ラットにおけるHydrometra-endometritis complexの病理発生について
正常性周期を示す31頭のラットの子宮頸管を結紮して79～88日後に剖検し, 13頭の17子宮角にHydrometraの発生を認めた. これらの症例は, 子宮腔に混濁ないし軽度混濁液, または透明液を貯留しており, 前者では子宮内膜炎の併発例が多く, 後者ではそれが少なかった. 子宮内膜炎併発例の子宮腔液からは1例を除いてStreptococcus sp.(Str.), P. pneumotropica (P.P.), Proteus sp.のうち1～2種の細菌が107/ml以上検出され, その他の症例の子宮腔液は細菌数106/ml以下, または無菌であった. いっぽう, 正常性周期の発情前期子...
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| Published in | Japanese journal of veterinary science Vol. 43; no. 3; pp. 387 - 398 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | Japanese |
| Published |
公益社団法人 日本獣医学会
1981
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| Online Access | Get full text |
| ISSN | 0021-5295 1881-1442 |
| DOI | 10.1292/jvms1939.43.387 |
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| Abstract | 正常性周期を示す31頭のラットの子宮頸管を結紮して79～88日後に剖検し, 13頭の17子宮角にHydrometraの発生を認めた. これらの症例は, 子宮腔に混濁ないし軽度混濁液, または透明液を貯留しており, 前者では子宮内膜炎の併発例が多く, 後者ではそれが少なかった. 子宮内膜炎併発例の子宮腔液からは1例を除いてStreptococcus sp.(Str.), P. pneumotropica (P.P.), Proteus sp.のうち1～2種の細菌が107/ml以上検出され, その他の症例の子宮腔液は細菌数106/ml以下, または無菌であった. いっぽう, 正常性周期の発情前期子宮腔液は無菌例が多いが, 細菌汚染例では103～105/ml程度のStr.やP.P.がみられた. 次に, 予め子宮腔内細菌の有無を調べた14頭のラット(細菌陽性子宮角14例, 陰性10例)において, 子宮結紮, 卵巣除去後estradiol 0.2μg/日の20日間皮下注射によりHydrometraの発生は認められず, 子宮内膜炎もほとんどの例に陰性で, わずかに細菌陽性群の3例に認められた. 以上の結果から, Hydrometraの子宮腔液は子宮内細菌の増殖を誘発し, その結果として惹起される子宮内膜の炎症により, Hydrometraは種々の修飾像を呈するものと解された. したがって, Hydrometraを含めてこれらの異常子宮をHydrometra-endometritis complexとして統括するのが妥当と思われる. |
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| AbstractList | 正常性周期を示す31頭のラットの子宮頸管を結紮して79～88日後に剖検し, 13頭の17子宮角にHydrometraの発生を認めた. これらの症例は, 子宮腔に混濁ないし軽度混濁液, または透明液を貯留しており, 前者では子宮内膜炎の併発例が多く, 後者ではそれが少なかった. 子宮内膜炎併発例の子宮腔液からは1例を除いてStreptococcus sp.(Str.), P. pneumotropica (P.P.), Proteus sp.のうち1～2種の細菌が107/ml以上検出され, その他の症例の子宮腔液は細菌数106/ml以下, または無菌であった. いっぽう, 正常性周期の発情前期子宮腔液は無菌例が多いが, 細菌汚染例では103～105/ml程度のStr.やP.P.がみられた. 次に, 予め子宮腔内細菌の有無を調べた14頭のラット(細菌陽性子宮角14例, 陰性10例)において, 子宮結紮, 卵巣除去後estradiol 0.2μg/日の20日間皮下注射によりHydrometraの発生は認められず, 子宮内膜炎もほとんどの例に陰性で, わずかに細菌陽性群の3例に認められた. 以上の結果から, Hydrometraの子宮腔液は子宮内細菌の増殖を誘発し, その結果として惹起される子宮内膜の炎症により, Hydrometraは種々の修飾像を呈するものと解された. したがって, Hydrometraを含めてこれらの異常子宮をHydrometra-endometritis complexとして統括するのが妥当と思われる. |
| Author | 東, 量三 本間, 惣太 |
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| References | [3] Black, W., Simon, J., McNutt, S., and Casida, L. (1953). Investigations on the physiological basis for the differential response of estrous and pseudopregnant rabbit uteri to induced infection. Am. J. Vet. Res. 14, 318-323. [4] Black, W., Ulberg, L., Kidder, H., Simon, J., McNutt, S., and Casida, L. (1953). Inflammatory response of the bovine endometrium. Am. J. Vet. Res. 14, 179-183. [14] Homma, S. (1968). Hydrometra complex induced by cervical ligation in rats. Natl. Inst. Anim. Health. Q. (Jpn.) 8, 40-52. [17] Jawetz, E. (1950). A pneumotropic pasteurella of laboratory animals. I. Bacteriological and serological characteristics of the organisms. J. Infect. Dis. 86, 172-183. [15] Homma, S. (1968). Effect of estradiol or progesterone against the development of hydrometra complex in rats. Natl. Inst. Anim. Health. Q. (Jpn.) 8, 92-104. [26] Tregier, A., and Homburger, F. (1961). Bacterial flora of the mous uterus. Proc. Soc. Exp. Biol. Med. 108, 152-154. [20] Kume, T., and Watanabe, S. (1958). Studies on the bacterial flora in genital organs of mare. Jpn. J. Bacteriol. 14, 99-104. [5] Brennan, P., Fritz, T., and Flynn, R. (1965). Pasteurella pneumotropica: Cultural and biochemical characteristics, and its association with disease in laboratory animals. Lab. Anim. Care. 13, 307-312. [10] Graham, W. (1963). Recovery of a pleuropneumonia-like organism (P. P. L. O.) from the genitalia of the female albino rat. Lab. Anim. Care. 13, 719-724. [21] McDonald, L., Black, W., McNutt, S., and Casida, L. (1952). The response of the rabbit uterus to instillation of semen at different phases of the estrous cycle. Am. J. Vet. Res. 13, 419-424. [29] Willet, E., McShan, W., and Meyer, R. (1952). Relation of stage of cycle and source of luteinizing hormone to superovulation in dairy cattle. Proc. Soc. Exp. Biol. Med. 79, 396-400. [7] Eto, T., Masuda, H., Suzuki, Y., and Hoshi, T. (1962). Progesterone and pregn-4-ene-20α-olone in rat ovarian venous blood at different stage in reproductive cycle. Jpn. J. Anim. Reprod. 8, 34-40. [12] Hoag, W., Wetmore, P., Rogers, J., and Meier, H. (1962). A study of latent pasteurella infection in a mouse colony. J. Infect. Dis. 111, 135-140. [24] Ochi, Y., Ogata, M., Uchida, K., Konishi, S., Takizawa, T., and Ishizaki, R. (1956). Studies on the treatment and prevention of reproductive failures in livestock. II. Bacteriological examination of the vagina and uterus of infertile cows. Jpn. J. Vet. Sci. 17, 217-223. [1] Azuma, R. (1967). Examination of bacteria in various lesions of domestic animals by the gas jet methods. Proceeding of symposium in the 40th general meeting of the Jpn. Soc. Bacteriol., p. 20-27. [18] Jawetz, E., and Baker, W. (1950). A pneumotropic pasteurella of laboratory animals. II. Pathological and immunological studies with the organism. J. Infect. Dis. 86, 184-196. [27] Yamauchi, M., Ashida, K., Mifune, R., and Nakahara, T. (1955). Study on the development of endometritis in the rabbit and cow. Jpn. J. Anim. Reprod. 1, 45-48. [23] Ochi, Y., Ogata, M., Konishi, S., and Yoshida, E. (1954). Studies on the treatment and prevention of reproductive failures in live-stock. I. Bacteriological examination of the vagina and uterus of healthy cows. Jpn. J. Vet. Sci. 16, 219-226. [8] Flynn, R., Brennan, P., and Fritz, T. (1965). Pathogen status of commercially produced laboratory mice. Lab. Anim. Care. 15, 440-447. [11] Hawk, H., Simon, J., Cohen, H., McNutt, S., and Casida, L. (1955). The relative bactericidal activity of the uterus and body cavities of estrous and pseudopregnant rabbit. J. Am. Vet. Med. Assoc. 126, 268-270. [22] Murphree, R., Black, W., Otto, G., and Casida, L. (1951). Effect of site of insemination upon the fertility of gonadotrophin-treated rabbits of different reproductive stages. Endocrinology. 48, 474-480. [6] Broom, A., and Lamming, G. (1958). The influence of ovarian hormones on resistance to uterine infection. Vet. Rec. 70, 603-604. [2] Black, W., Simon, J., Kidder, H., and Wiltbank, J. (1954). Bactericidal activity of the uterus in the rabbit and cow. Am. J. Vet. Res. 15, 247-251. [19] Kume, T., and Sasaki, N. (1960). Studies on pathogenicity of escherichia isolated from animals. 2. Experimental uterine infection of rabbit with escherichia isolated from obstetrical teritory of mare. Jpn. J. Bacterol. 15, 902-909. [13] Homburger, F., Grossman, M., and Tregier, A. (1955). Experimental hydro-uteri (hydrometra) in rodents and some factors determining their formation. Proc. Soc. Exp. Biol. Med. 90, 719-723. [28] Yamauchi, M., Ochi, T., Nakahara, T., Inui, S., and Maruyama, Y. (1957). Studies on the development of endometritis. II. Jpn. J. Anim. Reprod. 2, 107-113. [25] Rowson, L., Lamming, G., and Fry, R. (1953). The relationship between ovarian hormones and uterine infection. Vet. Rec. 65, 335-340. [9] Flynn, R., Simkins, R., Brennan, P., and Fritz, T. (1968). Uterine infection in mice. Z. Versuchstierkd. 10, 131-136. [16] Jawetz, E. (1948). A latent pneumotropic pasteurella of laboratory animals. Proc. Soc. Exp. Biol. Med. 68, 46-48. |
| References_xml | – reference: [11] Hawk, H., Simon, J., Cohen, H., McNutt, S., and Casida, L. (1955). The relative bactericidal activity of the uterus and body cavities of estrous and pseudopregnant rabbit. J. Am. Vet. Med. Assoc. 126, 268-270. – reference: [18] Jawetz, E., and Baker, W. (1950). A pneumotropic pasteurella of laboratory animals. II. Pathological and immunological studies with the organism. J. Infect. Dis. 86, 184-196. – reference: [10] Graham, W. (1963). Recovery of a pleuropneumonia-like organism (P. P. L. O.) from the genitalia of the female albino rat. Lab. Anim. Care. 13, 719-724. – reference: [19] Kume, T., and Sasaki, N. (1960). Studies on pathogenicity of escherichia isolated from animals. 2. Experimental uterine infection of rabbit with escherichia isolated from obstetrical teritory of mare. Jpn. J. Bacterol. 15, 902-909. – reference: [25] Rowson, L., Lamming, G., and Fry, R. (1953). The relationship between ovarian hormones and uterine infection. Vet. Rec. 65, 335-340. – reference: [5] Brennan, P., Fritz, T., and Flynn, R. (1965). Pasteurella pneumotropica: Cultural and biochemical characteristics, and its association with disease in laboratory animals. Lab. Anim. Care. 13, 307-312. – reference: [8] Flynn, R., Brennan, P., and Fritz, T. (1965). Pathogen status of commercially produced laboratory mice. Lab. Anim. Care. 15, 440-447. – reference: [26] Tregier, A., and Homburger, F. (1961). Bacterial flora of the mous uterus. Proc. Soc. Exp. Biol. Med. 108, 152-154. – reference: [23] Ochi, Y., Ogata, M., Konishi, S., and Yoshida, E. (1954). Studies on the treatment and prevention of reproductive failures in live-stock. I. Bacteriological examination of the vagina and uterus of healthy cows. Jpn. J. Vet. Sci. 16, 219-226. – reference: [2] Black, W., Simon, J., Kidder, H., and Wiltbank, J. (1954). Bactericidal activity of the uterus in the rabbit and cow. Am. J. Vet. Res. 15, 247-251. – reference: [3] Black, W., Simon, J., McNutt, S., and Casida, L. (1953). Investigations on the physiological basis for the differential response of estrous and pseudopregnant rabbit uteri to induced infection. Am. J. Vet. Res. 14, 318-323. – reference: [13] Homburger, F., Grossman, M., and Tregier, A. (1955). Experimental hydro-uteri (hydrometra) in rodents and some factors determining their formation. Proc. Soc. Exp. Biol. Med. 90, 719-723. – reference: [14] Homma, S. (1968). Hydrometra complex induced by cervical ligation in rats. Natl. Inst. Anim. Health. Q. (Jpn.) 8, 40-52. – reference: [17] Jawetz, E. (1950). A pneumotropic pasteurella of laboratory animals. I. Bacteriological and serological characteristics of the organisms. J. Infect. Dis. 86, 172-183. – reference: [16] Jawetz, E. (1948). A latent pneumotropic pasteurella of laboratory animals. Proc. Soc. Exp. Biol. Med. 68, 46-48. – reference: [20] Kume, T., and Watanabe, S. (1958). Studies on the bacterial flora in genital organs of mare. Jpn. J. Bacteriol. 14, 99-104. – reference: [22] Murphree, R., Black, W., Otto, G., and Casida, L. (1951). Effect of site of insemination upon the fertility of gonadotrophin-treated rabbits of different reproductive stages. Endocrinology. 48, 474-480. – reference: [9] Flynn, R., Simkins, R., Brennan, P., and Fritz, T. (1968). Uterine infection in mice. Z. Versuchstierkd. 10, 131-136. – reference: [1] Azuma, R. (1967). Examination of bacteria in various lesions of domestic animals by the gas jet methods. Proceeding of symposium in the 40th general meeting of the Jpn. Soc. Bacteriol., p. 20-27. – reference: [15] Homma, S. (1968). Effect of estradiol or progesterone against the development of hydrometra complex in rats. Natl. Inst. Anim. Health. Q. (Jpn.) 8, 92-104. – reference: [4] Black, W., Ulberg, L., Kidder, H., Simon, J., McNutt, S., and Casida, L. (1953). Inflammatory response of the bovine endometrium. Am. J. Vet. Res. 14, 179-183. – reference: [29] Willet, E., McShan, W., and Meyer, R. (1952). Relation of stage of cycle and source of luteinizing hormone to superovulation in dairy cattle. Proc. Soc. Exp. Biol. Med. 79, 396-400. – reference: [7] Eto, T., Masuda, H., Suzuki, Y., and Hoshi, T. (1962). Progesterone and pregn-4-ene-20α-olone in rat ovarian venous blood at different stage in reproductive cycle. Jpn. J. Anim. Reprod. 8, 34-40. – reference: [27] Yamauchi, M., Ashida, K., Mifune, R., and Nakahara, T. (1955). Study on the development of endometritis in the rabbit and cow. Jpn. J. Anim. Reprod. 1, 45-48. – reference: [28] Yamauchi, M., Ochi, T., Nakahara, T., Inui, S., and Maruyama, Y. (1957). Studies on the development of endometritis. II. Jpn. J. Anim. Reprod. 2, 107-113. – reference: [12] Hoag, W., Wetmore, P., Rogers, J., and Meier, H. (1962). A study of latent pasteurella infection in a mouse colony. J. Infect. Dis. 111, 135-140. – reference: [21] McDonald, L., Black, W., McNutt, S., and Casida, L. (1952). The response of the rabbit uterus to instillation of semen at different phases of the estrous cycle. Am. J. Vet. Res. 13, 419-424. – reference: [24] Ochi, Y., Ogata, M., Uchida, K., Konishi, S., Takizawa, T., and Ishizaki, R. (1956). Studies on the treatment and prevention of reproductive failures in livestock. II. Bacteriological examination of the vagina and uterus of infertile cows. Jpn. J. Vet. Sci. 17, 217-223. – reference: [6] Broom, A., and Lamming, G. (1958). The influence of ovarian hormones on resistance to uterine infection. Vet. Rec. 70, 603-604. |
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| Snippet | 正常性周期を示す31頭のラットの子宮頸管を結紮して79～88日後に剖検し, 13頭の17子宮角にHydrometraの発生を認めた. これらの症例は, 子宮腔に混濁ないし軽度混濁液,... |
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| Title | ラットにおけるHydrometra-endometritis complexの病理発生について |
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