セイシェル共和国における水銀と健康の問題
母親の食事由来の低濃度メチル水銀の胎児期曝露が,その後の児の発達に与える影響を検証する疫学的調査として良く知られているのは,デンマーク領フェロー諸島前向き研究(Faroe Islands Prospective Study)とセイシェル小児発達研究(Seychelles Child Development Study:SCDS)の2つである。両研究は,曝露量,対象集団の規模,および神経発達の検査法が比較的類似しているにも関わらず,結果的にはSCDSではフェロー諸島で認められた様な小児の神経・認知・行動への影響は見出されていない。本稿では調査の背景となったセイシェル共和国の自然と人々,生活様式,...
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| Published in | 環境科学会誌 Vol. 17; no. 3; pp. 163 - 168 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
社団法人 環境科学会
2004
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0915-0048 1884-5029 |
| DOI | 10.11353/sesj1988.17.163 |
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| Abstract | 母親の食事由来の低濃度メチル水銀の胎児期曝露が,その後の児の発達に与える影響を検証する疫学的調査として良く知られているのは,デンマーク領フェロー諸島前向き研究(Faroe Islands Prospective Study)とセイシェル小児発達研究(Seychelles Child Development Study:SCDS)の2つである。両研究は,曝露量,対象集団の規模,および神経発達の検査法が比較的類似しているにも関わらず,結果的にはSCDSではフェロー諸島で認められた様な小児の神経・認知・行動への影響は見出されていない。本稿では調査の背景となったセイシェル共和国の自然と人々,生活様式,を紹介するとともにこれまでの調査の主要な結果をまとめ,SCDSの位置づけなどを考えてみた。 |
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| AbstractList | 母親の食事由来の低濃度メチル水銀の胎児期曝露が,その後の児の発達に与える影響を検証する疫学的調査として良く知られているのは,デンマーク領フェロー諸島前向き研究(Faroe Islands Prospective Study)とセイシェル小児発達研究(Seychelles Child Development Study:SCDS)の2つである。両研究は,曝露量,対象集団の規模,および神経発達の検査法が比較的類似しているにも関わらず,結果的にはSCDSではフェロー諸島で認められた様な小児の神経・認知・行動への影響は見出されていない。本稿では調査の背景となったセイシェル共和国の自然と人々,生活様式,を紹介するとともにこれまでの調査の主要な結果をまとめ,SCDSの位置づけなどを考えてみた。 |
| Author | 岡, 知子 亀尾, 聡美 佐藤, 洋 仲井, 邦彦 |
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| References | 12) Davidson, P.W., Myers, G.J., Cox, C., Shamlaye, C.,Choisy, O., Sloane-Reeves, J., Cernichiari, E.,Marsh, D.O., Berlin, M., Tanner, M.A., Clarkson,T.W. (1995) Longitudinal neurodevelopmental study of Seychellois children following in utero exposure to methylmercury from maternal fish ingestion: outcomes at 19 and 29 months. Neurotoxicology, 16, 677-688. 5) Shamlaye, C.F., Marsh, D.O., Myers, G.J., Cox,C., Davidson, P.W., Choisy, O., Cernichiari, E.,Choi, A., Tanner, M.A., Clarkson, T.W.(1995).The Seychelles Child Development Study on neurodevelopmental outcomes in children following in utero exposure to methylmercury from a maternal fish diet:Background and demographics. Neurotoxicology,16,597-612. 2) Nakai, K, Satoh, H.(2002) Developmental neuro-toxicity following prenatal exposures to methylmer-cury and PCBs in humans from epidemiological studies. Tohoku J Exp Med,196,89-98. 4) Marsh, D.O., Clarkson, T.W., Myers, G.J., Davidson, P.W., Cox, C., Cernichiari, E., Tanner, M.A.,Lednar, W., Shamlaye, C.F., Choisy, C.H., Merlin, M. (1995)The Seychelles study of fetal methylmercury exposure and child development: Introduction. Neurotoxicology, 16, 583-586. 10) Myers, G.J., Marsh, D.O., Davidson, P.W., Cox, C.,Shamlaye, C.F., Tanner, M.A., Choi, A., Cernichiari, E., Choisy, O., Clarkson, T.W.(1995) Main neurodeveopmental study of Seychellois children following in utero exposure to methylmercury from a maternal fish diet: outcome at sixmonths. Neurotoxicology 16, 653-664. 1) Mahaffeg K.R.(1998) Methlmercury exposure and neurotoxicity{editorial;comment}. JAMA,280,737-8. 6) Cox, C., Clarkson, T.W., Marsh, D.O., Amin-Zaki, L., Tikriti, S., Myers, G.G. (1989) Dose-response analysis of infants prenatally exposed to methyl mercury: an application of a single compartmentmodel to single-strand hair analysis. Environ Res; 49, 318-32. 7) Myers, G.J., Marsh, D.O., Cox, C., Davidson, P.W., Shamlaye, C.F., Tanner, M.A., Choi, A., Cernichiari, E., Choisy, O., Clarkson, T.W.(1995) Apilot neurodevelopmental study of Seychellois children following in utero exposure to methylmercury from a maternal fish diet. Neurotoxicology,16,629-38. 13) Davidson, P.W., Myers, G.J., Cox, C., Axtell, C., Shamlaye, C., Sloane-Reeves, J., Cernichiari, E., Needham, L., Choi, A,. Wang, Y., Berlin, M., Clarkson, T.W. (1998) Effects of prenatal and postnatal methylmercury exposure from fish consumption on neurodevelopment:: Outcomes at 66 months of age in the Seychelles child Development Study. JAMA, 280, 701-707. 9) Myers, G.J., Davidson, P.W., Cox, C., Shamlaye, C.F., Tanner, M.A., Marsh, D.O., Cernichiari, E., Lapham, L.W., Berlin, M., Clarkson, T.W. (1995) Summary of the Seychelles Child DevelopmentStudy on the relationship of fetal methylmercury exposure to neurodevelopment. Neurotoxicology, 16, 711-716. 8) Myers, G.J., Davidson, P.W., Cox, C., Shamlaye,C.F., Tanner, M.A., Choisy, O., Sloane-Reeves J, Marsh DO, Cernichiari E, Choi A, Berlin M, and Clarkson TW.(1995) Neurodevelopmental outcomes of Seychellois children sixty six months af-ter in utero exposure to methylmercury from amaternal fish diet: pilot study. Neurotoxicology, 16, 639-652. 15) Myers, G.J., Davidson, P.W., Cox, C., Shamlaye,C.F, Palumbo, D., Cernichiari, E., Sloane-Reeves,J,.Wilding, G.E., Kost, J., Huang, L.S., Clarkson, T.W. (2003) Prenatal methylmercury exposure from ocean fish consumption in the Seychelles child development study. Lancet; 361 (9370), 1686-92. 14) 佐藤洋,「有機水銀の健康影響関する文献レビユー」重金属の健康影響に関する総合研究班総会,有機水銀の健康影響に関する研究,H10年度報告書(財)日本公衆衛生協会 11) 佐藤洋,「有機水銀の健康影響関する文献レビユー」重金属の健康影響に関する総合研究班総会,有機水銀の健康影響に関する研究,H9年度報告書(財)日本公衆衛生協会 3) Annual Report (2001) Seychelles Fishing Authority |
| References_xml | – reference: 5) Shamlaye, C.F., Marsh, D.O., Myers, G.J., Cox,C., Davidson, P.W., Choisy, O., Cernichiari, E.,Choi, A., Tanner, M.A., Clarkson, T.W.(1995).The Seychelles Child Development Study on neurodevelopmental outcomes in children following in utero exposure to methylmercury from a maternal fish diet:Background and demographics. Neurotoxicology,16,597-612. – reference: 7) Myers, G.J., Marsh, D.O., Cox, C., Davidson, P.W., Shamlaye, C.F., Tanner, M.A., Choi, A., Cernichiari, E., Choisy, O., Clarkson, T.W.(1995) Apilot neurodevelopmental study of Seychellois children following in utero exposure to methylmercury from a maternal fish diet. Neurotoxicology,16,629-38. – reference: 11) 佐藤洋,「有機水銀の健康影響関する文献レビユー」重金属の健康影響に関する総合研究班総会,有機水銀の健康影響に関する研究,H9年度報告書(財)日本公衆衛生協会 – reference: 1) Mahaffeg K.R.(1998) Methlmercury exposure and neurotoxicity{editorial;comment}. JAMA,280,737-8. – reference: 3) Annual Report (2001) Seychelles Fishing Authority – reference: 4) Marsh, D.O., Clarkson, T.W., Myers, G.J., Davidson, P.W., Cox, C., Cernichiari, E., Tanner, M.A.,Lednar, W., Shamlaye, C.F., Choisy, C.H., Merlin, M. (1995)The Seychelles study of fetal methylmercury exposure and child development: Introduction. Neurotoxicology, 16, 583-586. – reference: 13) Davidson, P.W., Myers, G.J., Cox, C., Axtell, C., Shamlaye, C., Sloane-Reeves, J., Cernichiari, E., Needham, L., Choi, A,. Wang, Y., Berlin, M., Clarkson, T.W. (1998) Effects of prenatal and postnatal methylmercury exposure from fish consumption on neurodevelopment:: Outcomes at 66 months of age in the Seychelles child Development Study. JAMA, 280, 701-707. – reference: 2) Nakai, K, Satoh, H.(2002) Developmental neuro-toxicity following prenatal exposures to methylmer-cury and PCBs in humans from epidemiological studies. Tohoku J Exp Med,196,89-98. – reference: 6) Cox, C., Clarkson, T.W., Marsh, D.O., Amin-Zaki, L., Tikriti, S., Myers, G.G. (1989) Dose-response analysis of infants prenatally exposed to methyl mercury: an application of a single compartmentmodel to single-strand hair analysis. Environ Res; 49, 318-32. – reference: 15) Myers, G.J., Davidson, P.W., Cox, C., Shamlaye,C.F, Palumbo, D., Cernichiari, E., Sloane-Reeves,J,.Wilding, G.E., Kost, J., Huang, L.S., Clarkson, T.W. (2003) Prenatal methylmercury exposure from ocean fish consumption in the Seychelles child development study. Lancet; 361 (9370), 1686-92. – reference: 8) Myers, G.J., Davidson, P.W., Cox, C., Shamlaye,C.F., Tanner, M.A., Choisy, O., Sloane-Reeves J, Marsh DO, Cernichiari E, Choi A, Berlin M, and Clarkson TW.(1995) Neurodevelopmental outcomes of Seychellois children sixty six months af-ter in utero exposure to methylmercury from amaternal fish diet: pilot study. Neurotoxicology, 16, 639-652. – reference: 9) Myers, G.J., Davidson, P.W., Cox, C., Shamlaye, C.F., Tanner, M.A., Marsh, D.O., Cernichiari, E., Lapham, L.W., Berlin, M., Clarkson, T.W. (1995) Summary of the Seychelles Child DevelopmentStudy on the relationship of fetal methylmercury exposure to neurodevelopment. Neurotoxicology, 16, 711-716. – reference: 14) 佐藤洋,「有機水銀の健康影響関する文献レビユー」重金属の健康影響に関する総合研究班総会,有機水銀の健康影響に関する研究,H10年度報告書(財)日本公衆衛生協会 – reference: 12) Davidson, P.W., Myers, G.J., Cox, C., Shamlaye, C.,Choisy, O., Sloane-Reeves, J., Cernichiari, E.,Marsh, D.O., Berlin, M., Tanner, M.A., Clarkson,T.W. (1995) Longitudinal neurodevelopmental study of Seychellois children following in utero exposure to methylmercury from maternal fish ingestion: outcomes at 19 and 29 months. Neurotoxicology, 16, 677-688. – reference: 10) Myers, G.J., Marsh, D.O., Davidson, P.W., Cox, C.,Shamlaye, C.F., Tanner, M.A., Choi, A., Cernichiari, E., Choisy, O., Clarkson, T.W.(1995) Main neurodeveopmental study of Seychellois children following in utero exposure to methylmercury from a maternal fish diet: outcome at sixmonths. Neurotoxicology 16, 653-664. |
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| SubjectTerms | メチル水銀,セイシェル共和国,小児神経発達影響 |
| Title | セイシェル共和国における水銀と健康の問題 |
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