Nitric oxide in the nervous system
The gas nitric oxide (NO) has burst upon neuroscience only recently, and yet it has permeated into almost every avenue of current research. The unique properties of this novel messenger have revolutionized our way ofthinking about neurotransmission. These special properties have also lead neuroscien...
Saved in:
| Main Author | |
|---|---|
| Format | eBook Book |
| Language | English |
| Published |
London ; Tokyo
Academic Press : Harcourt Brace
1995
Elsevier Science & Technology Academic Press |
| Edition | 1 |
| Series | Neuroscience perspectives |
| Subjects | |
| Online Access | Get full text |
| ISBN | 0127219854 9780127219851 |
Cover
| Abstract | The gas nitric oxide (NO) has burst upon neuroscience only recently, and yet it has permeated into almost every avenue of current research. The unique properties of this novel messenger have revolutionized our way ofthinking about neurotransmission. These special properties have also lead neuroscientists to invoke NO to explain many previously unexplained phenomena in neurobiology. Fortunately, the development of numerous pharmacological agents is now allowing thesehypotheses to be tested.This volume will provide a synopsis of what is now known about NO. How and where NO is produced, how it acts at the molecular level to activate the synthesis of cGMP, and the possible targets of cGMP in the nervous system are reviewed. The roles of theNO/cGMP signal transduction pathway in the central and peripheral nervous systems, in glial cells, and in neuropathology are then explored. Together, these reviews will lead to further work explaining the varied functions of NO.
Key Features* Describes how and why NO is produced in the nervous system* Examines all that is known of NOs role as a neurotransmitter* Explores cellular actions and physiological roles in the brain and peripheral nervous systemCovers NOs molecular synthesis to its role in neuropathology |
|---|---|
| AbstractList | The gas nitric oxide (NO) has burst upon neuroscience only recently, and yet it has permeated into almost every avenue of current research. The unique properties of this novel messenger have revolutionized our way ofthinking about neurotransmission. These special properties have also lead neuroscientists to invoke NO to explain many previously unexplained phenomena in neurobiology. Fortunately, the development of numerous pharmacological agents is now allowing thesehypotheses to be tested.This volume will provide a synopsis of what is now known about NO. How and where NO is produced, how it acts at the molecular level to activate the synthesis of cGMP, and the possible targets of cGMP in the nervous system are reviewed. The roles of theNO/cGMP signal transduction pathway in the central and peripheral nervous systems, in glial cells, and in neuropathology are then explored. Together, these reviews will lead to further work explaining the varied functions of NO.
Key Features* Describes how and why NO is produced in the nervous system* Examines all that is known of NOs role as a neurotransmitter* Explores cellular actions and physiological roles in the brain and peripheral nervous systemCovers NOs molecular synthesis to its role in neuropathology |
| Author | Vincent, Steven R |
| Author_xml | – sequence: 1 fullname: Vincent, Steven R |
| BackLink | https://cir.nii.ac.jp/crid/1130282269104138880$$DView record in CiNii |
| BookMark | eNpV0EtPwzAMAOAgHmIb_Q8VQkgcKjnPpkeYxkOa4IK4VknqamGlgaYb8O9pKRd8sA_-ZNmek6M2tHhAkiLXABokz6UsDskcKMsZLbQUJ2QmckXHLpySJMZXGIJRKriYkfNH33fepeHLV5j6Nu03mLbY7cMupvE79vh2Ro5r00RM_uqCvNyunpf32frp7mF5vc4M0wxYJqxCREMdq2tZM8ugYpyL3CpqnYZaCaXAVVDxGqRCEFYYxNxZjYUyVPMFuZoGm7jFz7gJTR_LfYM2hG0s_1042MvJvnfhY4exL3-Zw7bvTFOubpZ8-IAa4cUEW-9L58dMKYdhZaYKCoJyrTXwHw-IWcM |
| ContentType | eBook Book |
| DBID | RYH |
| DEWEY | 612.814 |
| DatabaseName | CiNii Complete |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Medicine |
| EISBN | 9780080537559 0080537553 |
| Edition | 1 |
| ExternalDocumentID | 9780080537559 EBC312769 BA25308382 |
| GroupedDBID | 089 20A 38. A4I A4J AAAAS AABBV AALRI AAORS AAXUO AAYWO AAZNM ABGWT ABMAC ABQQC ACXMD ADCEY AEPYD AFOST AGAMA AHMUE ALMA_UNASSIGNED_HOLDINGS AWBQH AZZ BBABE CFTFM CZZ HGY INJ IPQ MYL RYH SDK SHL SRW UO7 AJLYV |
| ID | FETCH-LOGICAL-a28202-4b6eeea1c2ff5f2b20d23347b61bc80f64660cd0d3f056e04b4aee7cb8e96a183 |
| ISBN | 0127219854 9780127219851 |
| IngestDate | Fri Nov 08 03:11:52 EST 2024 Fri May 30 22:26:33 EDT 2025 Fri Jun 27 00:16:54 EDT 2025 |
| IsPeerReviewed | false |
| IsScholarly | false |
| LCCallNum_Ident | QP364.7.N54 1995 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-a28202-4b6eeea1c2ff5f2b20d23347b61bc80f64660cd0d3f056e04b4aee7cb8e96a183 |
| Notes | Includes bibliographical references and index |
| OCLC | 476100800 |
| PQID | EBC312769 |
| PageCount | 333 |
| ParticipantIDs | askewsholts_vlebooks_9780080537559 proquest_ebookcentral_EBC312769 nii_cinii_1130282269104138880 |
| PublicationCentury | 1900 |
| PublicationDate | 1995 1995-04-07 |
| PublicationDateYYYYMMDD | 1995-01-01 1995-04-07 |
| PublicationDate_xml | – year: 1995 text: 1995 |
| PublicationDecade | 1990 |
| PublicationPlace | London ; Tokyo |
| PublicationPlace_xml | – name: London ; Tokyo – name: Chantilly |
| PublicationSeriesTitle | Neuroscience perspectives |
| PublicationYear | 1995 |
| Publisher | Academic Press : Harcourt Brace Elsevier Science & Technology Academic Press |
| Publisher_xml | – name: Academic Press : Harcourt Brace – name: Elsevier Science & Technology – name: Academic Press |
| SSID | ssj0000211434 ssib002888439 |
| Score | 1.7795857 |
| Snippet | The gas nitric oxide (NO) has burst upon neuroscience only recently, and yet it has permeated into almost every avenue of current research. The unique... |
| SourceID | askewsholts proquest nii |
| SourceType | Aggregation Database Publisher |
| SubjectTerms | Humans -- Nervous system -- Biochemistry Neural transmission Nitric oxide Nitric oxide -- Physiological effect |
| TableOfContents | Chapter 12. Nitric oxide in the autonomic and enteric nervous systems -- 12.1 Discovery of NO-mediated neuroeffector transmission -- 12.2 Criteria for establishing nitrergic transmission -- 12.3 Tissues innervated by autonomic nitrergic nerves -- 12.4 Nitrergic transmission in the gastrointestinal tract -- 12.5 Mechanisms of nitrergic transmission -- 12.6 Interactions between NO and other autonomic transmitters -- 12.7 Concluding remarks -- Chapter 13. Nitric oxide and the neural regulation of the penis -- 13.1 Introduction -- 13.2 Basic mechanisms of penile erection, smooth muscle effectors and haemodynamics -- 13.3 Efferent nerves -- 13.4 The debate on the neurotransmission of penile erection and the search for a transmitter -- 13.5 Nitric oxide as the principal transmitter candidate -- 13.6 Nitric oxide as likely mediator of cholinergic effects -- 13.7 Final considerations -- Index Front Cover -- Nitric Oxide in the Nervous System -- Copyright Page -- Contents -- Contributors -- Series Preface -- Preface -- Chapter 1. Molecular characterization of nitric oxide synthase -- 1.1 Introduction -- 1.2 Isolation of NOS -- 1.3 Molecular cloning -- 1.4 NOS cofactors -- 1.5 Physiologic functions for brain NOS -- Chapter 2. Biochemistry and molecular pharmacology of nitric oxide synthases -- 2.1 Introduction -- 2.2 Biochemical properties of NO synthases -- 2.3 Identification of cofactors -- 2.4 Mechanisms of NO synthesis -- 2.5 Regulation of NOS activity -- 2.6 Molecular pharmacology of NOS inhibition -- Chapter 3. The NO receptor: characterization and regulation of soluble gnanylyl cyclase -- 3.1 Introduction -- 3.2 Primary structure of soluble guanylyl cyclase -- 3.3 Catalytic activity -- 3.4 Isoforms -- 3.5 Regulation -- Chapter 4. Cyclic GMP receptor proteins: role in nervous system and other tissues -- 4.1 Cyclic GMP-dependent protein kinases -- 4.2 Cyclic GMP-regulated ion channels -- 4.3 Cyclic GMP-regulated phosphodiesterases -- 4.4 Role of cyclic GMP kinase in the nervous system -- Chapter 5. Localization of nitric oxide neurons in the central nervous system -- 5.1 Introduction -- 5.2 Caveats and cautions -- 5.3 Localization of NOS in the mammalian central nervous system -- 5.4 Non-mammalian species -- 5.5 NOS expression during development and following injury -- 5.6 Localization of soluble guanylyl cyclase, the NO receptor -- 5.7 Conclusions -- Chapter 6. Nitric oxide and excitatory amino acid-coupled signal transduction in the cerebellum and hippocampus -- 6.1 Historical background -- 6.2 Nitric oxide synthase (1.14.23) -- 6.3 Cerebellum -- 6.4 Hippocampus -- 6.5 Conclusions -- Chapter 7. Nitric oxide signalling, long-term potentiation and long-term depression -- 7.1 Introduction 7.2 Long-term potentiation, the hippocampus and memory -- 7.3 Nitric oxide and LTP -- 7.4 Long-term depression in the hippocampus -- 7.5 Long-term depression in the cerebellum -- 7.6 Conclusions -- Chapter 8. Nitric oxide signalling in the hypothalamus -- 8.1 Introduction -- 8.2 NOS in the hypothalamus -- 8.3 Corticotropin-releasing hormone neurosecretory system -- 8.4 Luteinizing hormone-releasing hormone neurosecretory system -- 8.5 Vasopressin neurosecretory system -- 8.6 Somatostatin release -- 8.7 Autonomic regulation -- 8.8 Functional considerations -- 8.9 Conclusions -- Chapter 9. Glial cells as nitric oxide sources and targets -- 9.1 Introduction -- 9.2 Evidence for a constitutive, calcium-activated nitric oxide synthase in astrocytes -- 9.3 Induction of NOS in glia in vitro -- 9.4 Regulation of the inducible NOS in glia -- 9.5 Induction of NOS in vivo -- 9.6 Glia as targets for NO -- 9.7 Summary -- Chapter 10. Nitric oxide toxicity in neuronal injury and degeneration -- 10.1 Introduction -- 10.2 The short half-life of nitric oxide -- 10.3 Nitric oxide is not highly reactive or toxic -- 10.4 Nitric oxide and transition metals -- 10.5 Diffusion of nitric oxide -- 10.6 Haemoglobin is a major trap for nitric oxide in vivo -- 10.7 Superoxide in cerebral ischaemic injury -- 10.8 Peroxynitrite as an oxidant -- 10.9 The interaction of superoxide and nitric oxide in cerebral ischaemia -- 10.10 Inhibition of nitric oxide synthesis in cerebral ischaemia -- 10.11 Superoxide dismutase and cerebral ischaemia -- 10.12 Superoxide dismutase-catalysed nitration -- 10.13 Motor neuron disease, superoxide dismutase and peroxynitrite -- Chapter 11. Nitric oxide and the regulation of cerebral arterial tone -- 11.1 Introduction -- 11.2 NO derived from vasodilator nerve -- 11.3 NO derived from the endothelium -- 11.4 Conclusion |
| Title | Nitric oxide in the nervous system |
| URI | https://cir.nii.ac.jp/crid/1130282269104138880 https://ebookcentral.proquest.com/lib/[SITE_ID]/detail.action?docID=312769 https://www.vlebooks.com/vleweb/product/openreader?id=none&isbn=9780080537559&uid=none |
| Volume | v.Volume - |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3PS8MwFI66kzupU5w6LUO8SKVr0rQ76pgOQU9zzFNJ2hSK2oGrP_96v2TZplMQvYS2sEC_l773veR7b4QcIki2faWYKwVlLlPgcBGVykUyRBFOU0ozXeB8dc17N-xyGAyXl14-V5eU8iR5_7Gu5D9WxTPYVVfJ_sGys0nxANewL0ZYGOMC-Z3d2mrZXDfWPx695qmaKhULfPVazzrpzTwFcpAXWn9pBV3wbFYhmNrKt2Ah0Z_r5U0Nid4w6OFbwIrTGwnCroNpZqhPlOGMItvN9WtL6bNTP6DgXhFi10oYaiVc7-J2tjWFsA8WxUwDIjsLs72KZrNWSVWM7-CH4aPLMQJzkeffwpmJ0f01UtF1G-tkWRUbpHZaiHL08OYcOUbjag4PaqQ5Ac4xwDl54QA4xwLnTIDbJIPzbr_Tc-2_RLgC6SL8OZNcKSVaiZ9lQeZL30t9SlkoeUsmkZdxxrmXpF5KM7A95THJhFJhIiPV5gIubYtUilGhtomTSsFZ2weHSigLEiG8TMtggxSXvJV5ddL89Nbx87050R7HGhpQ74CGSNDqpAEw4iTXY0sfDIOEcdAy8IUI7rJODqYwxeb3VoYbd886FADz9s4vM-yS1fkC2SOV8vFJNcCNSrlvLPkBFBoIVA |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.title=Nitric+oxide+in+the+nervous+system&rft.au=Vincent%2C+Steven+R&rft.date=1995-01-01&rft.pub=Academic+Press+%3A+Harcourt+Brace&rft.isbn=9780127219851&rft.externalDocID=BA25308382 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fvle.dmmserver.com%2Fmedia%2F640%2F97800805%2F9780080537559.jpg |