Cyclooxygenase-2 Inhibitors. 1,5-Diarylpyrrol-3-acetic Esters with Enhanced Inhibitory Activity toward Cyclooxygenase-2 and Improved Cyclooxygenase-2/Cyclooxygenase-1 Selectivity - Biava, Mariangela; Porretta, Giulio Cesare; Poce, Giovanna; Supino, Sibilla; Forli, Stefano; Rovini, Michele; Cappelli, Andrea; Manetti, Fabrizio; Botta, Maurizio; Sautebin, Lidia; Rossi, Antonietta; Pergola, Carlo; et al. (Journal of medicinal chemistry, 2007)
Keywords: Acetates - chemical synthesis; Acetates - chemistry; Acetates - pharmacology; Adult; Analgesics; Animals; Biological and medical sciences; Bones, joints and connective tissue. Antiinflammatory agents; Carrageenan; Cell Line; Chemistry, Medicinal; Cyclooxygenase 1 - metabolism; Cyclooxygenase 2 - metabolism; Cyclooxygenase 2 Inhibitors - chemical synthesis; Cyclooxygenase 2 Inhibitors - chemistry; Cyclooxygenase 2 Inhibitors - pharmacology; Dinoprostone - blood; Edema - chemically induced; Edema - prevention & control; Female; Humans; Life Sciences & Biomedicine; Male; Medical sciences; Mice; Models, Molecular; Neuropharmacology; Pain Measurement; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Pyrroles - chemical synthesis; Pyrroles - chemistry; Pyrroles - pharmacology; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Science & Technology; Structure-Activity Relationship; T-Box Domain Proteins - blood; TRIALS; POTENT; COX-2 INHIBITION; METAANALYSIS; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; HEALTHY-SUBJECTS; BIOLOGICAL EVALUATION; RISK; AGENTS; ASPIRIN; Enzyme; Cyclooxygenase 2; Rodentia; Enzyme inhibitor; Cyclooxygenase 2 inhibitor; Selectivity; Celecoxib; Acetic acid derivative; In vitro; Biological activity; Pyrrole derivatives; Non steroidal antiinflammatory agent; In vivo; Vertebrata; Mammalia; Analgesic; Structure activity relation; Mouse; Animal; Oxidoreductases; Fluorine Organic compounds; Chemical synthesis