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Prevalence, risk factors, outcomes, and molecular epidemiology of mcr-1-positive Enterobacteriaceae in patients and healthy adults from China: an epidemiological and clinical study
Wang, Yang, Tian, Guo-Bao, Zhang, Rong, Shen, Yingbo, Tyrrell, Jonathan M, Huang, Xi, Zhou, Hongwei, Lei, Lei, Li, Hong-Yu, Doi, Yohei, Fang, Ying, Ren, Hongwei, Zhong, Lan-Lan, Shen, Zhangqi, Zeng, Kun-Jiao, Wang, Shaolin, Liu, Jian-Hua, Wu, Congming, Walsh, Timothy R, Shen, Jianzhong
Published in The Lancet infectious diseases (01.04.2017)
Published in The Lancet infectious diseases (01.04.2017)
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Journal Article
Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases
Krajnc, Alen, Brem, Jürgen, Hinchliffe, Philip, Calvopiña, Karina, Panduwawala, Tharindi D, Lang, Pauline A, Kamps, Jos J. A. G, Tyrrell, Jonathan M, Widlake, Emma, Saward, Benjamin G, Walsh, Timothy R, Spencer, James, Schofield, Christopher J
Published in Journal of medicinal chemistry (26.09.2019)
Published in Journal of medicinal chemistry (26.09.2019)
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Journal Article
In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii
Juhas, Mario, Widlake, Emma, Teo, Jeanette, Huseby, Douglas L, Tyrrell, Jonathan M, Polikanov, Yury S, Ercan, Onur, Petersson, Anna, Cao, Sha, Aboklaish, Ali F, Rominski, Anna, Crich, David, Böttger, Erik C, Walsh, Timothy R, Hughes, Diarmaid, Hobbie, Sven N
Published in Journal of antimicrobial chemotherapy (01.04.2019)
Published in Journal of antimicrobial chemotherapy (01.04.2019)
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Journal Article
Comprehensive resistome analysis reveals the prevalence of NDM and MCR-1 in Chinese poultry production
Wang, Yang, Zhang, Rongmin, Li, Jiyun, Wu, Zuowei, Yin, Wenjuan, Schwarz, Stefan, Tyrrell, Jonathan M., Zheng, Yongjun, Wang, Shaolin, Shen, Zhangqi, Liu, Zhihai, Liu, Jianye, Lei, Lei, Li, Mei, Zhang, Qidi, Wu, Congming, Zhang, Qijing, Wu, Yongning, Walsh, Timothy R., Shen, Jianzhong
Published in Nature microbiology (06.02.2017)
Published in Nature microbiology (06.02.2017)
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Journal Article
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors
Brem, Jürgen, Panduwawala, Tharindi, Hansen, Jon Ulf, Hewitt, Joanne, Liepins, Edgars, Donets, Pawel, Espina, Laura, Farley, Alistair J. M., Shubin, Kirill, Campillos, Gonzalo Gomez, Kiuru, Paula, Shishodia, Shifali, Krahn, Daniel, Leśniak, Robert K., Schmidt (Adrian), Juliane, Calvopiña, Karina, Turrientes, María-Carmen, Kavanagh, Madeline E., Lubriks, Dmitrijs, Hinchliffe, Philip, Langley, Gareth W., Aboklaish, Ali F., Eneroth, Anders, Backlund, Maria, Baran, Andrei G., Nielsen, Elisabet I., Speake, Michael, Kuka, Janis, Robinson, John, Grinberga, Solveiga, Robinson, Lindsay, McDonough, Michael A., Rydzik, Anna M., Leissing, Thomas M., Jimenez-Castellanos, Juan Carlos, Avison, Matthew B., Da Silva Pinto, Solange, Pannifer, Andrew D., Martjuga, Marina, Widlake, Emma, Priede, Martins, Hopkins Navratilova, Iva, Gniadkowski, Marek, Belfrage, Anna Karin, Brandt, Peter, Yli-Kauhaluoma, Jari, Bacque, Eric, Page, Malcolm G. P., Björkling, Fredrik, Tyrrell, Jonathan M., Spencer, James, Lang, Pauline A., Baranczewski, Pawel, Cantón, Rafael, McElroy, Stuart P., Jones, Philip S., Baquero, Fernando, Suna, Edgars, Morrison, Angus, Walsh, Timothy R., Schofield, Christopher J.
Published in Nature chemistry (01.01.2022)
Published in Nature chemistry (01.01.2022)
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Journal Article
In vitro efficacy of imipenem-relebactam and cefepime-AAI101 against a global collection of ESBL-positive and carbapenemase-producing Enterobacteriaceae
Tselepis, Lucas, Langley, Gareth W., Aboklaish, Ali F., Widlake, Emma, Jackson, Dana E., Walsh, Timothy R., Schofield, Chris J., Brem, Jürgen, Tyrrell, Jonathan M.
Published in International journal of antimicrobial agents (01.07.2020)
Published in International journal of antimicrobial agents (01.07.2020)
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Journal Article
Dissemination of genetically diverse NDM-1, -5, -7 producing-Gram-negative pathogens isolated from pediatric patients in Pakistan
Qamar, Muhammad Usman, Walsh, Timothy R, Toleman, Mark A, Tyrrell, Jonathan M, Saleem, Sidrah, Aboklaish, Ali, Jahan, Shah
Published in Future microbiology (01.05.2019)
Published in Future microbiology (01.05.2019)
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Journal Article
Crystal structures of VIM‐1 complexes explain active site heterogeneity in VIM‐class metallo‐β‐lactamases
Salimraj, Ramya, Hinchliffe, Philip, Kosmopoulou, Magda, Tyrrell, Jonathan M., Brem, Jürgen, Berkel, Sander S., Verma, Anil, Owens, Raymond J., McDonough, Michael A., Walsh, Timothy R., Schofield, Christopher J., Spencer, James
Published in The FEBS journal (01.01.2019)
Published in The FEBS journal (01.01.2019)
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Journal Article
Clinical Validation of SensiTest Colistin, a Broth Microdilution-Based Method To Evaluate Colistin MICs
Carretto, Edoardo, Brovarone, Flavia, Russello, Giuseppe, Nardini, Paola, El-Bouseary, Maisra M., Aboklaish, Ali F., Walsh, Timothy R., Tyrrell, Jonathan M.
Published in Journal of clinical microbiology (01.04.2018)
Published in Journal of clinical microbiology (01.04.2018)
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Journal Article
Profiling interactions of vaborbactam with metallo-β-lactamases
Langley, Gareth W., Cain, Ricky, Tyrrell, Jonathan M., Hinchliffe, Philip, Calvopiña, Karina, Tooke, Catherine L., Widlake, Emma, Dowson, Christopher G., Spencer, James, Walsh, Timothy R., Schofield, Christopher J., Brem, Jürgen
Published in Bioorganic & medicinal chemistry letters (01.08.2019)
Published in Bioorganic & medicinal chemistry letters (01.08.2019)
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Journal Article
The polymyxin derivative NAB739 is synergistic with several antibiotics against polymyxin-resistant strains of Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii
Tyrrell, Jonathan M., Aboklaish, Ali F., Walsh, Timothy R., Vaara, Timo, Vaara, Martti
Published in Peptides (New York, N.Y. : 1980) (01.02.2019)
Published in Peptides (New York, N.Y. : 1980) (01.02.2019)
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Journal Article
Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates
Cahill, Samuel T., Tyrrell, Jonathan M., Navratilova, Iva Hopkins, Calvopiña, Karina, Robinson, Sean W., Lohans, Christopher T., McDonough, Michael A., Cain, Ricky, Fishwick, Colin W.G., Avison, Matthew B., Walsh, Timothy R., Schofield, Christopher J., Brem, Jürgen
Published in Biochimica et biophysica acta. General subjects (01.04.2019)
Published in Biochimica et biophysica acta. General subjects (01.04.2019)
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Journal Article
Novel partners with colistin to increase its in vivo therapeutic effectiveness and prevent the occurrence of colistin resistance in NDM- and MCR-co-producing Escherichia coli in a murine infection model
Yu, Yang, Walsh, Timothy R, Yang, Run-Shi, Zheng, Mei, Wei, Meng-Chao, Tyrrell, Jonathan M, Wang, Yang, Liao, Xiao-Ping, Sun, Jian, Liu, Ya-Hong
Published in Journal of antimicrobial chemotherapy (01.01.2019)
Published in Journal of antimicrobial chemotherapy (01.01.2019)
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Journal Article
‘Superbugs: A Pop-up Science Shop’: Increasing public awareness and knowledge of antimicrobial resistance by taking science to the city
Tyrrell, Jonathan M, Conlon, Christie S, Aboklaish, Ali F, Hatch, Sarah, Smith, Carl, Jordan, Mathias, Thomson, Kathryn, Eberl, Matthias
Published in bioRxiv (17.06.2021)
Published in bioRxiv (17.06.2021)
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Paper
‘Superbugs’: raising public awareness of antimicrobial resistance through a pop-up science shop
Tyrrell, Jonathan M., Conlon, Christie S., Aboklaish, Ali F., Hatch, Sarah, Smith, Carl, Mathias, Jordan, Thomson, Kathryn, Eberl, Matthias
Published in Research for all (15.02.2022)
Published in Research for all (15.02.2022)
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Journal Article