Vyzkoušejte nový nástroj s podporou AI
Summon Research Assistant
BETA
Antiviral Activity and Pharmacokinetics of the Hepatitis B Virus (HBV) Capsid Assembly Modulator GLS4 in Patients With Chronic HBV Infection
Zhang, Hong, Wang, Fengjiao, Zhu, Xiaoxue, Chen, Yunfu, Chen, Hong, Li, Xiaojiao, Wu, Min, Li, Cuiyun, Liu, Jingrui, Zhang, Yingjun, Ding, Yanhua, Niu, Junqi
Published in Clinical infectious diseases (15.07.2021)
Published in Clinical infectious diseases (15.07.2021)
Get full text
Journal Article
The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075
Vendeville, Sandrine, Amblard, Franck, Bassit, Leda, Beigelman, Leonid N., Blatt, Lawrence M., Chen, Xiaoyuan, Chou, Lang, Kum, Dieudonné Buh, Chanda, Sushmita, Deval, Jerome, Geng, Xiu, Gupta, Kusum, Jekle, Andreas, Hu, Haiyang, Hu, Xiaojuan, Kang, Hyunsoon, Liu, Cheng, Liu, Jyanwei, McGowan, David C., Misner, Dinah L., Raboisson, Pierre, Sanchez, Abel Acosta, Serebryany, Vladimir, Stoycheva, Antitsa D., Symons, Julian A., Tan, Hua, Vanrusselt, Hannah, Williams, Caroline, Welch, Michael, Zhang, Liangliang, Zhang, Qingling, Zhang, Yafeng, Schinazi, Raymond F., Smith, David B., Debing, Yannick
Published in Journal of medicinal chemistry (12.12.2024)
Published in Journal of medicinal chemistry (12.12.2024)
Get full text
Journal Article
Safety, Pharmacokinetics and Antiviral Efficacy of Capsid Assembly Modulator Freethiadine in Healthy Volunteers and Chronic Hepatitis B Patients
Li, Xiaojiao, Xu, Jia, Sun, Jixuan, Liu, Jingrui, Wu, Min, Zhang, Hong, Zhu, Xiaoxue, Li, Cuiyun, Zhang, Yingjun, Zhu, Jing, Chen, Yujie, Luo, Lin, He, Qingwei, Zhuang, Yulei, Chen, Yunfu, Niu, Junqi, Ding, Yanhua
Published in Liver international (01.01.2025)
Published in Liver international (01.01.2025)
Get full text
Journal Article
Safety, pharmacokinetics, and antiviral activity of the class II capsid assembly modulator ALG-000184 in subjects with chronic hepatitis B
Yuen, Man-Fung, Agarwal, Kosh, Gane, Edward J, Jucov, Alina, Schwabe, Christian, Niu, Junqi, Hou, Jinlin, Le, Kha, Massetto, Benedetta, Westland, Christopher, Zhang, Qingling, Lai, Felix, Venkatraman, Meenakshi, Blatt, Lawrence, Lin, Tse-I, Chanda, Sushmita, McClure, Matt, Fry, John
Published in Journal of hepatology (01.07.2022)
Published in Journal of hepatology (01.07.2022)
Get full text
Journal Article
SAT365 - Safety, pharmacokinetics, and antiviral activity of the class II capsid assembly modulator ALG-000184 in subjects with chronic hepatitis B
Yuen, Man-Fung, Agarwal, Kosh, Gane, Edward J, Jucov, Alina, Schwabe, Christian, Niu, Junqi, Hou, Jinlin, Le, Kha, Massetto, Benedetta, Westland, Christopher, Zhang, Qingling, Lai, Felix, Venkatraman, Meenakshi, Blatt, Lawrence, Lin, Tse-I, Chanda, Sushmita, McClure, Matt, Fry, John
Published in Journal of hepatology (01.07.2022)
Published in Journal of hepatology (01.07.2022)
Get full text
Journal Article
THU-242 Viral kinetics and sequence analysis of a phase I monotherapy study in subjects with chronic hepatitis B reveals a high barrier of resistance to the capsid assembly modulator ALG-000184
Jekle, Andreas, Jackson, Kathy, O’Keefe, Jacinta, Edwards, Ros, Yuen, Lilly, Chibo, Doris, Van, Thanh, Rito, Jen, Maderazo, Maida, Symons, Julian, Blatt, Lawrence, Viani, Rolando, Achneck, Hardean, Lin, Tse-I, Wu, Min
Published in Journal of hepatology (01.05.2025)
Published in Journal of hepatology (01.05.2025)
Get full text
Journal Article
THU-261 Monotherapy with the novel capsid assembly modulator ALG- 000184 for up to 96 weeks results in profound and sustained HBV DNA suppression in untreated subjects with chronic HBV infection
Yuen, Man-Fung, Agarwal, Kosh, Jucov, Alina, Haceatrean, Alexei, Wu, Min, Le, Kha, Van, Thanh, Rito, Jen, Blatt, Lawrence, Chanda, Sushmita, Lin, Tse-I, Achneck, Hardean, Gane, Edward J.
Published in Journal of hepatology (01.05.2025)
Published in Journal of hepatology (01.05.2025)
Get full text
Journal Article
SAT-192 - Treatment for up to 24 weeks with the capsid assembly modulator ALG-000184 results in dose related reductions in HBsAg in subjects with HBeAg positive chronic hepatitis B
Hou, Jinlin, Ding, Yanhua, Niu, Junqi, Liang, Xieer, Yuen, Man-Fung, Gane, Edward J., Agarwal, Kosh, Massetto, Benedetta, Wu, Min, Le, Kha, Venkatraman, Meenakshi, Zhang, Qingling, Westland, Christopher, Maderazo, Maida, Chanda, Sushmita, Beigelman, Leonid, Blatt, Lawrence, Lin, Tse-I, McClure, Matt, Fry, John
Published in Journal of hepatology (01.06.2023)
Published in Journal of hepatology (01.06.2023)
Get full text
Journal Article
Treatment for up to 24 weeks with the capsid assembly modulator ALG-000184 results in dose related reductions in HBsAg in subjects with HBeAg positive chronic hepatitis B
Hou, Jinlin, Ding, Yanhua, Niu, Junqi, Liang, Xieer, Yuen, Man-Fung, Gane, Edward J., Agarwal, Kosh, Massetto, Benedetta, Wu, Min, Le, Kha, Venkatraman, Meenakshi, Zhang, Qingling, Westland, Christopher, Maderazo, Maida, Chanda, Sushmita, Beigelman, Leonid, Blatt, Lawrence, Lin, Tse-I, McClure, Matt, Fry, John
Published in Journal of hepatology (01.06.2023)
Published in Journal of hepatology (01.06.2023)
Get full text
Journal Article
WED-361 Dosing with the Capsid Assembly Modulator ALG-000184 in Untreated HBeAg Negative CHB Subjects Results in Potent Antiviral Effects Including Suppression of HBV DNA/RNA and Declines in HBcrAg Levels
Agarwal, Kosh, Gane, Edward J., Yuen, Man-Fung, Schwabe, Christian, Jucov, Alina, Haceatrean, Alexei, Wu, Min, Le, Kha, Maderazo, Maida, Blatt, Lawrence, Chanda, Sushmita, Lin, Tse-I, McClure, Matt
Published in Journal of hepatology (01.06.2024)
Published in Journal of hepatology (01.06.2024)
Get full text
Journal Article
WED-365 Extended treatment of HBeAg+ CHB subjects with the Capsid assembly modulator ALG-000184 with or without Entecavir is associated with reductions in viral markers and favorable anti-HBeAb trends
Yuen, Man-Fung, Gane, Edward J., Agarwal, Kosh, Niu, Junqi, Ren, Hong, Ding, Yanhua, Liang, Xieer, Yu, Xian, Xu, Jia, Jucov, Alina, Haceatrean, Alexei, Wu, Min, Le, Kha, Maderazo, Maida, Blatt, Lawrence, Chanda, Sushmita, Lin, Tse-I, McClure, Matt, Hou, Jinlin
Published in Journal of hepatology (01.06.2024)
Published in Journal of hepatology (01.06.2024)
Get full text
Journal Article
Pharmacokinetics, Safety and Tolerability of JNJ-56136379, a Novel Hepatitis B Virus Capsid Assembly Modulator, in Healthy Subjects
Vandenbossche, Joris, Jessner, Wolfgang, van den Boer, Maarten, Biewenga, Jeike, Berke, Jan Martin, Talloen, Willem, De Zwart, Loeckie, Snoeys, Jan, Yogaratnam, Jeysen
Published in Advances in therapy (01.09.2019)
Published in Advances in therapy (01.09.2019)
Get full text
Journal Article
Safety, pharmacokinetics and antiviral activity of GST-HG141, a hepatitis B virus capsid assembly modulator, in subjects with chronic hepatitis B
Mai, Jiajia, Zhang, Hong, Wu, Min, Ding, Yanhua, Niu, Junqi, Bichko, Vadim, Tang, Yanan, Yan, Wenhao, Mao, John, Zhang, Dong, Wu, Wenqiang, Ren, Hong, Zhang, George, Li, Hongming, Chen, Shikui, Zhang, Yanhua, Zhigan, Jiang, He, Haiying, Chen, Shuhui
Published in Journal of hepatology (01.07.2022)
Published in Journal of hepatology (01.07.2022)
Get full text
Journal Article
SAT423 - Safety, pharmacokinetics and antiviral activity of GST-HG141, a hepatitis B virus capsid assembly modulator, in subjects with chronic hepatitis B
Mai, Jiajia, Zhang, Hong, Wu, Min, Ding, Yanhua, Niu, Junqi, Bichko, Vadim, Tang, Yanan, Yan, Wenhao, Mao, John, Zhang, Dong, Wu, Wenqiang, Ren, Hong, Zhang, George, Li, Hongming, Chen, Shikui, Zhang, Yanhua, Zhigan, Jiang, He, Haiying, Chen, Shuhui
Published in Journal of hepatology (01.07.2022)
Published in Journal of hepatology (01.07.2022)
Get full text
Journal Article
Safety, Tolerability, and Pharmacokinetics of the Novel Hepatitis B Virus Capsid Assembly Modulator GST-HG141 in Healthy Chinese Subjects: a First-in-Human Single- and Multiple-Dose Escalation Trial
Li, Cuiyun, Wu, Min, Zhang, Hong, Mai, Jiajia, Yang, Lizhi, Ding, Yanhua, Niu, Junqi, Mao, John, Wu, Wenqiang, Zhang, Dong, Tang, Yanan, Yan, Wenhao
Published in Antimicrobial agents and chemotherapy (17.09.2021)
Published in Antimicrobial agents and chemotherapy (17.09.2021)
Get full text
Journal Article
ALG-000184, a capsid assembly modulator, dosed with entecavir for up to 28 weeks is well tolerated and resulted in substantial declines in surface antigen levels in untreated Hepatitis B e antigen positive subjects with chronic hepatitis B
Hou, Jinlin, Ding, Yanhua, Niu, Junqi, Liang, Xieer, Yuen, Man-Fung, Gane, Edward J., Agarwal, Kosh, Wu, Min, Le, Kha, Venkatraman, Meenakshi, Westland, Christopher, Maderazo, Maida, Chanda, Sushmita, Beigelman, Leonid, Blatt, Lawrence, Lin, Tse-I, McClure, Matt, Fry, John
Published in Journal of hepatology (01.06.2023)
Published in Journal of hepatology (01.06.2023)
Get full text
Journal Article
LBP-18 - ALG-000184, a capsid assembly modulator, dosed with entecavir for up to 28 weeks is well tolerated and resulted in substantial declines in surface antigen levels in untreated Hepatitis B e antigen positive subjects with chronic hepatitis B
Hou, Jinlin, Ding, Yanhua, Niu, Junqi, Liang, Xieer, Yuen, Man-Fung, Gane, Edward J., Agarwal, Kosh, Wu, Min, Le, Kha, Venkatraman, Meenakshi, Westland, Christopher, Maderazo, Maida, Chanda, Sushmita, Beigelman, Leonid, Blatt, Lawrence, Lin, Tse-I, McClure, Matt, Fry, John
Published in Journal of hepatology (01.06.2023)
Published in Journal of hepatology (01.06.2023)
Get full text
Journal Article
Safety, pharmacokinetics, and antiviral efficacy of the novel capsid assembly modulator GST-HG141 in patients with chronic hepatitis B: a phase 1 trial with a randomized, placebo-controlled design
Wu, Min, Mai, Jiajia, Zhang, Hong, Zhang, George, Mao, John, Tang, Yanan, Yan, Wenhao, Wu, Wenqiang, Hou, Jinlin, Liang, Xieer, Liu, Zhihong, Ding, Yanhua, Niu, Junqi
Published in Virology journal (20.12.2024)
Published in Virology journal (20.12.2024)
Get full text
Journal Article
Correction to: Pharmacokinetics, Safety and Tolerability of JNJ-56136379, a Novel Hepatitis B Virus Capsid Assembly Modulator, in Healthy Subjects
Vandenbossche, Joris, Jessner, Wolfgang, van den Boer, Maarten, Biewenga, Jeike, Berke, Jan Martin, Talloen, Willem, De Zwart, Loeckie, Snoeys, Jan, Vandyck, Koen, Fry, John, Yogaratnam, Jeysen
Published in Advances in therapy (01.04.2020)
Published in Advances in therapy (01.04.2020)
Get full text
Journal Article
Safety, Tolerability, and Pharmacokinetics of a Novel Human Hepatitis B Virus Capsid Assembly Modulator Canocapavir: A Randomized First-in-Human Study
Jiang, Xiuhong, Hua, Bo, Liu, Gang, Xia, Tian, Deng, Aiyun, Lu, Hui, Guo, Ruoling, Wang, Zhe, Liang, Bo, Chen, Huanming, Jin, Qiu, Zhang, Zhijun
Published in Gastro hep advances (2023)
Published in Gastro hep advances (2023)
Get full text
Journal Article