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Tyk2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits
Diogo, Dorothée, Bastarache, Lisa, Liao, Katherine P., Graham, Robert R., Fulton, Robert S., Greenberg, Jeffrey D., Eyre, Steve, Bowes, John, Cui, Jing, Lee, Annette, Pappas, Dimitrios A., Kremer, Joel M., Barton, Anne, Coenen, Marieke J. H., Franke, Barbara, Kiemeney, Lambertus A., Mariette, Xavier, Richard-Miceli, Corrine, Canhao, Helena, Fonseca, João, de Vries, Niek, Tak, Paul P., Crusius, J. Bart A., Nurmohamed, Michael T., Kurreeman, Fina, Mikuls, Ted R., Okada, Yukinori, Stahl, Eli A., Larson, David E., Deluca, Tracie L., O'Laughlin, Michelle, Fronick, Catrina C., Fulton, Lucinda L., Kosoy, Roman, Ransom, Michael, Bhangale, Tushar R., Ortmann, Ward, Cagan, Andrew, Gainer, Vivian, Karlson, Elizabeth W., Kohane, Isaac, Murphy, Shawn N., Martin, Javier, Zhernakova, Alexandra, Klareskog, Lars, Padyukov, Leonid, Worthington, Jane, Mardis, Elaine R., Seldin, Michael F., Gregersen, Peter K., Behrens, Timothy, Raychaudhuri, Soumya, Denny, Joshua C., Plenge, Robert M.
Published in PloS one (07.04.2015)
Published in PloS one (07.04.2015)
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Journal Article
POS0341 DECONVOLUTION OF TRANSCRIPTOMICS CHANGES IN DEUCRAVACITINIB-TREATED SUBJECTS REVEALS NOVEL MECHANISTIC EFFECTS OF TYK2 INHIBITION IN LUPUS
Vital, E. M., Arriens, C., Kahlenberg, J. M., Crow, M. K., Saxena, A., Wu, C., Hu, Y., Hobar, C., Coles, A., Catlett, I. M.
Published in Annals of the rheumatic diseases (01.06.2024)
Published in Annals of the rheumatic diseases (01.06.2024)
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Journal Article
POS0957 EFFECT OF DEUCRAVACITINIB, AN ORAL, SELECTIVE, ALLOSTERIC TYROSINE KINASE 2 (TYK2) INHIBITOR, IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS (PSA) AND ENTHESITIS AT BASELINE: RESULTS FROM A PHASE 2 TRIAL
Mease, P. J., Dahan, S., Lehman, T., Koti, R., Colombo, M. J., Nowak, M., Deodhar, A.
Published in Annals of the rheumatic diseases (01.06.2024)
Published in Annals of the rheumatic diseases (01.06.2024)
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Journal Article
TRIM10 binds to IFN‐α/β receptor 1 to negatively regulate type I IFN signal transduction
Guo, Mengmeng, Cao, Wenyan, Chen, Shengwen, Tian, Renyun, Wang, Luoling, Liu, Qian, Zhang, Lini, Wang, Zhenghao, Zhao, Ming, Lu, Qianjin, Zhu, Haizhen
Published in European journal of immunology (01.07.2021)
Published in European journal of immunology (01.07.2021)
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Journal Article
AB1446 ASSOCIATION OF GENETICALLY PROXIED JANUS KINASE INHIBITOR TARGETS WITH CARDIOVASCULAR RISK: A DRUG-TARGET MENDELIAN RANDOMIZATION STUDY
Dai, L., Song, Q. Y., Zou, Y. W., Su, Y., Su, L. W., MA, J. D., Pan, J., Ouyang, Z. M., Lu, Y., Wu, T., Lin, J. Z., Jia, P. W., Zheng, H. W., Jun, D.
Published in Annals of the rheumatic diseases (01.06.2024)
Published in Annals of the rheumatic diseases (01.06.2024)
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Journal Article
POS0212 UNRAVELING JAK/STAT3 ACTIVATION PATTERNS IN DERMATOMYOSITIS: IMPLICATIONS FOR UNDERSTANDING THE IFN-I SIGNALING PATHWAYS
Del Vescovo, S., Cacciapaglia, F., Fornaro, M., Stano, S., Napoletano, A., Dipietrangelo, G. G., Bizzoca, R., Natuzzi, D., Iannone, F.
Published in Annals of the rheumatic diseases (01.06.2024)
Published in Annals of the rheumatic diseases (01.06.2024)
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Journal Article
Systematic Analysis and Biomarker Study for Alzheimer’s Disease
Li, Xinzhong, Wang, Haiyan, Long, Jintao, Pan, Genhua, He, Taigang, Anichtchik, Oleg, Belshaw, Robert, Albani, Diego, Edison, Paul, Green, Elaine K, Scott, James
Published in Scientific reports (26.11.2018)
Published in Scientific reports (26.11.2018)
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Journal Article
Multiple Sclerosis patients carry an increased burden of exceedingly rare genetic variants in the inflammasome regulatory genes
Vidmar, Lovro, Maver, Ales, Drulović, Jelena, Sepčić, Juraj, Novaković, Ivana, Ristič, Smiljana, Šega, Saša, Peterlin, Borut
Published in Scientific reports (24.06.2019)
Published in Scientific reports (24.06.2019)
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Journal Article
Mucosal Epithelial Jak Kinases in Health and Diseases
Kumar, Narendra, Kuang, Longxiang, Villa, Ryan, Kumar, Priyam, Mishra, Jayshree
Published in Mediators of inflammation (2021)
Published in Mediators of inflammation (2021)
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Journal Article
TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits: e0122271
Diogo, Dorothee, Bastarache, Lisa, Liao, Katherine P, Graham, Robert R, Fulton, Robert S, Greenberg, Jeffrey D, Eyre, Steve, Bowes, John, Cui, Jing, Lee, Annette
Published in PloS one (01.04.2015)
Published in PloS one (01.04.2015)
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Journal Article
Integrated analysis of competing endogenous RNA networks in peripheral blood mononuclear cells of systemic lupus erythematosus
Song, Wencong, Qiu, Jie, Yin, Lianghong, Hong, Xiaoping, Dai, Weier, Tang, Donge, Liu, Dongzhou, Dai, Yong
Published in Journal of translational medicine (21.08.2021)
Published in Journal of translational medicine (21.08.2021)
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Journal Article
P059 Ex vivo comparison of baricitinib, upadacitinib, filgotinib and tofacitinib for cytokine signalling in human leukocyte subpopulations
McInnes, IB, Higgs, R, Lee, J, Macias, WL, Na, S, Ortmann, RA, Rocha, G, Wehrman, T, Zhang, X, Zuckerman, SH, Taylor, PC, Perrier, C
Published in Annals of the rheumatic diseases (01.03.2018)
Published in Annals of the rheumatic diseases (01.03.2018)
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Journal Article
Kinome and phosphoproteome reprogramming underlies the aberrant immune responses in critically ill COVID-19 patients
Kaneko, Tomonori, Ezra, Sally, Abdo, Rober, Voss, Courtney, Zhong, Shanshan, Liu, Xuguang, Hovey, Owen, Slessarev, Marat, Van Nynatten, Logan Robert, Ye, Mingliang, Fraser, Douglas D., Li, Shawn Shun-Cheng
Published in Clinical proteomics (22.02.2024)
Published in Clinical proteomics (22.02.2024)
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Journal Article
Comprehensive analysis of three TYK2 gene variants in the susceptibility to Chagas disease infection and cardiomyopathy
Leon Rodriguez, Daniel A., Acosta-Herrera, Marialbert, Carmona, F. David, Dolade, Nuria, Vargas, Sofia, Echeverría, Luis Eduardo, González, Clara Isabel, Martin, Javier
Published in PloS one (05.01.2018)
Published in PloS one (05.01.2018)
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Journal Article
Increased mRNA Levels of ADAM17, IFITM3, and IFNE in Peripheral Blood Cells Are Present in Patients with Obesity and May Predict Severe COVID-19 Evolution
Pomar, Catalina A., Bonet, M. Luisa, Ferre-Beltrán, Adrián, Fraile-Ribot, Pablo A., García-Gasalla, Mercedes, Riera, Melchor, Picó, Catalina, Palou, Andreu
Published in Biomedicines (18.08.2022)
Published in Biomedicines (18.08.2022)
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Journal Article
Polymorphism V362F (rs2304256) of tyrosine kinase 2 is not associated with childhood- or adulthood-onset type 1 diabetes in southern Brazil
Graciolo, V, Welter, M, Campos, LP, Martins, BR, Souza, SW, França, SN, Réa, RR, Picheth, G, Rego, FGM
Published in Genetics and molecular research (2019)
Published in Genetics and molecular research (2019)
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Journal Article