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Identification of rare sequence variation underlying heritable pulmonary arterial hypertension
Gräf, Stefan, Haimel, Matthias, Bleda, Marta, Hadinnapola, Charaka, Southgate, Laura, Li, Wei, Hodgson, Joshua, Liu, Bin, Salmon, Richard M., Southwood, Mark, Machado, Rajiv D., Martin, Jennifer M., Treacy, Carmen M., Yates, Katherine, Daugherty, Louise C., Shamardina, Olga, Whitehorn, Deborah, Holden, Simon, Aldred, Micheala, Bogaard, Harm J., Church, Colin, Coghlan, Gerry, Condliffe, Robin, Corris, Paul A., Danesino, Cesare, Eyries, Mélanie, Gall, Henning, Ghio, Stefano, Ghofrani, Hossein-Ardeschir, Gibbs, J. Simon R., Girerd, Barbara, Houweling, Arjan C., Howard, Luke, Humbert, Marc, Kiely, David G., Kovacs, Gabor, MacKenzie Ross, Robert V., Moledina, Shahin, Montani, David, Newnham, Michael, Olschewski, Andrea, Olschewski, Horst, Peacock, Andrew J., Pepke-Zaba, Joanna, Prokopenko, Inga, Rhodes, Christopher J., Scelsi, Laura, Seeger, Werner, Soubrier, Florent, Stein, Dan F., Suntharalingam, Jay, Swietlik, Emilia M., Toshner, Mark R., van Heel, David A., Vonk Noordegraaf, Anton, Waisfisz, Quinten, Wharton, John, Wort, Stephen J., Ouwehand, Willem H., Soranzo, Nicole, Lawrie, Allan, Upton, Paul D., Wilkins, Martin R., Trembath, Richard C., Morrell, Nicholas W.
Published in Nature communications (12.04.2018)
Published in Nature communications (12.04.2018)
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Journal Article
An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension
Ryanto, Gusty R. T., Ikeda, Koji, Miyagawa, Kazuya, Tu, Ly, Guignabert, Christophe, Humbert, Marc, Fujiyama, Tomoyuki, Yanagisawa, Masashi, Hirata, Ken-ichi, Emoto, Noriaki
Published in Nature communications (19.03.2021)
Published in Nature communications (19.03.2021)
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Journal Article
Endothelial BMPR2 Loss Drives a Proliferative Response to BMP (Bone Morphogenetic Protein) 9 via Prolonged Canonical Signaling
Theilmann, Anne L., Hawke, Lindsey G., Hilton, L. Rhiannon, Whitford, Mara K.M., Cole, Devon V., Mackeil, Jodi L., Dunham-Snary, Kimberly J., Mewburn, Jeffrey, James, Paula D., Maurice, Donald H., Archer, Stephen L., Ormiston, Mark L.
Published in Arteriosclerosis, thrombosis, and vascular biology (01.11.2020)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.11.2020)
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Journal Article
Modulation of Endothelial Bone Morphogenetic Protein Receptor Type 2 Activity by Vascular Endothelial Growth Factor Receptor 3 in Pulmonary Arterial Hypertension
Hwangbo, Cheol, Lee, Heon-Woo, Kang, Hyeseon, Ju, Hyekyung, Wiley, David S., Papangeli, Irinna, Han, Jinah, Kim, Jun-Dae, Dunworth, William P., Hu, Xiaoyue, Lee, Seyoung, El-Hely, Omar, Sofer, Avraham, Pak, Boryeong, Peterson, Laura, Comhair, Suzy, Hwang, Eun Mi, Park, Jae-Yong, Thomas, Jean-Leon, Bautch, Victoria L., Erzurum, Serpil C., Chun, Hyung J., Jin, Suk-Won
Published in Circulation (New York, N.Y.) (06.06.2017)
Published in Circulation (New York, N.Y.) (06.06.2017)
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Journal Article
Screening for pulmonary arterial hypertension in adults carrying a BMPR2 mutation
Montani, David, Girerd, Barbara, Jaïs, Xavier, Laveneziana, Pierantonio, Lau, Edmund M.T., Bouchachi, Amir, Hascoët, Sébastien, Günther, Sven, Godinas, Laurent, Parent, Florence, Guignabert, Christophe, Beurnier, Antoine, Chemla, Denis, Hervé, Philippe, Eyries, Mélanie, Soubrier, Florent, Simonneau, Gérald, Sitbon, Olivier, Savale, Laurent, Humbert, Marc
Published in The European respiratory journal (01.07.2021)
Published in The European respiratory journal (01.07.2021)
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Journal Article
Genetic and Evolutionary Analyses of the Human Bone Morphogenetic Protein Receptor 2 (BMPR2) in the Pathophysiology of Obesity
Schleinitz, Dorit, Klöting, Nora, Böttcher, Yvonne, Wolf, Sara, Dietrich, Kerstin, Tönjes, Anke, Breitfeld, Jana, Enigk, Beate, Halbritter, Jan, Körner, Antje, Schön, Michael R., Jenkner, Jost, Tseng, Yu-Hua, Lohmann, Tobias, Dreβler, Miriam, Stumvoll, Michael, Blüher, Matthias, Kovacs, Peter
Published in PloS one (02.02.2011)
Published in PloS one (02.02.2011)
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Journal Article
Bone Morphogenetic Protein Receptor-2 Signaling Promotes Pulmonary Arterial Endothelial Cell Survival: Implications for Loss-of-Function Mutations in the Pathogenesis of Pulmonary Hypertension
Teichert-Kuliszewska, Krystyna, Kutryk, Michael J.B., Kuliszewski, Michael A., Karoubi, Golnaz, Courtman, David W., Zucco, Liana, Granton, John, Stewart, Duncan J.
Published in Circulation research (03.02.2006)
Published in Circulation research (03.02.2006)
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Journal Article
Alterations in oestrogen metabolism: implications for higher penetrance of familial pulmonary arterial hypertension in females
Austin, E. D, Cogan, J. D, West, J. D, Hedges, L. K, Hamid, R, Dawson, E. P, Wheeler, L. A, Parl, F. F, Loyd, J. E, Phillips, J. A., III
Published in The European respiratory journal (01.11.2009)
Published in The European respiratory journal (01.11.2009)
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Journal Article
Evidence of Dysfunction of Endothelial Progenitors in Pulmonary Arterial Hypertension
Toshner, Mark, Voswinckel, Robert, Southwood, Mark, Al-Lamki, Rafia, Howard, Luke S. G, Marchesan, Denis, Yang, Jun, Suntharalingam, Jay, Soon, Elaine, Exley, Andrew, Stewart, Susan, Hecker, Markus, Zhu, Zhenping, Gehling, Ursula, Seeger, Werner, Pepke-Zaba, Joanna, Morrell, Nicholas W
Published in American journal of respiratory and critical care medicine (15.10.2009)
Published in American journal of respiratory and critical care medicine (15.10.2009)
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Journal Article
Altered maturation and activation state of circulating monocytes is associated with their enhanced recruitment in pulmonary arterial hypertension
Harper, Rebecca L., Zhou, Xin, Marciano, David P., Cao, Aiqin, Wang, Lingli, Chen, Guibin, Adil, Mir S., Zhou, Wenyu, Maguire, Peter, Deivanayagam, Shanthi, Yu, Quan, Viswanathan, Vignesh, Yang, Dan, Martin, Marcy, Isobe, Sarasa, Otsuki, Shoichiro, Burgess, Jordan, Inglis, Audrey, Kelley, Devon, del Rosario, Patricia A., Hsi, Andrew, Haddad, Francois, Zamanian, Roham T., Boehm, Manfred, Snyder, Michael P., Rabinovitch, Marlene
Published in Respiratory research (15.04.2025)
Published in Respiratory research (15.04.2025)
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Journal Article
A Potential Role for Exosomal Translationally Controlled Tumor Protein Export in Vascular Remodeling in Pulmonary Arterial Hypertension
Ferrer, Elisabet, Dunmore, Benjamin J., Hassan, Dhiya, Ormiston, Mark L., Moore, Stephen, Deighton, John, Long, Lu, Yang, Xu Dong, Stewart, Duncan J., Morrell, Nicholas W.
Published in American journal of respiratory cell and molecular biology (01.10.2018)
Published in American journal of respiratory cell and molecular biology (01.10.2018)
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Journal Article
BMPRII deficiency impairs apoptosis via the BMPRII-ALK1-BclX-mediated pathway in pulmonary arterial hypertension
Chowdhury, H M, Sharmin, N, Yuzbasioglu Baran, Merve, Long, L, Morrell, N W, Trembath, R C, Nasim, Md Talat
Published in Human molecular genetics (01.07.2019)
Published in Human molecular genetics (01.07.2019)
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Journal Article
Genomewide RNA expression profiling in lung identifies distinct signatures in idiopathic pulmonary arterial hypertension and secondary pulmonary hypertension
Rajkumar, Revathi, Konishi, Kazuhisa, Richards, Thomas J., Ishizawar, David C., Wiechert, Andrew C., Kaminski, Naftali, Ahmad, Ferhaan
Published in American journal of physiology. Heart and circulatory physiology (01.04.2010)
Published in American journal of physiology. Heart and circulatory physiology (01.04.2010)
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Journal Article
Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension
Long, Lu, Ormiston, Mark L, Yang, Xudong, Southwood, Mark, Gräf, Stefan, Machado, Rajiv D, Mueller, Matthias, Kinzel, Bernd, Yung, Lai Ming, Wilkinson, Janine M, Moore, Stephen D, Drake, Kylie M, Aldred, Micheala A, Yu, Paul B, Upton, Paul D, Morrell, Nicholas W
Published in Nature medicine (01.07.2015)
Published in Nature medicine (01.07.2015)
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Journal Article
Id proteins are critical downstream effectors of BMP signaling in human pulmonary arterial smooth muscle cells
Yang, Jun, Li, Xiaohui, Li, Ying, Southwood, Mark, Ye, Lingying, Long, Lu, Al-Lamki, Rafia S., Morrell, Nicholas W.
Published in American journal of physiology. Lung cellular and molecular physiology (15.08.2013)
Published in American journal of physiology. Lung cellular and molecular physiology (15.08.2013)
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Journal Article
Elevated Levels of Inflammatory Cytokines Predict Survival in Idiopathic and Familial Pulmonary Arterial Hypertension
Soon, Elaine, Holmes, Alan M., Treacy, Carmen M., Doughty, Natalie J., Southgate, Laura, Machado, Rajiv D., Trembath, Richard C., Jennings, Simon, Barker, Lucy, Nicklin, Paul, Walker, Christoph, Budd, David C., Pepke-Zaba, Joanna, Morrell, Nicholas W.
Published in Circulation (New York, N.Y.) (31.08.2010)
Published in Circulation (New York, N.Y.) (31.08.2010)
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Journal Article
Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling
Nickel, Nils P, Spiekerkoetter, Edda, Gu, Mingxia, Li, Caiyun G, Li, Hai, Kaschwich, Mark, Diebold, Isabel, Hennigs, Jan K, Kim, Ki-Yoon, Miyagawa, Kazuya, Wang, Lingli, Cao, Aiqin, Sa, Silin, Jiang, Xinguo, Stockstill, Raymond W, Nicolls, Mark R, Zamanian, Roham T, Bland, Richard D, Rabinovitch, Marlene
Published in American journal of respiratory and critical care medicine (01.06.2015)
Published in American journal of respiratory and critical care medicine (01.06.2015)
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Journal Article
Induced Pluripotent Stem Cell Model of Pulmonary Arterial Hypertension Reveals Novel Gene Expression and Patient Specificity
Sa, Silin, Gu, Mingxia, Chappell, James, Shao, Ning-Yi, Ameen, Mohamed, Elliott, Kathryn A. T., Li, Dan, Grubert, Fabian, Li, Caiyun G., Taylor, Shalina, Cao, Aiqin, Ma, Yu, Fong, Ryan, Nguyen, Long, Wu, Joseph C., Snyder, Michael P., Rabinovitch, Marlene
Published in American journal of respiratory and critical care medicine (01.04.2017)
Published in American journal of respiratory and critical care medicine (01.04.2017)
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Journal Article
Deep phenotyping of unaffected carriers of pathogenic BMPR2 variants screened for pulmonary arterial hypertension
Tóth, Eszter N., Celant, Lucas R., Niglas, Marili, Jansen, Samara, Tramper, Jelco, Baxan, Nicoleta, Ashek, Ali, Wessels, Jeroen N., Marcus, J. Tim, Meijboom, Lilian J., Houweling, Arjan C., Nossent, Esther J., Aman, Jurjan, Grynblat, Julien, Perros, Frédéric, Montani, David, Vonk Noordegraaf, Anton, Zhao, Lan, de Man, Frances S., Bogaard, Harm Jan
Published in The European respiratory journal (01.10.2024)
Published in The European respiratory journal (01.10.2024)
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Journal Article
MicroRNA-424(322) as a new marker of disease progression in pulmonary arterial hypertension and its role in right ventricular hypertrophy by targeting SMURF1
Baptista, Rui, Marques, Carla, Catarino, Steve, Enguita, Francisco J, Costa, Marina C, Matafome, Paulo, Zuzarte, Mónica, Castro, Graça, Reis, Abílio, Monteiro, Pedro, Pêgo, Mariano, Pereira, Paulo, Girão, Henrique
Published in Cardiovascular research (01.01.2018)
Published in Cardiovascular research (01.01.2018)
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Journal Article