Effect of Backward Medication Switching on the Risks of Adverse Events of Schizophrenia Patients Using Atypical Antipsychotics
過去已有許多研究在探討由一代抗精神疾病用藥換爲二代抗精神用藥的影響，然而較少評估二代藥轉換成一代藥對病人健康之影響。本研究旨在瞭解已使用二代藥品的精神分裂病患在處方型態改變（由二代換爲一代藥品）或二代用藥減量時，其不良反應事件之風險是否會增加。本研究以爲期三年的全國性世代追蹤資料，針對12,107位使用二代抗精神疾病藥品且在固定醫院就醫的精神分裂症病患，比較暴露組（2003年更換藥品或減少二代藥劑量）的病患，其2004年發生不良事件（急診及住院）的風險是否較未暴露組爲高。資料來源爲衛生署提供之全民健保申報資料。在控制其他因素下，以Cox重複發生事件對比涉險模式估計不良事件發生的危險比。研究結果...
Saved in:
| Published in | Yàowu shi͡p︡in fenxi Vol. 16; no. 1; pp. 49 - 55 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Philadelphia
衛生福利部食品藥物管理署
2008
Food and Drug Administration |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1021-9498 2224-6614 |
| DOI | 10.38212/2224-6614.2378 |
Cover
| Abstract | 過去已有許多研究在探討由一代抗精神疾病用藥換爲二代抗精神用藥的影響，然而較少評估二代藥轉換成一代藥對病人健康之影響。本研究旨在瞭解已使用二代藥品的精神分裂病患在處方型態改變（由二代換爲一代藥品）或二代用藥減量時，其不良反應事件之風險是否會增加。本研究以爲期三年的全國性世代追蹤資料，針對12,107位使用二代抗精神疾病藥品且在固定醫院就醫的精神分裂症病患，比較暴露組（2003年更換藥品或減少二代藥劑量）的病患，其2004年發生不良事件（急診及住院）的風險是否較未暴露組爲高。資料來源爲衛生署提供之全民健保申報資料。在控制其他因素下，以Cox重複發生事件對比涉險模式估計不良事件發生的危險比。研究結果發現在控制病患及醫院特性後，暴露組病患在2004年發生急診及住院的風險爲未暴露組病患的1.15倍(HR=1.15, (1.00-1.31))。更換二代藥品或減少二代藥品劑量可能會增加已使用二代藥品之精神分裂症患者發生不良事件的風險。 |
|---|---|
| AbstractList | Many studies explore the effects of medication switching from second generation antipsychotic (SGA) to first generation antipsychotic (FGA), yet few exam the health effect of backward medication switching. This study investigated whether backward medication switching (from SGA to FGA) and reduced dosages on SGA increased adverse events in outpatient schizophrenia patients treated by SGA in Taiwan. This study applied a three-year historical cohort design and compared the risks of adverse events (outcome) in 2004, measured by emergency room and hospital admissions, of patients experienced backward medication switching or dosage reduction on SGA (exposure status) in 2003 with those who did not (control group). This study was based on a national fixed cohort (census) of 12,107 patients who have ever received SGA during the study period and used hospitals as regular source of care during 2002-2004. Most data were drawn from National Health Insurance claims provided by Department of Health. Cox proportional hazards model for recurrent events using Prentice, Williams and Peterson total-time approach was applied to estimate the hazard ratio (HR) of adverse events by exposure status of the patients while controlling the covariates. The results showed that backward medication switching in 2003 significantly increased the risk of emergency room or hospital admissions (HR=1.15, 1.00-1.31) in 2004. Backward medication switching and reduced dosages on SGA might increase the risk of adverse events of the schizophrenia patients treated by SGA in Taiwan. 過去已有許多研究在探討由一代抗精神疾病用藥換爲二代抗精神用藥的影響，然而較少評估二代藥轉換成一代藥對病人健康之影響。本研究旨在瞭解已使用二代藥品的精神分裂病患在處方型態改變（由二代換爲一代藥品）或二代用藥減量時，其不良反應事件之風險是否會增加。本研究以爲期三年的全國性世代追蹤資料，針對12,107位使用二代抗精神疾病藥品且在固定醫院就醫的精神分裂症病患，比較暴露組（2003年更換藥品或減少二代藥劑量）的病患，其2004年發生不良事件（急診及住院）的風險是否較未暴露組爲高。資料來源爲衛生署提供之全民健保申報資料。在控制其他因素下，以Cox重複發生事件對比涉險模式估計不良事件發生的危險比。研究結果發現在控制病患及醫院特性後，暴露組病患在2004年發生急診及住院的風險爲未暴露組病患的1.15倍(HR=1.15, (1.00-1.31))。更換二代藥品或減少二代藥品劑量可能會增加已使用二代藥品之精神分裂症患者發生不良事件的風險。 |
| Author | 李玉春(Yue-Chune Lee) 黃昱瞳(Yu-Tung Huang) 黃文鴻(Weng-Foung Huang) |
| Author_xml | – sequence: 1 fullname: 李玉春(Yue-Chune Lee) – sequence: 2 fullname: 黃昱瞳(Yu-Tung Huang) – sequence: 3 fullname: 黃文鴻(Weng-Foung Huang) |
| BookMark | eNpNkM1PAjEQxRuDiYCevTbxvNiP7e72uBL8SDAakXPT7bZugXRxWyB48G-3gDGeJvPmN28ybwB6rnUagGuMRrQgmNwSQtIky3A6IjQvzkD_T-iBPkYEJzzlxQUYeL9AKGOUkz74nhijVYCtgXdSLXeyq-Gzrq2SwbYOznY2qMa6Dxib0Gj4Zv3SH-iy3urOazjZaheOyiyCX-266bSzEr5Gg-Nk7g_rZdivo-kKli7Ytd-rpg1W-UtwbuTK66vfOgTz-8n7-DGZvjw8jctpIikqQlLxrK4ppQSjSrEK5VTnOTU15To3DKUyU2ltmCmY1qriGCOsZR5_5oWpKJN0CG5Ovuuu_dxoH8Si3XQunhSYxPRSXBAaKXqipO1ssP-YmN4hPEEQKhAVOBNYpFwwJiT9AYT1cx4 |
| ContentType | Journal Article |
| Copyright | Copyright Food and Drug Administration 2008 |
| Copyright_xml | – notice: Copyright Food and Drug Administration 2008 |
| DBID | 188 3V. 7RQ 7X2 7X7 7XB 88E 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ATCPS BENPR BGLVJ BHPHI CCPQU DWQXO FYUFA GHDGH HCIFZ K9. L6V M0K M0S M1P M7S PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PTHSS Q9U |
| DOI | 10.38212/2224-6614.2378 |
| DatabaseName | Chinese Electronic Periodical Services (CEPS) ProQuest Central (Corporate) Career & Technical Education Database Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Journals Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability (subscription) ProQuest Central UK/Ireland Agricultural & Environmental Science Collection ProQuest Central Technology Collection Natural Science Collection ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Engineering Collection Agriculture Science Database ProQuest Health & Medical Collection Medical Database Engineering Database ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition Engineering Collection ProQuest Central Basic |
| DatabaseTitle | Agricultural Science Database Technology Collection ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability ProQuest Health & Medical Research Collection ProQuest Engineering Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Agricultural & Environmental Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Engineering Database ProQuest Central Basic ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Career and Technical Education ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Materials Science & Engineering Collection ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) |
| DatabaseTitleList | Agricultural Science Database |
| Database_xml | – sequence: 1 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Diet & Clinical Nutrition |
| DocumentTitle_FL | 使用二代抗精神疾病藥品之精神分裂病患換回－代藥後對其不良反應事件風險的影響 |
| EISSN | 2224-6614 |
| EndPage | 55 |
| ExternalDocumentID | 2876516931 10219498_200803_16_1_49_55_a |
| GroupedDBID | --- 0R~ 0SF 188 2WC 3V. 53G 5GY 7RQ 7X2 7X7 88E 8FE 8FG 8FH 8FI 8FJ A8Z AACTN AAHBH AAWTL ABDBF ABFRF ABJCF ABUWG ACGFO ACGFS ACIWK AEFWE AENEX AFKRA AFRAH AHMBA AIAGR ALIPV ALMA_UNASSIGNED_HOLDINGS ATCPS BENPR BGLVJ BHPHI BPHCQ BVXVI CCPQU DIK DWQXO E3Z EAD EAP EAS ESTFP ESX FDB FYUFA GROUPED_DOAJ HCIFZ HMCUK HZ~ L6V LMWXZ M0K M1P M7S O9- OK1 P2P PC. PQQKQ PROAC PSQYO PTHSS TR2 UKHRP UNMZH W2D 7XB 8FK ACUHS AEUYN K9. PGMZT PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQUKI Q9U |
| ID | FETCH-LOGICAL-a308t-b96dd333210bc5b073e773fd39e7f504a6c4df5f85eecb91101ea710298fb35a3 |
| IEDL.DBID | 8FG |
| ISSN | 1021-9498 |
| IngestDate | Fri Jul 25 12:16:58 EDT 2025 Tue Oct 01 22:51:53 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | 二代抗精神疾病藥品 精神分裂症 medication switching 抗精神疾病藥物 antipsychotic schizophrenia atypical antipsychotic 變更處方 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-a308t-b96dd333210bc5b073e773fd39e7f504a6c4df5f85eecb91101ea710298fb35a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 |
| OpenAccessLink | https://doi.org/10.38212/2224-6614.2378 |
| PQID | 1282141823 |
| PQPubID | 906352 |
| PageCount | 7 |
| ParticipantIDs | proquest_journals_1282141823 airiti_journals_10219498_200803_16_1_49_55_a |
| PublicationCentury | 2000 |
| PublicationDate | 2008-00-00 |
| PublicationDateYYYYMMDD | 2008-01-01 |
| PublicationDate_xml | – year: 2008 text: 2008-00-00 |
| PublicationDecade | 2000 |
| PublicationPlace | Philadelphia |
| PublicationPlace_xml | – name: Philadelphia |
| PublicationTitle | Yàowu shi͡p︡in fenxi |
| PublicationTitle_FL | Food and Drug Analysis |
| PublicationYear | 2008 |
| Publisher | 衛生福利部食品藥物管理署 Food and Drug Administration |
| Publisher_xml | – name: 衛生福利部食品藥物管理署 – name: Food and Drug Administration |
| SSID | ssj0065392 ssib060475459 ssib023362442 |
| Score | 1.734492 |
| Snippet | 過去已有許多研究在探討由一代抗精神疾病用藥換爲二代抗精神用藥的影響，然而較少評估二代藥轉換成一代藥對病人健康之影響。本研究旨在瞭解已使用二代藥品的精神分裂病患在... Many studies explore the effects of medication switching from second generation antipsychotic (SGA) to first generation antipsychotic (FGA), yet few exam the... |
| SourceID | proquest airiti |
| SourceType | Aggregation Database Publisher |
| StartPage | 49 |
| SubjectTerms | Antipsychotics Drugs Emergency medical services Mental disorders |
| Title | Effect of Backward Medication Switching on the Risks of Adverse Events of Schizophrenia Patients Using Atypical Antipsychotics |
| URI | https://www.airitilibrary.com/Article/Detail/10219498-200803-16-1-49-55-a https://www.proquest.com/docview/1282141823 |
| Volume | 16 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2224-6614 dateEnd: 20200131 omitProxy: true ssIdentifier: ssj0065392 issn: 1021-9498 databaseCode: 7X7 dateStart: 19960701 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: http://www.proquest.com/pqcentral?accountid=15518 eissn: 2224-6614 dateEnd: 20200131 omitProxy: true ssIdentifier: ssj0065392 issn: 1021-9498 databaseCode: BENPR dateStart: 19960701 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Technology Collection customDbUrl: eissn: 2224-6614 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0065392 issn: 1021-9498 databaseCode: 8FG dateStart: 19960701 isFulltext: true titleUrlDefault: https://search.proquest.com/technologycollection1 providerName: ProQuest |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LS8QwEA66evAiPnF9LDmIJ6ttkzTtSXZ1VxFcxAfsreQJRdlVWxEv_nYzSVcEwWPblEBm-s108uUbhA6djW1m3d9JVhgdUa1UJPNCR6l08YIbZYXvRXAzzq4e6fWETdqCW93SKueY6IFazxTUyE8djqYJddkwOXt5jaBrFOyuti00FtFSkjpPgpPio8u5P6XEoTOlP-E7iylnXjslIDWosobdUKAp0CIP0j_ETZSeurhJIwheJymBHmzLogKVoT-Q7ePQaA2ttgkk7geLr6MFM91A3YvKNPgItyqfz3g8F9nfRF9BoBjPLB5Asc65BA7bM_Ac339UjedTYnfhskF8V9VPNYz2vZprg4dAifR37n8z9PBtkGStsacd4H7z-eLn7k-bqj3cVal6Cz2Ohg_nV1HbdSESJM6bSBaZ1oTA2R6pmHQQYDgnVpPCcMtiKjJFtWU2Z8Yo6bAyToyAPKXIrSRMkG3Umc6mZgfhOFXCkiTlnEkqtRudW0sTmwtIlGzcRcdhVcv2w6lLsAWYwrfHjEmZZGVS0qJkrBRdtD9f-18v_PjF7v-P99BK4HpA-WQfdZq3d3PgEopG9tAin_Ce950eWhoMx7d339HKyLQ |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LT9VAFJ4gmuiG4CteQZ2FurLSzqOPBTEXgVwEboxAcndlnkmjuRdpCWHjT_I3cs5Me0Ni4o5l22mbzjk935mZb75DyHuwsc89jE7yytlEWGMSXVY2YRrwonDGq1CL4HiaT87Et5mcrZC_w14YpFUOMTEEarswOEe-BXGUZQKyYf7l4neCVaNwdXUooRHd4tDdXMOQrd0-2AX7fmBsf-_06yTpqwokiqdll-gqt5Zz3LuijdTg4q4ouLe8coWXqVC5EdZLX0rnjIZYkGZOIQ5XpddcKg7PfUAeCp4K1OovZkv4ZhzQQIhlupCnopBBqyUiA6rAxtVXpEWIqoxSQxw-jG0BTosEwfIz41jz7ZFqUNXoH4gIuLe_Ttb6hJWOo4c9JStu_oyMdhvX0Y-0VxX9RaeDqP9z8icKItOFpzs4OQguSONyEF6nJ9dNF_ibFA4g-6Q_mvZni61DbejW0T2kYIYzJ3cZgfR7lIBtaaA50HF3cxHePZ53Tb-ZrDHtC3J2L_Z4SVbni7l7RWjKjPI8Y0UhtdAWWpfei8yXChMzn47Ip9irdf-jtjXaAk0RynGmvM7yOqtFVUtZqxHZHPr-zg1LP3z9_8vvyOPJ6fFRfXQwPdwgTyLPBKduNslqd3nl3kAy0-m3wYMoOb9vl70Fw_ADNg |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Nb9QwELVKQYgL4lNsW8AH4ETYxB9xcqjQwnbVUlhVlEp7S-3YliLQbtsEVb30h_HrmLGTVSUkbj0mcRLFM5k3tp_fEPIGbOxzD6OTvHQ2EbauE1OUNmEG8EK52utQi-DbPN8_EV8WcrFB_gx7YZBWOcTEEKjtqsY58jHEUZYJyIb52Pe0iKPp7OPZeYIVpHCldSinEV3k0F1dwvCt3T2Ygq3fMjbb-_F5P-krDCSap0WXmDK3lnPcx2JqacDdnVLcW1465WUqdF4L66UvpHO1gbiQZk4jJpeFN1xqDs-9Q-4qLjjSydRiDeWMAzIIsU4d8lQoGXRbIkqgImxciUWKhCiLKDvE4SPZGDBbJAicHxjH-m_3dIMKR__ARcDA2SPysE9e6SR622Oy4ZZPyGjauI6-o73C6C86HwT-n5LrKI5MV55-wolCcEcal4bwOj2-bLrA5aRwAJko_d60P1tsHepEt47uIR0znDm-yQ6kR1EOtqWB8kAn3dVZePdk2TX9xrKmbp-Rk1uxx3OyuVwt3QtCU1ZrzzOmlDTCWGhdeC8yX2hM0nw6Iu9jr1b9T9tWaAs0RSjNmfIqy6usEmUlZaVHZGfo-xs3rH1y6_-XX5P74KzV14P54TZ5ECknOIuzQza7i9_uJeQ1nXkVHIiS09v22L_YSQdx |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effect+of+Backward+Medication+Switching+on+the+Risks+of+Adverse+Events+of+Schizophrenia+Patients+Using+Atypical+Antipsychotics&rft.jtitle=%E8%97%A5%E7%89%A9%E9%A3%9F%E5%93%81%E5%88%86%E6%9E%90&rft.au=%E6%9D%8E%E7%8E%89%E6%98%A5%28Yue-Chune+Lee%29&rft.au=%E9%BB%83%E6%98%B1%E7%9E%B3%28Yu-Tung+Huang%29&rft.au=%E9%BB%83%E6%96%87%E9%B4%BB%28Weng-Foung+Huang%29&rft.date=2008&rft.pub=%E8%A1%9B%E7%94%9F%E7%A6%8F%E5%88%A9%E9%83%A8%E9%A3%9F%E5%93%81%E8%97%A5%E7%89%A9%E7%AE%A1%E7%90%86%E7%BD%B2&rft.issn=1021-9498&rft.volume=16&rft.issue=1&rft.spage=49&rft.epage=55&rft_id=info:doi/10.38212%2F2224-6614.2378&rft.externalDocID=10219498_200803_16_1_49_55_a |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fwww.airitilibrary.com%2Fjnltitledo%2F10219498-c.jpg |