Molecular Basis of Class A β-Lactamase Inhibition by Relebactam - Tooke, Catherine L.; Hinchliffe, Philip; Lang, Pauline A.; Mulholland, Adrian J.; Brem, Jürgen; Schofield, Christopher J.; Spencer, James (Antimicrobial agents and chemotherapy, 2019)
Keywords: Azabicyclo Compounds; Azabicyclo Compounds - chemistry; Azabicyclo Compounds - metabolism; Azabicyclo Compounds - pharmacology; Aztreonam - chemistry; Aztreonam - metabolism; Aztreonam - pharmacology; beta-Lactam Resistance; beta-Lactam Resistance - genetics; beta-Lactamase Inhibitors; beta-Lactamase Inhibitors - chemistry; beta-Lactamase Inhibitors - metabolism; beta-Lactamase Inhibitors - pharmacology; beta-Lactamases; beta-Lactamases - chemistry; beta-Lactamases - genetics; beta-Lactamases - metabolism; Binding Sites; Ceftazidime - chemistry; Ceftazidime - metabolism; Ceftazidime - pharmacology; Chromosomes, Bacterial - chemistry; Chromosomes, Bacterial - enzymology; Clinical Trials, Phase III as Topic; Cloning, Molecular; Drug Combinations; Escherichia coli - genetics; Escherichia coli - metabolism; Gene Expression; Genetic Vectors - chemistry; Genetic Vectors - metabolism; Humans; Imipenem - chemistry; Imipenem - metabolism; Imipenem - pharmacology; Isoenzymes - antagonists & inhibitors; Isoenzymes - chemistry; Isoenzymes - genetics; Isoenzymes - metabolism; Klebsiella pneumoniae; Klebsiella pneumoniae - drug effects; Klebsiella pneumoniae - enzymology; Klebsiella pneumoniae - genetics; Mechanisms of Resistance; Microbial Sensitivity Tests; Models, Molecular; Plasmids - chemistry; Plasmids - metabolism; Protein Binding; Protein Interaction Domains and Motifs; Recombinant Proteins - chemistry; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; Stenotrophomonas maltophilia; Stenotrophomonas maltophilia - drug effects; Stenotrophomonas maltophilia - enzymology; Stenotrophomonas maltophilia - genetics; relebactam; antibiotic resistance; avibactam; diazabicyclooctane; serine β-lactamase inhibitors