Simple Osthole/Nanocarrier Pesticide Efficiently Controls Both Pests and Diseases Fulfilling the Need of Green Production of Strawberry

The application of botanical pesticides is a good choice in organic agriculture. However, most botanical pesticides have limitations of slow action and short persistence for pest and disease management, which constrain their further application. With the objective of exploring a green pesticide for...

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Published in	ACS applied materials & interfaces Vol. 13; no. 30; pp. 36350 - 36360
Main Authors	Yan, Shuo, Hu, Qian, Jiang, Qinhong, Chen, Hongtao, Wei, Jie, Yin, Meizhen, Du, Xiangge, Shen, Jie
Format	Journal Article
Language	English
Published	American Chemical Society 04.08.2021
Subjects	Applications of Polymer, Composite, and Coating Materials cytoplasm cytotoxicity disease control electrostatic interactions endocytosis fruit quality hydrophobicity insects Myzus persicae nanocarriers organic production particle size polymers powdery mildew strawberries sustainable agriculture Tetranychus urticae enhanced bioactivity nanopesticide botanical pesticide drug delivery system sustainable agriculture
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ISSN	1944-8244 1944-8252 1944-8252
DOI	10.1021/acsami.1c09887

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Abstract	The application of botanical pesticides is a good choice in organic agriculture. However, most botanical pesticides have limitations of slow action and short persistence for pest and disease management, which constrain their further application. With the objective of exploring a green pesticide for controlling strawberry pests and diseases simultaneously, a star polymer (SPc) with a low production cost was synthesized as a pesticide nanocarrier through simple reactions. The SPc complexed with osthole quickly through electrostatic interaction and hydrophobic association, which decreased the particle size of osthole down to the nanoscale (17.66 nm). With the help of SPc, more nano-sized osthole was delivered into cytoplasm through endocytosis, leading to the enhanced cytotoxicity against insect cells. As a green botanical pesticide, the control efficacy of the osthole/SPc complex was improved against main strawberry pests (green peach aphid and two-spotted spider mite) and disease (powdery mildew), which fulfilled the need of both pest and disease management in sustainable production of strawberry. Meanwhile, the introduction of SPc not only improved plant-uptake but also decreased the residue of osthole due to the higher degradation rate. Furthermore, the application of the osthole/SPc complex exhibited no influence on the strawberry fruit quality and nontarget predators. To our knowledge, it is the first success to control plant pests and diseases simultaneously for sustainable agriculture by only one pesticidal formulation based on nanoparticle-delivered botanical pesticides.
AbstractList	The application of botanical pesticides is a good choice in organic agriculture. However, most botanical pesticides have limitations of slow action and short persistence for pest and disease management, which constrain their further application. With the objective of exploring a green pesticide for controlling strawberry pests and diseases simultaneously, a star polymer (SPc) with a low production cost was synthesized as a pesticide nanocarrier through simple reactions. The SPc complexed with osthole quickly through electrostatic interaction and hydrophobic association, which decreased the particle size of osthole down to the nanoscale (17.66 nm). With the help of SPc, more nano-sized osthole was delivered into cytoplasm through endocytosis, leading to the enhanced cytotoxicity against insect cells. As a green botanical pesticide, the control efficacy of the osthole/SPc complex was improved against main strawberry pests (green peach aphid and two-spotted spider mite) and disease (powdery mildew), which fulfilled the need of both pest and disease management in sustainable production of strawberry. Meanwhile, the introduction of SPc not only improved plant-uptake but also decreased the residue of osthole due to the higher degradation rate. Furthermore, the application of the osthole/SPc complex exhibited no influence on the strawberry fruit quality and nontarget predators. To our knowledge, it is the first success to control plant pests and diseases simultaneously for sustainable agriculture by only one pesticidal formulation based on nanoparticle-delivered botanical pesticides. The application of botanical pesticides is a good choice in organic agriculture. However, most botanical pesticides have limitations of slow action and short persistence for pest and disease management, which constrain their further application. With the objective of exploring a green pesticide for controlling strawberry pests and diseases simultaneously, a star polymer (SPc) with a low production cost was synthesized as a pesticide nanocarrier through simple reactions. The SPc complexed with osthole quickly through electrostatic interaction and hydrophobic association, which decreased the particle size of osthole down to the nanoscale (17.66 nm). With the help of SPc, more nano-sized osthole was delivered into cytoplasm through endocytosis, leading to the enhanced cytotoxicity against insect cells. As a green botanical pesticide, the control efficacy of the osthole/SPc complex was improved against main strawberry pests (green peach aphid and two-spotted spider mite) and disease (powdery mildew), which fulfilled the need of both pest and disease management in sustainable production of strawberry. Meanwhile, the introduction of SPc not only improved plant-uptake but also decreased the residue of osthole due to the higher degradation rate. Furthermore, the application of the osthole/SPc complex exhibited no influence on the strawberry fruit quality and nontarget predators. To our knowledge, it is the first success to control plant pests and diseases simultaneously for sustainable agriculture by only one pesticidal formulation based on nanoparticle-delivered botanical pesticides.The application of botanical pesticides is a good choice in organic agriculture. However, most botanical pesticides have limitations of slow action and short persistence for pest and disease management, which constrain their further application. With the objective of exploring a green pesticide for controlling strawberry pests and diseases simultaneously, a star polymer (SPc) with a low production cost was synthesized as a pesticide nanocarrier through simple reactions. The SPc complexed with osthole quickly through electrostatic interaction and hydrophobic association, which decreased the particle size of osthole down to the nanoscale (17.66 nm). With the help of SPc, more nano-sized osthole was delivered into cytoplasm through endocytosis, leading to the enhanced cytotoxicity against insect cells. As a green botanical pesticide, the control efficacy of the osthole/SPc complex was improved against main strawberry pests (green peach aphid and two-spotted spider mite) and disease (powdery mildew), which fulfilled the need of both pest and disease management in sustainable production of strawberry. Meanwhile, the introduction of SPc not only improved plant-uptake but also decreased the residue of osthole due to the higher degradation rate. Furthermore, the application of the osthole/SPc complex exhibited no influence on the strawberry fruit quality and nontarget predators. To our knowledge, it is the first success to control plant pests and diseases simultaneously for sustainable agriculture by only one pesticidal formulation based on nanoparticle-delivered botanical pesticides.
Author	Yan, Shuo Chen, Hongtao Wei, Jie Shen, Jie Du, Xiangge Yin, Meizhen Hu, Qian Jiang, Qinhong
AuthorAffiliation	Department of Plant Biosecurity and MOA Key Laboratory of Pest Monitoring and Green Management, College of Plant Protection State Key Laboratory of Chemical Resource Engineering, Beijing Lab of Biomedical Materials
AuthorAffiliation_xml	– name: State Key Laboratory of Chemical Resource Engineering, Beijing Lab of Biomedical Materials – name: Department of Plant Biosecurity and MOA Key Laboratory of Pest Monitoring and Green Management, College of Plant Protection
Author_xml	– sequence: 1 givenname: Shuo orcidid: 0000-0001-9685-9810 surname: Yan fullname: Yan, Shuo organization: Department of Plant Biosecurity and MOA Key Laboratory of Pest Monitoring and Green Management, College of Plant Protection – sequence: 2 givenname: Qian surname: Hu fullname: Hu, Qian organization: Department of Plant Biosecurity and MOA Key Laboratory of Pest Monitoring and Green Management, College of Plant Protection – sequence: 3 givenname: Qinhong surname: Jiang fullname: Jiang, Qinhong organization: Department of Plant Biosecurity and MOA Key Laboratory of Pest Monitoring and Green Management, College of Plant Protection – sequence: 4 givenname: Hongtao surname: Chen fullname: Chen, Hongtao organization: State Key Laboratory of Chemical Resource Engineering, Beijing Lab of Biomedical Materials – sequence: 5 givenname: Jie orcidid: 0000-0001-7935-1660 surname: Wei fullname: Wei, Jie organization: State Key Laboratory of Chemical Resource Engineering, Beijing Lab of Biomedical Materials – sequence: 6 givenname: Meizhen orcidid: 0000-0001-8519-8578 surname: Yin fullname: Yin, Meizhen organization: State Key Laboratory of Chemical Resource Engineering, Beijing Lab of Biomedical Materials – sequence: 7 givenname: Xiangge surname: Du fullname: Du, Xiangge email: duxge@cau.edu.cn organization: Department of Plant Biosecurity and MOA Key Laboratory of Pest Monitoring and Green Management, College of Plant Protection – sequence: 8 givenname: Jie surname: Shen fullname: Shen, Jie email: shenjie@cau.edu.cn organization: Department of Plant Biosecurity and MOA Key Laboratory of Pest Monitoring and Green Management, College of Plant Protection
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SubjectTerms	Applications of Polymer, Composite, and Coating Materials cytoplasm cytotoxicity disease control electrostatic interactions endocytosis fruit quality hydrophobicity insects Myzus persicae nanocarriers organic production particle size polymers powdery mildew strawberries sustainable agriculture Tetranychus urticae
Title	Simple Osthole/Nanocarrier Pesticide Efficiently Controls Both Pests and Diseases Fulfilling the Need of Green Production of Strawberry
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