Nitric oxide in the nervous system
The gas nitric oxide (NO) has burst upon neuroscience only recently, and yet it has permeated into almost every avenue of current research. The unique properties of this novel messenger have revolutionized our way ofthinking about neurotransmission. These special properties have also lead neuroscien...
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| Main Author | |
|---|---|
| Format | eBook Book |
| Language | English |
| Published |
London ; Tokyo
Academic Press : Harcourt Brace
1995
Elsevier Science & Technology Academic Press |
| Edition | 1 |
| Series | Neuroscience perspectives |
| Subjects | |
| Online Access | Get full text |
| ISBN | 0127219854 9780127219851 |
Cover
Table of Contents:
- Chapter 12. Nitric oxide in the autonomic and enteric nervous systems -- 12.1 Discovery of NO-mediated neuroeffector transmission -- 12.2 Criteria for establishing nitrergic transmission -- 12.3 Tissues innervated by autonomic nitrergic nerves -- 12.4 Nitrergic transmission in the gastrointestinal tract -- 12.5 Mechanisms of nitrergic transmission -- 12.6 Interactions between NO and other autonomic transmitters -- 12.7 Concluding remarks -- Chapter 13. Nitric oxide and the neural regulation of the penis -- 13.1 Introduction -- 13.2 Basic mechanisms of penile erection, smooth muscle effectors and haemodynamics -- 13.3 Efferent nerves -- 13.4 The debate on the neurotransmission of penile erection and the search for a transmitter -- 13.5 Nitric oxide as the principal transmitter candidate -- 13.6 Nitric oxide as likely mediator of cholinergic effects -- 13.7 Final considerations -- Index
- Front Cover -- Nitric Oxide in the Nervous System -- Copyright Page -- Contents -- Contributors -- Series Preface -- Preface -- Chapter 1. Molecular characterization of nitric oxide synthase -- 1.1 Introduction -- 1.2 Isolation of NOS -- 1.3 Molecular cloning -- 1.4 NOS cofactors -- 1.5 Physiologic functions for brain NOS -- Chapter 2. Biochemistry and molecular pharmacology of nitric oxide synthases -- 2.1 Introduction -- 2.2 Biochemical properties of NO synthases -- 2.3 Identification of cofactors -- 2.4 Mechanisms of NO synthesis -- 2.5 Regulation of NOS activity -- 2.6 Molecular pharmacology of NOS inhibition -- Chapter 3. The NO receptor: characterization and regulation of soluble gnanylyl cyclase -- 3.1 Introduction -- 3.2 Primary structure of soluble guanylyl cyclase -- 3.3 Catalytic activity -- 3.4 Isoforms -- 3.5 Regulation -- Chapter 4. Cyclic GMP receptor proteins: role in nervous system and other tissues -- 4.1 Cyclic GMP-dependent protein kinases -- 4.2 Cyclic GMP-regulated ion channels -- 4.3 Cyclic GMP-regulated phosphodiesterases -- 4.4 Role of cyclic GMP kinase in the nervous system -- Chapter 5. Localization of nitric oxide neurons in the central nervous system -- 5.1 Introduction -- 5.2 Caveats and cautions -- 5.3 Localization of NOS in the mammalian central nervous system -- 5.4 Non-mammalian species -- 5.5 NOS expression during development and following injury -- 5.6 Localization of soluble guanylyl cyclase, the NO receptor -- 5.7 Conclusions -- Chapter 6. Nitric oxide and excitatory amino acid-coupled signal transduction in the cerebellum and hippocampus -- 6.1 Historical background -- 6.2 Nitric oxide synthase (1.14.23) -- 6.3 Cerebellum -- 6.4 Hippocampus -- 6.5 Conclusions -- Chapter 7. Nitric oxide signalling, long-term potentiation and long-term depression -- 7.1 Introduction
- 7.2 Long-term potentiation, the hippocampus and memory -- 7.3 Nitric oxide and LTP -- 7.4 Long-term depression in the hippocampus -- 7.5 Long-term depression in the cerebellum -- 7.6 Conclusions -- Chapter 8. Nitric oxide signalling in the hypothalamus -- 8.1 Introduction -- 8.2 NOS in the hypothalamus -- 8.3 Corticotropin-releasing hormone neurosecretory system -- 8.4 Luteinizing hormone-releasing hormone neurosecretory system -- 8.5 Vasopressin neurosecretory system -- 8.6 Somatostatin release -- 8.7 Autonomic regulation -- 8.8 Functional considerations -- 8.9 Conclusions -- Chapter 9. Glial cells as nitric oxide sources and targets -- 9.1 Introduction -- 9.2 Evidence for a constitutive, calcium-activated nitric oxide synthase in astrocytes -- 9.3 Induction of NOS in glia in vitro -- 9.4 Regulation of the inducible NOS in glia -- 9.5 Induction of NOS in vivo -- 9.6 Glia as targets for NO -- 9.7 Summary -- Chapter 10. Nitric oxide toxicity in neuronal injury and degeneration -- 10.1 Introduction -- 10.2 The short half-life of nitric oxide -- 10.3 Nitric oxide is not highly reactive or toxic -- 10.4 Nitric oxide and transition metals -- 10.5 Diffusion of nitric oxide -- 10.6 Haemoglobin is a major trap for nitric oxide in vivo -- 10.7 Superoxide in cerebral ischaemic injury -- 10.8 Peroxynitrite as an oxidant -- 10.9 The interaction of superoxide and nitric oxide in cerebral ischaemia -- 10.10 Inhibition of nitric oxide synthesis in cerebral ischaemia -- 10.11 Superoxide dismutase and cerebral ischaemia -- 10.12 Superoxide dismutase-catalysed nitration -- 10.13 Motor neuron disease, superoxide dismutase and peroxynitrite -- Chapter 11. Nitric oxide and the regulation of cerebral arterial tone -- 11.1 Introduction -- 11.2 NO derived from vasodilator nerve -- 11.3 NO derived from the endothelium -- 11.4 Conclusion