Mortierella wolfii感染による新生子牛の壊死性小脳炎
北海道内の黒毛和種牛飼養農場で，子牛1頭が出生直後から起立不能，後弓反張及び意識混濁等の神経症状を呈し，生後3日目で死亡した．剖検では，小脳の大部分の領域で出血と軟化が認められた．肝臓及び腎臓に白色結節が散見され，脾臓に赤色結節が1カ所みられた．組織学的に，小脳では出血性壊死性炎症がみられ，病変部には多数の真菌がみられた．肝臓，腎臓及び脾臓には壊死を伴う真菌の増殖と肉芽腫の形成がみられた．真菌の形態と，小脳病変部のパラフィン切片から得られたDNAサンプルを用いた分子生物学的解析の結果より，本真菌はMortierella wolfii（M. wolfii）と同定され，本症例は新生子牛のM. wo...
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| Published in | Nippon Juishikai zasshi Vol. 68; no. 2; pp. 112 - 116 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
公益社団法人 日本獣医師会
20.02.2015
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0446-6454 2186-0211 |
| DOI | 10.12935/jvma.68.112 |
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| Abstract | 北海道内の黒毛和種牛飼養農場で，子牛1頭が出生直後から起立不能，後弓反張及び意識混濁等の神経症状を呈し，生後3日目で死亡した．剖検では，小脳の大部分の領域で出血と軟化が認められた．肝臓及び腎臓に白色結節が散見され，脾臓に赤色結節が1カ所みられた．組織学的に，小脳では出血性壊死性炎症がみられ，病変部には多数の真菌がみられた．肝臓，腎臓及び脾臓には壊死を伴う真菌の増殖と肉芽腫の形成がみられた．真菌の形態と，小脳病変部のパラフィン切片から得られたDNAサンプルを用いた分子生物学的解析の結果より，本真菌はMortierella wolfii（M. wolfii）と同定され，本症例は新生子牛のM. wolfii感染症と診断された． |
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| AbstractList | 北海道内の黒毛和種牛飼養農場で，子牛1頭が出生直後から起立不能，後弓反張及び意識混濁等の神経症状を呈し，生後3日目で死亡した。剖検では，小脳の大部分の領域で出血と軟化が認められた。肝臓及び腎臓に白色結節が散見され，脾臓に赤色結節が1カ所みられた。組織学的に，小脳では出血性壊死性炎症がみられ，病変部には多数の真菌がみられた。肝臓，腎臓及び脾臓には壊死を伴う真菌の増殖と肉芽腫の形成がみられた。真菌の形態と，小脳病変部のパラフィン切片から得られたDNAサンプルを用いた分子生物学的解析の結果より，本真菌はMortierella wolfii(M. wolfii)と同定され，本症例は新生子牛のM. wolfii感染症と診断された。 北海道内の黒毛和種牛飼養農場で，子牛1頭が出生直後から起立不能，後弓反張及び意識混濁等の神経症状を呈し，生後3日目で死亡した．剖検では，小脳の大部分の領域で出血と軟化が認められた．肝臓及び腎臓に白色結節が散見され，脾臓に赤色結節が1カ所みられた．組織学的に，小脳では出血性壊死性炎症がみられ，病変部には多数の真菌がみられた．肝臓，腎臓及び脾臓には壊死を伴う真菌の増殖と肉芽腫の形成がみられた．真菌の形態と，小脳病変部のパラフィン切片から得られたDNAサンプルを用いた分子生物学的解析の結果より，本真菌はMortierella wolfii（M. wolfii）と同定され，本症例は新生子牛のM. wolfii感染症と診断された． |
| Author | 小林, 亜由美 花房, 泰子 稲垣, 華絵 山本, 敦子 信本, 聖子 和田, 好洋 芝原, 友幸 |
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| References | [2] Wagner L, Stielow B, Hoffmann K, Petkovits T, Papp T, Vágvölgyi C, de Hoog GS, Verkley G, Voigt K : A comprehensive molecular phylogeny of the Mortierellales (Mortierellomycotina) based on nuclear ribosomal DNA, Persoonia, 30, 77-93 (2013) [15] Wada S, Ode H, Hobo S, Niwa, H, Katayama Y, Takatori K : Mortierella wolfii keratomycosis in a horse, Vet Ophthalmol, 14, 267-270 (2011) [1] White MM, James TY, O'Donnell K, Cafaro MJ, Tanabe Y, Sugiyama J : Phylogeny of the Zygomycota based on nuclear ribosomal sequence data, Mycologia, 98, 872-884 (2006) [12] Komoda M, Itoi Y, Ozai Y, Kimura Y, Koizumi S, Takatori K : An infection of cow with Mortierella wolfii, Mycopathologia, 101, 89-93 (1988) [19] Rocha MA, Barbosa EF, Guimarães SE, Dias Neto E, Gouveia AM : A high sensitivity-nested PCR assay for BHV-1 detection in semen of naturally infected bulls, Vet Microbiol, 63, 1-11 (1998) [7] MacDonald SM, Corbel MJ : Mortierella wolfii infection in cattle in Britain, Vet Rec, 109, 419-421 (1981) [9] Neilan MC, McCausland IP, Maslen M : Mycotic pneumonia, placentitis and neonatal encephalitis in dairy cattle caused by Mortierella wolfii, Aust Vet J, 59, 48-49 (1982) [8] Munday JS, Laven RA, Orbell GM, Pandey SK : Meningoencephalitis in an adult cow due to Mortierella woiflii, J Vet Diagn Invest, 18, 619-622 (2006) [18] Vilcek S, Herring AJ, Herring JA, Nettleton PF, Lowings JP, Paton DJ : Pestivirus isolated from pigs, cattle and sheep can be allocated into at least three genogroups using polymerase chain reaction and restriction endonuclease analysis, Arch Virol, 136, 309-323 (1994) [14] Carter ME, Cordes DO, di Menna ME, Hunter R : Fungi isolated from bovine mycotic abortion and pneumonia with special reference to Mortierella wolfii, Res Vet Sci, 14, 201-206 (1973) [22] Jensen HE, Aalbaek B, Lind P, Krogh HV : Immunohistochemical diagnosis of systemic bovine zygomycosis by murine monoclonal antibodies, Vet Pathol, 33, 176-183 (1996) [6] Johnson CT, Lupson GR, Lawrence KE : Mortierella wolfii abortion in British cows, Vet Rec, 127, 363 (1990) [16] Yokota T, Shibahara T, Wada Y, Hiraki R, Ishikawa Y, Kadota K : Aspergillus fumigatus infection in an ostrich (Struthio camelus), J Vet Med Sci, 66, 201-204 (2004) [17] White TJ, Bruns T, Lee S, Taylor J : Amplication and direct sequencing of fungal ribosomal RNA genes for phylogenetics, PCR Protocols, Innis MA, et al eds, 315-322, Academic Press INC, London (1990) [11] Munday JS, Wolfe AG, Lawrence KE, Pandey SK : Disseminated Mortierella wolfii infection in a neonatal calf, N Z Vet J, 58, 62-63 (2010) [10] Wohlgemuth K, Knudtson WU : Abortion associated with Mortierella wolfii in cattle, J Am Vet Med Assoc, 171, 437-439 (1977) [3] Davies JL, Ngeleka M, Wobeser GA : Systemic infection with Mortierella wolfii following abortion in a cow, Can Vet J, 51, 1391-1393 (2010) [4] Done SH, Sharp MW, Lupson GR : Isolation of Mortierella wolfii from bovine lung, Vet Rec, 134, 194 (1994) [5] Gabor LJ : Mycotic pneumonia in a dairy cow caused by Mortierella wolfii, Aust Vet J, 81, 409-410 (2003) [13] Uzal FA, Connole MD, O'Boyle D, Dobrenov B, Kelly WR : Mortierella wolfii isolated from the liver of a cow in Australia, Vet Rec, 145, 260-261 (1999) [21] Jensen HE, Krogh HV, Schønheyder H : Bovine mycotic abortion--a comparative study of diagnostic methods, Zentralbl Veterinarmed B, 38, 33-40 (1991) [20] Akashi H, Onuma S, Nagano H, Ohta M, Fukutomi T : Detection and differentiation of Aino and Akabane Simbu serogroup bunyaviruses by nested polymerase chain reaction, Arch Virol, 144, 2101-2109 (1999) |
| References_xml | – reference: [1] White MM, James TY, O'Donnell K, Cafaro MJ, Tanabe Y, Sugiyama J : Phylogeny of the Zygomycota based on nuclear ribosomal sequence data, Mycologia, 98, 872-884 (2006) – reference: [16] Yokota T, Shibahara T, Wada Y, Hiraki R, Ishikawa Y, Kadota K : Aspergillus fumigatus infection in an ostrich (Struthio camelus), J Vet Med Sci, 66, 201-204 (2004) – reference: [7] MacDonald SM, Corbel MJ : Mortierella wolfii infection in cattle in Britain, Vet Rec, 109, 419-421 (1981) – reference: [22] Jensen HE, Aalbaek B, Lind P, Krogh HV : Immunohistochemical diagnosis of systemic bovine zygomycosis by murine monoclonal antibodies, Vet Pathol, 33, 176-183 (1996) – reference: [6] Johnson CT, Lupson GR, Lawrence KE : Mortierella wolfii abortion in British cows, Vet Rec, 127, 363 (1990) – reference: [13] Uzal FA, Connole MD, O'Boyle D, Dobrenov B, Kelly WR : Mortierella wolfii isolated from the liver of a cow in Australia, Vet Rec, 145, 260-261 (1999) – reference: [3] Davies JL, Ngeleka M, Wobeser GA : Systemic infection with Mortierella wolfii following abortion in a cow, Can Vet J, 51, 1391-1393 (2010) – reference: [9] Neilan MC, McCausland IP, Maslen M : Mycotic pneumonia, placentitis and neonatal encephalitis in dairy cattle caused by Mortierella wolfii, Aust Vet J, 59, 48-49 (1982) – reference: [11] Munday JS, Wolfe AG, Lawrence KE, Pandey SK : Disseminated Mortierella wolfii infection in a neonatal calf, N Z Vet J, 58, 62-63 (2010) – reference: [20] Akashi H, Onuma S, Nagano H, Ohta M, Fukutomi T : Detection and differentiation of Aino and Akabane Simbu serogroup bunyaviruses by nested polymerase chain reaction, Arch Virol, 144, 2101-2109 (1999) – reference: [12] Komoda M, Itoi Y, Ozai Y, Kimura Y, Koizumi S, Takatori K : An infection of cow with Mortierella wolfii, Mycopathologia, 101, 89-93 (1988) – reference: [15] Wada S, Ode H, Hobo S, Niwa, H, Katayama Y, Takatori K : Mortierella wolfii keratomycosis in a horse, Vet Ophthalmol, 14, 267-270 (2011) – reference: [14] Carter ME, Cordes DO, di Menna ME, Hunter R : Fungi isolated from bovine mycotic abortion and pneumonia with special reference to Mortierella wolfii, Res Vet Sci, 14, 201-206 (1973) – reference: [18] Vilcek S, Herring AJ, Herring JA, Nettleton PF, Lowings JP, Paton DJ : Pestivirus isolated from pigs, cattle and sheep can be allocated into at least three genogroups using polymerase chain reaction and restriction endonuclease analysis, Arch Virol, 136, 309-323 (1994) – reference: [2] Wagner L, Stielow B, Hoffmann K, Petkovits T, Papp T, Vágvölgyi C, de Hoog GS, Verkley G, Voigt K : A comprehensive molecular phylogeny of the Mortierellales (Mortierellomycotina) based on nuclear ribosomal DNA, Persoonia, 30, 77-93 (2013) – reference: [5] Gabor LJ : Mycotic pneumonia in a dairy cow caused by Mortierella wolfii, Aust Vet J, 81, 409-410 (2003) – reference: [21] Jensen HE, Krogh HV, Schønheyder H : Bovine mycotic abortion--a comparative study of diagnostic methods, Zentralbl Veterinarmed B, 38, 33-40 (1991) – reference: [17] White TJ, Bruns T, Lee S, Taylor J : Amplication and direct sequencing of fungal ribosomal RNA genes for phylogenetics, PCR Protocols, Innis MA, et al eds, 315-322, Academic Press INC, London (1990) – reference: [8] Munday JS, Laven RA, Orbell GM, Pandey SK : Meningoencephalitis in an adult cow due to Mortierella woiflii, J Vet Diagn Invest, 18, 619-622 (2006) – reference: [4] Done SH, Sharp MW, Lupson GR : Isolation of Mortierella wolfii from bovine lung, Vet Rec, 134, 194 (1994) – reference: [19] Rocha MA, Barbosa EF, Guimarães SE, Dias Neto E, Gouveia AM : A high sensitivity-nested PCR assay for BHV-1 detection in semen of naturally infected bulls, Vet Microbiol, 63, 1-11 (1998) – reference: [10] Wohlgemuth K, Knudtson WU : Abortion associated with Mortierella wolfii in cattle, J Am Vet Med Assoc, 171, 437-439 (1977) |
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| Snippet | 北海道内の黒毛和種牛飼養農場で，子牛1頭が出生直後から起立不能，後弓反張及び意識混濁等の神経症状を呈し，生後3日目で死亡した．剖検では，小脳の大部分の領域で出... 北海道内の黒毛和種牛飼養農場で，子牛1頭が出生直後から起立不能，後弓反張及び意識混濁等の神経症状を呈し，生後3日目で死亡した。剖検では，小脳の大部分の領域で出血と... |
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| SubjectTerms | Mortierella wolfii 壊死性小脳炎 新生子牛 |
| Title | Mortierella wolfii感染による新生子牛の壊死性小脳炎 |
| URI | https://www.jstage.jst.go.jp/article/jvma/68/2/68_112/_article/-char/ja https://agriknowledge.affrc.go.jp/RN/2010891217 |
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