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The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy
Gopalakrishnan, Vancheswaran, Helmink, Beth A., Spencer, Christine N., Reuben, Alexandre, Wargo, Jennifer A.
Published in Cancer cell (09.04.2018)
Published in Cancer cell (09.04.2018)
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Journal Article
Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration
Johnson, Lincoln V, Forest, David L, Banna, Christopher D, Radeke, Carolyn M, Maloney, Michelle A, Hu, Jane, Spencer, Christine N, Walker, Aimee M, Tsie, Marlene S, Bok, Dean, Radeke, Monte J, Anderson, Don H
Published in Proceedings of the National Academy of Sciences - PNAS (08.11.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (08.11.2011)
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Journal Article
Associations between immune checkpoint inhibitor response, immune-related adverse events, and steroid use in RADIOHEAD: a prospective pan-tumor cohort study
Quandt, Zoe, Lucas, Anastasia, Liang, Samantha I, Yang, EnJun, Stone, Samantha, Fadlullah, Muhammad Zaki Hidayatullah, Bayless, Nicholas L, Marr, Sara Siebel, Thompson, Marshall A, Padron, Lacey J, Bucktrout, Samantha, Butterfield, Lisa H, Tan, Aik Choon, Herold, Kevan C, Bluestone, Jeffrey A, Anderson, Mark S, Spencer, Christine N, Young, Arabella, Connolly, John E
Published in Journal for immunotherapy of cancer (12.05.2025)
Published in Journal for immunotherapy of cancer (12.05.2025)
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Journal Article
B cells and tertiary lymphoid structures promote immunotherapy response
Helmink, Beth A., Reddy, Sangeetha M., Gao, Jianjun, Zhang, Shaojun, Basar, Rafet, Thakur, Rohit, Yizhak, Keren, Sade-Feldman, Moshe, Blando, Jorge, Han, Guangchun, Gopalakrishnan, Vancheswaran, Xi, Yuanxin, Zhao, Hao, Amaria, Rodabe N., Tawbi, Hussein A., Cogdill, Alex P., Liu, Wenbin, LeBleu, Valerie S., Kugeratski, Fernanda G., Patel, Sapna, Davies, Michael A., Hwu, Patrick, Lee, Jeffrey E., Gershenwald, Jeffrey E., Lucci, Anthony, Arora, Reetakshi, Woodman, Scott, Keung, Emily Z., Gaudreau, Pierre-Olivier, Reuben, Alexandre, Spencer, Christine N., Burton, Elizabeth M., Haydu, Lauren E., Lazar, Alexander J., Zapassodi, Roberta, Hudgens, Courtney W., Ledesma, Deborah A., Ong, SuFey, Bailey, Michael, Warren, Sarah, Rao, Disha, Krijgsman, Oscar, Rozeman, Elisa A., Peeper, Daniel, Blank, Christian U., Schumacher, Ton N., Butterfield, Lisa H., Zelazowska, Monika A., McBride, Kevin M., Kalluri, Raghu, Allison, James, Petitprez, Florent, Fridman, Wolf Herman, Sautès-Fridman, Catherine, Hacohen, Nir, Rezvani, Katayoun, Sharma, Padmanee, Tetzlaff, Michael T., Wang, Linghua, Wargo, Jennifer A.
Published in Nature (London) (23.01.2020)
Published in Nature (London) (23.01.2020)
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Journal Article
T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants
Hirschhorn, Daniel, Budhu, Sadna, Kraehenbuehl, Lukas, Gigoux, Mathieu, Schröder, David, Chow, Andrew, Ricca, Jacob M., Gasmi, Billel, De Henau, Olivier, Mangarin, Levi Mark B., Li, Yanyun, Hamadene, Linda, Flamar, Anne-Laure, Choi, Hyejin, Cortez, Czrina A., Liu, Cailian, Holland, Aliya, Schad, Sara, Schulze, Isabell, Betof Warner, Allison, Hollmann, Travis J., Arora, Arshi, Panageas, Katherine S., Rizzuto, Gabrielle A., Duhen, Rebekka, Weinberg, Andrew D., Spencer, Christine N., Ng, David, He, Xue-Yan, Albrengues, Jean, Redmond, David, Egeblad, Mikala, Wolchok, Jedd D., Merghoub, Taha
Published in Cell (30.03.2023)
Published in Cell (30.03.2023)
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Journal Article
Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma
Amaria, Rodabe N, Reddy, Sangeetha M, Tawbi, Hussein A, Davies, Michael A, Ross, Merrick I, Glitza, Isabella C, Cormier, Janice N, Lewis, Carol, Wen-Jen Hwu, Hanna, Ehab, Diab, Adi, Wong, Michael K, Royal, Richard, Gross, Neil, Weber, Randal, Lai, Stephen Y, Ehlers, Richard, Blando, Jorge, Milton, Denái R, Woodman, Scott, Kageyama, Robin, Wells, Daniel K, Hwu, Patrick, Patel, Sapna P, Lucci, Anthony, Hessel, Amy, Lee, Jeffrey E, Gershenwald, Jeffrey, Simpson, Lauren, Burton, Elizabeth M, Posada, Liberty, Haydu, Lauren, Wang, Linghua, Zhang, Shaojun, Lazar, Alexander J, Hudgens, Courtney W, Gopalakrishnan, Vancheswaran, Reuben, Alexandre, Andrews, Miles C, Spencer, Christine N, Prieto, Victor, Sharma, Padmanee, Allison, James, Tetzlaff, Michael T, Wargo, Jennifer A
Published in Nature medicine (01.11.2018)
Published in Nature medicine (01.11.2018)
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Journal Article
Prior anti-CTLA-4 therapy impacts molecular characteristics associated with anti-PD-1 response in advanced melanoma
Campbell, Katie M., Amouzgar, Meelad, Pfeiffer, Shannon M., Howes, Timothy R., Medina, Egmidio, Travers, Michael, Steiner, Gabriela, Weber, Jeffrey S., Wolchok, Jedd D., Larkin, James, Hodi, F. Stephen, Boffo, Silvia, Salvador, Lisa, Tenney, Daniel, Tang, Tracy, Thompson, Marshall A., Spencer, Christine N., Wells, Daniel K., Ribas, Antoni
Published in Cancer cell (10.04.2023)
Published in Cancer cell (10.04.2023)
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Journal Article
Neoadjuvant plus adjuvant dabrafenib and trametinib versus standard of care in patients with high-risk, surgically resectable melanoma: a single-centre, open-label, randomised, phase 2 trial
Amaria, Rodabe N, Prieto, Peter A, Tetzlaff, Michael T, Reuben, Alexandre, Andrews, Miles C, Ross, Merrick I, Glitza, Isabella C, Cormier, Janice, Hwu, Wen-Jen, Tawbi, Hussein A, Patel, Sapna P, Lee, Jeffrey E, Gershenwald, Jeffrey E, Spencer, Christine N, Gopalakrishnan, Vancheswaran, Bassett, Roland, Simpson, Lauren, Mouton, Rosalind, Hudgens, Courtney W, Zhao, Li, Zhu, Haifeng, Cooper, Zachary A, Wani, Khalida, Lazar, Alexander, Hwu, Patrick, Diab, Adi, Wong, Michael K, McQuade, Jennifer L, Royal, Richard, Lucci, Anthony, Burton, Elizabeth M, Reddy, Sangeetha, Sharma, Padmanee, Allison, James, Futreal, Phillip A, Woodman, Scott E, Davies, Michael A, Wargo, Jennifer A
Published in The lancet oncology (01.02.2018)
Published in The lancet oncology (01.02.2018)
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Journal Article
Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade
Chen, Pei-Ling, Roh, Whijae, Reuben, Alexandre, Cooper, Zachary A., Spencer, Christine N., Prieto, Peter A., Miller, John P., Bassett, Roland L., Gopalakrishnan, Vancheswaran, Wani, Khalida, De Macedo, Mariana Petaccia, Austin-Breneman, Jacob L., Jiang, Hong, Chang, Qing, Reddy, Sangeetha M., Chen, Wei-Shen, Tetzlaff, Michael T., Broaddus, Russell J., Davies, Michael A., Gershenwald, Jeffrey E., Haydu, Lauren, Lazar, Alexander J., Patel, Sapna P., Hwu, Patrick, Hwu, Wen-Jen, Diab, Adi, Glitza, Isabella C., Woodman, Scott E., Vence, Luis M., Wistuba, Ignacio I., Amaria, Rodabe N., Kwong, Lawrence N., Prieto, Victor, Davis, R. Eric, Ma, Wencai, Overwijk, Willem W., Sharpe, Arlene H., Hu, Jianhua, Futreal, P. Andrew, Blando, Jorge, Sharma, Padmanee, Allison, James P., Chin, Lynda, Wargo, Jennifer A.
Published in Cancer discovery (01.08.2016)
Published in Cancer discovery (01.08.2016)
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Journal Article
Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity
Glitza, Isabella C., Seo, Yongwoo David, Spencer, Christine N., Wortman, Jennifer R., Burton, Elizabeth M., Alayli, Farah A., Loo, Christopher P., Gautam, Shikha, Damania, Ashish, Densmore, Julie, Fairchild, Justin, Cabanski, Christopher R., Wong, Matthew C., Peterson, Christine B., Weiner, Brian, Hicks, Nathan, Aunins, John, McChalicher, Christopher, Walsh, Emily, Tetzlaff, Michael T., Hamid, Omid, Ott, Patrick A., Boland, Genevieve M., Sullivan, Ryan J., Grossmann, Kenneth F., Ajami, Nadim J., LaVallee, Theresa, Henn, Matthew R., Tawbi, Hussein A., Wargo, Jennifer A.
Published in Cancer discovery (01.07.2024)
Published in Cancer discovery (01.07.2024)
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Journal Article
Circulating KRAS G12D but not G12V is associated with survival in metastatic pancreatic ductal adenocarcinoma
Till, Jacob E., McDaniel, Lee, Chang, Changgee, Long, Qi, Pfeiffer, Shannon M., Lyman, Jaclyn P., Padrón, Lacey J., Maurer, Deena M., Yu, Jia Xin, Spencer, Christine N., Gherardini, Pier Federico, Da Silva, Diane M., LaVallee, Theresa M., Abbott, Charles, Chen, Richard O., Boyle, Sean M., Bhagwat, Neha, Cannas, Samuele, Sagreiya, Hersh, Li, Wenrui, Yee, Stephanie S., Abdalla, Aseel, Wang, Zhuoyang, Yin, Melinda, Ballinger, Dominique, Wissel, Paul, Eads, Jennifer, Karasic, Thomas, Schneider, Charles, O’Dwyer, Peter, Teitelbaum, Ursina, Reiss, Kim A., Rahma, Osama E., Fisher, George A., Ko, Andrew H., Wainberg, Zev A., Wolff, Robert A., O’Reilly, Eileen M., O’Hara, Mark H., Cabanski, Christopher R., Vonderheide, Robert H., Carpenter, Erica L.
Published in Nature communications (09.07.2024)
Published in Nature communications (09.07.2024)
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Journal Article
Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma
Mitra, Akash, Andrews, Miles C., Roh, Whijae, De Macedo, Marianna Petaccia, Hudgens, Courtney W., Carapeto, Fernando, Singh, Shailbala, Reuben, Alexandre, Wang, Feng, Mao, Xizeng, Song, Xingzhi, Wani, Khalida, Tippen, Samantha, Ng, Kwok-Shing, Schalck, Aislyn, Sakellariou-Thompson, Donald A., Chen, Eveline, Reddy, Sangeetha M., Spencer, Christine N., Wiesnoski, Diana, Little, Latasha D., Gumbs, Curtis, Cooper, Zachary A., Burton, Elizabeth M., Hwu, Patrick, Davies, Michael A., Zhang, Jianhua, Bernatchez, Chantale, Navin, Nicholas, Sharma, Padmanee, Allison, James P., Wargo, Jennifer A., Yee, Cassian, Tetzlaff, Michael T., Hwu, Wen-Jen, Lazar, Alexander J., Futreal, P. Andrew
Published in Nature communications (15.04.2020)
Published in Nature communications (15.04.2020)
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Journal Article
Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma
Reuben, Alexandre, Spencer, Christine N., Prieto, Peter A., Gopalakrishnan, Vancheswaran, Reddy, Sangeetha M., Miller, John P., Mao, Xizeng, De Macedo, Mariana Petaccia, Chen, Jiong, Song, Xingzhi, Jiang, Hong, Chen, Pei-Ling, Beird, Hannah C., Garber, Haven R., Roh, Whijae, Wani, Khalida, Chen, Eveline, Haymaker, Cara, Forget, Marie-Andrée, Little, Latasha D., Gumbs, Curtis, Thornton, Rebecca L., Hudgens, Courtney W., Chen, Wei-Shen, Austin-Breneman, Jacob, Sloane, Robert Szczepaniak, Nezi, Luigi, Cogdill, Alexandria P., Bernatchez, Chantale, Roszik, Jason, Hwu, Patrick, Woodman, Scott E., Chin, Lynda, Tawbi, Hussein, Davies, Michael A., Gershenwald, Jeffrey E., Amaria, Rodabe N., Glitza, Isabella C., Diab, Adi, Patel, Sapna P., Hu, Jianhua, Lee, Jeffrey E., Grimm, Elizabeth A., Tetzlaff, Michael T., Lazar, Alexander J., Wistuba, Ignacio I., Clise-Dwyer, Karen, Carter, Brett W., Zhang, Jianhua, Futreal, P. Andrew, Sharma, Padmanee, Allison, James P., Cooper, Zachary A., Wargo, Jennifer A.
Published in Npj genomic medicine (07.04.2017)
Published in Npj genomic medicine (07.04.2017)
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Journal Article
Parallel profiling of immune infiltrate subsets in uveal melanoma versus cutaneous melanoma unveils similarities and differences: A pilot study
Qin, Yong, Petaccia de Macedo, Mariana, Reuben, Alexandre, Forget, Marie-Andrée, Haymaker, Cara, Bernatchez, Chantale, Spencer, Christine N., Gopalakrishnan, Vancheswaran, Reddy, Sujan, Cooper, Zachary A., Fulbright, Orenthial J., Ramachandran, Renjith, Wahl, Arely, Flores, Esteban, Thorsen, Shawne T., Tavera, Rene J., Conrad, Claudius, Williams, Michelle D., Tetzlaff, Michael T., Wang, Wei-Lien, Gombos, Dan S., Esmaeli, Bita, Amaria, Rodabe N., Hwu, Patrick, Wargo, Jennifer A., Lazar, Alexander J., Patel, Sapna P.
Published in Oncoimmunology (03.06.2017)
Published in Oncoimmunology (03.06.2017)
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Journal Article
Distinct clinical patterns and immune infiltrates are observed at time of progression on targeted therapy versus immune checkpoint blockade for melanoma
Cooper, Zachary A., Reuben, Alexandre, Spencer, Christine N., Prieto, Peter A., Austin-Breneman, Jacob L., Jiang, Hong, Haymaker, Cara, Gopalakrishnan, Vancheswaran, Tetzlaff, Michael T., Frederick, Dennie T., Sullivan, Ryan J., Amaria, Rodabe N., Patel, Sapna P., Hwu, Patrick, Woodman, Scott E., Glitza, Isabella C., Diab, Adi, Vence, Luis M., Rodriguez-Canales, Jaime, Parra, Edwin R., Wistuba, Ignacio I., Coussens, Lisa M., Sharpe, Arlene H., Flaherty, Keith T., Gershenwald, Jeffrey E., Chin, Lynda, Davies, Michael A., Clise-Dwyer, Karen, Allison, James P., Sharma, Padmanee, Wargo, Jennifer A.
Published in Oncoimmunology (03.03.2016)
Published in Oncoimmunology (03.03.2016)
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Journal Article
Author Correction: Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma
Amaria, Rodabe N, Reddy, Sangeetha M, Tawbi, Hussein A, Davies, Michael A, Ross, Merrick I, Glitza, Isabella C, Cormier, Janice N, Lewis, Carol, Wen-Jen Hwu, Hanna, Ehab, Diab, Adi, Wong, Michael K, Royal, Richard, Gross, Neil, Weber, Randal, Lai, Stephen Y, Ehlers, Richard, Blando, Jorge, Milton, Denái R, Woodman, Scott, Kageyama, Robin, Wells, Daniel K, Hwu, Patrick, Patel, Sapna P, Lucci, Anthony, Hessel, Amy, Lee, Jeffrey E, Gershenwald, Jeffrey, Simpson, Lauren, Burton, Elizabeth M, Posada, Liberty, Haydu, Lauren, Wang, Linghua, Zhang, Shaojun, Lazar, Alexander J, Hudgens, Courtney W, Gopalakrishnan, Vancheswaran, Reuben, Alexandre, Andrews, Miles C, Spencer, Christine N, Prieto, Victor, Sharma, Padmanee, Allison, James, Tetzlaff, Michael T, Wargo, Jennifer A
Published in Nature medicine (01.12.2018)
Published in Nature medicine (01.12.2018)
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Journal Article
Publisher Correction: Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma
Amaria, Rodabe N, Reddy, Sangeetha M, Tawbi, Hussein A, Davies, Michael A, Ross, Merrick I, Glitza, Isabella C, Cormier, Janice N, Lewis, Carol, Wen-Jen Hwu, Hanna, Ehab, Diab, Adi, Wong, Michael K, Royal, Richard, Gross, Neil, Weber, Randal, Lai, Stephen Y, Ehlers, Richard, Blando, Jorge, Milton, Denái R, Woodman, Scott, Kageyama, Robin, Wells, Daniel K, Hwu, Patrick, Patel, Sapna P, Lucci, Anthony, Hessel, Amy, Lee, Jeffrey E, Gershenwald, Jeffrey, Simpson, Lauren, Burton, Elizabeth M, Posada, Liberty, Haydu, Lauren, Wang, Linghua, Zhang, Shaojun, Lazar, Alexander J, Hudgens, Courtney W, Gopalakrishnan, Vancheswaran, Reuben, Alexandre, Andrews, Miles C, Spencer, Christine N, Prieto, Victor, Sharma, Padmanee, Allison, James, Tetzlaff, Michael T, Wargo, Jennifer A
Published in Nature medicine (01.12.2018)
Published in Nature medicine (01.12.2018)
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Journal Article
878 T cell immunotherapies recruit and activate neutrophils to eliminate tumor antigen escape variants
Hirschhorn, Daniel, Budhu, Sadna, Kraehenbuehl, Lukas, Gigoux, Mathieu, Schröder, David, Chow, Andrew, Ricca, Jacob M, Gasmi, Billel, De Henau, Olivier, Mangarin, Levi Mark B, Li, Yanyun, Flamar, Anne-Laure, Choi, Heyjin, Cortez, Czrina A, Liu, Cailian, Holland, Aliya, Schad, Sara, Schulze, Isabell, Hamadene, Linda, Warner, Allison Betof, Hollmann, Travis, Arora, Arshi, Panageas, Katherine S, Duhen, Rebekka, Weinberg, Andrew D, Rizzuto, Gabrielle A, Spencer, Christine N, Ng, David, He, Xue-Yan, Albrengues, Jean, Redmond, David, Egeblad, Mikala, Wolchok, Jedd D, Merghoub, Taha
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Abstract 2392: Genomic and immune heterogeneity in synchronous melanoma metastases is associated with differential tumor growth and response to therapy
Reuben, Alexandre, Spencer, Christine N., Prieto, Peter A., Miller, John P., Mao, Xizeng, Chen, Wei-Shen, Cheung, Hannah, Jiang, Hong, Haymaker, Cara, Petaccia De Macedo, Mariana, Garber, Haven R., Chen, Pei-Ling, Gopalakrishnan, Vancheswaran, Austin-Breneman, Jacob, Hudgens, Courtney W., Roszik, Jason, Hwu, Patrick, Woodman, Scott E., Chin, Lynda, Davies, Michael A., Amaria, Rodabe N., Patel, Sapna P., Lazar, Alexander J., Tetzlaff, Michael T., Dwyer, Karen C., Wistuba, Ignacio I., Sharma, Padmanee, Allison, James P., Zhang, Jianhua, Futreal, Andrew, Cooper, Zachary A., Wargo, Jennifer A.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article