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Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
Grembecka, Jolanta, He, Shihan, Shi, Aibin, Purohit, Trupta, Muntean, Andrew G, Sorenson, Roderick J, Showalter, Hollis D, Murai, Marcelo J, Belcher, Amalia M, Hartley, Thomas, Hess, Jay L, Cierpicki, Tomasz
Published in Nature chemical biology (29.01.2012)
Published in Nature chemical biology (29.01.2012)
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Journal Article
Novel Inhibitors of Staphylococcus aureus Virulence Gene Expression and Biofilm Formation
Ma, Yibao, Xu, Yuanxi, Yestrepsky, Bryan D., Sorenson, Roderick J., Chen, Meng, Larsen, Scott D., Sun, Hongmin
Published in PloS one (15.10.2012)
Published in PloS one (15.10.2012)
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Journal Article
Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors
Pfefferkorn, Jeffrey A., Song, Yuntao, Sun, Kuai-Lin, Miller, Steven R., Trivedi, Bharat K., Choi, Chulho, Sorenson, Roderick J., Bratton, Larry D., Unangst, Paul C., Larsen, Scott D., Poel, Toni-Jo, Cheng, Xue-Min, Lee, Chitase, Erasga, Noe, Auerbach, Bruce, Askew, Valerie, Dillon, Lisa, Hanselman, Jeffrey C., Lin, Zhiwu, Lu, Gina, Robertson, Andrew, Olsen, Karl, Mertz, Thomas, Sekerke, Catherine, Pavlovsky, Alexander, Harris, Melissa S., Bainbridge, Graeme, Caspers, Nicole, Chen, Huifen, Eberstadt, Matthias
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
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Journal Article
Direct and Systemic Administration of a CNS-Permeant Tamoxifen Analog Reduces Amphetamine-Induced Dopamine Release and Reinforcing Effects
Carpenter, Colleen, Zestos, Alexander G, Altshuler, Rachel, Sorenson, Roderick J, Guptaroy, Bipasha, Showalter, Hollis D, Kennedy, Robert T, Jutkiewicz, Emily, Gnegy, Margaret E
Published in Neuropsychopharmacology (New York, N.Y.) (01.09.2017)
Published in Neuropsychopharmacology (New York, N.Y.) (01.09.2017)
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Journal Article
Design and synthesis of triarylacrylonitrile analogues of tamoxifen with improved binding selectivity to protein kinase C
Carpenter, Colleen, Sorenson, Roderick J., Jin, Yafei, Klossowski, Szymon, Cierpicki, Tomasz, Gnegy, Margaret, Showalter, Hollis D.
Published in Bioorganic & medicinal chemistry (01.11.2016)
Published in Bioorganic & medicinal chemistry (01.11.2016)
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Journal Article
Pharmacokinetic optimitzation of CCG-203971: Novel inhibitors of the Rho/MRTF/SRF transcriptional pathway as potential antifibrotic therapeutics for systemic scleroderma
Hutchings, Kim M., Lisabeth, Erika M., Rajeswaran, Walajapet, Wilson, Michael W., Sorenson, Roderick J., Campbell, Phillip L., Ruth, Jeffrey H., Amin, Asif, Tsou, Pei-Suen, Leipprandt, Jeffrey R., Olson, Samuel R., Wen, Bo, Zhao, Ting, Sun, Duxin, Khanna, Dinesh, Fox, David A., Neubig, Richard R., Larsen, Scott D.
Published in Bioorganic & medicinal chemistry letters (15.04.2017)
Published in Bioorganic & medicinal chemistry letters (15.04.2017)
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Journal Article
Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Substituted Di-tert-butylphenols as a Novel Class of Potent, Selective, and Orally Active Cyclooxygenase-2 Inhibitors. 1. Thiazolone and Oxazolone Series
Song, Yuntao, Connor, David T, Doubleday, Robert, Sorenson, Roderick J, Sercel, Anthony D, Unangst, Paul C, Roth, Bruce D, Gilbertsen, Richard B, Chan, Kam, Schrier, Denis J, Guglietta, Antonio, Bornemeier, Dirk A, Dyer, Richard D
Published in Journal of medicinal chemistry (08.04.1999)
Published in Journal of medicinal chemistry (08.04.1999)
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Journal Article
A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination
Kapuria, Vaibhav, Levitzki, Alexander, Bornmann, William G., Maxwell, David, Priebe, Waldemar, Sorenson, Roderick J., Showalter, Hollis D., Talpaz, Moshe, Donato, Nicholas J.
Published in Cellular signalling (01.12.2011)
Published in Cellular signalling (01.12.2011)
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Journal Article
Novel inhibitors of bacterial virulence: Development of 5,6-dihydrobenzo[h]quinazolin-4(3H)-ones for the inhibition of group A streptococcal streptokinase expression
Yestrepsky, Bryan D., Xu, Yuanxi, Breen, Meghan E., Li, Xiaoqin, Rajeswaran, Walajapet G., Ryu, Jenny G., Sorenson, Roderick J., Tsume, Yasuhiro, Wilson, Michael W., Zhang, Wenpeng, Sun, Duxin, Sun, Hongmin, Larsen, Scott D.
Published in Bioorganic & medicinal chemistry (01.04.2013)
Published in Bioorganic & medicinal chemistry (01.04.2013)
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Journal Article
Enediol mimics as inhibitors of the d-arabinose 5-phosphate isomerase (KdsD) from Francisella tularensis
Yep, Alejandra, Sorenson, Roderick J., Wilson, Michael R., Hollis Showalter, H.D., Larsen, Scott D., Keller, Paul R., Woodard, Ronald W.
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
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Journal Article
Inhibition of E-Selectin-, ICAM-1-, and VCAM-1-Mediated Cell Adhesion by Benzo[b]thiophene-, Benzofuran-, Indole-, and Naphthalene-2-carboxamides: Identification of PD 144795 as an Antiinflammatory Agent
Boschelli, Diane H, Kramer, James B, Khatana, Sonya S, Sorenson, Roderick J, Connor, David T, Ferin, Mark A, Wright, Clifford D, Lesch, Mark E, Imre, Kathleen
Published in Journal of medicinal chemistry (01.10.1995)
Published in Journal of medicinal chemistry (01.10.1995)
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Journal Article
Synthesis and SAR of selective benzothiophene, benzofuran, and indole-based peroxisome proliferator-activated receptor δ agonists
Filzen, Gary F., Bratton, Larry, Cheng, Xue-Min, Erasga, Noe, Geyer, Andrew, Lee, Chitase, Lu, Gina, Pulaski, Jim, Sorenson, Roderick J., Unangst, Paul C., Trivedi, B.K., Xu, Xiangyang
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
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Journal Article
Novel benzothiophene-, benzofuran-, and naphthalenecarboxamidotetrazoles as potential antiallergy agents
Connor, David T, Cetenko, Wiaczeslaw A, Mullican, Michael D, Sorenson, Roderick J, Unangst, Paul C, Weikert, Robert J, Adolphson, Richard L, Kennedy, John A, Thueson, David O
Published in Journal of medicinal chemistry (01.03.1992)
Published in Journal of medicinal chemistry (01.03.1992)
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Journal Article
Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Substituted Di-tert-butylphenols as a Novel Class of Potent, Selective, and Orally Active Cyclooxygenase-2 Inhibitors. 2. 1,3,4- and 1,2,4-Thiadiazole Series
Song, Yuntao, Connor, David T, Sercel, Anthony D, Sorenson, Roderick J, Doubleday, Robert, Unangst, Paul C, Roth, Bruce D, Beylin, Vlad G, Gilbertsen, Richard B, Chan, Kam, Schrier, Denis J, Guglietta, Antonio, Bornemeier, Dirk A, Dyer, Richard D
Published in Journal of medicinal chemistry (08.04.1999)
Published in Journal of medicinal chemistry (08.04.1999)
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Journal Article
Pyrazole inhibitors of HMG-CoA reductase: An attempt to dramatically reduce synthetic complexity through minimal analog re-design
Larsen, Scott D., Poel, Toni-Jo, Filipski, Kevin J., Kohrt, Jeffrey T., Pfefferkorn, Jeffrey A., Sorenson, Roderick J., Tait, Bradley D., Askew, Valerie, Dillon, Lisa, Hanselman, Jeffrey C., Lu, Gina H., Robertson, Andrew, Sekerke, Catherine, Kowala, Mark C., Auerbach, Bruce J.
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
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Journal Article
Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity
Unangst, Paul C, Connor, David T, Cetenko, Wiaczeslaw A, Sorenson, Roderick J, Kostlan, Catherine R, Sircar, Jagadish C, Wright, Clifford D, Schrier, Denis J, Dyer, Richard D
Published in Journal of medicinal chemistry (01.01.1994)
Published in Journal of medicinal chemistry (01.01.1994)
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Journal Article
Kynurenic Acid Derivatives Inhibit the Binding of Nerve Growth Factor (NGF) to the Low-Affinity p75 NGF Receptor
Jaen, Juan C, Laborde, Edgardo, Bucsh, Ruth A, Caprathe, Bradley W, Sorenson, Roderick J, Fergus, James, Spiegel, Katharyn, Marks, James, Dickerson, Melvin R, Davis, Robert E
Published in Journal of medicinal chemistry (01.10.1995)
Published in Journal of medicinal chemistry (01.10.1995)
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