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Hematopoietic niche drives FLT3-ITD acute myeloid leukemia resistance to quizartinib via STAT5-and hypoxia-dependent upregulation of AXL

by Dumas, Pierre-Yves, Naudin, Cécile, Martin-Lannerée, Séverine, Izac, Brigitte, Casetti, Luana, Mansier, Olivier, Rousseau, Benoît, Artus, Alexandre, Dufossée, Mélody, Giese, Alban, Dubus, Pierre, Pigneux, Arnaud, Praloran, Vincent, Bidet, Audrey, Villacreces, Arnaud, Guitart, Amélie, Milpied, Noël, Kosmider, Olivier, Vigon, Isabelle, Desplat, Vanessa, Dusanter-Fourt, Isabelle, Pasquet, Jean-Max
Published in Haematologica (Roma) (01.10.2019)

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Dual Inhibition of FLT3 and AXL by Gilteritinib Overcomes Hematopoietic Niche-Driven Resistance Mechanisms in FLT3 -ITD Acute Myeloid Leukemia

by Dumas, Pierre-Yves, Villacreces, Arnaud, Guitart, Amélie V., El-habhab, Ali, Massara, Layal, Mansier, Olivier, Bidet, Audrey, Martineau, Delphine, Fernandez, Solene, Leguay, Thibaut, Pigneux, Arnaud, Vigon, Isabelle, Pasquet, Jean-Max, Desplat, Vanessa
Published in Clinical cancer research (01.11.2021)

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HOXC4 homeoprotein efficiently expands human hematopoietic stem cells and triggers similar molecular alterations as HOXB4

by Auvray, C., Delahaye, A., Pflumio, F., Haddad, R., Amsellem, S., Miri-Nezhad, A., Broix, L., Yacia, A., Bulle, F., Fichelson, S., Vigon, I.
Published in Haematologica (Roma) (01.02.2012)

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Efficient in vitro myogenic reprogramming of human primary mesenchymal stem cells and endothelial cells by Myf5

by Dimicoli-Salazar, Sophie, Bulle, Frederique, Yacia, Azzedine, Massé, Jean-Marc, Fichelson, Serge, Vigon, Isabelle
Published in Biology of the cell (01.11.2011)

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HYR, an extracellular module involved in cellular adhesion and related to the immunoglobulin-like fold

by CALLEBAUT, ISABELLE, GILGÈS, DELPHINE, VIGON, ISABELLE, MORNON, JEAN-PAUL
Published in Protein science (01.07.2000)

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A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors

by Souyri, Michèle, Vigon, Isabelle, Penciolelli, Jean-François, Heard, Jean-Michel, Tambourin, Pierre, Wendling, Françoise
Published in Cell (21.12.1990)

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PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells

by Naudin, Cécile, Hattabi, Aurore, Michelet, Fabio, Miri-Nezhad, Ayda, Benyoucef, Aissa, Pflumio, Françoise, Guillonneau, François, Fichelson, Serge, Vigon, Isabelle, Dusanter-Fourt, Isabelle, Lauret, Evelyne
Published in Blood (04.05.2017)

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3120 – DECIPHERING HEMATOPOIETIC STEM CELLS METABOLISM DURING EXPANSION

by Lauvinerie, Claire, Villacreces, Arnaud, Desplat, Vanessa, Dumas, Pierre-Yves, Vigon, Isabelle, Pasquet, Jean-Max, Guitart, Amélie
Published in Experimental hematology (2022)

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3084 – DECIPHERING HEMATOPOIETIC STEM CELLS METABOLISM DURING EXPANSION

by Lauvinerie, Claire, Villacreces, Arnaud, Desplat, Vanessa, Dumas, Pierre-Yves, Vigon, Isabelle, Pasquet, Jean-Max, Guitart, Amélie
Published in Experimental hematology (01.08.2021)

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Dual targeting of CDK6 and LSD1 is synergistic and overcomes differentiation blockade in AML

by Brault, Lise, Voisset, Edwige, Desaunay, Mathieu, Boudet, Antonia, Kousteridou, Paraskevi, Letard, Sébastien, Carbuccia, Nadine, Goubard, Armelle, Castellano, Rémy, Collette, Yves, Vernerey, Julien, Vigon, Isabelle, Pasquet, Jean-Max, Dubreuil, Patrice, Lopez, Sophie, De Sepulveda, Paulo
Published in EMBO molecular medicine (29.08.2025)

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Targeting Tyrosine Kinases in Acute Myeloid Leukemia: Why, Who and How?

by Fernandez, Solène, Desplat, Vanessa, Villacreces, Arnaud, Guitart, Amélie V., Milpied, Noël, Pigneux, Arnaud, Vigon, Isabelle, Pasquet, Jean-Max, Dumas, Pierre-Yves
Published in International journal of molecular sciences (12.07.2019)

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Dual Inhibition of FLT3 and AXL by Gilteritinib Overcomes Hematopoietic Niche-Driven Resistance Mechanisms in FLT3 -ITD Acute Myeloid Leukemia

by Dumas, Pierre-Yves, Villacreces, Arnaud, Guitart, Amélie, El-Habhab, Ali, Massara, Layal, Mansier, Olivier, Bidet, Audrey, Martineau, Delphine, Fernandez, Solene, Leguay, Thibaut, Pigneux, Arnaud, Vigon, Isabelle, Pasquet, Jean-Max, Desplat, Vanessa
Published in Clinical cancer research (01.11.2021)

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Autophagy Targeting and Hematological Mobilization in FLT3-ITD Acute Myeloid Leukemia Decrease Repopulating Capacity and Relapse by Inducing Apoptosis of Committed Leukemic Cells

by Dupont, Marine, Huart, Mathilde, Lauvinerie, Claire, Bidet, Audrey, Guitart, Amélie Valérie, Villacreces, Arnaud, Vigon, Isabelle, Desplat, Vanessa, El Habhab, Ali, Pigneux, Arnaud, Ivanovic, Zoran, Brunet De la Grange, Philippe, Dumas, Pierre-Yves, Pasquet, Jean-Max
Published in Cancers (17.01.2022)

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CBL controls a tyrosine kinase network involving AXL, SYK and LYN in nilotinib-resistant chronic myeloid leukaemia

by Gioia, Romain, Trégoat, Claire, Dumas, Pierre-Yves, Lagarde, Valérie, Prouzet-Mauléon, Valérie, Desplat, Vanessa, Sirvent, Audrey, Praloran, Vincent, Lippert, Eric, Villacreces, Arnaud, Leconet, Wilhem, Robert, Bruno, Vigon, Isabelle, Roche, Serge, Mahon, François-Xavier, Pasquet, Jean-Max
Published in The Journal of pathology (01.09.2015)

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Chronic myeloid leukemia progenitor cells require autophagy when leaving hypoxia-induced quiescence

by Ianniciello, Angela, Dumas, Pierre-Yves, Drullion, Claire, Guitart, Amélie, Villacreces, Arnaud, Peytour, Yan, Chevaleyre, Jean, Brunet de la Grange, Philippe, Vigon, Isabelle, Desplat, Vanessa, Priault, Muriel, Sbarba, Persio Dello, Ivanovic, Zoran, Mahon, François-Xavier, Pasquet, Jean-Max
Published in Oncotarget (14.11.2017)

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Neuraminidase enhances in vitro expansion of human erythroid progenitors

by Bodivit, Gwellaouen, Chadebech, Philippe, Vigon, Isabelle, Yacia, Azzedine, Roziers, Nicolas Burin Des, Pirenne, France, Fichelson, Serge
Published in European cytokine network (Montrouge) (01.06.2016)

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Neuraminidase enhances in vitro expansion of human erythroid progenitors

by Bodivit, Gwellaouen, Chadebech, Philippe, Vigon, Isabelle, Yacia, Azzedine, Roziers, Nicolas Burin Des, Pirenne, France, Fichelson, Serge
Published in European cytokine network (Montrouge) (01.06.2016)

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Neuraminidase enhances in vitro expansion of human erythroid progenitors

by Bodivit, Gwellaouen, Chadebech, Philippe, Vigon, Isabelle, Yacia, Azzedine, Roziers, Nicolas Burin des, Pirenne, France, Fichelson, Serge
Published in European cytokine network (Montrouge) (01.06.2016)

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CBL controls a tyrosine kinase network involving AXL, SYK and LYN in nilotinib-resistant chronic myeloid leukaemia: CBL controls kinase expression

by Gioia, Romain, Trégoat, Claire, Dumas, Pierre-Yves, Lagarde, Valérie, Prouzet-Mauléon, Valérie, Desplat, Vanessa, Sirvent, Audrey, Praloran, Vincent, Lippert, Eric, Villacreces, Arnaud, Leconet, Wilhem, Robert, Bruno, Vigon, Isabelle, Roche, Serge, Mahon, François-Xavier, Pasquet, Jean-Max
Published in The Journal of pathology (01.09.2015)

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The HOXB4 Homeoprotein Differentially Promotes Ex Vivo Expansion of Early Human Lymphoid Progenitors

by Haddad, Rima, Pflumio, Françoise, Vigon, Isabelle, Visentin, Géraldine, Auvray, Céline, Fichelson, Serge, Amsellem, Sophie
Published in Stem cells (Dayton, Ohio) (01.02.2008)

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