The future of genomics for developmentalists
The momentum of genomic science will carry it far into the future and into the heart of research on typical and atypical behavioral development. The purpose of this paper is to focus on a few implications and applications of these advances for understanding behavioral development. Quantitative genet...
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| Published in | Development and psychopathology Vol. 25; no. 4pt2; pp. 1263 - 1278 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.11.2013
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0954-5794 1469-2198 1469-2198 |
| DOI | 10.1017/S0954579413000606 |
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| Abstract | The momentum of genomic science will carry it far into the future and into the heart of research on typical and atypical behavioral development. The purpose of this paper is to focus on a few implications and applications of these advances for understanding behavioral development. Quantitative genetics is genomic and will chart the course for molecular genomic research now that these two worlds of genetics are merging in the search for many genes of small effect. Although current attempts to identify specific genes have had limited success, known as the missing heritability problem, whole-genome sequencing will improve this situation by identifying all DNA sequence variations, including rare variants. Because the heritability of complex traits is caused by many DNA variants of small effect in the population, polygenic scores that are composites of hundreds or thousands of DNA variants will be used by developmentalists to predict children's genetic risk and resilience. The most far-reaching advance will be the widespread availability of whole-genome sequence for children, which means that developmentalists would no longer need to obtain DNA or to genotype children in order to use genomic information in research or in the clinic. |
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| AbstractList | The momentum of genomic science will carry it far into the future and into the heart of research on typical and atypical behavioral development. The purpose of this paper is to focus on a few implications and applications of these advances for understanding behavioral development. Quantitative genetics is genomic and will chart the course for molecular genomic research now that these two worlds of genetics are merging in the search for many genes of small effect. Although current attempts to identify specific genes have had limited success, known as the missing heritability problem, whole-genome sequencing will improve this situation by identifying all DNA sequence variations, including rare variants. Because the heritability of complex traits is caused by many DNA variants of small effect in the population, polygenic scores that are composites of hundreds or thousands of DNA variants will be used by developmentalists to predict children's genetic risk and resilience. The most far-reaching advance will be the widespread availability of whole-genome sequence for children, which means that developmentalists would no longer need to obtain DNA or to genotype children in order to use genomic information in research or in the clinic. The momentum of genomic science will carry it far into the future and into the heart of research on typical and atypical behavioral development. The purpose of this paper is to focus on a few implications and applications of these advances for understanding behavioral development. Quantitative genetics is genomic and will chart the course for molecular genomic research now that these two worlds of genetics are merging in the search for many genes of small effect. Although current attempts to identify specific genes have had limited success, known as the missing heritability problem, whole-genome sequencing will improve this situation by identifying all DNA sequence variation including rare variants. Because the heritability of complex traits is caused by many DNA variants of small effect in the population, polygenic scores that are composites of hundreds or thousands of DNA variants will be used by developmentalists to predict children’s genetic risk and resilience. The most far-reaching advance will be the widespread availability of whole-genome sequence for children, which means that developmentalists would no longer need to obtain DNA or to genotype children in order to use genomic information in research or in the clinic. The momentum of genomic science will carry it far into the future and into the heart of research on typical and atypical behavioral development. The purpose of this paper is to focus on a few implications and applications of these advances for understanding behavioral development. Quantitative genetics is genomic and will chart the course for molecular genomic research now that these two worlds of genetics are merging in the search for many genes of small effect. Although current attempts to identify specific genes have had limited success, known as the missing heritability problem, whole-genome sequencing will improve this situation by identifying all DNA sequence variations, including rare variants. Because the heritability of complex traits is caused by many DNA variants of small effect in the population, polygenic scores that are composites of hundreds or thousands of DNA variants will be used by developmentalists to predict children's genetic risk and resilience. The most far-reaching advance will be the widespread availability of whole-genome sequence for children, which means that developmentalists would no longer need to obtain DNA or to genotype children in order to use genomic information in research or in the clinic.The momentum of genomic science will carry it far into the future and into the heart of research on typical and atypical behavioral development. The purpose of this paper is to focus on a few implications and applications of these advances for understanding behavioral development. Quantitative genetics is genomic and will chart the course for molecular genomic research now that these two worlds of genetics are merging in the search for many genes of small effect. Although current attempts to identify specific genes have had limited success, known as the missing heritability problem, whole-genome sequencing will improve this situation by identifying all DNA sequence variations, including rare variants. Because the heritability of complex traits is caused by many DNA variants of small effect in the population, polygenic scores that are composites of hundreds or thousands of DNA variants will be used by developmentalists to predict children's genetic risk and resilience. The most far-reaching advance will be the widespread availability of whole-genome sequence for children, which means that developmentalists would no longer need to obtain DNA or to genotype children in order to use genomic information in research or in the clinic. |
| Author | Simpson, Michael A. Plomin, Robert |
| AuthorAffiliation | 1 King’s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, United Kingdom 2 King’s College London, Department of Medical and Molecular Genetics, London, SE1 9RT, United Kingdom |
| AuthorAffiliation_xml | – name: 2 King’s College London, Department of Medical and Molecular Genetics, London, SE1 9RT, United Kingdom – name: 1 King’s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, United Kingdom |
| Author_xml | – sequence: 1 givenname: Robert surname: Plomin fullname: Plomin, Robert – sequence: 2 givenname: Michael A. surname: Simpson fullname: Simpson, Michael A. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24342839$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/nature08872 10.1038/nrg2989 10.1038/nrg3373 10.1016/j.jaac.2013.07.016 10.1038/nature08185 10.1038/nature10781 10.1017/thg.2012.147 10.1023/A:1013385125887 10.1093/ije/dyr225 10.1007/s00439-012-1199-6 10.1017/S0954579412000764 10.1017/S0954579412000806 10.1101/gr.136598.111 10.2217/pgs.12.170 10.1016/j.ajhg.2008.06.024 10.1016/j.tics.2011.07.003 10.1002/elps.201200272 10.1126/science.1229277 10.1038/nrg2344 10.1038/ng.286 10.1016/j.biopsych.2012.03.011 10.1038/ng.940 10.1038/nature08516 10.1177/0956797611435528 10.1038/nrg2670 10.1038/nature05911 10.1093/hmg/dds491 10.1176/appi.ajp.2010.10020223 10.1534/genetics.109.102798 10.1002/gepi.20576 10.1038/ng.2507 10.1038/ng.1108 10.1038/nrg3243 10.1371/journal.pgen.1002004 10.1177/0956797612457952 10.1001/archpediatrics.2012.131 10.1017/S095457941200079X 10.1073/pnas.1120666109 10.1016/j.tig.2012.03.004 10.1371/annotation/b91ba224-10be-409d-93f4-7423d502cba0 10.1038/nature08979 10.1093/bioinformatics/bts474 10.1038/ng.943 10.1038/ng.686 10.1111/j.1469-7610.2005.01515.x 10.1017/S0954579412000612 10.1038/ejhg.2010.26 10.1097/GIM.0b013e3182217a06 10.1111/j.1467-8624.2012.01757.x 10.1038/ng.2555 10.1007/s10519-013-9594-x 10.1016/j.neuron.2013.01.010 10.1016/j.ajhg.2011.02.002 10.1017/S0954579412000818 10.1371/journal.pgen.1002254 10.1186/gb-2012-13-1-237 10.1007/s00335-003-3033-x 10.1038/nrg3241 10.1002/gepi.21625 10.1176/appi.ajp.2011.11060822 10.4161/epi.5.6.12226 10.1038/mp.2011.85 10.1016/j.intell.2013.07.011 10.1176/appi.ajp.2010.09091335 10.1038/nrg2735 10.1126/science.1235488 10.1016/j.jaac.2010.01.026 10.1371/journal.pgen.1003264 10.1038/mp.2011.94 10.1371/journal.pgen.1000008 10.1016/j.ajhg.2010.11.011 10.1016/S0140-6736(09)60072-6 10.1126/science.1215040 10.1038/ng.2250 10.1017/S0954579412000740 10.1017/S0954579412000703 10.1038/ng.608 10.1016/j.ajhg.2010.06.009 10.1017/S0954579412000648 10.1016/j.cell.2012.02.039 10.1111/j.1399-0004.2011.01720.x 10.1017/S0954579412000739 10.1126/science.337.6099.1159 10.1038/ng.2480 10.1016/S0140-6736(12)62129-1 10.1016/j.jaac.2010.06.008 10.1002/gepi.20450 10.1007/s00439-012-1213-z 10.1017/S0954579412000636 10.1016/j.tig.2010.12.005 10.1056/NEJMra0905980 10.1002/humu.20526 10.1038/ng.909 10.1097/01.GIM.0000105751.71430.79 10.1038/ng853 10.1038/nature09410 10.1017/S0954579412000685 10.1038/nrg3118 10.1038/mp.2009.107 10.1038/nrg796 10.1016/j.ajhg.2011.11.029 10.1037/0033-2909.131.4.592 10.1017/S0954579412000776 10.1056/NEJMoa1200395 10.1016/j.ajhg.2012.10.010 |
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| References | Vukcevic (S0954579413000606_ref104) 2011; 35 S0954579413000606_ref102 S0954579413000606_ref81 S0954579413000606_ref103 S0954579413000606_ref82 S0954579413000606_ref106 S0954579413000606_ref83 S0954579413000606_ref105 S0954579413000606_ref84 S0954579413000606_ref108 S0954579413000606_ref107 S0954579413000606_ref85 S0954579413000606_ref86 S0954579413000606_ref88 S0954579413000606_ref89 S0954579413000606_ref100 Trzaskowski (S0954579413000606_ref98) 2013 O'Reilly (S0954579413000606_ref66) 2012; 7 S0954579413000606_ref70 S0954579413000606_ref71 S0954579413000606_ref73 S0954579413000606_ref74 S0954579413000606_ref75 S0954579413000606_ref76 S0954579413000606_ref77 S0954579413000606_ref78 S0954579413000606_ref79 Plomin (S0954579413000606_ref72) 2013 S0954579413000606_ref60 S0954579413000606_ref61 S0954579413000606_ref62 S0954579413000606_ref63 S0954579413000606_ref64 S0954579413000606_ref65 (S0954579413000606_ref56) 2012; 18 S0954579413000606_ref67 S0954579413000606_ref68 S0954579413000606_ref69 (S0954579413000606_ref37) 2009; 460 S0954579413000606_ref109 S0954579413000606_ref113 Collins (S0954579413000606_ref10) 2010 S0954579413000606_ref112 S0954579413000606_ref115 S0954579413000606_ref114 S0954579413000606_ref50 S0954579413000606_ref51 S0954579413000606_ref52 Benyamin (S0954579413000606_ref6) 2013 S0954579413000606_ref53 S0954579413000606_ref54 S0954579413000606_ref55 S0954579413000606_ref57 S0954579413000606_ref58 S0954579413000606_ref111 S0954579413000606_ref59 S0954579413000606_ref39 Wong (S0954579413000606_ref110) 2013 Vinkhuyzen (S0954579413000606_ref101) 2012; 2 S0954579413000606_ref40 S0954579413000606_ref41 S0954579413000606_ref42 S0954579413000606_ref43 S0954579413000606_ref44 S0954579413000606_ref45 S0954579413000606_ref46 S0954579413000606_ref47 S0954579413000606_ref48 S0954579413000606_ref49 S0954579413000606_ref28 S0954579413000606_ref29 S0954579413000606_ref30 S0954579413000606_ref31 S0954579413000606_ref32 S0954579413000606_ref33 S0954579413000606_ref34 S0954579413000606_ref35 S0954579413000606_ref36 S0954579413000606_ref38 S0954579413000606_ref17 S0954579413000606_ref18 S0954579413000606_ref19 S0954579413000606_ref20 Rochman (S0954579413000606_ref80) 2012; 180 S0954579413000606_ref21 S0954579413000606_ref22 S0954579413000606_ref23 S0954579413000606_ref24 S0954579413000606_ref25 S0954579413000606_ref26 S0954579413000606_ref27 S0954579413000606_ref1 S0954579413000606_ref9 S0954579413000606_ref8 S0954579413000606_ref7 S0954579413000606_ref5 S0954579413000606_ref4 S0954579413000606_ref3 S0954579413000606_ref2 S0954579413000606_ref90 S0954579413000606_ref91 S0954579413000606_ref92 S0954579413000606_ref93 So (S0954579413000606_ref87) 2011; 35 S0954579413000606_ref94 S0954579413000606_ref95 S0954579413000606_ref96 S0954579413000606_ref97 S0954579413000606_ref99 S0954579413000606_ref11 S0954579413000606_ref12 S0954579413000606_ref13 S0954579413000606_ref14 S0954579413000606_ref15 S0954579413000606_ref16 |
| References_xml | – ident: S0954579413000606_ref70 doi: 10.1038/nature08872 – ident: S0954579413000606_ref67 doi: 10.1038/nrg2989 – ident: S0954579413000606_ref105 doi: 10.1038/nrg3373 – ident: S0954579413000606_ref95 doi: 10.1016/j.jaac.2013.07.016 – volume: 460 start-page: 748 year: 2009 ident: S0954579413000606_ref37 article-title: Common polygenic variation contributes to risk of schizophrenia and bipolar disorder publication-title: Nature doi: 10.1038/nature08185 – ident: S0954579413000606_ref16 doi: 10.1038/nature10781 – ident: S0954579413000606_ref35 doi: 10.1017/thg.2012.147 – ident: S0954579413000606_ref75 doi: 10.1023/A:1013385125887 – ident: S0954579413000606_ref32 doi: 10.1093/ije/dyr225 – volume: 35 start-page: 447 year: 2011 ident: S0954579413000606_ref87 article-title: Uncovering the total heritability explained by all true susceptibility variants in a genome-wide association study publication-title: Genetic Epidemiology – ident: S0954579413000606_ref113 doi: 10.1007/s00439-012-1199-6 – ident: S0954579413000606_ref62 doi: 10.1017/S0954579412000764 – ident: S0954579413000606_ref7 doi: 10.1017/S0954579412000806 – ident: S0954579413000606_ref24 doi: 10.1101/gr.136598.111 – volume: 18 start-page: 497 year: 2012 ident: S0954579413000606_ref56 article-title: A mega-analysis of genome-wide association studies for major depressive disorder publication-title: Molecular Psychiatry – ident: S0954579413000606_ref47 doi: 10.2217/pgs.12.170 – ident: S0954579413000606_ref48 doi: 10.1016/j.ajhg.2008.06.024 – ident: S0954579413000606_ref20 doi: 10.1016/j.tics.2011.07.003 – ident: S0954579413000606_ref55 doi: 10.1002/elps.201200272 – ident: S0954579413000606_ref28 doi: 10.1126/science.1229277 – ident: S0954579413000606_ref59 doi: 10.1038/nrg2344 – ident: S0954579413000606_ref39 doi: 10.1038/ng.286 – ident: S0954579413000606_ref53 doi: 10.1016/j.biopsych.2012.03.011 – ident: S0954579413000606_ref83 doi: 10.1038/ng.940 – ident: S0954579413000606_ref11 doi: 10.1038/nature08516 – ident: S0954579413000606_ref9 doi: 10.1177/0956797611435528 – ident: S0954579413000606_ref73 doi: 10.1038/nrg2670 – ident: S0954579413000606_ref106 doi: 10.1038/nature05911 – ident: S0954579413000606_ref44 doi: 10.1093/hmg/dds491 – ident: S0954579413000606_ref49 doi: 10.1176/appi.ajp.2010.10020223 – year: 2013 ident: S0954579413000606_ref110 article-title: Methylomic analysis of monozygotic twins discordant for autism spectrum disorder (ASD) and related behavioural traits publication-title: Molecular Psychiatry – ident: S0954579413000606_ref86 doi: 10.1534/genetics.109.102798 – volume: 35 start-page: 278 year: 2011 ident: S0954579413000606_ref104 article-title: Disease model distortion in association studies publication-title: Genetic Epidemiology doi: 10.1002/gepi.20576 – ident: S0954579413000606_ref36 doi: 10.1038/ng.2507 – ident: S0954579413000606_ref43 doi: 10.1038/ng.1108 – ident: S0954579413000606_ref99 doi: 10.1038/nrg3243 – ident: S0954579413000606_ref114 doi: 10.1371/journal.pgen.1002004 – ident: S0954579413000606_ref74 doi: 10.1177/0956797612457952 – ident: S0954579413000606_ref4 doi: 10.1001/archpediatrics.2012.131 – ident: S0954579413000606_ref8 doi: 10.1017/S095457941200079X – ident: S0954579413000606_ref5 doi: 10.1073/pnas.1120666109 – ident: S0954579413000606_ref78 doi: 10.1016/j.tig.2012.03.004 – ident: S0954579413000606_ref18 doi: 10.1371/annotation/b91ba224-10be-409d-93f4-7423d502cba0 – ident: S0954579413000606_ref107 doi: 10.1038/nature08979 – ident: S0954579413000606_ref46 doi: 10.1093/bioinformatics/bts474 – ident: S0954579413000606_ref77 doi: 10.1038/ng.943 – ident: S0954579413000606_ref89 doi: 10.1038/ng.686 – volume: 180 year: 2012 ident: S0954579413000606_ref80 article-title: ‘Want to know my future’? Parents grapple with delving into their kids' publication-title: DNA. Time – ident: S0954579413000606_ref29 doi: 10.1111/j.1469-7610.2005.01515.x – ident: S0954579413000606_ref26 doi: 10.1017/S0954579412000612 – volume: 7 year: 2012 ident: S0954579413000606_ref66 article-title: MultiPhen: Joint model of multiple phenotypes can increase discovery in GWAS publication-title: PLoS ONE – ident: S0954579413000606_ref85 doi: 10.1038/ejhg.2010.26 – year: 2013 ident: S0954579413000606_ref6 article-title: Childhood intelligence is heritable, highly polygenic and associated with FNBP1L publication-title: Molecular Psychiatry – ident: S0954579413000606_ref82 doi: 10.1097/GIM.0b013e3182217a06 – ident: S0954579413000606_ref71 doi: 10.1111/j.1467-8624.2012.01757.x – ident: S0954579413000606_ref25 doi: 10.1038/ng.2555 – ident: S0954579413000606_ref96 doi: 10.1007/s10519-013-9594-x – ident: S0954579413000606_ref91 doi: 10.1016/j.neuron.2013.01.010 – volume-title: The language of life: DNA and the revolution in personalized medicine year: 2010 ident: S0954579413000606_ref10 – ident: S0954579413000606_ref45 doi: 10.1016/j.ajhg.2011.02.002 – ident: S0954579413000606_ref64 doi: 10.1017/S0954579412000818 – ident: S0954579413000606_ref13 doi: 10.1371/journal.pgen.1002254 – ident: S0954579413000606_ref61 doi: 10.1186/gb-2012-13-1-237 – ident: S0954579413000606_ref19 doi: 10.1007/s00335-003-3033-x – ident: S0954579413000606_ref100 doi: 10.1038/nrg3241 – ident: S0954579413000606_ref2 doi: 10.1002/gepi.21625 – ident: S0954579413000606_ref108 doi: 10.1176/appi.ajp.2011.11060822 – ident: S0954579413000606_ref109 doi: 10.4161/epi.5.6.12226 – ident: S0954579413000606_ref15 doi: 10.1038/mp.2011.85 – ident: S0954579413000606_ref97 doi: 10.1016/j.intell.2013.07.011 – ident: S0954579413000606_ref34 doi: 10.1176/appi.ajp.2010.09091335 – ident: S0954579413000606_ref27 doi: 10.1038/nrg2735 – ident: S0954579413000606_ref79 doi: 10.1126/science.1235488 – ident: S0954579413000606_ref31 doi: 10.1016/j.jaac.2010.01.026 – ident: S0954579413000606_ref115 doi: 10.1371/journal.pgen.1003264 – ident: S0954579413000606_ref92 doi: 10.1038/mp.2011.94 – ident: S0954579413000606_ref33 doi: 10.1371/journal.pgen.1000008 – ident: S0954579413000606_ref112 doi: 10.1016/j.ajhg.2010.11.011 – ident: S0954579413000606_ref50 doi: 10.1016/S0140-6736(09)60072-6 – ident: S0954579413000606_ref54 doi: 10.1126/science.1215040 – ident: S0954579413000606_ref90 doi: 10.1038/ng.2250 – ident: S0954579413000606_ref81 doi: 10.1017/S0954579412000740 – ident: S0954579413000606_ref30 doi: 10.1017/S0954579412000703 – ident: S0954579413000606_ref111 doi: 10.1038/ng.608 – ident: S0954579413000606_ref51 doi: 10.1016/j.ajhg.2010.06.009 – ident: S0954579413000606_ref103 doi: 10.1017/S0954579412000648 – ident: S0954579413000606_ref57 doi: 10.1016/j.cell.2012.02.039 – ident: S0954579413000606_ref94 doi: 10.1111/j.1399-0004.2011.01720.x – ident: S0954579413000606_ref22 doi: 10.1017/S0954579412000739 – ident: S0954579413000606_ref68 doi: 10.1126/science.337.6099.1159 – ident: S0954579413000606_ref17 doi: 10.1038/ng.2480 – ident: S0954579413000606_ref14 doi: 10.1016/S0140-6736(12)62129-1 – ident: S0954579413000606_ref65 doi: 10.1016/j.jaac.2010.06.008 – ident: S0954579413000606_ref63 doi: 10.1002/gepi.20450 – ident: S0954579413000606_ref1 doi: 10.1007/s00439-012-1213-z – ident: S0954579413000606_ref60 doi: 10.1017/S0954579412000636 – ident: S0954579413000606_ref3 doi: 10.1016/j.tig.2010.12.005 – ident: S0954579413000606_ref58 doi: 10.1056/NEJMra0905980 – year: 2013 ident: S0954579413000606_ref98 article-title: DNA evidence for strong genetic stability and increasing heritability of intelligence from age 7 to 12 publication-title: Molecular Psychiatry – ident: S0954579413000606_ref84 doi: 10.1002/humu.20526 – ident: S0954579413000606_ref12 doi: 10.1038/ng.909 – ident: S0954579413000606_ref40 doi: 10.1097/01.GIM.0000105751.71430.79 – ident: S0954579413000606_ref69 doi: 10.1038/ng853 – ident: S0954579413000606_ref42 doi: 10.1038/nature09410 – volume-title: Behavioral genetics year: 2013 ident: S0954579413000606_ref72 – ident: S0954579413000606_ref38 doi: 10.1017/S0954579412000685 – ident: S0954579413000606_ref21 doi: 10.1038/nrg3118 – ident: S0954579413000606_ref52 doi: 10.1038/mp.2009.107 – volume: 2 year: 2012 ident: S0954579413000606_ref101 article-title: Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion publication-title: Translational Psychiatry – ident: S0954579413000606_ref93 doi: 10.1038/nrg796 – ident: S0954579413000606_ref102 doi: 10.1016/j.ajhg.2011.11.029 – ident: S0954579413000606_ref76 doi: 10.1037/0033-2909.131.4.592 – ident: S0954579413000606_ref41 doi: 10.1017/S0954579412000776 – ident: S0954579413000606_ref23 doi: 10.1056/NEJMoa1200395 – ident: S0954579413000606_ref88 doi: 10.1016/j.ajhg.2012.10.010 |
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| Snippet | The momentum of genomic science will carry it far into the future and into the heart of research on typical and atypical behavioral development. The purpose of... |
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| SubjectTerms | Child Child Development - physiology Child Psychiatry - trends Genetics, Behavioral - trends Genomics - trends Humans Mental Disorders - genetics Mental Disorders - psychology |
| Title | The future of genomics for developmentalists |
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