Synergistic Role of the AuAg-Fe3O4 Nanoenzyme for Ultrasensitive Immunoassay of Dengue Virus

A combination of magnetic and noble metal nanoparticles (NPs) has recently emerged as a potential substance for rapid and sensitive immunosorbent assays. However, to make the assay an alternative method for Enzyme-linked immunosorbent assay, the individual role of each nanoparticle must be explored...

Full description

Saved in:
Bibliographic Details
Published inACS omega Vol. 9; no. 38; pp. 40051 - 40060
Main Authors Dasgupta, Uddipan, Ghosh, Malabika, Gangopadhyay, Rupali, Anh, Nguyen Thi Ngoc, Doong, Ruey-An, Sadhukhan, Provash Chandra, Dutta Chowdhury, Ankan
Format Journal Article
LanguageEnglish
Published American Chemical Society 24.09.2024
Online AccessGet full text
ISSN2470-1343
2470-1343
DOI10.1021/acsomega.4c05937

Cover

Abstract A combination of magnetic and noble metal nanoparticles (NPs) has recently emerged as a potential substance for rapid and sensitive immunosorbent assays. However, to make the assay an alternative method for Enzyme-linked immunosorbent assay, the individual role of each nanoparticle must be explored properly. In this work, an immunoassay has been proposed using two antibody-conjugated iron oxide nanoparticles (Fe3O4NPs) and gold–silver bimetallic nanoparticles (AuAgNPs) to enhance the sensitivity of virus detection by colorimetric TMB/H2O2 signal amplification. A synergistic effect is monitored between Fe3O4NPs and AuAgNPs, which is explored for colorimetric virus detection. The sensor exploits the synergistic effect between the nanoparticles to successfully detect a wide range of dengue virus-like particle (DENV-LP) concentrations ranging from 10 to 100 pg/mL with a detection limit of up to 2.6 fg/mL. In the presence of a target DENV-LP, a sandwich-like structure is formed, which restricts the electron transfer and the associated synergistic effect between the nanoparticles, restricting the TMB oxidation process. Therefore, the synergistic effect is the key to the present work, which accounts for the enhanced rate of the enzymatic reaction on TMB and makes the current method of virus detection more sensitive and reliable compared to the others.
AbstractList A combination of magnetic and noble metal nanoparticles (NPs) has recently emerged as a potential substance for rapid and sensitive immunosorbent assays. However, to make the assay an alternative method for Enzyme-linked immunosorbent assay, the individual role of each nanoparticle must be explored properly. In this work, an immunoassay has been proposed using two antibody-conjugated iron oxide nanoparticles (Fe3O4NPs) and gold–silver bimetallic nanoparticles (AuAgNPs) to enhance the sensitivity of virus detection by colorimetric TMB/H2O2 signal amplification. A synergistic effect is monitored between Fe3O4NPs and AuAgNPs, which is explored for colorimetric virus detection. The sensor exploits the synergistic effect between the nanoparticles to successfully detect a wide range of dengue virus-like particle (DENV-LP) concentrations ranging from 10 to 100 pg/mL with a detection limit of up to 2.6 fg/mL. In the presence of a target DENV-LP, a sandwich-like structure is formed, which restricts the electron transfer and the associated synergistic effect between the nanoparticles, restricting the TMB oxidation process. Therefore, the synergistic effect is the key to the present work, which accounts for the enhanced rate of the enzymatic reaction on TMB and makes the current method of virus detection more sensitive and reliable compared to the others.
A combination of magnetic and noble metal nanoparticles (NPs) has recently emerged as a potential substance for rapid and sensitive immunosorbent assays. However, to make the assay an alternative method for Enzyme-linked immunosorbent assay, the individual role of each nanoparticle must be explored properly. In this work, an immunoassay has been proposed using two antibody-conjugated iron oxide nanoparticles (Fe3O4NPs) and gold–silver bimetallic nanoparticles (AuAgNPs) to enhance the sensitivity of virus detection by colorimetric TMB/H2O2 signal amplification. A synergistic effect is monitored between Fe3O4NPs and AuAgNPs, which is explored for colorimetric virus detection. The sensor exploits the synergistic effect between the nanoparticles to successfully detect a wide range of dengue virus-like particle (DENV-LP) concentrations ranging from 10 to 100 pg/mL with a detection limit of up to 2.6 fg/mL. In the presence of a target DENV-LP, a sandwich-like structure is formed, which restricts the electron transfer and the associated synergistic effect between the nanoparticles, restricting the TMB oxidation process. Therefore, the synergistic effect is the key to the present work, which accounts for the enhanced rate of the enzymatic reaction on TMB and makes the current method of virus detection more sensitive and reliable compared to the others.
A combination of magnetic and noble metal nanoparticles (NPs) has recently emerged as a potential substance for rapid and sensitive immunosorbent assays. However, to make the assay an alternative method for Enzyme-linked immunosorbent assay, the individual role of each nanoparticle must be explored properly. In this work, an immunoassay has been proposed using two antibody-conjugated iron oxide nanoparticles (Fe3O4NPs) and gold-silver bimetallic nanoparticles (AuAgNPs) to enhance the sensitivity of virus detection by colorimetric TMB/H2O2 signal amplification. A synergistic effect is monitored between Fe3O4NPs and AuAgNPs, which is explored for colorimetric virus detection. The sensor exploits the synergistic effect between the nanoparticles to successfully detect a wide range of dengue virus-like particle (DENV-LP) concentrations ranging from 10 to 100 pg/mL with a detection limit of up to 2.6 fg/mL. In the presence of a target DENV-LP, a sandwich-like structure is formed, which restricts the electron transfer and the associated synergistic effect between the nanoparticles, restricting the TMB oxidation process. Therefore, the synergistic effect is the key to the present work, which accounts for the enhanced rate of the enzymatic reaction on TMB and makes the current method of virus detection more sensitive and reliable compared to the others.A combination of magnetic and noble metal nanoparticles (NPs) has recently emerged as a potential substance for rapid and sensitive immunosorbent assays. However, to make the assay an alternative method for Enzyme-linked immunosorbent assay, the individual role of each nanoparticle must be explored properly. In this work, an immunoassay has been proposed using two antibody-conjugated iron oxide nanoparticles (Fe3O4NPs) and gold-silver bimetallic nanoparticles (AuAgNPs) to enhance the sensitivity of virus detection by colorimetric TMB/H2O2 signal amplification. A synergistic effect is monitored between Fe3O4NPs and AuAgNPs, which is explored for colorimetric virus detection. The sensor exploits the synergistic effect between the nanoparticles to successfully detect a wide range of dengue virus-like particle (DENV-LP) concentrations ranging from 10 to 100 pg/mL with a detection limit of up to 2.6 fg/mL. In the presence of a target DENV-LP, a sandwich-like structure is formed, which restricts the electron transfer and the associated synergistic effect between the nanoparticles, restricting the TMB oxidation process. Therefore, the synergistic effect is the key to the present work, which accounts for the enhanced rate of the enzymatic reaction on TMB and makes the current method of virus detection more sensitive and reliable compared to the others.
Author Ghosh, Malabika
Doong, Ruey-An
Anh, Nguyen Thi Ngoc
Gangopadhyay, Rupali
Dutta Chowdhury, Ankan
Dasgupta, Uddipan
Sadhukhan, Provash Chandra
AuthorAffiliation Department of Chemistry
Vinh Long University of Technology Education
ICMR-National Institute of Cholera and Enteric Diseases (NICED)
Division of Virus Laboratory
Institute of Analytical and Environmental Sciences
AuthorAffiliation_xml – name: Institute of Analytical and Environmental Sciences
– name: Vinh Long University of Technology Education
– name: Department of Chemistry
– name: Division of Virus Laboratory
– name: ICMR-National Institute of Cholera and Enteric Diseases (NICED)
Author_xml – sequence: 1
  givenname: Uddipan
  surname: Dasgupta
  fullname: Dasgupta, Uddipan
– sequence: 2
  givenname: Malabika
  surname: Ghosh
  fullname: Ghosh, Malabika
– sequence: 3
  givenname: Rupali
  surname: Gangopadhyay
  fullname: Gangopadhyay, Rupali
  organization: Department of Chemistry
– sequence: 4
  givenname: Nguyen Thi Ngoc
  surname: Anh
  fullname: Anh, Nguyen Thi Ngoc
  organization: Vinh Long University of Technology Education
– sequence: 5
  givenname: Ruey-An
  orcidid: 0000-0002-4913-0602
  surname: Doong
  fullname: Doong, Ruey-An
  organization: Institute of Analytical and Environmental Sciences
– sequence: 6
  givenname: Provash Chandra
  orcidid: 0000-0002-7014-0530
  surname: Sadhukhan
  fullname: Sadhukhan, Provash Chandra
  organization: ICMR-National Institute of Cholera and Enteric Diseases (NICED)
– sequence: 7
  givenname: Ankan
  orcidid: 0000-0002-6391-5895
  surname: Dutta Chowdhury
  fullname: Dutta Chowdhury, Ankan
  email: adchowdhury@kol.amity.edu
BookMark eNp1kEFv1DAQRiNUJErpnWOOHNjisR3bOaFVaWGlikpAOSFZE2eSZpXYi50UhV9Pll0QPXCyZc_39M17np344CnLXgK7AMbhDboUBmrxQjpWlEI_yU651GwFQoqTf-7PsvOUtowxUIYbrk6zb59nT7Ht0ti5_FPoKQ9NPt5Tvp7W7eqaxK3MP6IP5H_OA-VNiPldP0ZM5FM3dg-Ub4Zh8gFTwnmffUe-nSj_2sUpvcieNtgnOj-eZ9nd9dWXyw-rm9v3m8v1zQqFKccVuaJytSgRdY0SDHdArNCy1AZR6EaBFFALqERd81IxXjlttMQanCBRNeIs2xy4dcCt3cVuwDjbgJ39_RBiazEuC_ZkOSucNEqTUlwWKEooC2WUUg2aGpVeWHBgTX6H8w_s-79AYHZv2_6xbY-2l8zbQ2Y3VQPVjvxiqH9U5PGP7-5tGx4sgOSFYWYhvDoSYvg-URrt0CVHfY-ewpSsAICluir2o68Po0sNuw1T9Iva_3f7BaEXqe4
ContentType Journal Article
Copyright 2024 The Authors. Published by American Chemical Society
2024 The Authors. Published by American Chemical Society.
2024 The Authors. Published by American Chemical Society 2024 The Authors
Copyright_xml – notice: 2024 The Authors. Published by American Chemical Society
– notice: 2024 The Authors. Published by American Chemical Society.
– notice: 2024 The Authors. Published by American Chemical Society 2024 The Authors
DBID N~.
7X8
5PM
ADTOC
UNPAY
DOA
DOI 10.1021/acsomega.4c05937
DatabaseName American Chemical Society (ACS) Open Access
MEDLINE - Academic
PubMed Central (Full Participant titles)
Unpaywall for CDI: Periodical Content
Unpaywall
DOAJ: Directory of Open Access Journals
DatabaseTitle MEDLINE - Academic
DatabaseTitleList

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: N~.
  name: American Chemical Society (ACS) Open Access
  url: https://pubs.acs.org
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: UNPAY
  name: Unpaywall
  url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
EISSN 2470-1343
EndPage 40060
ExternalDocumentID oai_doaj_org_article_205c4867e66245a3919568666fa8da67
10.1021/acsomega.4c05937
PMC11425808
h58137685
GroupedDBID 53G
AAFWJ
AAHBH
ABUCX
ACS
ADBBV
AFEFF
AFPKN
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BCNDV
EBS
GROUPED_DOAJ
HYE
M~E
N~.
OK1
RPM
VF5
7X8
ABBLG
ADUCK
5PM
ADTOC
EJD
ROL
UNPAY
ID FETCH-LOGICAL-a389t-ec5bcd39aa7da4182c1e0574978aa37f61431d31b3dd29602bc7874ad1c3e3bf3
IEDL.DBID UNPAY
ISSN 2470-1343
IngestDate Wed Aug 27 01:30:31 EDT 2025
Sun Sep 07 11:29:17 EDT 2025
Tue Sep 30 17:07:04 EDT 2025
Fri Jul 11 04:29:46 EDT 2025
Wed Sep 25 08:57:40 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 38
Language English
License Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-a389t-ec5bcd39aa7da4182c1e0574978aa37f61431d31b3dd29602bc7874ad1c3e3bf3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0002-4913-0602
0000-0002-7014-0530
0000-0002-6391-5895
OpenAccessLink https://proxy.k.utb.cz/login?url=https://doi.org/10.1021/acsomega.4c05937
PQID 3111205658
PQPubID 23479
PageCount 10
ParticipantIDs doaj_primary_oai_doaj_org_article_205c4867e66245a3919568666fa8da67
unpaywall_primary_10_1021_acsomega_4c05937
pubmedcentral_primary_oai_pubmedcentral_nih_gov_11425808
proquest_miscellaneous_3111205658
acs_journals_10_1021_acsomega_4c05937
PublicationCentury 2000
PublicationDate 20240924
PublicationDateYYYYMMDD 2024-09-24
PublicationDate_xml – month: 09
  year: 2024
  text: 20240924
  day: 24
PublicationDecade 2020
PublicationTitle ACS omega
PublicationTitleAlternate ACS Omega
PublicationYear 2024
Publisher American Chemical Society
Publisher_xml – name: American Chemical Society
SSID ssj0001682826
Score 2.2866225
Snippet A combination of magnetic and noble metal nanoparticles (NPs) has recently emerged as a potential substance for rapid and sensitive immunosorbent assays....
A combination of magnetic and noble metal nanoparticles (NPs) has recently emerged as a potential substance for rapid and sensitive immunosorbent assays....
SourceID doaj
unpaywall
pubmedcentral
proquest
acs
SourceType Open Website
Open Access Repository
Aggregation Database
Publisher
StartPage 40051
SummonAdditionalLinks – databaseName: American Chemical Society Journals
  dbid: ACS
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELagHMoFyktdoMhIcEHyEr_yOC4Lq4IESJRFPSBZ40eWim1SNRtV21_fcTbbsgWkXhONI4_tmW8ynm8IeWULpwrlc2bLImFKJJKhG_KMZygh0CgrF2uHP39J96fq06E-vKLJuZ7BF_wtuKY-DjMYKhfbz2W3yR2R5jwGWqPxwdX_lBRjh667mlBZwrhUss9K_muQ6Itc0_P0b4DL61cjt9vqBJZnMJ__4Xcm91cNjJqOrjBeN_k9bBd26M7_JnO8wZR2yL0eftLRar88ILdC9ZBsj9dd3x6RnwfLWA3Y0TfTb_U80LqkCBLpqB3N2CTIr4qiRa5Ddb48DhQhL53OcQ5NvAgfTSf9GCtOasTksIyy70M1awP9cXTaNo_JdPLh-3if9R0YGCCQWbDgtHVeFgCZB4WhiOMBAV7sSgcgsxJ9u-Reciu9FxgLCevQACjw3MkgbSmfkK2qrsIuoTaLaEXrkNpCCcFBBwu5TS3Pc52AHJDXqBbTn6DGdMlxwc1aV6bX1YC8i2tmTlZkHCbSY3cPUMGmP21GJNpFKsGQpkJpkEVXFYmRWgm5hxQHeblecYP6jTkSqELdNkai7UdpxGUDkm9shY0vbr6pjn51xNyxLlnnCYq-udw1l2L_m9DTG078GbkrEFCxLiP2nGwtTtuwh4BoYV90J-EC2wcHiw
  priority: 102
  providerName: American Chemical Society
– databaseName: DOAJ: Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3fa9RAEF6kL_VF1FY8tbKCfRG2XvZHLnk8q0ctVEF70gdhmd2dnIVrUpoL5fzrnd3LlbuC-OJrwrDJzGbmm8zON4y9daXXpQ6FcFU5FFoOlaAwFEQ2IglJTln72Dt89iU_merTC3OxMeornglb0QOvFEfJufGRFQ7zXGoDqkwNbgS6KygC5KmPnMLYRjKV_q7klEnIdV2S4th78G1zhTM40j5OsUvRyLc9U_8WvLx_OHK3q69heQvz-UbkmTxmj3rIyMerR33CHmD9lO0erye17bGf35exgy9RLvNvzRx5U3ECdnzcjWdiguqr5uRFG6x_L6-QE0zl0zmt2sbD69Hd8c-xS6QhHA3LKPsR61mH_MflTdfus-nk0_nxieinJggg8LEQ6I3zQZUAowCa0gefIYGyOEkOQI0qiscqCypzKgRJ-Yt0nj5aDSHzCpWr1DO2Uzc1PmfcjSLCMAZzV2opMzDooHC5y4rCDEEN2CHp0Pa7vrWpoC0zu9a17XU9YB-ilu31ikDDRkrrdIEMbXtD238ZesDerG1kSb-xrgE1Nl1rFflrkiYsNWDFlvG2Vty-U1_-SmTasZfYFEMSfXdn5zuxv73Qi__xQi_ZQ0kISaQS1yu2s7jp8IAQzsK9Tpv5D7tG-aU
  priority: 102
  providerName: Directory of Open Access Journals
Title Synergistic Role of the AuAg-Fe3O4 Nanoenzyme for Ultrasensitive Immunoassay of Dengue Virus
URI http://dx.doi.org/10.1021/acsomega.4c05937
https://www.proquest.com/docview/3111205658
https://pubmed.ncbi.nlm.nih.gov/PMC11425808
https://doi.org/10.1021/acsomega.4c05937
https://doaj.org/article/205c4867e66245a3919568666fa8da67
UnpaywallVersion publishedVersion
Volume 9
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVABC
  databaseName: American Chemical Society (ACS) Open Access
  customDbUrl:
  eissn: 2470-1343
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0001682826
  issn: 2470-1343
  databaseCode: N~.
  dateStart: 20160731
  isFulltext: true
  titleUrlDefault: https://pubs.acs.org
  providerName: American Chemical Society
– providerCode: PRVABC
  databaseName: American Chemical Society Journals
  customDbUrl:
  eissn: 2470-1343
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0001682826
  issn: 2470-1343
  databaseCode: ACS
  dateStart: 20160731
  isFulltext: true
  titleUrlDefault: https://pubs.acs.org/action/showPublications?display=journals
  providerName: American Chemical Society
– providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 2470-1343
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0001682826
  issn: 2470-1343
  databaseCode: DOA
  dateStart: 20160101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources
  customDbUrl:
  eissn: 2470-1343
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0001682826
  issn: 2470-1343
  databaseCode: M~E
  dateStart: 20160101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
– providerCode: PRVAQN
  databaseName: PubMed Central
  customDbUrl:
  eissn: 2470-1343
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0001682826
  issn: 2470-1343
  databaseCode: RPM
  dateStart: 20160101
  isFulltext: true
  titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/
  providerName: National Library of Medicine
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwELdG9zBegPGhlY_KSPCC5BJ_5OuxdKsG0gpiFA0JyTo7TpnokmlphLqH_e2c03RaJpDgJQ9JLpHP9t3PPt_vCHllUqtSlSXM5GnAlAgkQzeUMR6jhECjrKzPHT6aRocz9eEkPGn3O3wuTCd-L_hbsFV55uYwVNYXn4vvkO3Ih5J6ZHs2_TT65mvHqThgXCrZRiH_JOZ9j61aXv4OmLx9FHKnLs5h9QsWixt-ZnJ_TXpUNfSE_njJz2G9NEN7eYu88V-a8IDca8EmHa1Hxy7ZcsVDsjPe1Hh7RL4fr3zuX0PWTD-XC0fLnCIkpKN6NGcTJz8qiva3dMXl6sxRBLh0tsAWVP7YuzeU9L3PLykRgcPKy-67Yl47-vX0oq4ek9nk4Mv4kLX1FhggbFkyZ0NjM5kCxBkoXHhY7hDO-Rp0ADLO0ZNLnkluZJYJXPkIY3G6K8i4lU6aXD4hvaIs3B6hJvbYJAxdZFIlBIfQGUhMZHiShAHIPnmNatHtfKl0EwoXXG90pVtd9ck732P6fE29oT0ZdnMDFazbuaVFEFpPHOiiSKgQZNrkQOK6LIckgwg_8nLT3xr16yMiULiyrrRES4_SiML6JOkMhM4fu0-K0x8NDbfPQg6TAEXfXI-Za7G_Nejp_7z8jNwViKFYEwR7TnrLi9q9QAy0NANcA4yPB80OAl6Prg7wOr0aDtpp8RtaSQrW
linkProvider Unpaywall
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELZKOSwXVF5ioYCR4ILkEr_yOC6F1RbaRYIu6gHJGj-yVNomVbMRWg78dsZptmURSFwTjR3P2DPfZDwzhLywhVOF8jmzZZEwJRLJ0Ax5xjOkEKiUlYu5w0fTdDJT70_0yRbh61wY_IgGR2q6IP51dQH-Gp_VZ2EOe8rFLnTZDXJTpyqPW3v6c-_6t0qKLkTXZE2oLGFcKtkHJ_82SDRJrunL9W9gzD9vSA7a6hxW32Gx-M38jHfI7R430tGloO-QrVDdJYP9dbu2e-Tr51VM4-vqLtNP9SLQuqSI7uioHc3ZOMiPiqIqrUP1Y3UWKGJVOlvgrE28wR51Hj2IqSI1gmlYRdq3oZq3gX45vWib-2Q2fne8P2F96wQGiECWLDhtnZcFQOZBoQ_heEBkFtvJAcisRKMsuZfcSu8FOjHCOjy5Cjx3Mkhbygdku6qr8JBQm0WYoXVIbaGE4KCDhdymlue5TkAOyUvkoem3fmO6qLbgZs1r0_N6SN5ELpvzyyoaJta17h6gpE1_TIxItIs1AEOaCqVBFl06I7pYJeQeUhzk-VpGBvkbgxtQhbptjESljdQIqIYk3xDexoybb6rTb11F7ZhQrPMESV9dyfmK7F8LevSfC39GBpPjo0NzeDD98JjcEoiKWBfW2iXby4s2PEFUs7RPu338Cy0a8_4
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Zb9QwELZKkSgvVbnU5ShGghckl_jK8bi0rFqOBQGL-oBkjY8slbbJqtmoWh747YzTbGERSLwmGjuesWe-yXhmCHlqC6cK5XNmyyJhSiSSoRnyjGdIIVApKxdzh9-N06OJen2iTzaIXuXC4Ec0OFLTBfHjqZ77sq8wwF_g8_osTGFfudiJLrtGriMekXF7j3_s__q1kqIb0TVaEypLGJdK9gHKvw0SzZJr-pL9azjzz1uSW201h-UFzGa_maDRDtnusSMdXgr7FtkI1W2ydbBq2XaHfP20jKl8Xe1l-rGeBVqXFBEeHbbDKRsF-V5RVKd1qL4vzwJFvEonM5y1ibfYo96jxzFdpEZADctIexiqaRvol9PztrlLJqNXnw-OWN8-gQGikAULTlvnZQGQeVDoRzgeEJ3FlnIAMivRMEvuJbfSe4GOjLAOT68Cz50M0pbyHtms6irsEmqzCDW0DqktlBAcdLCQ29TyPNcJyAF5hjw0_fZvTBfZFtyseG16Xg_Iy8hlM7-spGFibevuAUrb9EfFiES7WAcwpKlQGmTRpTSim1VC7iHFQZ6sZGSQvzHAAVWo28ZIVNxIjaBqQPI14a3NuP6mOv3WVdWOScU6T5D0-ZWcr8j-taD7_7nwx-TGh8OReXs8fvOA3BQIjFgX2XpINhfnbXiEwGZh97pt_BOxDPUL
linkToUnpaywall http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3da9RAEF_0-lBf_JaeX6ygL8Ke2Y98PZ7VowpWUU8qCMvsZnMWr0lpLsj1r3cmlyumKOhrkknY2dmZ32Z2fsPYU5d7k5siE67MI2FUpAWGoULIFCUUOmXjqXb43WFyMDdvj-Kj_n8H1cIM8vdKvgDf1CdhARPjqflcepXtJJRKGrGd-eGH6VfqHWfSSEhtdJ-F_JMYxR7f9Lz8AzB5-SjkbludwvonLJe_xZnZjQ3pUdPRE9Lxkh-TduUm_vwSeeO_DOEmu96DTT7dWMctdiVUt9nu_rbH2x327dOaav86smb-sV4GXpccISGfttOFmAX93nD0v3WoztcngSPA5fMljqChY-_kKPkbqi-pEYHDmmRfhWrRBv7l-Kxt7rL57PXn_QPR91sQgLBlJYKPnS90DpAWYHDj4WVAOEc96AB0WmIk17LQ0umiULjzUc7jcjdQSK-DdqW-x0ZVXYU9xl1K2CSOQ-Jyo5SEODjIXOJklsUR6DF7hmqx_XppbJcKV9JudWV7XY3ZS5oxe7qh3rBEht1dQAXbfm1ZFcWeiANDkigTg867Gkjcl5WQFZDgS55s59uifikjAlWo28Zq9PQojShszLKBIQy-OLxTHX_vaLipCjnOIhR9fmEzF2J_G9D9_3n4AbumEEOJLgn2kI1WZ214hBho5R735v8Lk6UGnQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Synergistic+Role+of+the+AuAg-Fe3O4+Nanoenzyme+for+Ultrasensitive+Immunoassay+of+Dengue+Virus&rft.jtitle=ACS+omega&rft.au=Dasgupta%2C+Uddipan&rft.au=Ghosh%2C+Malabika&rft.au=Gangopadhyay%2C+Rupali&rft.au=Anh%2C+Nguyen+Thi+Ngoc&rft.date=2024-09-24&rft.pub=American+Chemical+Society&rft.issn=2470-1343&rft.eissn=2470-1343&rft.volume=9&rft.issue=38&rft.spage=40051&rft.epage=40060&rft_id=info:doi/10.1021%2Facsomega.4c05937&rft.externalDocID=h58137685
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2470-1343&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2470-1343&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2470-1343&client=summon