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Predicting In Vivo Efficacy from In Vitro Data: Quantitative Systems Pharmacology Modeling for an Epigenetic Modifier Drug in Cancer
Bouhaddou, Mehdi, Yu, Li J., Lunardi, Serena, Stamatelos, Spyros K., Mack, Fiona, Gallo, James M., Birtwistle, Marc R., Walz, Antje‐Christine
Published in Clinical and translational science (01.03.2020)
Published in Clinical and translational science (01.03.2020)
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Journal Article
Mathematical model of uptake and metabolism of arsenic(III) in human hepatocytes - Incorporation of cellular antioxidant response and threshold-dependent behavior
Stamatelos, Spyros K, Brinkerhoff, Christopher J, Isukapalli, Sastry S, Georgopoulos, Panos G
Published in BMC systems biology (25.01.2011)
Published in BMC systems biology (25.01.2011)
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Journal Article
From Cold to Hot: Changing Perceptions and Future Opportunities for Quantitative Systems Pharmacology Modeling in Cancer Immunotherapy
Lemaire, Vincent, Bassen, David, Reed, Mike, Song, Roy, Khalili, Samira, Lien, Yi Ting (Kayla), Huang, Lu, Singh, Aman P., Stamatelos, Spyros, Bottino, Dean, Hua, Fei
Published in Clinical pharmacology and therapeutics (01.05.2023)
Published in Clinical pharmacology and therapeutics (01.05.2023)
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Journal Article
Abstract 685: Development of a multiscale QSP model to characterize the tumor suppressive effects of a cytokine mRNA immunotherapy in a preclinical melanoma mouse model
Pierre, Kamau, Lin, Lin, Gruenbaum, Lore, Young, Carissa, Apgar, Joshua, Hotz, Christian, Wagenaar, Timothy, Stamatelos, Spyros K.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Development of an Integrated Human Model of Electrophysiology and Actin-Myosin Binding to Describe Sarcomere Force Generation in Cardiomyocytes
Abrams, Ruth E., Schneider, Hans-Christoph, Radziun, Tatiana, Goebel, Britta, Lucats, Laurence, Azer, Karim, Surks, Howard, Sobie, Eric, Stamatelos, Spyros
Published in Biophysical journal (15.02.2019)
Published in Biophysical journal (15.02.2019)
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Journal Article
Abstract 2796: Predicting in vivo efficacy from in vitro data: Quantitative systems pharmacology modeling for an epigenetic modifier drug in cancer
Bouhaddou, Mehdi, Yu, Li J., Lunardi, Serena, Stamatelos, Spyros K., Mack, Fiona, Gallo, James M., Birtwistle, Marc R., Walz, Antje-Christine
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract CT276: Preliminary analysis of pharmacokinetic (PK) and target engagement biomarkers from a first in human phase 1 study of immunomodulatory aryl hydrocarbon receptor (AhR) inhibitor BAY2416964
Papadopoulos, Kyriakos, Cecchini, Michael, Lopez, Juanita S., Jäger, Dirk, Chung, Ki Young, Platten, Michael, Prinz, Florian, Ishii, Yuko, Schaer, David, Gutcher, Ilona, Leder, Gabriele, Pencheva, Radost, Wagener, Thomas, Scheerans, Christian, Zieschang, Carsten, Wagner, Andrea, Stamatelos, Spyros, Dumbrava, Ecaterina
Published in Cancer research (Chicago, Ill.) (14.04.2023)
Published in Cancer research (Chicago, Ill.) (14.04.2023)
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Journal Article