluorescence intravital microscopy in real time. Finally, we demonstrate that such magnetically enhanced cancer targeting augments the biological functions of molecules linked to the nanoparticle surface. Early detection and targeted therapy are two major challenges in the battle against cancer. Novel imaging contrast agents and targeting approaches are greatly needed to improve the sensitivity and specificity of cancer theranostic agents. Here, we implemented a novel approach using a magnetic micromesh and biocompatible fluorescent magnetic nanoparticles (FMN) to magnetically enhance cancer targeting in living subjects. This approach enables magnetic targeting of systemically administered individual FMN, containing a single 8 nm superparamagnetic iron oxide (SPIO) core. Using a human glioblastoma mouse model, we show that nanoparticles can be magnetically retained in both the tumor neovasculature and surrounding tumor tissues. Magnetic accumulation of nanoparticles within the neovasculature was observable by fluorescence intravital microscopy in real time. Finally, we demonstrate that such magnetically enhanced cancer targeting augments the biological functions of molecules linked to the nanoparticle surface. Early detection and targeted therapy are two major challenges in the battle against cancer. Novel imaging contrast agents and targeting approaches are greatly needed to improve the sensitivity and specificity of cancer theranostic agents. Here, we implemented a novel approach using a magnetic micromesh and biocompatible fluorescent magnetic nanoparticles (FMN) to magnetically enhance cancer targeting in living subjects. This approach enables magnetic targeting of systemically administered individual FMN, containing a single 8 nm superparamagnetic iron oxide core. Using a human glioblastoma mouse model, we show that nanoparticles can be magnetically retained in both the tumor neovasculature and surrounding tumor tissues. Magnetic accumulation of nanoparticles within the neovasculature was observable by fluorescence intravital microscopy in real time. Finally, we demonstrate that such magnetically enhanced cancer targeting augments the biological functions of molecules linked to the nanoparticle surface.Early detection and targeted therapy are two major challenges in the battle against cancer. Novel imaging contrast agents and targeting approaches are greatly needed to improve the sensitivity and specificity of cancer theranostic agents. Here, we implemented a novel approach using a magnetic micromesh and biocompatible fluorescent magnetic nanoparticles (FMN) to magnetically enhance cancer targeting in living subjects. This approach enables magnetic targeting of systemically administered individual FMN, containing a single 8 nm superparamagnetic iron oxide core. Using a human glioblastoma mouse model, we show that nanoparticles can be magnetically retained in both the tumor neovasculature and surrounding tumor tissues. Magnetic accumulation of nanoparticles within the neovasculature was observable by fluorescence intravital microscopy in real time. Finally, we demonstrate that such magnetically enhanced cancer targeting augments the biological functions of molecules linked to the nanoparticle surface. |
| Author | Guccione, Samira Wilson, Robert J Mullenix, Joyce Akin, Demir Wang, Shan X Earhart, Chris Smith, Bryan R Fu, Aihua Gambhir, Sanjiv S |
| AuthorAffiliation | Department of Bioengineering, Bio-X Program Stanford University NVIGEN Inc Department of Materials Science and Engineering Department of Radiology Molecular Imaging Program at Stanford |
| AuthorAffiliation_xml | – name: Department of Radiology – name: NVIGEN Inc – name: Molecular Imaging Program at Stanford – name: Department of Bioengineering, Bio-X Program – name: Stanford University – name: Department of Materials Science and Engineering – name: 1 Department of Materials Science and Engineering, Stanford University, Stanford, California 94305 USA – name: 4 Department of Bioengineering, Bio-X Program, Stanford University, Stanford, California 94305 USA – name: 5 NVIGEN Inc, 265 Sobrante Way, Suite H, Sunnyvale, CA 94086 – name: 2 Department of Radiology, Stanford University, Stanford, California 94305 USA – name: 3 Molecular Imaging Program, Stanford University, Stanford, California 94305 USA |
| Author_xml | – sequence: 1 givenname: Aihua surname: Fu fullname: Fu, Aihua email: sgambhir@stanford.edu, sxwang@stanford.edu, aihuafu@nvigen.com – sequence: 2 givenname: Robert J surname: Wilson fullname: Wilson, Robert J – sequence: 3 givenname: Bryan R surname: Smith fullname: Smith, Bryan R – sequence: 4 givenname: Joyce surname: Mullenix fullname: Mullenix, Joyce – sequence: 5 givenname: Chris surname: Earhart fullname: Earhart, Chris – sequence: 6 givenname: Demir surname: Akin fullname: Akin, Demir – sequence: 7 givenname: Samira surname: Guccione fullname: Guccione, Samira – sequence: 8 givenname: Shan X surname: Wang fullname: Wang, Shan X email: sgambhir@stanford.edu, sxwang@stanford.edu, aihuafu@nvigen.com – sequence: 9 givenname: Sanjiv S surname: Gambhir fullname: Gambhir, Sanjiv S email: sgambhir@stanford.edu, sxwang@stanford.edu, aihuafu@nvigen.com |
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| SubjectTerms | Animals Cancer Cell Line, Tumor Fluorescence Fluorescent Dyes - chemistry Glioblastoma - pathology Human Humans Imaging Iron oxides Magnetic Fields Magnetite Nanoparticles Materials Testing Mice Mice, SCID Microscopy Microscopy, Fluorescence - methods Nanocapsules - chemistry Nanocapsules - ultrastructure Nanoparticles Nanostructure Particle Size Tumors |
| Title | Fluorescent Magnetic Nanoparticles for Magnetically Enhanced Cancer Imaging and Targeting in Living Subjects |
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