Synthesis of 3,5-Disubstituted Isoxazoles via Cope-Type Hydroamination of 1,3-Dialkynes
An efficient method for the synthesis of 3,5-disubstituted isoxazoles is described. The reactions of 1,3-dialkynes with hydroxylamine proceeded smoothly in DMSO under mild reaction conditions to produce 3,5-disubstituted isoxazoles in satisfactory to excellent yields.
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| Published in | Organic letters Vol. 14; no. 9; pp. 2418 - 2421 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
WASHINGTON
American Chemical Society
04.05.2012
Amer Chemical Soc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1523-7060 1523-7052 1523-7052 |
| DOI | 10.1021/ol300872e |
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| Abstract | An efficient method for the synthesis of 3,5-disubstituted isoxazoles is described. The reactions of 1,3-dialkynes with hydroxylamine proceeded smoothly in DMSO under mild reaction conditions to produce 3,5-disubstituted isoxazoles in satisfactory to excellent yields. |
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| AbstractList | An efficient method for the synthesis of 3,5-disubstituted Isoxazoles is described. The reactions of 1,3-dialkynes with hydroxylamine proceeded smoothly in DMSO under mild reaction conditions to produce 3,5-disubstituted isoxazoles In satisfactory to excellent yields. An efficient method for the synthesis of 3,5-disubstituted isoxazoles is described. The reactions of 1,3-dialkynes with hydroxylamine proceeded smoothly in DMSO under mild reaction conditions to produce 3,5-disubstituted isoxazoles in satisfactory to excellent yields.An efficient method for the synthesis of 3,5-disubstituted isoxazoles is described. The reactions of 1,3-dialkynes with hydroxylamine proceeded smoothly in DMSO under mild reaction conditions to produce 3,5-disubstituted isoxazoles in satisfactory to excellent yields. |
| Author | Wang, Liangguang Bao, Ming Feng, Xiujuan Yu, Xiaoqiang |
| AuthorAffiliation | Dalian University of Technology |
| AuthorAffiliation_xml | – name: Dalian University of Technology |
| Author_xml | – sequence: 1 givenname: Liangguang surname: Wang fullname: Wang, Liangguang – sequence: 2 givenname: Xiaoqiang surname: Yu fullname: Yu, Xiaoqiang email: yuxiaoqiang@dlut.edu.cn, mingbao@dlut.edu.cn – sequence: 3 givenname: Xiujuan surname: Feng fullname: Feng, Xiujuan – sequence: 4 givenname: Ming surname: Bao fullname: Bao, Ming email: yuxiaoqiang@dlut.edu.cn, mingbao@dlut.edu.cn |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22537143$$D View this record in MEDLINE/PubMed |
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| Snippet | An efficient method for the synthesis of 3,5-disubstituted isoxazoles is described. The reactions of 1,3-dialkynes with hydroxylamine proceeded smoothly in... An efficient method for the synthesis of 3,5-disubstituted Isoxazoles is described. The reactions of 1,3-dialkynes with hydroxylamine proceeded smoothly in... |
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| SubjectTerms | Amination Catalysis chemical reactions chemical structure Chemistry Chemistry, Organic Combinatorial Chemistry Techniques Cyclization dimethyl sulfoxide Diynes - chemistry hydroxylamine Isoxazoles - chemical synthesis Isoxazoles - chemistry Molecular Structure Physical Sciences Science & Technology Stereoisomerism |
| Title | Synthesis of 3,5-Disubstituted Isoxazoles via Cope-Type Hydroamination of 1,3-Dialkynes |
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