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Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells
Oh, Min-Hee, Sun, Im-Hong, Zhao, Liang, Leone, Robert D., Sun, Im-Meng, Xu, Wei, Collins, Samuel L., Tam, Ada J., Blosser, Richard L., Patel, Chirag H., Englert, Judson M., Arwood, Matthew L., Wen, Jiayu, Chan-Li, Yee, Tenora, Lukáš, Majer, Pavel, Rais, Rana, Slusher, Barbara S., Horton, Maureen R., Powell, Jonathan D.
Published in The Journal of clinical investigation (01.07.2020)
Published in The Journal of clinical investigation (01.07.2020)
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Journal Article
Discovery of tert -Butyl Ester Based 6-Diazo-5-oxo- l -norleucine Prodrugs for Enhanced Metabolic Stability and Tumor Delivery
Novotná, Kateřina, Tenora, Lukáš, Prchalová, Eva, Paule, James, Alt, Jesse, Veeravalli, Vijay, Lam, Jenny, Wu, Ying, Šnajdr, Ivan, Gori, Sadakatali, Mettu, Vijaya Saradhi, Tsukamoto, Takashi, Majer, Pavel, Slusher, Barbara S., Rais, Rana
Published in Journal of medicinal chemistry (23.11.2023)
Published in Journal of medicinal chemistry (23.11.2023)
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Journal Article
JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress
Zhu, Xiaolei, Nedelcovych, Michael T., Thomas, Ajit G., Hasegawa, Yuto, Moreno-Megui, Aisa, Coomer, Wade, Vohra, Varun, Saito, Atsushi, Perez, Gabriel, Wu, Ying, Alt, Jesse, Prchalova, Eva, Tenora, Lukáš, Majer, Pavel, Rais, Rana, Rojas, Camilo, Slusher, Barbara S., Kamiya, Atsushi
Published in Neuropsychopharmacology (New York, N.Y.) (01.03.2019)
Published in Neuropsychopharmacology (New York, N.Y.) (01.03.2019)
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Journal Article
Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug
Rais, Rana, Lemberg, Kathryn M., Tenora, Lukáš, Arwood, Matthew L., Pal, Arindom, Alt, Jesse, Wu, Ying, Lam, Jenny, Aguilar, Joanna Marie H., Zhao, Liang, Peters, Diane E., Tallon, Carolyn, Pandey, Rajeev, Thomas, Ajit G., Dash, Ranjeet P., Seiwert, Tanguy, Majer, Pavel, Leone, Robert D., Powell, Jonathan D., Slusher, Barbara S.
Published in Science advances (16.11.2022)
Published in Science advances (16.11.2022)
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Journal Article
The Novel Glutamine Antagonist Prodrug JHU395 Has Antitumor Activity in Malignant Peripheral Nerve Sheath Tumor
Lemberg, Kathryn M., Zhao, Liang, Wu, Ying, Veeravalli, Vijayabhaskar, Alt, Jesse, Aguilar, Joanna Marie H., Dash, Ranjeet P., Lam, Jenny, Tenora, Lukáš, Rodriguez, Chabely, Nedelcovych, Michael T., Brayton, Cory, Majer, Pavel, Blakeley, Jaishri O., Rais, Rana, Slusher, Barbara S.
Published in Molecular cancer therapeutics (01.02.2020)
Published in Molecular cancer therapeutics (01.02.2020)
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Journal Article
Discovery of Orally Available Prodrugs of the Glutamate Carboxypeptidase II (GCPII) Inhibitor 2-Phosphonomethylpentanedioic Acid (2-PMPA)
Majer, Pavel, Jančařík, Andrej, Krečmerová, Marcela, Tichý, Tomáš, Tenora, Lukáš, Wozniak, Krystyna, Wu, Ying, Pommier, Elie, Ferraris, Dana, Rais, Rana, Slusher, Barbara S.
Published in Journal of medicinal chemistry (24.03.2016)
Published in Journal of medicinal chemistry (24.03.2016)
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Journal Article
ALK5 kinase inhibitory activity and synthesis of 2,3,4-substituted 5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles
Řezníčková, Eva, Tenora, Lukáš, Pospíšilová, Pavlína, Galeta, Juraj, Jorda, Radek, Berka, Karel, Majer, Pavel, Potáček, Milan, Kryštof, Vladimír
Published in European journal of medicinal chemistry (15.02.2017)
Published in European journal of medicinal chemistry (15.02.2017)
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Journal Article
Correction: JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress
Zhu, Xiaolei, Nedelcovych, Michael T., Thomas, Ajit G., Hasegawa, Yuto, Moreno-Megui, Aisa, Coomer, Wade, Vohra, Varun, Saito, Atsushi, Perez, Gabriel, Wu, Ying, Alt, Jesse, Prchalova, Eva, Tenora, Lukáš, Majer, Pavel, Rais, Rana, Rojas, Camilo, Slusher, Barbara S., Kamiya, Atsushi
Published in Neuropsychopharmacology (New York, N.Y.) (01.05.2019)
Published in Neuropsychopharmacology (New York, N.Y.) (01.05.2019)
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Journal Article
Identification of Novel Carbonic Anhydrase IX Inhibitors Using High-Throughput Screening of Pooled Compound Libraries by DNA-Linked Inhibitor Antibody Assay (DIANA)
Tykvart, Jan, Navrátil, Václav, Kugler, Michael, Šácha, Pavel, Schimer, Jiří, Hlaváčková, Anna, Tenora, Lukáš, Zemanová, Jitka, Dejmek, Milan, Král, Vlastimil, Potáček, Milan, Majer, Pavel, Jahn, Ullrich, Brynda, Jiří, Řezáčová, Pavlína, Konvalinka, Jan
Published in SLAS discovery (01.10.2020)
Published in SLAS discovery (01.10.2020)
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Journal Article
Discovery of 6‑Diazo-5-oxo‑l‑norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma
Rais, Rana, Jančařík, Andrej, Tenora, Lukáš, Nedelcovych, Michael, Alt, Jesse, Englert, Judson, Rojas, Camilo, Le, Anne, Elgogary, Amira, Tan, Jessica, Monincová, Lenka, Pate, Kelly, Adams, Robert, Ferraris, Dana, Powell, Jonathan, Majer, Pavel, Slusher, Barbara S
Published in Journal of medicinal chemistry (22.09.2016)
Published in Journal of medicinal chemistry (22.09.2016)
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Journal Article
Discovery of Orally Bioavailable and Brain-Penetrable Prodrugs of the Potent nSMase2 Inhibitor DPTIP
Pal, Arindom, Gori, Sadakatali, Yoo, Seung-wan, Thomas, Ajit G., Wu, Ying, Friedman, Jacob, Tenora, Lukáš, Bhasin, Harshit, Alt, Jesse, Haughey, Norman, Slusher, Barbara S., Rais, Rana
Published in Journal of medicinal chemistry (25.08.2022)
Published in Journal of medicinal chemistry (25.08.2022)
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Journal Article
Tumor-Targeted Delivery of 6‑Diazo-5-oxo‑l‑norleucine (DON) Using Substituted Acetylated Lysine Prodrugs
Tenora, Lukáš, Alt, Jesse, Dash, Ranjeet P, Gadiano, Alexandra J, Novotná, Kateřina, Veeravalli, Vijayabhaskar, Lam, Jenny, Kirkpatrick, Quinn R, Lemberg, Kathryn M, Majer, Pavel, Rais, Rana, Slusher, Barbara S
Published in Journal of medicinal chemistry (11.04.2019)
Published in Journal of medicinal chemistry (11.04.2019)
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Journal Article
Discovery of Orally Available Prodrugs of Itaconate and Derivatives
Lee, Chae Bin, Šnajdr, Ivan, Tenora, Lukáš, Alt, Jesse, Gori, Sadakatali, Krečmerová, Marcela, Maragakis, R. Michael, Paule, James, Tiwari, Sandhya, Iyer, Jitesh, Talwar, Rashmi, Garza, Luis, Majer, Pavel, Slusher, Barbara S., Rais, Rana
Published in Journal of medicinal chemistry (13.02.2025)
Published in Journal of medicinal chemistry (13.02.2025)
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Journal Article
Pharmacokinetic evaluation of neutral-sphinghomyelinase2 (nSMase2) inhibitor prodrugs in dogs
Ranjit, Arina, Tenora, Lukas, Alt, Jesse, Slusher, Barbara, Rais, Rana
Published in Drug metabolism and pharmacokinetics (01.06.2025)
Published in Drug metabolism and pharmacokinetics (01.06.2025)
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Journal Article
Discovery of a para-Acetoxy-benzyl Ester Prodrug of a Hydroxamate-Based Glutamate Carboxypeptidase II Inhibitor as Oral Therapy for Neuropathic Pain
Rais, Rana, Vávra, Jan, Tichý, Tomáš, Dash, Ranjeet P, Gadiano, Alexandra J, Tenora, Lukáš, Monincová, Lenka, Bařinka, Cyril, Alt, Jesse, Zimmermann, Sarah C, Slusher, C. Ethan, Wu, Ying, Wozniak, Krystyna, Majer, Pavel, Tsukamoto, Takashi, Slusher, Barbara S
Published in Journal of medicinal chemistry (28.09.2017)
Published in Journal of medicinal chemistry (28.09.2017)
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Journal Article
N‑(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6‑Diazo-5-oxo‑l‑norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders
Nedelcovych, Michael T, Tenora, Lukáš, Kim, Boe-Hyun, Kelschenbach, Jennifer, Chao, Wei, Hadas, Eran, Jančařík, Andrej, Prchalová, Eva, Zimmermann, Sarah C, Dash, Ranjeet P, Gadiano, Alexandra J, Garrett, Caroline, Furtmüller, Georg, Oh, Byoungchol, Brandacher, Gerald, Alt, Jesse, Majer, Pavel, Volsky, David J, Rais, Rana, Slusher, Barbara S
Published in Journal of medicinal chemistry (24.08.2017)
Published in Journal of medicinal chemistry (24.08.2017)
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Journal Article
Enhanced Oral Bioavailability of 2‑(Phosphonomethyl)-pentanedioic Acid (2-PMPA) from its (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (ODOL)-Based Prodrugs
Dash, Ranjeet P, Tichý, Tomáš, Veeravalli, Vijayabhaskar, Lam, Jenny, Alt, Jesse, Wu, Ying, Tenora, Lukáš, Majer, Pavel, Slusher, Barbara S, Rais, Rana
Published in Molecular pharmaceutics (07.10.2019)
Published in Molecular pharmaceutics (07.10.2019)
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Journal Article
N‑Substituted Prodrugs of Mebendazole Provide Improved Aqueous Solubility and Oral Bioavailability in Mice and Dogs
Zimmermann, Sarah C, Tichý, Tomáš, Vávra, Jan, Dash, Ranjeet P, Slusher, C. Ethan, Gadiano, Alexandra J, Wu, Ying, Jančařík, Andrej, Tenora, Lukáš, Monincová, Lenka, Prchalová, Eva, Riggins, Gregory J, Majer, Pavel, Slusher, Barbara S, Rais, Rana
Published in Journal of medicinal chemistry (10.05.2018)
Published in Journal of medicinal chemistry (10.05.2018)
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Journal Article