Imaging in Stem Cell Transplant and Cell-Based Therapy
This text provides a review of imaging techniques and applications in stem cell transplantation and other cell-based therapies. The basis of different molecular imaging techniques is explained in detail, as is the current state of interventional radiology techniques. While the whole is a comprehensi...
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| Main Author | |
|---|---|
| Format | eBook |
| Language | English |
| Published |
Cham
Springer International Publishing AG
2017
Humana Press Springer International Publishing |
| Edition | 1 |
| Series | Stem Cell Biology and Regenerative Medicine |
| Subjects | |
| Online Access | Get full text |
| ISBN | 9783319518312 3319518313 |
| ISSN | 2196-8985 2196-8993 |
| DOI | 10.1007/978-3-319-51833-6 |
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| Abstract | This text provides a review of imaging techniques and applications in stem cell transplantation and other cell-based therapies. The basis of different molecular imaging techniques is explained in detail, as is the current state of interventional radiology techniques. While the whole is a comprehensive discussion, each chapter is self-sufficient enough so that each can be reviewed independently. |
|---|---|
| AbstractList | This text provides a review of imaging techniques and applications in stem cell transplantation and other cell-based therapies. The basis of different molecular imaging techniques is explained in detail, as is the current state of interventional radiology techniques. While the whole is a comprehensive discussion, each chapter is self-sufficient enough so that each can be reviewed independently. |
| Author | Pandey, Tarun |
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| DOI | 10.1007/978-3-319-51833-6 |
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| Editor | Pandey, Tarun |
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| PublicationSeriesTitle | Stem Cell Biology and Regenerative Medicine |
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| PublicationYear | 2017 |
| Publisher | Springer International Publishing AG Humana Press Springer International Publishing |
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| RelatedPersons | Turksen, Kursad |
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| Snippet | This text provides a review of imaging techniques and applications in stem cell transplantation and other cell-based therapies. The basis of different... |
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| SubjectTerms | Biomedical and Life Sciences Cardiac Imaging Cellular therapy Hematology Interventional Radiology Life Sciences Nuclear Medicine Stem Cells |
| TableOfContents | Intro -- Preface -- Contents -- Contributors -- About the Editor -- Part I: Imaging in Stem Cell Transplant -- Chapter 1: Current Indications and Overview of Molecular Imaging Techniques in Stem Cell Transplantation -- 1.1 Introduction -- 1.1.1 Stem Cell Types: Definitions and Classification -- 1.1.2 History of Stem Cells -- 1.1.3 Clinical Applications of Stem Cells -- 1.1.3.1 Understanding Genetic and Molecular Controls of Cell Division and Differentiation -- 1.1.3.2 Drug Testing -- 1.1.3.3 Cell-Based Therapy -- 1.2 Imaging in Stem Cell Transplant -- 1.3 Use of Imaging Techniques in Stem Cell Transplant -- 1.4 Conclusion -- References -- Chapter 2: Nanotechnology-Based Stem Cell Applications and Imaging -- 2.1 Introduction -- 2.2 Nanotechnology -- 2.3 Tracking of Nanoparticles In Vivo -- 2.3.1 Fluorescent Imaging (Light/Confocal/Two-Photon Microscopy) -- 2.3.2 Magnetic Resonance Imaging (MRI) -- 2.3.3 Photoacoustic Imaging: Photoacoustic Microscopy and Photoacoustic Tomography -- 2.4 Different Nanoparticles and Their Uses in Stem Cell Applications -- 2.4.1 Superparamagnetic Iron Oxide Nanoparticles -- 2.4.2 Quantum Dots -- 2.4.3 Silica Nanoparticles -- 2.4.4 Polymer Nanoparticles -- 2.4.5 Gold Nanoparticles -- 2.5 Nanoenvironments and Nano-Scaffolds -- 2.6 General Safety -- 2.7 Conclusions -- References -- Chapter 3: Radiologic Procedures Used in Pediatric Stem Cell Transplantation -- 3.1 Introduction -- 3.2 Imaging Modalities in Stem Cell Transplant -- 3.2.1 Computed Tomography -- 3.2.2 Positron Emission Tomography (PET)/Magnetic Resonance Imaging (MR) -- 3.2.3 Radionuclide Imaging for Patients Undergoing Hematopoietic Stem Cell Transplantation (HSCT) -- 3.3 Role of Radio-Labeled MIBG Imaging in Children with Neuroblastoma -- 3.4 Ongoing Clinical Trials with MIBI -- 3.5 Diagnostic Use of MIBI -- References 6.2.1 Murine-Human Model for Myeloma -- 6.2.2 Radiography and ELISA -- 6.2.3 Bioluminescence Imaging -- 6.2.4 Magnetic Resonance Imaging -- 6.2.5 18F-FDG-PET Imaging -- 6.3 Conclusion -- References -- Chapter 7: The Emerging Role of Cardiac Stem Cells in Cardiac Regeneration -- 7.1 Introduction -- 7.2 Cardiac Stem Cells (CSCs) -- 7.3 CSCs and In Vivo Fate-Tracing Studies -- 7.4 Animal Studies with CSCs -- 7.5 Clinical Trials with CSCs -- 7.6 Engineering of CSCs: Ex-Vivo Manipulation Studies -- 7.7 Stimulation of Endogenous CSCs -- 7.8 Other Stem Cell Sources for Heart Regeneration -- 7.9 Conclusion -- References -- Chapter 8: Cardiac Imaging and Stem Cell Transplantation -- 8.1 Stem Cell Therapy and Homing -- 8.2 Cardiovascular Applications of Stem Cells -- 8.3 Cardiac Imaging in Stem Cell Therapy -- 8.4 Non-invasive Methods of Cardiac Imaging Post Stem Cell Therapy -- 8.4.1 Direct Labeling of Cells Using Magnetic Resonance Agents -- 8.4.2 Direct Labeling of Cells Using Radionuclides -- 8.4.3 Reporter Genes for Cardiovascular Cell Imaging -- 8.5 Cardiac Imaging for Functional Effects of Stem Cell Therapy -- 8.5.1 LV Function -- 8.5.2 Infarct Size -- 8.5.3 Myocardial Perfusion -- 8.5.4 Myocardial Viability -- 8.6 Summary -- References -- Chapter 9: Bone Marrow Cell Therapy for Ischemic Heart Disease and the Role of Cardiac Imaging in Evaluation of Outcomes -- 9.1 Evolution of Cardiac Cell Therapy -- 9.2 Bone Marrow Cell Therapy for Ischemic Heart Disease -- 9.3 Meta-Analyses of Pooled Data from Clinical Trials of BMC Therapy -- 9.4 Impact of Imaging Modalities on Outcomes of BMC Therapy -- 9.5 Assessment of Clinical Outcomes -- 9.6 Conclusions -- References -- Chapter 10: Uterine Stem Cells and Their Future Therapeutic Potential in Regenerative Medicine -- 10.1 Introduction -- 10.2 Origin of Endometrial Stem Cells (EnSCs) Chapter 4: Clinical Applications of Stem Cell Transplant in Treating Non-Hematologic Conditions -- 4.1 Introduction -- 4.2 Mesenchymal Stem Cells: Unique Attributes -- 4.3 Central Nervous System -- 4.3.1 Brain and Spinal Cord Diseases -- 4.3.1.1 Amyotrophic Lateral Sclerosis (ALS) -- 4.3.1.2 Multiple Sclerosis (MS) -- 4.3.1.3 Alzheimer's Disease -- 4.3.1.4 Stroke -- 4.3.1.5 Spinal Cord Injury (SCI) -- 4.3.2 Musculoskeletal System -- 4.3.2.1 Osteoarthritis -- 4.3.2.2 Rheumatoid Arthritis -- 4.3.2.3 Osteogenesis Imperfecta (OI) -- 4.3.2.4 Degenerative Disc Disease -- 4.4 Gastrointestinal System -- 4.4.1 Cirrhosis -- 4.4.2 Inflammatory Bowel Disease -- 4.5 Pulmonary Diseases -- 4.5.1 Chronic Obstructive Pulmonary Disease (COPD) -- 4.6 Cardiovascular Diseases -- 4.7 Endocrine Diseases -- 4.7.1 Type 1 Diabetes Mellitus -- 4.8 Autoimmune Diseases -- 4.8.1 Systemic Lupus Erythematosus -- 4.8.2 Systemic Sclerosis -- 4.8.3 Inflammatory Myopathies -- 4.9 Inborn Errors of Metabolism -- 4.9.1 Metachromatic Leukodystrophy and Hurler Syndrome: (MLD) -- 4.10 Conclusion -- References -- Part II: Applications in Stem Cell and Cell Based Therapies -- Chapter 5: Stem Cell Transplantation for Multiple Myeloma -- 5.1 Multiple Myeloma -- 5.2 HD-Chemotherapy and ASCT -- 5.2.1 Historic Background -- 5.2.2 Chemotherapy Versus ASCT -- 5.2.3 Single Versus Tandem ASCT -- 5.2.4 ASCT in Relapsed MM -- 5.2.5 ASCT in Elderly Patients -- 5.3 Mobilization and Collection of Peripheral Blood Stem Cells -- 5.4 Total Therapy in MM -- 5.5 Allogeneic Stem Cell Transplantation -- 5.6 Conclusion -- References -- Chapter 6: Simultaneous MRI and 18F-FDG-PET Imaging in Multiple Myeloma: A Model for Evaluation of the Disease and Therapeutic Changes in SCID-hu Mice -- 6.1 Introduction -- 6.2 Current Methods for Assessment of Tumor Burden in Murine Model of hu-myeloma 10.2.1 Epithelial Progenitor Cells -- 10.2.2 Mesenchymal Stem Cells -- 10.2.3 Endothelial Progenitor Cells -- 10.2.4 Endometrial Side Population (SP) Cells -- 10.2.5 Endometrial Regenerative Cells (ERC) -- 10.3 Identification of EnSCs in Murine Models -- 10.4 Markers Identifying Human EnSCs -- 10.5 Multi-dynamic Properties of EnSCs -- 10.5.1 Clonogenecity -- 10.5.2 Immunogenicity -- 10.5.3 Differentiation -- 10.6 EnSCs: Association with Disease Pathogenesis -- 10.7 Therapeutic Utility of Uterine Stem Cells -- 10.7.1 Eutopic MSCs for Targeted Delivery of Anti-angiogenic Agents in Endometriosis -- 10.7.2 Myogenic Differentiation Potential of EnSCs -- 10.7.3 Cardiac Regeneration Potential of EnSCs -- 10.7.4 Neural Regeneration -- 10.7.4.1 Stroke -- 10.7.4.2 Multiple Sclerosis -- 10.7.4.3 Parkinson's Disease (PD) -- 10.7.5 Pancreatic Differentiation -- 10.7.6 Endometrial SCs: Contribution in Tissue Engineering -- 10.7.7 Other Therapeutic Benefits of EnSCs -- 10.7.7.1 Bone Regeneration -- 10.7.7.2 Glioma -- 10.8 EnSCs in Clinical Trials: Success Stories -- 10.9 Pros and Cons of EnSC Therapy -- 10.10 Conclusions -- References |
| Title | Imaging in Stem Cell Transplant and Cell-Based Therapy |
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