「健康食品」の安全性・有効性情報の収載データ分析から示される健康食品と医薬品の併用における注目すべき有害事象
病者が健康食品を摂取している状況から，健康食品と医薬品の併用による有害事象の発生が懸念されている．そこで過去の有害事象を症状の重篤度と医薬品の薬効の視点で分析し，注目すべき事項を検討した．事例は，『健康食品』の安全性・有効性情報（HFNet）の収載論文64報，その中の患者71名を対象とした．その結果，症状としては肝障害，医薬品としては抗てんかん剤，抗悪性腫瘍剤，不整脈用剤，血液凝固阻止剤等のハイリスク薬が，健康食品と医薬品の相互作用において注目すべき事項であることが明らかとなった．また，論文中の健康食品の素材・成分に関する情報が曖昧で不十分な点が，相互作用の影響を検討する際の障害となることが示...
Saved in:
| Published in | Shokuhin eiseigaku zasshi Vol. 59; no. 2; pp. 80 - 88 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
公益社団法人 日本食品衛生学会
25.04.2018
日本食品衛生学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0015-6426 1882-1006 |
| DOI | 10.3358/shokueishi.59.80 |
Cover
| Abstract | 病者が健康食品を摂取している状況から，健康食品と医薬品の併用による有害事象の発生が懸念されている．そこで過去の有害事象を症状の重篤度と医薬品の薬効の視点で分析し，注目すべき事項を検討した．事例は，『健康食品』の安全性・有効性情報（HFNet）の収載論文64報，その中の患者71名を対象とした．その結果，症状としては肝障害，医薬品としては抗てんかん剤，抗悪性腫瘍剤，不整脈用剤，血液凝固阻止剤等のハイリスク薬が，健康食品と医薬品の相互作用において注目すべき事項であることが明らかとなった．また，論文中の健康食品の素材・成分に関する情報が曖昧で不十分な点が，相互作用の影響を検討する際の障害となることが示唆された． |
|---|---|
| AbstractList | 病者が健康食品を摂取している状況から，健康食品と医薬品の併用による有害事象の発生が懸念されている。そこで過去の有害事象を症状の重篤度と医薬品の薬効の視点で分析し，注目すべき事項を検討した。事例は，「健康食品」の安全性・有効性情報(HFNet)の収載論文64報，その中の患者71名を対象とした。その結果，症状としては肝障害，医薬品としては抗てんかん剤，抗悪性腫瘍剤，不整脈用剤，血液凝固阻止剤等のハイリスク薬が，健康食品と医薬品の相互作用において注目すべき事項であることが明らかとなった。また，論文中の健康食品の素材・成分に関する情報が曖昧で不十分な点が，相互作用の影響を検討する際の障害となることが示唆された。 病者が健康食品を摂取している状況から, 健康食品と医薬品の併用による有害事象の発生が懸念されている. そこで過去の有害事象を症状の重篤度と医薬品の薬効の視点で分析し, 注目すべき事項を検討した. 事例は, 『健康食品』の安全性・有効性情報(HFNet)の収載論文64報, その中の患者71名を対象とした. その結果, 症状としては肝障害, 医薬品としては抗てんかん剤, 抗悪性腫瘍剤, 不整脈用剤, 血液凝固阻止剤等のハイリスク薬が, 健康食品と医薬品の相互作用において注目すべき事項であることが明らかとなった. また, 論文中の健康食品の素材・成分に関する情報が曖昧で不十分な点が, 相互作用の影響を検討する際の障害となることが示唆された. 病者が健康食品を摂取している状況から，健康食品と医薬品の併用による有害事象の発生が懸念されている．そこで過去の有害事象を症状の重篤度と医薬品の薬効の視点で分析し，注目すべき事項を検討した．事例は，『健康食品』の安全性・有効性情報（HFNet）の収載論文64報，その中の患者71名を対象とした．その結果，症状としては肝障害，医薬品としては抗てんかん剤，抗悪性腫瘍剤，不整脈用剤，血液凝固阻止剤等のハイリスク薬が，健康食品と医薬品の相互作用において注目すべき事項であることが明らかとなった．また，論文中の健康食品の素材・成分に関する情報が曖昧で不十分な点が，相互作用の影響を検討する際の障害となることが示唆された． |
| Author | 千葉, 剛 梅垣, 敬三 小島, 彩子 佐藤, 陽子 |
| Author_xml | – sequence: 1 fullname: 佐藤, 陽子 organization: 国立研究開発法人医薬基盤・健康・栄養研究所 国立健康・栄養研究所 – sequence: 1 fullname: 千葉, 剛 organization: 国立研究開発法人医薬基盤・健康・栄養研究所 国立健康・栄養研究所 – sequence: 1 fullname: 梅垣, 敬三 organization: 昭和女子大学 食安全マネジメント学科 – sequence: 1 fullname: 小島, 彩子 organization: 国立研究開発法人医薬基盤・健康・栄養研究所 国立健康・栄養研究所 |
| BackLink | https://agriknowledge.affrc.go.jp/RN/2030922074$$DView record in AgriKnowledge |
| BookMark | eNpVUV1rE0EUHaSCsfbdP5F4d2c32XmUoFUo-GKfh9ndmWTT7W7ZTRHfMgmtpkmr4geI4rcYUBZKEWla8cdMdxP_hbNGER_uvQfOPefemXsRLUVxxBG6bEANY9u5krbjjW0epO2gZpOaA-dQxXAcs2oA1JdQBcCwq3XLrF9AK2kauABAGiY2zQp6p3rjXH7Mp99-vn-dP5aqt69klmfDfGdS9D6pwUnxcpjvHWtcDHbyN4cl--BgfjpUg3tqcKr6P_L7u8Wrh0qOVH84-zBV8qnqj1V_9J-tnOTjk_mzL79xdvb96-zJRMnPSu4p-Ug3F0eT2YtMyedKHiu5Xw7Njs6mo_nh20vovGBhylf-1GW0fv3a7eaN6tqt1ZvNq2tVhgnotwrTtXwPez64Rh1cuyGEANeyXW572CKM-RwEbxDictf0mcM8sy4wMXyBMXdsvIwaC18mRBJ0KWslwUYU3wm53-I0ZgEtCY-2YtrZomBQAP3HxAKtXF0oN7kfeCyMozCIOO3E20mkN6Y8tkUc-21qguFoma331aUMB8pEsAb6HtqpuXDqpF2mp24lwSZL7lKWdAMv5PTfoalNqFkm7fCX9dosoR2GfwGX2uB6 |
| ContentType | Journal Article |
| Copyright | 2018 公益社団法人 日本食品衛生学会 |
| Copyright_xml | – notice: 2018 公益社団法人 日本食品衛生学会 |
| CorporateAuthor | 昭和女子大学 食安全マネジメント学科 国立研究開発法人医薬基盤・健康・栄養研究所 国立健康・栄養研究所 |
| CorporateAuthor_xml | – name: 昭和女子大学 食安全マネジメント学科 – name: 国立研究開発法人医薬基盤・健康・栄養研究所 国立健康・栄養研究所 |
| DBID | N5S |
| DOI | 10.3358/shokueishi.59.80 |
| DatabaseName | AgriKnowledge Free |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Public Health |
| EISSN | 1882-1006 |
| EndPage | 88 |
| ExternalDocumentID | oai_affrc_go_jp_01_00882940 eo5foodh_2018_005902_002_0080_00893080322 article_shokueishi_59_2_59_80_article_char_ja |
| GroupedDBID | .LE 5GY AENEX ALMA_UNASSIGNED_HOLDINGS CS3 DIK DU5 F5P KQ8 MOJWN OK1 RJT 2WC N5S |
| ID | FETCH-LOGICAL-a3902-1f2b4dc3cd0b160b57fff0b45be5c349aade0fe799beb2da8ac26f391df33e853 |
| ISSN | 0015-6426 |
| IngestDate | Fri Sep 19 12:21:38 EDT 2025 Thu Jul 10 16:14:47 EDT 2025 Wed Sep 03 06:28:51 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-a3902-1f2b4dc3cd0b160b57fff0b45be5c349aade0fe799beb2da8ac26f391df33e853 |
| Notes | 922074 ZZ00009680 |
| OpenAccessLink | https://agriknowledge.affrc.go.jp/RN/2030922074 |
| PageCount | 9 |
| ParticipantIDs | affrit_agriknowledge_oai_affrc_go_jp_01_00882940 medicalonline_journals_eo5foodh_2018_005902_002_0080_00893080322 jstage_primary_article_shokueishi_59_2_59_80_article_char_ja |
| PublicationCentury | 2000 |
| PublicationDate | 20180425 |
| PublicationDateYYYYMMDD | 2018-04-25 |
| PublicationDate_xml | – month: 04 year: 2018 text: 20180425 day: 25 |
| PublicationDecade | 2010 |
| PublicationTitle | Shokuhin eiseigaku zasshi |
| PublicationTitleAlternate | 食品衛生学雑誌 |
| PublicationYear | 2018 |
| Publisher | 公益社団法人 日本食品衛生学会 日本食品衛生学会 |
| Publisher_xml | – name: 公益社団法人 日本食品衛生学会 – name: 日本食品衛生学会 |
| References | 32) Leitolf, H., Dixit, K. C., Higham, C. E., Brabant, G. Licorice- or more? Exp. Clin. Endocrinol. Diabetes, 118, 250–253 （2010）. 20) Bilgi, N., Bell, K., Ananthakrishnan, A. N., Atallah, E. Imatinib and Panax ginseng: a potential interaction resulting in liver toxicity. Ann, Pharmacother., 44, 926–928 （2010）. 29) Kijima, M., Honda, H., Hayakawa, T., Suzuki, T., Matuda, K., Shimooka, Y. A case of complete atrioventricular block induced by doxifluridine and dietary supplement. Shinzo, 43, 1096–1101 （2011）. 19) Bossaer, J. B., Odle, B. L. Probable etoposide interaction with Echinacea. J. Diet. Suppl., 9, 90–95 （2012）. 23) Tam, L. S., Chan, T. Y., Leung, W. K., Critchley, J. A. Warfarin interactions with Chinese traditional medicines: danshen and methyl salicylate medicated oil. Aust. NZ J. Med., 25, 258 （1995）. 15) Kang, Y. C., Chen, M. H., Lai, S. L. Potentially unsafe herb-drug interactions between a commercial product of noni juice and phenytoin—A case report. Acta Neurol. Taiwan, 24, 43–46 （2015）. 28) Mukai, H., Watanabe, T., Ando, M., Katsumata, N. An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients. Jpn. J. Clin. Oncol., 36, 808–810 （2006）. 30) Machado, M. C., Rizvi, A. A. The “calcium supplement syndrome”: modern-day reemergence of a bygone disorder. JSC Med. Assoc., 109, 88–91 （2013）. 41) Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum （Lingzhi） mushroom powder. J. Med. Assoc. Thai, 90, 179–181 （2007）. 27) Sobieraj, D. M., Freyer, C. W. Probable hypoglycemic adverse drug reaction associated with prickly pear cactus, glipizide, and metformin in a patient with type 2 diabetes mellitus. Ann. Pharmacother., 44, 1334–1337 （2010）. 8) Levy, I., Attias, S., Ben-Arye, E., Goldstein, L., Schiff, E. Adverse events associated with interactions with dietary and herbal supplements among inpatients. Br. J. Clin. Pharmacol., 83, 836–845 （2017）. 17) Myers, A. P., Watson, T. A., Strock, S. B. Drug reaction with eosinophilia and systemic symptoms syndrome probably induced by a lamotrigine–ginseng drug interaction. Pharmacotherapy, 35, e9–e12 （2015）. 12) Takikawa, H., Sakisaka, S., Aiso, M., Ayada, M., Hisamochi, A., Murata, Y., Tsuji, K., Yasuda, H., Deguchi, A. Recent status of drug-induced liver injury: an analysis of 366 cases between 2002 and 2006. Kanzo, 48, 517–521 （2007）. 36) Stadlbauer, V., Weiss, S., Payer, F., Stauber, R. E. Herbal does not at all mean innocuous: the sixth case of hepatotoxicity associated with morinda citrifolia （noni）. Am. J. Gastroenterol., 103, 2406–2407 （2008）. 13) Striano, P., Zara, F., Minetti, C., Striano, S. Chitosan may decrease serum valproate and increase the risk of seizure reappearance. BMJ, 339, b3751 （2009）. 37) Prichard, M., Turner, K. J. Acute hypersensitivity to ingested processed pollen. Aust. NZ J. Med., 15, 346–347 （1985）. 4) Wada, A., Aoki, K., Sasase, N., Doi, K., Muramoto, Y., Kim, K. I., Akamatsu, M., Hyodo, I., Yagi, K., Hirai, M. Investigation of healthfoods used among hospital inpatients and related information provided by pharmacies and websites. Iryo Yakugaku （Japanese Journal of Pharmaceutical Health Care and Sciences）, 29, 237–246 （2003）. 7) Adachi, M., Takane, H., Shinozuka, K., Moriki, K., Ogawa, K., Kaneda, T., Shiinoki, Y., Shimada, M. Analysis of pharmaceutical interventions administered to inpatients who were taking dietary supplements and establishment of a management algorithm. Iryo Yakugaku （Japanese Journal of Pharmaceutical Health Care and Sciences）, 42, 217–227 （2016）. 31) Farese, R. V., Jr., Biglieri, E. G., Shackleton, C. H., Irony, I., Gomez-Fontes, R. Licorice-induced hypermineralocorticoidism. N. Engl. J. Med., 325, 1223–1227 （1991）. 40) Sinisalo, M., Enkovaara, A. L., Kivisto, K. T. Possible hepatotoxic effect of rooibos tea: a case report. Eur. J. Clin. Pharmacol., 66, 427–428 （2010）. 2) Chiba, T., Sato, Y., Suzuki, S., Umegaki, K. Concomitant use of dietary supplements and medicines in patients due to miscommunication with physicians in Japan. Nutrients, 7, 2947–2960 （2015）. 16) Mrzljak, A., Kosuta, I., Skrtic, A., Kanizaj, T. F., Vrhovac, R. Drug-induced liver injury associated with noni （Morinda citrifolia） juice and phenobarbital. Case Rep. Gastroenterol., 7, 19–24 （2013）. 24) Matsui, K., Goso, Y., Nakagawa, K., Hirai, T., Kameyama, T., Nozawa, T., Asanoi, H., Inoue, H. A case of mitral stenosis complicated with embolism of femoral artery induced with an adverse effect of dietary supplementation on warfarin. Shinzo, 33, 525–528 （2001）. 1) Chiba, T., Sato, Y., Nakanishi, T., Yokotani, K., Suzuki, S., Umegaki, K. Inappropriate usage of dietary supplements in patients by miscommunication with physicians in Japan. Nutrients, 6, 5392–5404 （2014）. 11) Onji, M., Takikawa, H., Murata, Y., Kojima, Y., Hashimoto, N., Hisamochi, A., Sumida, T., Omori, S., Murata, H., Watanabe, M., Taniguchi, H., Maeda, N., Kumaji, T., Kang, J.-H., Ito, T., Aono, R., Ayada, M. Surveillance of folk medicine-induced hepatitis. Kanzo, 46, 142–148 （2005）. 34) Iwasa, M., Yamamoto, M., Tanaka, Y., Kaito, M., Adachi, Y. Spirulina-associated hepatotoxicity. Am. J. Gastroenterol., 97, 3212–3213 （2002）. 18) Baretta, Z., Ghiotto, C., Marino, D., Jirillo, A. Aloe-induced hypokalemia in a patient with breast cancer during chemotherapy. Ann. Oncol., 20, 1445–1446 （2009）. 21) Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern. Med., 47, 467–469 （2008）. 25) Van Strater, A. C., Bogers, J. P. Interaction of St John's wort （Hypericum perforatum） with clozapine. Int. Clin. Psychopharmacol., 27, 121–124 （2012）. 39) Tamura, S., Warabi, Y., Matsubara, S. Severe liver dysfunction possibly caused by the combination of interferon beta-1b therapy and melilot （sweet clover） supplement. J. Clin. Pharm. Ther., 37, 724–725 （2012）. 6) Alsanad, S. M., Howard, R. L., Williamson, E. M. An assessment of the impact of herb–drug combinations used by cancer patients. BMC Complement Altern Med., 16, 393 （2016）. 38) Lowe, H., Cusano, N. E., Binkley, N., Blaner, W. S., Bilezikian, J. P. Vitamin D toxicity due to a commonly available “over the counter” remedy from the Dominican Republic. J. Clin. Endocrinol. Metab., 96, 291–295 （2011）. 14) Kupiec, T., Raj, V. Fatal seizures due to potential herb-drug interactions with Ginkgo biloba. J. Anal. Toxicol., 29, 755–758 （2005）. 35) Sadarmin, P. P., Timperley, J. An unusual case of Butcher's Broom precipitating diabetic ketoacidosis. J. Emerg. Med., 45, e63–e65 （2013）. 22) Suvarna, R., Pirmohamed, M., Henderson, L. Possible interaction between warfarin and cranberry juice. Bmj, 327, 1454 （2003）. 3) Kokuryo, T., Yamamoto, Y., Nakata, M., Haraguchi, H., Yamakawa, M. A Survey of the Intake of Supplements and the Risk Assessment of the Interaction between Medicines and Supplements in Hospitalized Patients. Journal of Japanese Society of Hospital Pharmacists, 52, 418–422 （2016）. 10) Takigawa, H. Diagnosis and Treatment of drug-induced liver injury. The Journal of the Japanese Sciety of Internal Medicine, 104, 991–997 （2015）. 33) Hilepo, J. N., Bellucci, A. G., Mossey, R. T. Acute renal failure caused by ‘cat's claw’ herbal remedy in a patient with systemic lupus erythematosus. Nephron, 77, 361 （1997）. 9) Will-Shahab, L., Bauer, S., Kunter, U., Roots, I., Brattstrom, A. St John's wort extract （Ze 117） does not alter the pharmacokinetics of a low-dose oral contraceptive. Eur. J. Clin. Pharmacol., 65, 287–294 （2009）. 26) Miyamoto, K., Kawai, H., Aoyama, R., Watanabe, H., Suzuki, K., Suga, N., Kitagawa, W., Miura, N., Nishikawa, K., Imai, H. Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licorice. Clin. Exp. Nephrol., 14, 164–167 （2010）. 5) Peng, C. C., Glassman, P. A., Trilli, L. E., Hayes-Hunter, J., Good, C. B. Incidence and severity of potential drug-dietary supplement interactions in primary care patients: an exploratory study of 2 outpatient practices. Arch. Intern. Med., 164, 630–636 （2004）. |
| References_xml | – reference: 19) Bossaer, J. B., Odle, B. L. Probable etoposide interaction with Echinacea. J. Diet. Suppl., 9, 90–95 （2012）. – reference: 39) Tamura, S., Warabi, Y., Matsubara, S. Severe liver dysfunction possibly caused by the combination of interferon beta-1b therapy and melilot （sweet clover） supplement. J. Clin. Pharm. Ther., 37, 724–725 （2012）. – reference: 15) Kang, Y. C., Chen, M. H., Lai, S. L. Potentially unsafe herb-drug interactions between a commercial product of noni juice and phenytoin—A case report. Acta Neurol. Taiwan, 24, 43–46 （2015）. – reference: 34) Iwasa, M., Yamamoto, M., Tanaka, Y., Kaito, M., Adachi, Y. Spirulina-associated hepatotoxicity. Am. J. Gastroenterol., 97, 3212–3213 （2002）. – reference: 41) Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum （Lingzhi） mushroom powder. J. Med. Assoc. Thai, 90, 179–181 （2007）. – reference: 2) Chiba, T., Sato, Y., Suzuki, S., Umegaki, K. Concomitant use of dietary supplements and medicines in patients due to miscommunication with physicians in Japan. Nutrients, 7, 2947–2960 （2015）. – reference: 26) Miyamoto, K., Kawai, H., Aoyama, R., Watanabe, H., Suzuki, K., Suga, N., Kitagawa, W., Miura, N., Nishikawa, K., Imai, H. Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licorice. Clin. Exp. Nephrol., 14, 164–167 （2010）. – reference: 29) Kijima, M., Honda, H., Hayakawa, T., Suzuki, T., Matuda, K., Shimooka, Y. A case of complete atrioventricular block induced by doxifluridine and dietary supplement. Shinzo, 43, 1096–1101 （2011）. – reference: 1) Chiba, T., Sato, Y., Nakanishi, T., Yokotani, K., Suzuki, S., Umegaki, K. Inappropriate usage of dietary supplements in patients by miscommunication with physicians in Japan. Nutrients, 6, 5392–5404 （2014）. – reference: 7) Adachi, M., Takane, H., Shinozuka, K., Moriki, K., Ogawa, K., Kaneda, T., Shiinoki, Y., Shimada, M. Analysis of pharmaceutical interventions administered to inpatients who were taking dietary supplements and establishment of a management algorithm. Iryo Yakugaku （Japanese Journal of Pharmaceutical Health Care and Sciences）, 42, 217–227 （2016）. – reference: 16) Mrzljak, A., Kosuta, I., Skrtic, A., Kanizaj, T. F., Vrhovac, R. Drug-induced liver injury associated with noni （Morinda citrifolia） juice and phenobarbital. Case Rep. Gastroenterol., 7, 19–24 （2013）. – reference: 38) Lowe, H., Cusano, N. E., Binkley, N., Blaner, W. S., Bilezikian, J. P. Vitamin D toxicity due to a commonly available “over the counter” remedy from the Dominican Republic. J. Clin. Endocrinol. Metab., 96, 291–295 （2011）. – reference: 6) Alsanad, S. M., Howard, R. L., Williamson, E. M. An assessment of the impact of herb–drug combinations used by cancer patients. BMC Complement Altern Med., 16, 393 （2016）. – reference: 13) Striano, P., Zara, F., Minetti, C., Striano, S. Chitosan may decrease serum valproate and increase the risk of seizure reappearance. BMJ, 339, b3751 （2009）. – reference: 9) Will-Shahab, L., Bauer, S., Kunter, U., Roots, I., Brattstrom, A. St John's wort extract （Ze 117） does not alter the pharmacokinetics of a low-dose oral contraceptive. Eur. J. Clin. Pharmacol., 65, 287–294 （2009）. – reference: 32) Leitolf, H., Dixit, K. C., Higham, C. E., Brabant, G. Licorice- or more? Exp. Clin. Endocrinol. Diabetes, 118, 250–253 （2010）. – reference: 31) Farese, R. V., Jr., Biglieri, E. G., Shackleton, C. H., Irony, I., Gomez-Fontes, R. Licorice-induced hypermineralocorticoidism. N. Engl. J. Med., 325, 1223–1227 （1991）. – reference: 24) Matsui, K., Goso, Y., Nakagawa, K., Hirai, T., Kameyama, T., Nozawa, T., Asanoi, H., Inoue, H. A case of mitral stenosis complicated with embolism of femoral artery induced with an adverse effect of dietary supplementation on warfarin. Shinzo, 33, 525–528 （2001）. – reference: 4) Wada, A., Aoki, K., Sasase, N., Doi, K., Muramoto, Y., Kim, K. I., Akamatsu, M., Hyodo, I., Yagi, K., Hirai, M. Investigation of healthfoods used among hospital inpatients and related information provided by pharmacies and websites. Iryo Yakugaku （Japanese Journal of Pharmaceutical Health Care and Sciences）, 29, 237–246 （2003）. – reference: 30) Machado, M. C., Rizvi, A. A. The “calcium supplement syndrome”: modern-day reemergence of a bygone disorder. JSC Med. Assoc., 109, 88–91 （2013）. – reference: 33) Hilepo, J. N., Bellucci, A. G., Mossey, R. T. Acute renal failure caused by ‘cat's claw’ herbal remedy in a patient with systemic lupus erythematosus. Nephron, 77, 361 （1997）. – reference: 22) Suvarna, R., Pirmohamed, M., Henderson, L. Possible interaction between warfarin and cranberry juice. Bmj, 327, 1454 （2003）. – reference: 20) Bilgi, N., Bell, K., Ananthakrishnan, A. N., Atallah, E. Imatinib and Panax ginseng: a potential interaction resulting in liver toxicity. Ann, Pharmacother., 44, 926–928 （2010）. – reference: 3) Kokuryo, T., Yamamoto, Y., Nakata, M., Haraguchi, H., Yamakawa, M. A Survey of the Intake of Supplements and the Risk Assessment of the Interaction between Medicines and Supplements in Hospitalized Patients. Journal of Japanese Society of Hospital Pharmacists, 52, 418–422 （2016）. – reference: 14) Kupiec, T., Raj, V. Fatal seizures due to potential herb-drug interactions with Ginkgo biloba. J. Anal. Toxicol., 29, 755–758 （2005）. – reference: 28) Mukai, H., Watanabe, T., Ando, M., Katsumata, N. An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients. Jpn. J. Clin. Oncol., 36, 808–810 （2006）. – reference: 11) Onji, M., Takikawa, H., Murata, Y., Kojima, Y., Hashimoto, N., Hisamochi, A., Sumida, T., Omori, S., Murata, H., Watanabe, M., Taniguchi, H., Maeda, N., Kumaji, T., Kang, J.-H., Ito, T., Aono, R., Ayada, M. Surveillance of folk medicine-induced hepatitis. Kanzo, 46, 142–148 （2005）. – reference: 10) Takigawa, H. Diagnosis and Treatment of drug-induced liver injury. The Journal of the Japanese Sciety of Internal Medicine, 104, 991–997 （2015）. – reference: 27) Sobieraj, D. M., Freyer, C. W. Probable hypoglycemic adverse drug reaction associated with prickly pear cactus, glipizide, and metformin in a patient with type 2 diabetes mellitus. Ann. Pharmacother., 44, 1334–1337 （2010）. – reference: 36) Stadlbauer, V., Weiss, S., Payer, F., Stauber, R. E. Herbal does not at all mean innocuous: the sixth case of hepatotoxicity associated with morinda citrifolia （noni）. Am. J. Gastroenterol., 103, 2406–2407 （2008）. – reference: 5) Peng, C. C., Glassman, P. A., Trilli, L. E., Hayes-Hunter, J., Good, C. B. Incidence and severity of potential drug-dietary supplement interactions in primary care patients: an exploratory study of 2 outpatient practices. Arch. Intern. Med., 164, 630–636 （2004）. – reference: 21) Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern. Med., 47, 467–469 （2008）. – reference: 40) Sinisalo, M., Enkovaara, A. L., Kivisto, K. T. Possible hepatotoxic effect of rooibos tea: a case report. Eur. J. Clin. Pharmacol., 66, 427–428 （2010）. – reference: 18) Baretta, Z., Ghiotto, C., Marino, D., Jirillo, A. Aloe-induced hypokalemia in a patient with breast cancer during chemotherapy. Ann. Oncol., 20, 1445–1446 （2009）. – reference: 12) Takikawa, H., Sakisaka, S., Aiso, M., Ayada, M., Hisamochi, A., Murata, Y., Tsuji, K., Yasuda, H., Deguchi, A. Recent status of drug-induced liver injury: an analysis of 366 cases between 2002 and 2006. Kanzo, 48, 517–521 （2007）. – reference: 17) Myers, A. P., Watson, T. A., Strock, S. B. Drug reaction with eosinophilia and systemic symptoms syndrome probably induced by a lamotrigine–ginseng drug interaction. Pharmacotherapy, 35, e9–e12 （2015）. – reference: 8) Levy, I., Attias, S., Ben-Arye, E., Goldstein, L., Schiff, E. Adverse events associated with interactions with dietary and herbal supplements among inpatients. Br. J. Clin. Pharmacol., 83, 836–845 （2017）. – reference: 23) Tam, L. S., Chan, T. Y., Leung, W. K., Critchley, J. A. Warfarin interactions with Chinese traditional medicines: danshen and methyl salicylate medicated oil. Aust. NZ J. Med., 25, 258 （1995）. – reference: 25) Van Strater, A. C., Bogers, J. P. Interaction of St John's wort （Hypericum perforatum） with clozapine. Int. Clin. Psychopharmacol., 27, 121–124 （2012）. – reference: 37) Prichard, M., Turner, K. J. Acute hypersensitivity to ingested processed pollen. Aust. NZ J. Med., 15, 346–347 （1985）. – reference: 35) Sadarmin, P. P., Timperley, J. An unusual case of Butcher's Broom precipitating diabetic ketoacidosis. J. Emerg. Med., 45, e63–e65 （2013）. |
| SSID | ssib000972322 ssib031740856 ssib038076159 ssib020472796 ssib002484602 ssj0060308 |
| Score | 2.2074122 |
| Snippet | 病者が健康食品を摂取している状況から，健康食品と医薬品の併用による有害事象の発生が懸念されている．そこで過去の有害事象を症状の重篤度と医薬品の薬効の視点で分... 病者が健康食品を摂取している状況から, 健康食品と医薬品の併用による有害事象の発生が懸念されている. そこで過去の有害事象を症状の重篤度と医薬品の薬効の視点で分... 病者が健康食品を摂取している状況から，健康食品と医薬品の併用による有害事象の発生が懸念されている。そこで過去の有害事象を症状の重篤度と医薬品の薬効の視点で分... |
| SourceID | affrit medicalonline jstage |
| SourceType | Open Access Repository Publisher |
| StartPage | 80 |
| SubjectTerms | ハイリスク医薬品 健康食品 有害事象 相互作用 |
| Title | 「健康食品」の安全性・有効性情報の収載データ分析から示される健康食品と医薬品の併用における注目すべき有害事象 |
| URI | https://www.jstage.jst.go.jp/article/shokueishi/59/2/59_80/_article/-char/ja http://mol.medicalonline.jp/en/journal/download?GoodsID=eo5foodh/2018/005902/002&name=0080-0089j https://agriknowledge.affrc.go.jp/RN/2030922074 |
| Volume | 59 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | 食品衛生学雑誌, 2018/04/25, Vol.59(2), pp.80-88 |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1882-1006 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0060308 issn: 0015-6426 databaseCode: KQ8 dateStart: 19600101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1882-1006 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0060308 issn: 0015-6426 databaseCode: DIK dateStart: 19600101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9RGELdC-lIJIShFhALKQ_epurD-WN-u1AfsO0e0VftSkHizbJ-dXBAcyscLT3EiPkISPkRbqWoFFFo1UquTEEKIAOKPWXwJ_wUzu747h6AK-hBnzvvb2dkZr3dm7R0bxpetLE0wsVMNnAer5rTiqMZdG6KUhNcFjBCLWbjB-fsf3FNnnG_PsrMjo0HlraWF-XgiufTefSX_x6pwDuyKu2Q_wrIDpnACaLAvHMHCcPwgG5PAxjcVeIMEDFxC4jEkfI_4dRII4tlETOIZYWNpCW4qAsABFsGRC1UdaE4CFzFeXWFs4vt4RjT6GOAsKhgXMVw16lHimzs480nCgeDE19UVQz7g3FCERXwlIeeEu6qtgAha8uF-icHqdeI52DVdJFi_qM8HwR-oBFP1lGFd7CAnwiVeYxcGhIcWm8Rn2LpwVC1d5PclHMhjVsRwiW8rMNTyFR-NESXh9wm0RUW9gISKgeomV4KBSj2zGj_8ON05tzCNaV7ac2l7Kjq38NUlCH-m2_2Bo_pOUflIgJ5dHETqR5N4upkmEXSIV31EnYMelJIVXqC4ULAbz1BssCDiTZS85A-U8IcwUKlVXhtgU7CCgrloOdQ1tAomF9VFJ5Pj8zO9Qb0_kZqsBqGrW51Iy9Tu7cp6hp4V9be6-v4Vf9_MbdsMd6PMoRZTXH2dYDDc6dBL2ZkPPctmk3CqE85cDKkZUowThUP3GJ9YddfFD5k0v_muEkXU4UY08OItTJBayTIJHjSm-Rv-5ri2h16-duhcTOmkHTrdZ_22A0p84l15wY9F2doYpc5AeId5O_ae149cdeqbivd6er-xrww7xz19DzlgjMxEnxl79Zr9uN6KeNB4IBfXivyvYvPpm4f3iju5XFyXebforhSXN3qLf8vl573fV4rrz4DuLV8u7j_C0ps3tl-syOWrcvmFXHpVXLvSu3tL5qtyaWXrz02Z_yyX1uTS6g62-Uax9nz7l38V3X398snWTxsy_0fm12V-G8C9xxtbv3Vl_qvMn8l8HRvtPn69ubr96I_PjTOTwenGqVr5DZdaZAv8blJmxU4rsZMWjU2XxqyeZRmNHRanLLEdEUWtlGZpXYg4ja1WxKPEcjNbmK3MtlOIJQ4Zoxc6F9LDxji1EqhlOilY2mE8jSA0ix2TU-6amaDxmEG17sNoanb4SCL8jwtmzPhaWym8qHP7hOW9PBwaNmQitPDA6aAUd8SGM9GYcXKHbcNybpgL0w7LOp3WdIiDJ9RJsuAf_ql8zBAlAgEX5ZGPF_oL49PhkDxqjM7PLqTHIDKaj4-r6_4tnJZE9w |
| linkProvider | Flying Publisher |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E3%80%8C%E5%81%A5%E5%BA%B7%E9%A3%9F%E5%93%81%E3%80%8D%E3%81%AE%E5%AE%89%E5%85%A8%E6%80%A7%E3%83%BB%E6%9C%89%E5%8A%B9%E6%80%A7%E6%83%85%E5%A0%B1%E3%81%AE%E5%8F%8E%E8%BC%89%E3%83%87%E3%83%BC%E3%82%BF%E5%88%86%E6%9E%90%E3%81%8B%E3%82%89%E7%A4%BA%E3%81%95%E3%82%8C%E3%82%8B%E5%81%A5%E5%BA%B7%E9%A3%9F%E5%93%81%E3%81%A8%E5%8C%BB%E8%96%AC%E5%93%81%E3%81%AE%E4%BD%B5%E7%94%A8%E3%81%AB%E3%81%8A%E3%81%91%E3%82%8B%E6%B3%A8%E7%9B%AE%E3%81%99%E3%81%B9%E3%81%8D%E6%9C%89%E5%AE%B3%E4%BA%8B%E8%B1%A1&rft.jtitle=Shokuhin+eiseigaku+zasshi&rft.au=%E5%B0%8F%E5%B3%B6%2C+%E5%BD%A9%E5%AD%90&rft.au=%E4%BD%90%E8%97%A4%2C+%E9%99%BD%E5%AD%90&rft.au=%E5%8D%83%E8%91%89%2C+%E5%89%9B&rft.au=%E6%A2%85%E5%9E%A3%2C+%E6%95%AC%E4%B8%89&rft.date=2018-04-25&rft.issn=0015-6426&rft.volume=59&rft.issue=2&rft.spage=80&rft.epage=88&rft_id=info:doi/10.3358%2Fshokueishi.59.80&rft.externalDocID=oai_affrc_go_jp_01_00882940 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0015-6426&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0015-6426&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0015-6426&client=summon |