HKOCl‑2 Series of Green BODIPY-Based Fluorescent Probes for Hypochlorous Acid Detection and Imaging in Live Cells
A HKOCl-2 series of new fluorescent probes for hypochlorous acid (HOCl) detection in live cells is reported. The probes exhibit excellent selectivity, sensitivity, and chemostability toward HOCl. In particular, HKOCl-2b rapidly and selectively detects endogenous HOCl in both human and mouse macropha...
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| Published in | Organic letters Vol. 16; no. 13; pp. 3544 - 3547 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
WASHINGTON
American Chemical Society
03.07.2014
Amer Chemical Soc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1523-7060 1523-7052 1523-7052 |
| DOI | 10.1021/ol501496n |
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| Abstract | A HKOCl-2 series of new fluorescent probes for hypochlorous acid (HOCl) detection in live cells is reported. The probes exhibit excellent selectivity, sensitivity, and chemostability toward HOCl. In particular, HKOCl-2b rapidly and selectively detects endogenous HOCl in both human and mouse macrophages. These probes could therefore serve as promising discovery tools to help elucidate biological functions of HOCl. |
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| AbstractList | A HKOCl-2 series of new fluorescent probes for hypochlorous acid (HOCl) detection in live cells is reported. The probes exhibit excellent selectivity, sensitivity, and chemostability toward HOCl. In particular, HKOCl-2b rapidly and selectively detects endogenous HOCl in both human and mouse macrophages. These probes could therefore serve as promising discovery tools to help elucidate biological functions of HOCl. A HKOCl-2 series of new fluorescent probes for hypochlorous acid (HOCl) detection in live cells is reported. The probes exhibit excellent selectivity, sensitivity, and chemostability toward HOCl. In particular, HKOCl-2b rapidly and selectively detects endogenous HOCl in both human and mouse macrophages. These probes could therefore serve as promising discovery tools to help elucidate biological functions of HOCl.A HKOCl-2 series of new fluorescent probes for hypochlorous acid (HOCl) detection in live cells is reported. The probes exhibit excellent selectivity, sensitivity, and chemostability toward HOCl. In particular, HKOCl-2b rapidly and selectively detects endogenous HOCl in both human and mouse macrophages. These probes could therefore serve as promising discovery tools to help elucidate biological functions of HOCl. |
| Author | Hu, Jun Jacob Wong, Nai-Kei Gu, Qiangshuai Ye, Sen Yang, Dan Bai, Xiaoyu |
| AuthorAffiliation | The University of Hong Kong Morningside Laboratory for Chemical Biology, Department of Chemistry |
| AuthorAffiliation_xml | – name: The University of Hong Kong – name: Morningside Laboratory for Chemical Biology, Department of Chemistry |
| Author_xml | – sequence: 1 givenname: Jun Jacob surname: Hu fullname: Hu, Jun Jacob – sequence: 2 givenname: Nai-Kei surname: Wong fullname: Wong, Nai-Kei – sequence: 3 givenname: Qiangshuai surname: Gu fullname: Gu, Qiangshuai – sequence: 4 givenname: Xiaoyu surname: Bai fullname: Bai, Xiaoyu – sequence: 5 givenname: Sen surname: Ye fullname: Ye, Sen – sequence: 6 givenname: Dan surname: Yang fullname: Yang, Dan email: yangdan@hku.hk |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24950390$$D View this record in MEDLINE/PubMed |
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| Keywords | TURN-ON OXIDATION MYELOPEROXIDASE REACTIVE OXYGEN NEUTROPHIL PHAGOSOME DYES MITOCHONDRIA ATHEROSCLEROSIS SELECTIVE DETECTION OXIDANTS |
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| Snippet | A HKOCl-2 series of new fluorescent probes for hypochlorous acid (HOCl) detection in live cells is reported. The probes exhibit excellent selectivity,... |
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| SubjectTerms | Animals Boron Compounds - chemistry chemical reactions chemical structure Chemistry Chemistry, Organic Diagnostic Imaging fluorescent dyes Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Humans Hypochlorous Acid - analysis Hypochlorous Acid - chemistry image analysis macrophages Macrophages - metabolism Mice Molecular Structure organic compounds Physical Sciences Science & Technology |
| Title | HKOCl‑2 Series of Green BODIPY-Based Fluorescent Probes for Hypochlorous Acid Detection and Imaging in Live Cells |
| URI | http://dx.doi.org/10.1021/ol501496n http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=FullRecord&UT=000340808000032 https://www.ncbi.nlm.nih.gov/pubmed/24950390 https://www.proquest.com/docview/1543280419 https://www.proquest.com/docview/2020874123 |
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