持続性の高リン血症と皮膚石灰沈着症を示した若齢猫の1例
7カ月齢の日本猫が，左前肢の跛行と掌球部の石灰沈着に伴う白斑を主訴に来院した．血液検査では持続的な高リン血症がみられたが，血漿カルシウム値は正常範囲内であった．また，腎不全，甲状腺機能亢進症及び原発性上皮小体機能低下症は認められず，当初は血清中のビタミンD値が高値を示した．リン制限食給与並びにリン吸着剤の投与により，血漿無機リン（iP）値は有意に減少し，カルシウム・リン溶解度積も減少した．また，ビタミンD値は正常値に復した．しかし，血漿iP値は依然正常範囲より高値であった．跛行は改善したものの，掌球の石灰沈着症は初診から2年半以上にわたり観察された．本例の高リン血症の原因は明らかにできなかった...
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| Published in | Nippon Juishikai zasshi Vol. 67; no. 12; pp. 923 - 927 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
公益社団法人 日本獣医師会
20.12.2014
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0446-6454 2186-0211 |
| DOI | 10.12935/jvma.67.923 |
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| Abstract | 7カ月齢の日本猫が，左前肢の跛行と掌球部の石灰沈着に伴う白斑を主訴に来院した．血液検査では持続的な高リン血症がみられたが，血漿カルシウム値は正常範囲内であった．また，腎不全，甲状腺機能亢進症及び原発性上皮小体機能低下症は認められず，当初は血清中のビタミンD値が高値を示した．リン制限食給与並びにリン吸着剤の投与により，血漿無機リン（iP）値は有意に減少し，カルシウム・リン溶解度積も減少した．また，ビタミンD値は正常値に復した．しかし，血漿iP値は依然正常範囲より高値であった．跛行は改善したものの，掌球の石灰沈着症は初診から2年半以上にわたり観察された．本例の高リン血症の原因は明らかにできなかった． |
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| AbstractList | 7カ月齢の日本猫が，左前肢の跛行と掌球部の石灰沈着に伴う白斑を主訴に来院した。血液検査では持続的な高リン血症がみられたが，血漿カルシウム値は正常範囲内であった。また，腎不全，甲状腺機能亢進症及び原発性上皮小体機能低下症は認められず，当初は血清中のビタミンD値が高値を示した。リン制限食給与並びにリン吸着剤の投与により，血漿無機リン(iP)値は有意に減少し，カルシウム・リン溶解度積も減少した。また，ビタミンD値は正常値に復した。しかし，血漿iP値は依然正常範囲より高値であった。跛行は改善したものの，掌球の石灰沈着症は初診から2年半以上にわたり観察された。本例の高リン血症の原因は明らかにできなかった。 7カ月齢の日本猫が，左前肢の跛行と掌球部の石灰沈着に伴う白斑を主訴に来院した．血液検査では持続的な高リン血症がみられたが，血漿カルシウム値は正常範囲内であった．また，腎不全，甲状腺機能亢進症及び原発性上皮小体機能低下症は認められず，当初は血清中のビタミンD値が高値を示した．リン制限食給与並びにリン吸着剤の投与により，血漿無機リン（iP）値は有意に減少し，カルシウム・リン溶解度積も減少した．また，ビタミンD値は正常値に復した．しかし，血漿iP値は依然正常範囲より高値であった．跛行は改善したものの，掌球の石灰沈着症は初診から2年半以上にわたり観察された．本例の高リン血症の原因は明らかにできなかった． |
| Author | 黒田, 聡史 村岡, 登 伊藤, 直之 佐々木, 伸雄 |
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| References | [2] Croom AL, Houston DM : Hyperphosphatemic tumoral calcinosis in a young dog with renal failure, Can Vet J, 35, 438-440 (1994) [1] Alabaz D, Mungan N, Turgut M, Dalay C : Unusual idiopathic calcinosis cutis universalis in a child, Case Reports Dermatol, 1, 16-22 (2009) [12] Cheng CY, Kuro-o M, Razzaque MS : Molecular regulation of phosphate metabolism by fibroblast growth factor-23-klotho system, Adv Chronic Kidney Dis, 18, 91-97 (2011) [5] Kidder AC, Chew D : Treatment options for hyperphosphatemia in feline CKD: whatʼs out there?, J Feline Med Surg, 11, 913-924 (2009) [3] Komori S, Washizu M : Metastatic calcinosis circumscripta treated with an oral charcoal absorbent in a dog, J Vet Med Sci, 63, 913-916 (2001) [9] Jackson HA, Barber PJ : Resolution of metastatic calcification in the paws of a cat with successful dietary management of renal hyperparathyroidism, J Small Anim Pract, 39, 495-497 (1998) [14] Jyothsna G, Michel B : Genetic disorders of phosphate regulation, Pediatr Nephrol, 27, 1477-1487 (2012) [13] Nakai K, Komaba H, Fukagawa M : New insights into the role of fibroblast growth factor 23 in chronic kidney disease, J Nephrol, 23, 619-625 (2010) [7] Bertazzolo W, Toscani L, Calcaterra S, Crippa L, Caniatti M, Bonfanti U : Clinicopathological findings in five cats with paw calcification, J Feline Med Surg, 5, 11-17 (2003) [8] Declercq J, Bhatti S : Calcinosis involving multiple paws in a cat with chronic renal failure and in a cat with hyperthyroidism, Vet Dermatol, 16, 74-78 (2005) [10] Morita T, Awakura T, Shimada A, Umemura T, Nagai T, Haruna A : Vitamin D toxicosis in cats: natural outbreak and experimental study, J Vet Med Sci, 57, 831-837 (1995) [4] Richard WN : Electrolyte imbalance, Small Animal Internal Medicine, Richard WN, et al eds, 3rd ed, 828, Mosby, St. Louis (2003) [6] Anderson WI, Cline JM, Scott DW : Calcinosis circumscripta of the tongue in a cat, Cornell Vet, 78, 381-384 (1988) [11] Lees GE, Brown SA, Elliott J, Grauer GE, Vaden SL : Assessment and management of proteinuria in dogs and cats: 2004 ACVIM Forum Consensus Statement (small animal), J Vet Intern Med, 19, 377-385 (2005) |
| References_xml | – reference: [10] Morita T, Awakura T, Shimada A, Umemura T, Nagai T, Haruna A : Vitamin D toxicosis in cats: natural outbreak and experimental study, J Vet Med Sci, 57, 831-837 (1995) – reference: [1] Alabaz D, Mungan N, Turgut M, Dalay C : Unusual idiopathic calcinosis cutis universalis in a child, Case Reports Dermatol, 1, 16-22 (2009) – reference: [4] Richard WN : Electrolyte imbalance, Small Animal Internal Medicine, Richard WN, et al eds, 3rd ed, 828, Mosby, St. Louis (2003) – reference: [13] Nakai K, Komaba H, Fukagawa M : New insights into the role of fibroblast growth factor 23 in chronic kidney disease, J Nephrol, 23, 619-625 (2010) – reference: [7] Bertazzolo W, Toscani L, Calcaterra S, Crippa L, Caniatti M, Bonfanti U : Clinicopathological findings in five cats with paw calcification, J Feline Med Surg, 5, 11-17 (2003) – reference: [11] Lees GE, Brown SA, Elliott J, Grauer GE, Vaden SL : Assessment and management of proteinuria in dogs and cats: 2004 ACVIM Forum Consensus Statement (small animal), J Vet Intern Med, 19, 377-385 (2005) – reference: [2] Croom AL, Houston DM : Hyperphosphatemic tumoral calcinosis in a young dog with renal failure, Can Vet J, 35, 438-440 (1994) – reference: [5] Kidder AC, Chew D : Treatment options for hyperphosphatemia in feline CKD: whatʼs out there?, J Feline Med Surg, 11, 913-924 (2009) – reference: [9] Jackson HA, Barber PJ : Resolution of metastatic calcification in the paws of a cat with successful dietary management of renal hyperparathyroidism, J Small Anim Pract, 39, 495-497 (1998) – reference: [14] Jyothsna G, Michel B : Genetic disorders of phosphate regulation, Pediatr Nephrol, 27, 1477-1487 (2012) – reference: [12] Cheng CY, Kuro-o M, Razzaque MS : Molecular regulation of phosphate metabolism by fibroblast growth factor-23-klotho system, Adv Chronic Kidney Dis, 18, 91-97 (2011) – reference: [8] Declercq J, Bhatti S : Calcinosis involving multiple paws in a cat with chronic renal failure and in a cat with hyperthyroidism, Vet Dermatol, 16, 74-78 (2005) – reference: [3] Komori S, Washizu M : Metastatic calcinosis circumscripta treated with an oral charcoal absorbent in a dog, J Vet Med Sci, 63, 913-916 (2001) – reference: [6] Anderson WI, Cline JM, Scott DW : Calcinosis circumscripta of the tongue in a cat, Cornell Vet, 78, 381-384 (1988) |
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| Snippet | 7カ月齢の日本猫が，左前肢の跛行と掌球部の石灰沈着に伴う白斑を主訴に来院した．血液検査では持続的な高リン血症がみられたが，血漿カルシウム値は正常範囲... 7カ月齢の日本猫が，左前肢の跛行と掌球部の石灰沈着に伴う白斑を主訴に来院した。血液検査では持続的な高リン血症がみられたが，血漿カルシウム値は正常範囲... |
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| Title | 持続性の高リン血症と皮膚石灰沈着症を示した若齢猫の1例 |
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